Clinical trials: Chronic Post-operative Pain
Pain, Postoperative, Pain, Acute
Opioid Sparing Anesthesia in Lumbar Spine Surgery
The aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus remifentanil analgesia in lumbar…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Nociceptive
- Trial name
- NCT05594407
- Testing
- dexmedetomidine-ketamine-lidocaine, Remifentanil
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aretaieion University Hospital
Chronic Pain, Opioid Use
Reducing Opioid Use for Chronic Pain Patients Following Surgery
Patients with chronic pain are often prescribed long-term opioid therapy, despite the serious risks and growing concerns related to opioid use.
- Conditions
- Chronic Pain, Opioid Use, Postoperative Pain, Opioid Dependence
- Trial name
- RECOUP (NCT03675386)
- Testing
- Interventional Group, Control Intervention
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- University Health Network, Toronto
Phantom Limb Pain
Electrical Stimulus Therapy for Chronic Phantom Limb Pain
The goal of this pilot study is to assess the effectiveness of an electrical stimulation therapy option for the treatment of chronic phantom limb pain in upper or lower limb amputees.
- Trial name
- NCT03030079
- Testing
- Experimental Electrical Stimulation Regimen
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hip Osteoarthritis, Hip Arthropathy
PENG Block for Total Hip Arthroplasty
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the pericapsular nerve group block on postoperative rehabilitation.
- Conditions
- Hip Osteoarthritis, Hip Arthropathy, Hip Disease, Hip Pain Chronic
- Trial name
- NCT05944380
- Testing
- Ropivacaine 0.5% Injectable Solution, 0,9% normal saline
- Where
- Poland
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Failed Back Surgery Syndrome
Efficacy Study of the Octapolar Lead in Patients With Failed Back Surgery Syndrome (FBSS) With Chronic Pain
Spinal cord stimulation (SCS) has been used for over 40 years to treat neuropathic pain. Various clinical studies have shown a beneficial effect of SCS on pain in patients with Failed Back Surgery Syndrome (FBSS).
- Trial name
- NCT01096147
- Testing
- Spinal cord stimulation with eight polar electrode
- Where
- 8 sites in Belgium, Norway and 1 more
- Volunteers
- 80 people
- Sponsor
- Rik Buschman, PhD
Low Back Pain, Opiate Addiction
Study of Opioid Use After Lumbar and Cervical Spine Surgery
The purpose of this project is to assess the impact of an educational video on the use of prescription opioid medication during a 6-month period following spine surgery.
- Conditions
- Low Back Pain, Opiate Addiction, Neck Pain
- Trial name
- SOULCS (NCT02674711)
- Testing
- Educational Video
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brooke Army Medical Center
Spinal Fusion, Radiculopathy Lumbar
SynerFuse Spinal Fusion and Neuromodulation Proof of Concept Study
The purpose of the study is to evaluate the safety and tolerability of DRG stimulation when placing a neurostimulator during the same procedure as implantation of spinal fixation with or without interbody cage systems in patients…
- Conditions
- Spinal Fusion, Radiculopathy Lumbar, Chronic Pain
- Trial name
- NCT04054401
- Testing
- DRG Neurostimulation with Spinal Fusion
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- SynerFuse, Inc
Pain
From ACute To Chronic Postoperative Pain in Patients for Elective Cholecystectomy
Chronic Pain is a wellknown complication after cholecystectomy. Intensity of the pain in the first week after the operation is a predictive factor for the development of chronic pain, but it is unknown whether the risk is more…
- Trial name
- FACTS1 (NCT01553253)
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Surgery, Pain
Peri-operative Psychology and Post-operative Pain Study
The experience of pain is common among hospital inpatients. Orthopaedic surgery often results in significant pain, which may last for some time.
- Conditions
- Surgery, Pain, Anxiety, Depression
- Trial name
- 4P (NCT02004431)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University Hospital Plymouth NHS Trust
Chronic Postoperative Pain
Persistent Postoperative Pain After Major Emergency Abdominal Surgery
Perioperative pain is one of the most significant complaints and problems for patients undergoing major open surgery. Pain after surgery carry an abundance of consequences such as reduced mobilization, reduced nutrition intake…
- Trial name
- NCT04508465
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Zealand University Hospital
Chronic Post-surgical Pain
Duloxetine to Prevent Chronic Postsurgical Pain After Inguinal Hernia Repair in Patients at High Risk
The clinical trial will be conducted in 14 Spanish hospitals. It is estimated, based on our previous studies, that 2855 patients scheduled for elective inguinal hernia surgery will have to be assessed to detect patients with ≥…
- Trial name
- GENDOLCAT3 (NCT06606067)
- Testing
- Duloxetine
- Where
- Spain
- Volunteers
- 294 people
- Sponsor
- Parc de Salut Mar
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Chronic Pain, Low Back Pain
Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain
The purpose of this study is to investigate, in two phases: (1) the feasibility and safety of Virtual Embodiment Therapy in treating chronic pain of lower back and upper limbs and (2) the efficacy of Virtual Embodiment Therapy on…
- Conditions
- Chronic Pain, Low Back Pain, Fibromyalgia, Upper Extremity Dysfunction
- Trial name
- NCT04060875
- Testing
- Karuna Labs Virtual Reality Software
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karuna Labs Inc.
Addiction Opiate, Chronic Pain
Suboxone User Perioperative Early Referral and Enhanced Recovery After Surgery- Orthopaedic Trauma Surgery Population
This is a randomized controlled trial. Patients will be randomly assigned to either the control or treatment group, with equal allocation using block randomization.
- Conditions
- Addiction Opiate, Chronic Pain, Fractures, Bone, Buprenorphine Dependence
- Trial name
- SUPER-ERAS (NCT04464512)
- Testing
- Sufentanil
- Where
- United States
- Sponsor
- West Virginia University
Pain, Postoperative, Hip Pain Chronic
PENG Block Versus LP Block for THA Postop Pain
The purpose of this randomized, double blinded, prospective study is to compare the postoperative analgesia provided by the PENG block to that provided by the LPB for patients undergoing primary anterior approach THA.
- Trial name
- NCT05261009
- Testing
- Peri-capsular Nerve Group (PENG), Lumbar Plexus Block (LPB)
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Wake Forest University Health Sciences
Children, Postoperative Pain
Acupuncture for Tonsillectomy Pain
Pain after tonsillectomy can be severe and last ten days. Various new surgical instruments have been developed over the years in an attempt to reduce postoperative pain with mixed results and increased costs; no single…
- Conditions
- Children, Postoperative Pain, Tonsillar Hypertrophy, Obstructive Sleep Apnea
- Trial name
- NCT01389349
- Testing
- Acupuncture
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Children's ENT of San Diego, Inc.
Chronic Postoperative Pain
Validation of Predictive Scale of Chronic Postsurgical Pain
To asses the precision of a score to predict chronic post surgical pain in patients undergoing inguinal hernia repair, abdominal hysterectomy, vaginal hysterectomy and thoracotomy.
- Trial name
- NCT02991287
- Testing
- Inguinal hernia repair, Abdominal hysterectomy, Vaginal hysterectomy
- Where
- 21 sites in Spain
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Scoliosis Correction, Postoperative Analgesia
Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes
Chronic postsurgical pain (CPSP) refers to pain that occurs or increases after surgery and lasts longer than 3 months. Severe postoperative acute pain is one of the major risk factors of CPSP.
- Conditions
- Scoliosis Correction, Postoperative Analgesia, Esketamine, Dexmedetomidine
- Trial name
- NCT05718544
- Testing
- Esketamine, Dexmedetomidine, Sufentanil
- Where
- China
- Volunteers
- 199 people
- Sponsor
- Peking University First Hospital
Pain, Postoperative, Scoliosis Idiopathic
Gabapentin and Chronic Post Surgical Pain
The purpose of this study is to investigate the effect of a common pain medication (gabapentin) on chronic postsurgical pain in pediatric patients who require surgery for idiopathic scoliosis.
- Trial name
- CPSP (NCT03867240)
- Testing
- Gabapentin
- Where
- United States
- Sponsor
- Emory University
Chronic Postoperative Pain
Low Dose Peri-operative IV Ketamine for Chronic Post-surgery Pain Prevention
This study will test the null hypothesis that low-dose ketamine given peri-operatively will have no effect on the development of chronic post-surgical pain, in patients undergoing thoracotomy or video assisted thoracic surgery…
- Trial name
- NCT01296347
- Testing
- Ketamine
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- Imperial College Healthcare NHS Trust