Clinical trials: Chronic Post-operative Pain
Neuropathic Pain, Postherpetic Neuralgia
Simultaneous Engagement of Networks for Alleviating Pain (SENAP)
This trial is investigating the acceptability and efficacy of PFM-guided cortical stimulation for the treatment of central neuropathic pain.
- Trial name
- NCT07057206
- Testing
- PFM-guided cortical stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Mastectomy, Rhomboid Intercostal Block
Effects of Rhomboid Intercostal Block on Postoperative Pain Management and Chronic Pain Incidence in Mastectomies
The goal of this clinical trial is to evaluate the effects of the Rhomboid Intercostal Block (RIB) on postoperative chronic pain prevalence at 3 months (primary outcome) and on acute pain control, total opioid consumption, and…
- Conditions
- Mastectomy, Rhomboid Intercostal Block, Chronic Pain Following Surgical Procedure for Cancer
- Trial name
- NCT06756048
- Testing
- Rhomboid Intercostal Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Koç University
Scar, Cesarean Section; Dehiscence
A Comparison of Scar Infiltration, Scar Deactivation, and Standard of Care for the Treatment of Chronic, Post-Surgical Pain After Cesarean Section
To compare scar infiltration with 0.5-1% Lidocaine at a dose of 3 mg/kg (max dose 300 mg) or scar deactivation with acupuncture surface release technique to determine which is more effective in reducing pain in adult patients…
- Trial name
- NCT03936309
- Testing
- Scar Deactivation Surface Release Technique protocol, Scar Infiltration with 0.25-1% Lidocaine, Physical therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Jennifer Loomis
Chronic Rhinosinusitis (CRS), Emergence Agitation
Trans-nasal Sphenopalatine Ganglion Block for Prevention of Emergence Agitation Following Functional Endoscopic Sinus Surgery
This randomized double-blind controlled trial aims to evaluate whether bilateral trans-nasal sphenopalatine ganglion block (SPGB) using bupivacaine reduces the incidence of emergence agitation following Functional Endoscopic…
- Trial name
- SPGB-EA (NCT07645521)
- Testing
- Bilateral Trans-nasal Sphenopalatine Ganglion Block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Hypertension
Postoperative Pain and Angiotensin II Receptor Antagonists
An angiotensin II type 2 receptor (AT2R) antagonist has been assessed for its efficacy in neuropathic pain with promising results.
- Trial name
- PP&ARA (NCT02513979)
- Testing
- Angiotensin type II receptor antagonists
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- University of Athens
Surgery
Collecting Outcomes and Managing Pain After Surgery
The primary aim of this study is to measure pain and psychosocial patient reported outcomes, objective functionality, and actual daily at home opioid usage in orthopedic patients.
- Trial name
- COMPAS (NCT03834818)
- Testing
- COMPAS Participants
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Duke University
Chronic Postoperative Pain, Cardiac Surgery
Cardiac Surgery, the Incidence and Impact of Chronic postOperative Pain: a Survey
This survey study aims to investigate the incidence of Chronic post surgical pain (CPSP) in cardiac surgery patients treated at UZ Leuven.
- Trial name
- Cardiac COPS (NCT07640646)
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Pain Due to Injury, Neuroma of Lower Limb
Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation
Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life.
- Conditions
- Chronic Pain Due to Injury, Neuroma of Lower Limb, Neural Injury, Neuroma of Upper Limb
- Trial name
- NEUROQUIET (NCT07626983)
- Testing
- Botulinum Toxin Type A (BoNT-A), Local Anesthetic Solution
- Where
- 2 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Postoperative Pain, Video-Assisted Thoracoscopic Surgery
US-Guided SAPB Versus ESPB on Acute and Chronic Pain After VATS
Postoperative acute and chronic pain is frequently observed in patients undergoing video assisted thoracoscopic surgery (VATS). This prolongs the discharge time of patients and increases the frequency of postoperative pulmonary…
- Conditions
- Postoperative Pain, Video-Assisted Thoracoscopic Surgery, Serratus Anterior Plane Block, Erector Spinae Plane Block
- Trial name
- NCT05160961
- Testing
- Serratus anterior plane block, Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Chronic Pain, Sciatica
NAPS: Non-awake Versus Awake Placement of Spinal Cord Stimulators
The primary objective is to demonstrate the safety and efficacy of a non-awake implantation method (EMG neuromonitoring) of a SCS paddle lead as compared to an awake implantation method (with local anesthesia and patient…
- Conditions
- Chronic Pain, Sciatica, Failed Back Surgery Syndrome
- Trial name
- NAPS (NCT02284542)
- Testing
- Awake, Non-Awake
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- St. Luke's Hospital, Pennsylvania
Cardiac Surgery, Chronic Postsurgical Pain
SPIP vs ESP Block in Cardiac Surgery
This multicentre, randomized, assessor-blinded, non-inferiority trial will compare the analgesic efficacy of bilateral superficial parasternal intercostal plane (SPIP) block with bilateral erector spinae plane (ESP) block in…
- Conditions
- Cardiac Surgery, Chronic Postsurgical Pain, Postoperative Pain
- Trial name
- SPARE (NCT07780773)
- Testing
- Bilateral Superficial Parasternal Intercostal Plane Block, Bilateral Erector Spinae Plane Block, morphine PCA
- Where
- Turkey (Türkiye)
- Volunteers
- 308 people
- Sponsor
- Ondokuz Mayıs University
Breast Cancer, Chronic Pain
Can Chronic Post-surgical Pain be Reduced by Preserving Intercostobrachial Nerve During Axillary Lymph Node Dissection? : A Randomized Controlled Trial
Intercostobrachial nerve (ICBN) is a cutaneous nerve that provides sensation to the lateral chest, upper medial arm and axilla. It arises from the second intercostal nerve and leave intercostal space at the level of midaxillary…
- Conditions
- Breast Cancer, Chronic Pain, Intercostobrachial Nerve Injury
- Trial name
- PAINE (NCT05198622)
- Testing
- Intercostobrachial Nerve Preserving Axillary Lymph Node Dissection, Intercostobrachial Nerve Sacrificing Axillary Lymph Node Dissection
- Where
- Pakistan
- Volunteers
- 182 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Chronic Anal Fissure, Hemorrhoidal Disease
Female Sexual Function After Surgery for Benign Perianal Diseases
Benign perianal diseases such as chronic anal fissure, hemorrhoidal disease, and cryptoglandular anal fistula may negatively affect female sexual function through pain, bleeding, discharge, discomfort, and impairment in quality…
- Conditions
- Chronic Anal Fissure, Hemorrhoidal Disease, Cryptoglandular Anal Fistula
- Trial name
- PERISEX (NCT07666035)
- Testing
- Surgical Treatment for Benign Perianal Diseases
- Volunteers
- 120 people
- Sponsor
- Gazi University
Persistent Postsurgical Pain
Risk Factors and Mechanisms for Persistent Postsurgical Pain After Total Knee Replacement
Osteoarthritis (OA) is the single most common cause of disability in mid and late life. About 27 million people in the United States suffer from this incurable process and 10 million have OA of the knee.
- Trial name
- PPP-TKA (NCT01320150)
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- Rush University Medical Center
Revision Spine Surgery, Fusion of Spine
Pre-Operative Ketamine Infusion for Post Operative Pain Control After Revision Spinal Surgery
To determine if a pre-operative ketamine infusion would provide a similar decrease in post-operative analgesic and opioid consumption as intra-operative ketamine, but expand the monitoring period through the post-operative phase…
- Conditions
- Revision Spine Surgery, Fusion of Spine, Cervical Fusion, Lumbar Fusion
- Trial name
- KIPSs (NCT06066879)
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- AXIS Spine Center- a division of Northwest Specialty Hospital
Acute Pain, Chronic Post Operative Pain
Understanding the Acute Pain Phenotype in Patients Undergoing Surgery
The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and…
- Conditions
- Acute Pain, Chronic Post Operative Pain, Opioid Use
- Trial name
- NCT06466941
- Testing
- regional anesthesia, no regional anesthesia, acute pain consultation
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Brigham and Women's Hospital
Pain
From Acute to Chronic Postoperative Pain in Patients for Elective Cholecystectomy. Immunological Tests
Chronic Pain after Cholecystectomy is a well known problem. One theory is that it is due to persisting inflammation. The purpose of the study is to measure inflammatory factors in cerebrospinal fluid and blod at patients 12…
- Trial name
- NCT01546480
- Where
- 2 sites in Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Chronic Low Back Pain, After Lumbar Spine Surgery
Efficacy of Cognitive Functional Therapy in Individuals With Chronic Low Back Pain After Spinal Surgery
Chronic low back pain after spinal surgery is a complex and disabling condition influenced by biopsychosocial factors. Cognitive Functional Therapy (CFT) is a promising intervention targeting these multidimensional aspects.
- Conditions
- Chronic Low Back Pain, After Lumbar Spine Surgery, Failed Back Surgery Syndrome (FBSS)
- Trial name
- NCT07576062
- Testing
- CFT
- Volunteers
- 90 people
- Sponsor
- Centro Universitário Augusto Motta
Pain, Chronic Pain
Efficacy and Tolerability of Lidocaine Plaster for Treatment of Long-term Local Nerve Pain
The purpose of this trial is to investigate the efficacy and safety of lidocaine 5% medicated plaster in localized chronic post-operative neuropathic pain in comparison to placebo plaster.
- Conditions
- Pain, Chronic Pain, Neuropathic Pain, Postoperative Pain
- Trial name
- NCT01752322
- Testing
- Lidocaine 5% medicated plaster
- Where
- 42 sites in Austria, Belgium and 6 more
- Volunteers
- 444 people
- Sponsor
- Grünenthal GmbH
Inguinal Hernia, Inguinal Hernia Repair
Comparative Study of Inguinodynia After Inguinal Hernia Repair
To evaluate the postoperative pain and the relapse after the repair of the inguinal hernia by Lichtenstein technique with four different mesh types with different types of fixation in patients undergoing major ambulatory surgery.
- Conditions
- Inguinal Hernia, Inguinal Hernia Repair, Open Inguinal Hernia
- Trial name
- NCT03678272
- Testing
- HERNIOPLASTY WITH PANAVALE MESH, HERNIOPLASTY WITH PARIETEX PROGRIP MESH, HERNIOPLASTY WITH ADHESIX MESH
- Volunteers
- 270 people
- Sponsor
- Hospital General Universitario Elche