Clinical trials: Chronic Posttraumatic Stress Disorder
Stress Disorders, Post-Traumatic
Intensive Treatment for Chronic Pain and Posttraumatic Stress Disorder (PTSD)
This study is investigating the efficacy of an intensive (3 week) integrated treatment for Veterans with both pain and PTSD.
- Trial name
- NCT01120067
- Testing
- Intensive Treatment, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Headache, Combat Disorders
Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
The purpose of this study is to determine if prazosin is more effective than placebo in decreasing frequency, severity, disability, and other negative effects of headaches related to mild traumatic brain injury in Service Members…
- Conditions
- Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache
- Trial name
- NCT02266329
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- VA Office of Research and Development
Chronic Posttraumatic Stress Disorder
Enhancing Extinction Learning in Post Traumatic Stress Disorder (PTSD)
Posttraumatic stress disorder (PTSD) is a condition that involves intense memories of a traumatic event and intense, persistent feelings of anxiety.
- Trial name
- HELP (NCT01188694)
- Testing
- Psychotherapy plus Methylene Blue, USP, Delayed Psychotherapy
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of Washington
Chronic Pain, Traumatic Brain Injury
Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans
This is a research study of an interdisciplinary pain management program for U.S. military veterans who served during the post-9/11 combat eras (e.g., Operations Iraqi Freedom [OIF], Enduring Freedom [OEF], New Dawn [OND])…
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression
- Trial name
- NCT02657317
- Testing
- FORT-A, VA Treatment as Usual
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder (PTSD)
Randomized, Double-blind, Placebo-Controlled Pilot Study of MDMA-assisted Therapy for PTSD
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective in people with chronic, treatment-resistant PTSD.
- Trial name
- NCT01689740
- Testing
- Full Dose MDMA-assisted therapy (125 mg), Open-Label Full Dose MDMA-assisted therapy (125 mg), Psychotherapy
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Resilient Pharmaceuticals
Posttraumatic Stress Disorder
Pilot Study of the Safety and Efficacy of Four Different Potencies of Smoked Marijuana in 76 Veterans With PTSD
This pilot study gathered preliminary evidence of the safety and efficacy of four potencies of smoked cannabis to manage chronic, treatment-resistant PTSD among veterans: (1) High THC/ Low CBD (High THC), (2) Low THC/High CBD…
- Trial name
- NCT02759185
- Testing
- High THC cannabis, High CBD cannabis, THC/CBD cannabis
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Multidisciplinary Association for Psychedelic Studies
Chronic Pain, Traumatic Brain Injury
Neuromodulatory Treatments for Pain Management in TBI
Traumatic brain injury (TBI) and chronic pain are common and serious health problems for military veterans and often co-occur, leading to poor post-deployment adjustment.
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder
- Trial name
- NCT03418129
- Testing
- Mindfulness, Neurofeedback, Relaxation
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Duke University
Combat Disorders, Post-traumatic Stress Disorder
Treatment of Older Veterans With Chronic Posttraumatic Stress Disorder
This project represents the first randomized clinical trial of psychotherapy for older veterans with posttraumatic stress disorder (PTSD). It will compare relaxation training (RT) to prolonged exposure therapy (PE).
- Trial name
- NCT00539279
- Testing
- Prolonged Exposure Therapy (PE), Relaxation Training (RT)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- US Department of Veterans Affairs
Post-Traumatic Stress Disorder
Effectiveness of Three Different Psychotherapies for Chronic Post-Traumatic Stress Disorder
This study will examine whether interpersonal psychotherapy is as effective in treating post-traumatic stress disorder as the established therapies of prolonged exposure and relaxation.
- Trial name
- NCT00739765
- Testing
- Interpersonal Psychotherapy, Prolonged Exposure Therapy, Relaxation Therapy
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- New York State Psychiatric Institute
Chronic Pain, Post Traumatic Stress Disorder (PTSD)
Transcranial Direct Current Stimulation Treatment for Warriors Experiencing Chronic Pain
The Veteran population has been known to deal with co-morbid chronic pain and PTSD. As a result, they use healthcare services at a higher rate than those Veterans with pain or PTSD alone which leads to an amplified burden on…
- Conditions
- Chronic Pain, Post Traumatic Stress Disorder (PTSD), Depression
- Trial name
- Warriors (NCT05254379)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Emory University
Posttraumatic Stress Disorder
Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy Trial
This study will consist of a single session of MDMA-assisted therapy with a full dose of MDMA for people who took part in a study of MDMA-assisted therapy in people with posttraumatic stress disorder (PTSD) whose PTSD symptoms…
- Trial name
- NCT01458327
- Testing
- Midomafetamine, Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Resilient Pharmaceuticals
Chronic Low Back Pain, Posttraumatic Stress Disorder
Exercise Maintenance in Chronic Pain and PTSD
The primary purpose of the R21 is using an experimental medicine research approach to study whether a chronic, progressive-based exercise program will help Veterans suffering from chronic low back pain (cLBP) and PTSD achieve…
- Trial name
- NCT03644927
- Testing
- Progressive exercise training, Waitlist Control
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston University
Posttraumatic Stress Disorder, Depression
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
The overarching goal of this UH2-UH3 proposal is to work with the NIH Health Care Systems Research Collaboratory to develop and implement a large scale, cluster randomized pragmatic clinical trial demonstration project that…
- Conditions
- Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation
- Trial name
- TSOS6 (NCT02655354)
- Testing
- Motivational Interviewing, Cognitive Behavioral Therapy Elements, Care Management
- Where
- 24 sites in United States
- Volunteers
- 635 people
- Sponsor
- University of Washington
PTSD, Alcohol Abuse
Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy
The proposed project aims to: 1. Obtain a preliminary assessment of the efficacy of topiramate treatment in reducing alcohol use in veterans with Post Traumatic Stress Disorder (PTSD) and alcohol dependence; 2.
- Conditions
- PTSD, Alcohol Abuse, Alcoholism
- Trial name
- TAP (NCT01087736)
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Posttraumatic Stress Disorder
MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder
The goal of this clinical trial is to compare MDMA-assisted therapy to placebo with therapy in people with chronic, treatment-resistant posttraumatic stress disorder (PTSD).
- Trial name
- NCT00090064
- Testing
- Midomafetamine HCl, Therapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Resilient Pharmaceuticals