Clinical trials: Chronic Pulmonary Disease
Constipation Chronic Idiopathic, Cystic Fibrosis
Maralixibat in Patients With Cystic Fibrosis and Constipation
Chronic constipation is common in children with cystic fibrosis (CF), likely due to impaired chloride channel function that reduces intestinal secretions.
- Trial name
- NCT06413368
- Testing
- Maralixibat 9.5 MG/ML [Livmarli]
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Los Angeles
Low Back Pain
Dose of Spinal Manipulation for Chronic Low Back Pain
This study will determine the number of visits to a chiropractor for spinal manipulation, light massage, and ultrasound necessary for optimal relief of chronic low back pain.
- Trial name
- NCT00376350
- Testing
- Spinal Manipulation, Light Massage, Pulsed Ultrasound
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Western States
Post COVID-19, Cognitive Dysfunction
Multimodal Investigation of Post COVID-19 in Females
The purpose of this study is to investigate the effects of transcutaneous vagus nerve stimulation (t-VNS) on Long Covid symptoms in females and to identify factors influencing susceptibility and recovery-particularly in the…
- Trial name
- NCT05225220
- Testing
- Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
COPD (Chronic Obstructive Pulmonary Disease)
Effect of Aronia Berry Consumption on Inflammatory Parameters
The study will aim to evaluate the effects of consuming freeze-dried aronia berries as an adjunct to medical treatment in patients with chronic obstructive pulmonary disease (COPD), focusing on anti-inflammatory, respiratory, and…
- Trial name
- NCT06702696
- Testing
- Black chokeberry (Aronia melanocarpa)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Amasya University
COPD, COPD Exacerbation
Healthy At Home Pilot
The objective is to conduct a pilot-feasibility trial of the "Healthy at Home" program, a multimodal intervention aimed at preventing acute care needs among COPD patients.
- Conditions
- COPD, COPD Exacerbation, Emphysema or COPD
- Trial name
- NCT06000696
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Massachusetts, Worcester
COVID-19, Chronic Kidney Disease stage4
Safety and Clinical and Virologic Outcomes in CKD Patients Treated With Nirmatrelvir-ritonavir
Nirmatrelvir-ritonavir is approved for coronavirus disease 2019 (COVID-19) but not initially recommended in patients with severe renal impairment.
- Conditions
- COVID-19, Chronic Kidney Disease stage4, Chronc Kidney Disease Stage 5
- Trial name
- NCT05624840
- Testing
- Nirmatrelvir/ritonavir
- Where
- Hong Kong
- Volunteers
- 85 people
- Sponsor
- Chinese University of Hong Kong
Radiation
CODP Imaging From a Dose Perspective
The noncontrast-enhanced chest computed tomography (CT) is an emerging diagnostical tool in patient with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT03581110
- Testing
- computed tomography
- Volunteers
- 1,957 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Pulmonary Disease, Chronic Obstructive
Trial Comparing Treatment With Tiotropium Inhalation Capsules to Combivent® Inhalation Aerosol in COPD Patients.
The objective of this study is to evaluate the efficacy and safety of 12 weeks treatment with tiotro pium HandiHaler® 18 mcg daily compared to Combivent® MDI CFC Inhalation Aerosol 2 actuations qid in COPD patients currently…
- Trial name
- NCT00388882
- Testing
- tiotropium, ipratropium bromide / albuterol
- Where
- 40 sites in United States, Argentina and 3 more
- Volunteers
- 327 people
- Sponsor
- Boehringer Ingelheim
Long COVID, Post-Acute COVID-19 Syndrome
A Study of Amantadine for Cognitive Dysfunction in Patients With Long-Covid
Purpose: To decrease symptom burden, improve cognitive function, improve endurance, and decrease fatigue in subjects with post-acute sequelae of COVID-19 (PASC) or "long-hauler" COVID using amantadine.
- Trial name
- NCT06234462
- Testing
- Amantadine, Physical, Occupational, Speech Therapy, Provider Counseling
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Pulmonary Disease, Chronic Obstructive
12 Week Comparison of 5 Mcg and 10 Mcg of Tiotropium / Respimat, Placebo and Ipratropium MDI in COPD
The primary objective was to compare the bronchodilator efficacy of two doses (5 mcg and 10 mcg) of tiotropium inhalation solution delivered by the Respimat inhaler once daily to placebo and to ipratropium bromide MDI four times…
- Trial name
- NCT00240435
- Testing
- 5 mcg once daily tiotropium inhalation solution delivered by the Respimat inhaler, 10 mcg once daily tiotropium inhalation solution delivered by the Respimat inhaler
- Where
- 25 sites in United States, Canada
- Volunteers
- 491 people
- Sponsor
- Boehringer Ingelheim
Copd
The Impact of Interprofessional Training to Improve the Uptake of Noninvasive Ventilation in Patients Hospitalized With Severe COPD Exacerbation
COPD is the fourth leading cause of death in the US, and COPD exacerbations result in approximately 700,000 hospitalizations annually.
- Trial name
- COPD-NIV (NCT04206735)
- Testing
- Interprofessional Education (IPE), Usual care
- Where
- United States
- Sponsor
- Baystate Medical Center
Pulmonary Disease, Chronic Obstructive
Respiratory and Cardiovascular Effects in COPD
The purpose of this study is to find out if subjects with chronic obstructive pulmonary disease have signs of accelerated ageing in their airways.
- Trial name
- KOLIN (NCT02729220)
- Testing
- Bronchoscopy
- Where
- Sweden
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Dr Annelie F Behndig, MD PhD
Acute Respiratory Failure
Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index
To compare the rapid shallow breathing index (RSBI) values, the incidence of adverse reactions, and the predictive accuracy measured under 5 different ventilator strategies in the same patient group.
- Trial name
- NCT00632320
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Chronic Obstructive Pulmonary Disease
Longitudinal Study of Oscillatory Positive Expiratory Pressure (oPEP) in Stable COPD
The purpose of this study is to evaluate the safety and efficacy of four times daily oscillatory Positive Expiratory Pressure (oPEP) (Aerobika ®) use over 4 weeks in individuals with stable chronic obstructive pulmonary disease…
- Trial name
- NCT02282189
- Testing
- Oscillating Positive Expiratory Pressure (Aerobika ®)
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Western University, Canada
Pulmonary Disease, Autonomic Dysfunction
Meditative Movement for COPD Symptoms in Non-Smoking Flight Attendants
This study will explore the a Qigong based exercise intervention, here referred to as Meditative Movement (MM), to ameliorate the symptoms associated with chronic obstructive pulmonary disease (COPD) and its co-morbidities.
- Conditions
- Pulmonary Disease, Autonomic Dysfunction, COPD
- Trial name
- MMforFA (NCT02612389)
- Testing
- Meditative Movement taught via DVD
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pulmonary Disease, Chronic Obstructive
A 3 Way Cross-over Study Evaluating the Effects of ADOAIR Twice Daily Plus Tiotropium Bromide Once Daily Compared With the Individual Treatments of Japanese Subjects
The purpose of this study is to evaluate the effects on lung function of a combination of ADOAIR 50/250mcg twice daily plus tiotropium bromide 18mcg once daily compared with the individual treatments (tiotropium bromide 18mcg…
- Trial name
- SCO116572 (NCT01751113)
- Testing
- fluticasone propionate/salmeterol, tiotropium bromide, fluticasone propionate/salmeterol plus tiotropium bromide
- Where
- 3 sites in Japan
- Volunteers
- 53 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Integrated Care Program for Chronic Obstructive Pulmonary Disease
Integrated eHealth is an innovative, proactive approach to the management of patients with chronic cardiopulmonary disease. Our overall goal is to improve the health of patients by integrating guideline-based education, remote…
- Trial name
- NCT01045213
- Testing
- Integrated Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
COPD, Nurse-Patient Relations
Effectiveness of Motivational Interviewing in Patients With COPD
To determine the effect of motivational interviewing based on Pender's health promotion model on patient-reported outcomes in patients with COPD.
- Trial name
- NCT06783582
- Testing
- Motivational interviewing based on Pender's health promotion model
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zeynep Yildirim
Chronic Obstructive Pulmonary Disease
Clinical Study to Assess the Mode of Action of QBW251 in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study was to determine whether potentiating the cystic fibrosis transmembrane conductance regulator (CFTR) with QBW251 in subjects with COPD would be efficacious with regards to reducing lung and systemic…
- Trial name
- NCT04268823
- Testing
- QBW251
- Where
- 12 sites in Austria, Germany and 2 more
- Volunteers
- 54 people
- Sponsor
- Novartis Pharmaceuticals
Copd, Athletes
Effects of CreaSafe® on Kidney, Muscle, and Cardiopulmonary Function in Athletes and COPD Patients
Creatine supplementation (CS) offers numerous health benefits, with no proven side effects reported to date. CS positively impacts all organs and systems of the body.
- Trial name
- NCT06991426
- Testing
- CreaSafe® creatine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
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