Clinical trials: Chronic Pulmonary Disease
COPD
Portable Oxygen Concentrator Improvements to Physical Activity, Oxygen Usage, and Quality of Life in Chronic Obstructive Pulmonary Disease Patients Using Long-term Oxygen Therapy (POC-STEP)
To evaluate changes in activity based on the use of portable oxygen concentrators combined with standard of care (SOC) long- term oxygen therapy versus SOC long-term oxygen therapy alone at 12 weeks in patients with COPD who…
- Trial name
- POC-STEP (NCT03513068)
- Testing
- Portable Oxygen Concentrator (POC)
- Where
- 11 sites in United States
- Volunteers
- 108 people
- Sponsor
- ResMed
Pulmonary Disease, Chronic Obstructive, E-cigarettes
Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study
Determination of the acute pulmonary toxicities of e-cigarettes in young adults is of major public health importance, as e-cigarette vapor contains established toxicants that as hypothesized cause acute damage to the airways and…
- Trial name
- VaPE-Tox (NCT02783768)
- Testing
- E-cigarette, Hyperpolarized 3-Helium, Gadolinium
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Columbia University
COPD
Bronchodilators and Lung Mechanics During Exercise in COPD
Bronchodilators are medications that open the bronchi to help patients with COPD to breathe better. It is still not known exactly how this effect improves shortness of breath in people with COPD.
- Trial name
- SOUND (NCT06825013)
- Testing
- Bronchodilators inhalation
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Dr. J. Alberto Neder
Myalgic Encephalomyelitis, Long-COVID
Low Dose Rapamycin in ME/CFS, Long-COVID, and Other Infection Associated Chronic Conditions
The goal of this observational study is to assess the clinical response and the effect of autophagy function in patients before, during and throughout oral low dose sirolimus (rapamycin) therapy.
- Trial name
- NCT06257420
- Testing
- Rapamycin
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Simmaron Research Inc.
Chronic Obstructive Pulmonary Disease
Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease
This study aims to investigate the expression level of SLC25A48, a mitochondrial choline transporter, in peripheral blood mononuclear cells of patients with chronic obstructive pulmonary disease, and to analyze its correlation…
- Trial name
- NCT07474220
- Where
- 2 sites in Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University
Chronic Obstructive Pulmonary Disease Exacerbation, Magnesium Sulfate
Acute Exacerbation of COPD and Nebulized Magnesium Sulphate
This study is designed to determine the effect of Nebulized Magnesium Sulphate as an add-on therapy with conventional treatment on In-hospital outcome in patients having acute exacerbation of COPD.
- Trial name
- NCT05699720
- Testing
- Nebulized Magnesium Sulphate
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- King Edward Medical University
Acute Graft-versus-host Disease, Acute GVHD
Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease
Dendritic cells (DCs) serve as sentries for the immune system. DCs recognize foreign compounds (antigens) in the body, which they internalize and process.
- Conditions
- Acute Graft-versus-host Disease, Acute GVHD, Chronic Graft-versus-host Disease, Chronic GVHD
- Trial name
- NCT02611180
- Testing
- Skin punch biopsy, Peripheral blood draw
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Washington University School of Medicine
Bronchiolitis Obliterans Syndrome
A Retrospective Chart Review Study of Patients With CLAD-BOS Post Lung Transplantation
The Primary Objective of this study was to evaluate the FEV1 trajectory of patients diagnosed with CLAD-BOS. The Secondary Objectives of this study were: To describe demographics of patients diagnosed with CLAD-BOS To describe…
- Trial name
- NCT06503770
- Where
- 6 sites in United States, Belgium and 1 more
- Volunteers
- 284 people
- Sponsor
- Zambon SpA
Pulmonary Disease, Chronic Obstructive
The Nasal Airway in Chronic Obstructive Pulmonary Disease
The study is based on the theory of a "unified airway" that considers the nose and paranasal sinuses together with lower airways as one integrated unit.
- Trial name
- COPD (NCT02826954)
- Testing
- Upper airway assessment, including nasal biopsy
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Chronic Obstructive Pulmonary Disease, Emphysema
Lung Volume Reduction Coil Microbiome Study
Studying the microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema
- Trial name
- LVRC-Micro (NCT03010566)
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
Anti-inflammatory Effects of Caffeine in Chronic Obstructive Pulmonary Disease (COPD) Subjects
Nowadays it has become evident that a chronic systemic inflammation is present in patients suffering from chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00826566
- Testing
- Caffeine
- Where
- Netherlands
- Sponsor
- Maastricht University Medical Center
COPD (Chronic Obstructive Pulmonary Disease)
Inhaler Training to Enhance Nurses' Competency in Patient Inhaler Education
Nurses play a pivotal role in assessing, educating, and regularly reviewing patients' inhaler techniques. However, inadequate knowledge and skills among nurses can hinder their ability to accurately assess patients' inhaler…
- Trial name
- NCT07527455
- Testing
- Theory-based inhaler training, Usual training
- Volunteers
- 82 people
- Sponsor
- Hong Kong Metropolitan University
Chronic Obstructive Pulmonary Disease
Phase 4 COPD and Suboptimal Inspiratory Flow Rate
Study is a randomized, double-blind, double-dummy, parallel-group study evaluating efficacy and safety of revefenacin vs. tiotropium in adults with severe to very severe COPD and suboptimal PIFR.
- Trial name
- PIFR-2 (NCT05165485)
- Testing
- Revefenacin, Tiotropium
- Where
- 76 sites in United States
- Volunteers
- 404 people
- Sponsor
- Theravance Biopharma
COPD, Osa Syndrome
Screening and Early Warning of Chronic Obstructive Pulmonary Disease Combined With Sleep Respiratory Disease Based on Medical Internet of Things
Chronic obstructive pulmonary disease (COPD) is a common disease that endangers people's health, causing severe economic and treatment burdens.
- Trial name
- NCT04833725
- Testing
- wearable devices
- Where
- China
- Volunteers
- 680 people
- Sponsor
- Peking University Third Hospital
Sarcoidosis, Pulmonary Sarcoidosis
Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS)
An randomized trial of two maintenance doses of Acthar Gel for patients with chronic pulmonary sarcoidosis. Patients will be observed for 24 weeks of treatment.
- Trial name
- ACPS (NCT02188017)
- Testing
- Acthar gel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
COPD
Home-based Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease
This project aims to assess the short-term effectiveness and responsiveness of a home-based pulmonary rehabilitation (PR) program (reabilitAR) in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT04722224
- Testing
- Home-based pulmonary rehabilitation
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Polytechnic Institute of Porto
COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection
Impact of Switching COPD Patients From Inhaler Devices to the Omron C28P Nebuliser.
The cornerstone of COPD therapy is based on the use of inhalation drugs. The correct use of devices is crucial; a suboptimal use technique is the cause of a possible clinical deterioration with a consequent increase in…
- Trial name
- OMRON (NCT06061679)
- Testing
- Omron C28P nebuliser
- Volunteers
- 99 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Long COVID
PERCEIVE-Outreach: A Scalable, Risk-Based Model for Managing Persistent Cardiovascular Impact in Long COVID
Some people who had COVID-19 continue to have symptoms for weeks, months, or even years after their infection. This is often called "Long COVID" or Post-Acute Sequelae of SARS-CoV-2 (PASC).
- Trial name
- NCT07661862
- Testing
- PERCEIVE-Outreach Disease Management Program
- Where
- 2 sites in Australia
- Volunteers
- 577 people
- Sponsor
- University of Tasmania
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Neuromuscular Electrical Stimulation as an Adjunct to Exercise Training in Stable Chronic Obstructive Pulmonary Disease (COPD)
Skeletal muscle dysfunction impairs exercise capacity, quality of life and prognosis in chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01658046
- Testing
- Neuromuscular electrical stimulation, Endurance training, Quadriceps strength training
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Hacettepe University
COPD Exacerbation
Early Assisted Discharge for COPD Exacerbations With Telemonitoring.
To determine if an early assisted discharge program for acute exacerbations of COPD (AECOPD), with telemonitoring and telephone control, is equally effective and more efficient in terms of use of health care resources, that a…
- Trial name
- NCT01951261
- Testing
- Telemonitoring and telephone control
- Where
- Spain
- Volunteers
- 116 people
- Sponsor
- Dr. López Viña
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