Clinical trials: Chronic Pulmonary Obstruction
Emphysema or Chronic Obstructive Pulmonary Disease
BENTO - Bronchoscopic Lung Volume Reduction in Severe Emphysema Using Thermoablation
Prospective, 2-arm, randomised (2:1), multicentre, open-label clinical trial in patients with severe emphysema. The intervention arm will be treated with Bronchoscopic lung volume reduction in severe emphysema using…
- Trial name
- NCT05717192
- Testing
- InterVapor®-System
- Where
- 12 sites in Germany
- Volunteers
- 224 people
- Sponsor
- IHF GmbH - Institut für Herzinfarktforschung
Osteoarthritis, Chronic Obstructive Pulmonary Disease
The Impact of Bundled Payments on Quality and Cost of Care
Bundled payment is a new payment reform that encourages health care providers to improve quality and contain costs of care. These arrangements are being rapidly expanded across the country, but evidence about their impact are…
- Conditions
- Osteoarthritis, Chronic Obstructive Pulmonary Disease, Pneumonia
- Trial name
- NCT02743507
- Volunteers
- 440 people
- Sponsor
- University of Pennsylvania
Chronic Obstructive Lung Disease, Interstitial Lung Disease
Evaluation of a Lightweight Nasal Interface and Ventilator in Patients With Respiratory Disease
A preliminary study to evaluate a new nasal interface and portable ventilator system in comparison to standard oxygen therapy in patients with severe chronic lung disease.
- Trial name
- NCT02278107
- Testing
- Tidal Assist Ventilator System, Nasal Cannula Oxygen
- Volunteers
- 20 people
- Sponsor
- New Aera, Inc
Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Postural Control in Patients With Respiratory Disease at Altitude
In this trial, the investigators will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on postural control at acute altitude exposure in patients with COPD.
- Trial name
- NCT03177811
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 127 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease
Long-term Maintenance Benefits of a Pulmonary Rehabilitation Program Using a Mobile Digital Solution: a Prospective, Randomized, Controlled, Multicenter Study in a Population of COPD Patients
Chronic obstructive pulmonary disease (COPD) is a public health problem: high prevalence; increasing morbidity and mortality; impact on health costs.
- Trial name
- m-Rehab COPD (NCT04550741)
- Testing
- telerehabilitation
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
COPD (Chronic Obstructive Pulmonary Disease)
Effectiveness of DITM Versus IMT in COPD Patients
The goal of this clinical trial is to learn if digital inhaled therapy management (DITM) and inspiratory muscle training (IMT), alone or in combination, can improve outcomes in adults aged 40 years and older with symptomatic…
- Trial name
- NCT06958666
- Testing
- Digital Inhaled Therapy Management, Inspiratory Muscle Training
- Where
- 9 sites in China
- Volunteers
- 410 people
- Sponsor
- Sir Run Run Shaw Hospital
Type 2 Diabetes, COPD (Chronic Obstructive Pulmonary Disease)
Lung Cancer Risk in Type 2 Diabetes With COPD: SGLT2 Inhibitors vs. Sulfonylureas
The goal of this observational study is to learn if a specific diabetes medicine can lower the risk of lung cancer in people with type 2 diabetes and chronic obstructive pulmonary disease (COPD).
- Conditions
- Type 2 Diabetes, COPD (Chronic Obstructive Pulmonary Disease), Lung Cancer (Diagnosis)
- Trial name
- NCT07332156
- Testing
- SGLT2 inhibitor, Sulfonylureas (SU), DPP4 inhibitors
- Volunteers
- 21,692 people
- Sponsor
- Samsung Medical Center
COPD, Hypercapnic Respiratory Failure
HFNC vs NPPV After Early Extubation for Patients With COPD
High-flow nasal cannula oxygen therapy(HFNC) has proved no significant difference compared with noninvasive positive pressure ventilation (NPPV) in preventing postextubation respiratory failure and reintubation in patients with…
- Trial name
- NCT04156139
- Testing
- HFNC, NPPV
- Where
- China
- Volunteers
- 502 people
- Sponsor
- Chinese PLA General Hospital
Chronic Obstructive Pulmonary Disease With Chronic Bronchitis
A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Study Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis
The purpose of the study is to investigate the efficacy of galvokimig versus placebo in the time to the first acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in study participants with moderate-to-severe COPD…
- Trial name
- SCALA (NCT07725939)
- Testing
- Galvokimig
- Where
- 23 sites in United States, China
- Volunteers
- 402 people
- Sponsor
- UCB Biopharma SRL
COPD, Tobacco Use
Effects of Electronic Cigarettes in Cigarette Smokers With Mild to Moderate COPD
This study evaluates the effects of electronic cigarette use on cigarette smoking and markers of tobacco use, as well as respiratory symptoms and function in smokers with mild to moderate chronic obstructive pulmonary disease…
- Trial name
- NCT03379025
- Testing
- Electronic cigarette
- Sponsor
- Massachusetts General Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Informational Tool for Smoking Cessation in COPD Patients
Chronic obstructive pulmonary disease (COPD) is a lung disease that affects nearly 8% of the adult population and causes 18,000 deaths per year in France. The most frequent cause of this pathology is smoking.
- Trial name
- IMPACT-BPCO (NCT06872450)
- Testing
- informational intervention
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hopital Nord Franche-Comte
Pulmonary Disease, Chronic Obstructive
Interest of a 30 Minutes' Intermittent Work Exercise Test in Patients With Chronic Obstructive Pulmonary Disease: Cardiac and Pulmonary Functions
The aim of the study is to observe the ventilatory and cardiac function (included the pulmonary arterial pressure) during an intermittent work exercise test with high density work load.
- Trial name
- NCT00295113
- Testing
- EFR
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Strasbourg, France
COPD
Study of the Effects of Education on Patients With Chronic Obstructive Pulmonary Disease
The investigators hypothesize that education will improve exercise capacity, symptoms and quality of life in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01633697
- Testing
- Pranayama, Education alone
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of Vermont
Chronic Obstructive Pulmonary Disease (COPD)
A Study to Investigate the Pharmacokinetics, Safety and Tolerability of CHF 5993 pMDI in Subjects With Renal Impairment.
The study is performed to characterize the pharmacokinetics of glycopyrrolate bromide after single administration of CHF 5993 pressurised Metered Dose Inhaler (pMDI) in subjects with different level of renal impairment in…
- Trial name
- TRIPLE10 (NCT02040597)
- Testing
- Beclometasone/Formoterol/Glycopyrrolate
- Where
- 2 sites in Poland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Cardiovascular Diseases, Coronary Disease
Honolulu Heart Program
To investigate coronary heart disease and stroke among American men of Japanese ancestry who were living on the island of Oahu in 1965. Morbidity and mortality surveillance of the original cohort is continuing.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Heart Diseases
- Trial name
- NCT00005123
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Obstructive Pulmonary Disease
Influence of Electronic Cigarettes in the Evaluation of the Inflammatory Response in Patients With a Diagnosis of COPD
This study evaluates the local and systemic inflammatory response in the airway in COPD patients who consume electronic cigarettes compared with conventional cigarette smokers.
- Trial name
- NCT02892396
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fundacio Catalana de Pneumologia
Dyspnea, Chronic Obstructive Pulmonary Disease
The Effect of Music Therapy on Dyspnea Severity and Vital Signs
This study aims to investigate the effect of music therapy on dyspnea severity and quality of life indicators in patients with Chronic Obstructive Pulmonary Disease (COPD) admitted to the intensive care unit.
- Trial name
- NCT06358235
- Testing
- Music Therapy, No Music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Suleyman Demirel University
Chronic Obstructive Pulmonary Disease
Effects of Supplemental Oxygen Delivered by a Portable Oxygen Concentrator Compared to a Liquid Oxygen Device in COPD
The aim of this study is to investigate the effects of supplemental oxygen on blood oxygenation at rest in Patients with severe to very severe COPD comparing the portable oxygen concentrator (Activox™ 4L) to a liquid continuous…
- Trial name
- NCT03174210
- Testing
- liquid oxygen device (LOD), portable oxygen concentrator (POC)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Pulmonary Disease, Chronic Obstructive, Obesity
INtervention Study In overweiGHT Patients With COPD
Symptoms of chronic obstructive pulmonary disease (COPD) and high body mass index (BMI) overlap. The investigators are trying to find out if a program proven to help people lose a modest amount of weight and increase their…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Obesity, Weight Loss, Life Style
- Trial name
- INSIGHT COPD (NCT02634268)
- Testing
- Lifestyle Intervention
- Where
- 39 sites in United States
- Volunteers
- 684 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Chronic Obstructive Pulmonary Disease
Acute Effect of Aclidinium on Hyperinflation and Ventilation Inhomogeneity in Severe COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is characterized by lung hyperinflation and flow limitation. These physiopathological modifications are secondary to loss of elastic recoil and bronchial obstruction due to emphysema.
- Trial name
- NCT02181023
- Testing
- Aclidinium Bromide, Glycopyrronium Bromide
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- University of Milan
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.