Clinical trials: Chronic Pulmonary Obstruction
COPD (Chronic Obstructive Pulmonary Disease)
Virtual Pulmonary Rehabilitation Program for COPD Patients; a Pilot Study
The goal of this pilot study is to investigate the feasibility of a virtual rehabilitation program in COPD patients. The main questions it aims to answer are: 1.
- Trial name
- e-PURE (NCT06915740)
- Testing
- Exercise
- Where
- 2 sites in Finland
- Volunteers
- 50 people
- Sponsor
- Turku University Hospital
COPD
High Protein Diet and Physical Activity in COPD
COPD outpatients with severe and very severe (grade III-IV) disease at risk of malnutrition commencing rehabilitation (7-10-week physical activity program) were randomized to receive a high protein diet (≥ 25 energy percentage)…
- Trial name
- NCT04888182
- Testing
- intervention
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Jens Rikardt Andersen
Chronic Pulmonary Obstructive Disease
Effects of Yoga on Clinical Impact and Psychosocial Aspects of COPD
The aim of this study is to investigate weather the breathing exercises of Yoga are effective in altering clinical impact, anxiety, depression and quality of life in Chronic Obstructive Pulmonary Disease patients.
- Trial name
- NCT02539524
- Testing
- Yoga bhastrika pranayama breathing exercise, Pulmonary Rehabilitation
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- University of Sao Paulo
Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Two Fixed Dose Combinations of Aclidinium Bromide With Formoterol Fumarate
The purpose of this multicenter, dose-ranging study is to compare two Fixed-Dose Combinations of aclidinium bromide and formoterol fumarate with placebo, aclidinium bromide and formoterol fumarate, all administered BID in…
- Trial name
- ALIGHT-COPD (NCT01078623)
- Testing
- Aclidinium 200 μg / formoterol 12 μg, Formoterol 12 μg, Aclidinium 200 μg
- Where
- 10 sites in Czechia, Romania
- Volunteers
- 176 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Bufei Yishen Granule for Reducing Acute Exacerbation in GOLD Stage 3 or 4 COPD
This study aims to establish the treatment scheme of Bufei Yishen granule for GOLD stage 3 or 4 chronic obstructive pulmonary disease (COPD), reducing acute exacerbation, improving exercise capacity and forming high quality…
- Trial name
- NCT03976713
- Testing
- Bufei Yishen granule, Tiotropium Bromide Powder for Inhalation
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Pulmonary Disease, Chronic Obstructive
Study to Assess the Safety of Ipratropium Bromide, in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Study to assess the safety of two-week administration of 80 and 160 mcg of ipratropium bromide as delivered by the RESPIMAT® device and as determined by 24 hours ambulatory ECG monitoring in COPD patients.
- Trial name
- NCT02236182
- Testing
- Ipratropium Bromide low dose, Ipratropium Bromide high dose
- Volunteers
- 57 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease
Pulmonary Diffusing Capacity During Acute Exercise in Patients With COPD
The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) during exercise may be a useful physiological measure of alveolar-capillary reserve in patients with Chronic…
- Trial name
- DiffLung2 (NCT05583396)
- Testing
- Acute exercise
- Where
- 2 sites in Denmark
- Volunteers
- 15 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Obstructive Pulmonary Disease (COPD)
Progressive Muscle Relaxation and Deep Breathing Exercises in Patients With COPD
This randomized controlled trial evaluated the effects of progressive muscle relaxation and deep breathing exercises on fatigue and sleep quality in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07773194
- Testing
- Progressive Muscle Relaxation, Deep Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Firat University
Chronic Obstructive Pulmonary Disease
A Study to Evaluate the Symptoms Over 24 Hours in Patients With Chronic Obstructive Pulmonary Disease - LASSYC Study
No previous studies have evaluated the frequency and severity of Chronic Obstructive Pulmonary Disease (COPD) symptoms over a period of 24 hours (early morning, daytime and nigth-time symptoms) in stable COPD patients seen in…
- Trial name
- LASSYC (NCT03381560)
- Where
- 8 sites in Brazil
- Volunteers
- 602 people
- Sponsor
- AstraZeneca
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Phase 1 Safety and Pharmacokinetic Study of AI-700 in Patients With Diminished DLCO and COPD and/or CHF
This study was conducted to evaluate the safety and pharmacokinetics of an echocardiographic contrast agent, AI-700, in patients with moderate to severe chronic obstructive pulmonary disease (COPD) and/or congestive heart failure…
- Trial name
- NCT00156780
- Testing
- AI-700
- Where
- United States
- Sponsor
- Acusphere
Chronic Obstructive Pulmonary Disease
Effectivity of Inspiratory Muscle Trainer in the Chronic Obstructive Pulmonary Disease Rehabilitation Program
This study aimed to reveal the role of inspiratory muscles exercise using Inspiratory Muscle Trainer (IMT), which is a form of weight training.
- Trial name
- NCT03739879
- Testing
- Inspiratory Muscle Trainer Philips Respironics
- Where
- Indonesia
- Volunteers
- 15 people
- Sponsor
- Universitas Indonesia
Chronic Obstructive Pulmonary Disease
High Flow Nasal Cannula During Pulmonary Rehabilitation
The primary purpose of this study is to compare and assess the immediate and long-term effects on pulmonary rehabilitation training with the usage of HFNC or conventional oxygen therapy device.
- Trial name
- NCT03237962
- Testing
- High Flow Nasal Cannula, Nasal Cannula
- Where
- 2 sites in Taiwan
- Volunteers
- 32 people
- Sponsor
- Chang Gung University
Chronic Obstructive Pulmonary Disease
Effect of Ketoconazole on Breathlessness
Beta-endorphins, which are naturally occurring narcotic substances, have been shown to alter the perception of breathlessness. Oral ketoconazole, an antifungal antibiotic, increases blood levels of beta-endorphins.
- Trial name
- KetoRLB (NCT01378520)
- Testing
- ketoconazole, inert powder
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chronic Obstructive Pulmonary Disease
A COPD Quality Improvement Program（QIP）
QIP(Quality Improvement Programme) is a COPD quality improvement program in China. The initial step of this program is to set up the Quality Standards(QS) of COPD management in clinical practice, then embed Quality Standards into…
- Trial name
- QIP (NCT05638646)
- Testing
- Intervention group, control group
- Where
- China
- Volunteers
- 1,107 people
- Sponsor
- Shenzhen People's Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Postural Control in Chronic Obstructive Pulmonary Disease
Postural control impairment is common in people with COPD (pwCOPD), which can increase the risk of falls and affect quality of life.
- Trial name
- NEUROTIGUE P (NCT06863246)
- Testing
- Evaluation of cognitive task on static balance, Evaluation of visual feedback on static balance
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease
The Characteristic of Airway Microbiome Profiling of COPD-bronchiectasis Overlap Patients and Its Association With Acute Exacerbation
The overlap between chronic obstructive pulmonary disease (COPD) and bronchiectasis is a neglected area of research, and it is not covered by guidelines for clinical practice.
- Conditions
- Bronchiectasis Adult, Chronic Obstructive Pulmonary Disease, Overlap, Microbiome
- Trial name
- NCT04865861
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Early Warning System
The study will begin in 2013 whereby patients having an early warning system (EWS) alert will be randomized to be seen by the rapid response team (RRT) for triage versus usual care.
- Conditions
- Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Cancer, Diabetes Mellitus
- Trial name
- NCT01741480
- Testing
- Early warning system monitoring., routine care
- Where
- United States
- Volunteers
- 571 people
- Sponsor
- Washington University School of Medicine
COPD
Characteristics of People With Advanced Chronic Obstructive Pulmonary Disease (COPD) - A Multicenter Study
Pulmonary rehabilitation (PR) is a cornerstone of care for people with COPD. There is robust evidence that PR improves exercise capacity, enhances health-related quality of life (QoL) and reduces healthcare utilization.
- Trial name
- REPORT (NCT04249388)
- Testing
- No Intervention, just observation
- Where
- 4 sites in Denmark
- Volunteers
- 102 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Chronic Obstructive Pulmonary Disease (COPD)
Safety and Efficacy Study of Glyco pMDI After Single and Repeated Administration
The purpose of this study is to evaluate the safety and the efficacy of Glycopyrrolate as pMDI after single and repeated administration.
- Trial name
- GLY2 (NCT01176903)
- Testing
- Glycopyrrolate, Tiotropium
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Obstructive Pulmonary Disease (COPD), Emphysema
Home Pulmonary Rehabilitation for COPD
Regular physical activity has been found to be important in maintaining health and well-being in people with COPD. The purpose of this study is to test new technology and health coaching aimed to help people with COPD become more…
- Trial name
- NCT03480386
- Testing
- Home Based Pulmonary Rehabilitation
- Where
- 3 sites in United States
- Volunteers
- 375 people
- Sponsor
- Mayo Clinic