Clinical trials: Chronic Pulmonary Obstruction
COPD, Oxygen Therapy
Closed-loop System for Oxygen Delivery and Exercise in Chronic Obstructive Pulmonary Disease
The purpose of this study is to investigate the benefit of Closed-loop System for Oxygen Delivery (FreeO2) as compared with fixed oxygen flow during endurance shuttle walking test in patients with Chronic obstructive pulmonary…
- Conditions
- COPD, Oxygen Therapy, Hypercapnia
- Trial name
- FreeO2-rehab (NCT01575327)
- Testing
- Automated settings on the oxygen delivery device, Manual settings with FreeO2 system in collection mode
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- AGIR à Dom
Chronic Obstructive Pulmonary Disease
COPD: A Multi-center Supervised Tele-rehabilitation Study
Chronic obstructive pulmonary disease(COPD) patients could benefit from pulmonary rehabilitation(PR) in better managing of the disease and its symptoms and in avoiding future relapses and hospitalizations.
- Trial name
- COPDMUST (NCT06085261)
- Testing
- home-based telerehabilitation group, center-based traditional rehabilitation group
- Where
- China
- Volunteers
- 360 people
- Sponsor
- China-Japan Friendship Hospital
Chronic Obstructive Pulmonary Disease, Emphysema
Macrophages in Smokers' Lung
Cigarette smoking causes an increase in inflammation in the lungs. In about 20% of smokers this inflammation leads to damage in lungs including making holes in the lung tissue.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis
- Trial name
- NCT00298402
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
Pulmonary Disease, Chronic Obstructive
Greek NIS Spiolto ELLACTO
Open-label observational study: including COPD patients receiving treatment with Spiolto® Respimat® for approximately 6 weeks, which is the average time between two medical consultations
- Trial name
- NCT03419962
- Testing
- MaxSpiolto® Respimat® 160 Characters...
- Where
- 15 sites in Greece
- Volunteers
- 1,360 people
- Sponsor
- Boehringer Ingelheim
Cough, Chronic Obstructive Pulmonary Disease
The Effect of Azithromycin in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Chronic Productive Cough
The purpose of this study is to demonstrate the efficacy of azithromycin to produce a significant change in the cough-related health status, measured with the Dutch version of the Leicester Cough Questionnaire in patiënts with…
- Conditions
- Cough, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
- Trial name
- CACTUS (NCT01071161)
- Testing
- azithromycin
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- Isala
COPD
Effect of Education and Respiratory Rehabilitation on Quality of Life in COPD Patients
In patients with COPD and a history of recent exacerbation, to compare the quality of life after completing a joint program of health education and respiratory rehabilitation with those patients who only receive respiratory…
- Trial name
- EDUEPOC (NCT03889054)
- Testing
- Education program
- Volunteers
- 66 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
COPD (Chronic Obstructive Pulmonary Disease)
Digital High-Intensity Respiratory Muscle Training on COPD Patients
The goal of this Randomize control trail is to determine the effect of Digital High-Intensity Respiratory Muscle Training on ventilatory Function and Functional Capacity in Patients with COPD It will also learn about the safety…
- Trial name
- COPD (NCT07346261)
- Testing
- Digital Sonmol Respiratory Muscle Trainer, conventional respiratory rehabilitation
- Volunteers
- 60 people
- Sponsor
- Cairo University
Chronic Obstructive Pulmonary Disease
A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD
The purpose of this study is to evaluate the efficacy and safety of ensifentrine in patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT04535986
- Testing
- Ensifentrine
- Where
- 122 sites in United States, Bulgaria and 10 more
- Volunteers
- 763 people
- Sponsor
- Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA
COPD (Chronic Obstructive Pulmonary Disease)
GRACE - Graduated Response for Advanced COPD With Enhanced Support
The aim of this study is to explore the feasibility and potential for a positive impact of a graduated response for advanced COPD with Enhanced Support.
- Trial name
- GRACE (NCT06967324)
- Testing
- Stepped care, Usual Care
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Chronic Obstructive Pulmonary Disease, Heart Failure
Well Being and Rehabilitation in Chronically Ill Patients: Structured Patient Education and Physical Exercise
This study addresses self management and maintenance of health through evaluation of a program of patient education in combination with physical training and with a structured follow-up.
- Conditions
- Chronic Obstructive Pulmonary Disease, Heart Failure, Stroke
- Trial name
- NCT00989456
- Testing
- Self management education programme, exercise only
- Where
- 5 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Norwegian University of Science and Technology
COPD Exacerbation Acute
The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 2
The proposed study will explore whether remote monitoring of a COPD patient can be undertaken using a wearable medical device.
- Trial name
- BREATH-TRACHER (NCT06419062)
- Testing
- Frontier X2
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Strathclyde
COPD (Chronic Obstructive Pulmonary Disease)
Inhaled Treprostinil for Dyspnea and Exercise Intolerance in Mild COPD
The goal of this clinical trial is to evaluate the impact of inhaled Treprostinil on breathlessness and low exercise capacity in patients living with mild chronic obstructive pulmonary disease.
- Trial name
- NCT06969573
- Testing
- Treprostinil Inhalation Solution 36 mcg, Treprostinil Inhalation Solution 78 mcg
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Chronic Obstructive Pulmonary Disease
Home-based Body Weight Exercise With Blood Flow Restriction (BFR): Feasibility of a Novel Rehabilitation Intervention in COPD Patients (HomeBFR-COPD)
The primary aim of this randomised controlled trial is to investigate the feasibility and acceptability of low-intensity exercise with blood flow restriction (BFR) in patients with Chronic Obstructive Pulmonary disease (COPD).
- Trial name
- HomeBFR-COPD (NCT05984823)
- Testing
- Home based body weight type exercises with blood flow restriction, Home based body weight type exercises
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- Mrs Hanoof Aljohani
Chronic Obstructive Pulmonary Disease (COPD)
The Effect of Pranayama Practiced With Rain Sounds on Self-Efficacy, Dyspnea, and Respiratory Functions in Patients With COPD
Chronic obstructive pulmonary disease (COPD) ranks third among the leading causes of death worldwide. It causes a variety of symptoms resulting from irreversible obstruction of the airways.
- Trial name
- NCT07820059
- Testing
- pranayama breathing exercises, A group will perform pranayama breathing exercises accompanied by the sound of rain.
- Volunteers
- 114 people
- Sponsor
- Inonu University
Lung Diseases, Obstructive, Asthma
Monitoring Asthma and COPD in Primary Care
The purpose of this study is to determine the clinical effectiveness and cost-effectiveness of a written expert advice for GPs on additional diagnostic, treatment, and referral of patients based on half-yearly monitoring routines…
- Trial name
- Monaco (NCT00542061)
- Testing
- half-yearly monitoring routine
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Pulmonary Disease, Chronic Obstructive
Interest of a 30 Minutes' Intermittent Work Exercise Test in Patients With Chronic Obstructive Pulmonary Disease: Cardiac and Pulmonary Functions
The aim of the study is to observe the ventilatory and cardiac function (included the pulmonary arterial pressure) during an intermittent work exercise test with high density work load.
- Trial name
- NCT00295113
- Testing
- EFR
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Strasbourg, France
COPD
Safety, Tolerability and Pharmacodynamics of QAX028 Compared to Open-label Tiotropium Bromide and Placebo in Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD) Patients.
This will be a single dose Proof-of-Concept study in mild-to-moderate COPD patients. The study will investigate the safety and tolerability of QAX028 as well as the bronchodilatory effects of QAX028 compared to tiotropium and…
- Trial name
- NCT00568503
- Testing
- QAX028, Tiotropium bromide
- Where
- Denmark
- Volunteers
- 29 people
- Sponsor
- Novartis
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Withdrawal of Non-invasive Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Acute Hypercapnic Respiratory Failure
The investigators design a pilot randomised, single-centred, controlled trial to compare different withdrawal methods of Non-invasive ventilation.
- Trial name
- NCT01523470
- Testing
- BIPAP Synchrony
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- United Christian Hospital
Chronic Obstructive Pulmonary Disease
CHARM-COPD Program of Care
The investigators' goal for this project is to evaluate the feasibility, acceptability, and actual usage of a program of care for patients with COPD recently discharged after an acute exacerbation.
- Trial name
- NCT06253013
- Testing
- Hyfe Smartwatch, FitBit Versa 2, Home Spirometer
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Chronic Obstructive Pulmonary Disease, COPD
Perforomist Versus Foradil Evaluated by Inspiratory Capacity and High Resolution Computed Tomography (HRCT)
The purpose of this study is to compare the effects of nebulized formoterol fumarate (Perforomist) to dry-powder inhaler formoterol fumarate (Foradil).
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Chronic Bronchitis, Emphysema
- Trial name
- NCT00633776
- Testing
- formoterol fumarate
- Where
- United States
- Sponsor
- University of California, Los Angeles
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