Clinical trials: Chronic Pulmonary Obstruction
Lower Respiratory Tract Infection, Acute Bronchitis
Evaluating a Host-response Based Diagnostic for Distinguishing Between Bacterial and Viral Etiology in Patients With Lower Respiratory Tract Infection (LRTI)
The purpose of this study is to validate the diagnostic accuracy of a novel host-response based diagnostic tool for differentiating between bacterial and viral etiologies in adult patients aged 18 years and older with clinical…
- Conditions
- Lower Respiratory Tract Infection, Acute Bronchitis, Pneumonia, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- OBSERVER (NCT03011515)
- Where
- Israel
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Copd, Smoking
Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers
Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease that affects only a fraction of those who smoke tobacco.
- Conditions
- Copd, Smoking, Tobacco Use
- Trial name
- Pre-COPD Pilot (NCT04722835)
- Testing
- Bronchoscopy with Bronchoalveolar Lavage (BAL)
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
COPD
Comorbidity and Pulmonary Rehabilitation in COPD
Our aim in this study is to determine the distribution of comorbidity in patients with COPD participating in the pulmonary rehabilitation program and to examine the effect of severity of comorbidy on pulmonary rehabilitation…
- Trial name
- NCT03319108
- Testing
- Exercise
- Volunteers
- 173 people
- Sponsor
- Izmir Katip Celebi University
Dyspnea, Decompensated Heart Failure ; COPD Exacerbation
Diagnosis of Heart Failure in Chronic Obstructive Pulmonary Disease Using the Lung Ultrasound
Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis.
- Trial name
- NCT05352490
- Testing
- calculate LUS score
- Where
- Tunisia
- Volunteers
- 350 people
- Sponsor
- University of Monastir
Chronic Obstructive Pulmonary Disease (COPD), Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Active Cycle Of Breathing Technique And Pursed Lip Breathing in Moderate to Severe COPD Patients
Purpose of the Study Chronic Obstructive Pulmonary Disease (COPD) is a progressive, long-term lung condition that limits airflow and makes breathing difficult.
- Trial name
- NCT07742033
- Testing
- Active Cycle of Breathing Technique (ACBT), Pursed Lip Breathing (PLB)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- University of Lahore
Obstructive Sleep Apnea
Pathophysiology of the Upper Airway in Patients With COPD and Concomitant OSA
The purpose of study is to evaluate the physiologic effects of pulmonary tissue/structural changes associated with COPD and upper airway inflammation on upper airway collapsibility.
- Trial name
- NCT02567448
- Testing
- Sleep and pulmonary physiologic measurements
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
COPD
Efficacy and Safety of QMF149 vs. Salmeterol Xinafoate/Fluticasone Propionate in Patients With Chronic Obstructive Pulmonary Disease (COPD)
To compare the efficacy, safety and pharmacokinetics of QMF149 delivered via Concept1 to salmeterol xinafoate/fluticasone propionate delivered via Accuhaler in adult patients with COPD
- Trial name
- NCT01636076
- Testing
- QMF149, Salmeterol
- Where
- 115 sites in Australia, Belgium and 16 more
- Volunteers
- 629 people
- Sponsor
- Novartis Pharmaceuticals
COPD, EBV
Epstein-Barr Virus Suppression in Chronic Obstructive Pulmonary Disease (EViSCO): a Phase 2 Randomised Control Trial
COPD is a major public health problem and will shortly become the third most common cause of global mortality. There are currently no treatments that can meaningfully alter the progression of COPD or the time to death.
- Trial name
- EViSCO (NCT03699904)
- Testing
- Valaciclovir
- Where
- United Kingdom
- Volunteers
- 85 people
- Sponsor
- Belfast Health and Social Care Trust
Rehabilitation, COPD (Chronic Obstructive Pulmonary Disease)
Long-term Effects and Maintenance of Exercise Habits in Individuals With COPD
The study aims to evaluate exercise habits and relevant health outcomes at 6 months and again 12 to 18 months after participation in the COPDEX trial (NCT06551441).
- Trial name
- COPDEXlifelong (NCT07870655)
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Obstructive Pulmonary Disease
The Effectiveness of an Innovative Inhalation Training Device in Improving Medication Accuracy, Dyspnea, and Quality of Life in Elderly Patients With Chronic Obstructive Pulmonary Disease
This study aims to evaluate the effectiveness of an innovative inhaler training device, "Golden Rhino" (pMDI Practice Tool), in improving inhalation technique accuracy, dyspnea severity, and quality of life among elderly patients…
- Trial name
- pMDII (NCT07305649)
- Testing
- Innovative Inhaler Training Device (金犀利), Standard pMDI Inhaler Education
- Where
- Taiwan
- Volunteers
- 82 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
COPD, Tobacco Use
Effects of Electronic Cigarettes in Cigarette Smokers With Mild to Moderate COPD
This study evaluates the effects of electronic cigarette use on cigarette smoking and markers of tobacco use, as well as respiratory symptoms and function in smokers with mild to moderate chronic obstructive pulmonary disease…
- Trial name
- NCT03379025
- Testing
- Electronic cigarette
- Sponsor
- Massachusetts General Hospital
Pulmonary Disease, Chronic Obstructive
Assessment of Physical Functioning and Handling of Spiolto® Respimat® in Patients With Chronic Obstructive Pulmonary Disease (COPD) Requiring Long-acting Dual Bronchodilation in Routine Clinical Practice
The primary objective of the study is to measure changes in physical functioning - serving as a surrogate for physical activity and exercise capacity - in COPD patients being treated with Spiolto® Respimat® after approximately 6…
- Trial name
- NCT02675517
- Testing
- Spiolto Respimat
- Where
- Germany
- Volunteers
- 1,737 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease
Ryme Medical TLD Pilot Study
Targeted lung denervation (TLD) with the Ryme Medical Lung Denervation System in patients with chronic obstructive pulmonary disease (COPD) - Ryme Medical TLD Pilot Study
- Trial name
- NCT05967091
- Testing
- Targeted Lung Denervation
- Where
- 7 sites in Australia, Austria and 4 more
- Volunteers
- 60 people
- Sponsor
- Ryme Medical, Inc.
Chronic Obstructive Pulmonary Disease
Analyzing Acoustic Properties of the Vowel "a" Collected Via Mobile Phone From Individuals Diagnosed With Chronic Obstructive Pulmonary Disease and Health Control Groups
The Study aims to identify the changes in voice caused by Chronic Obstructive Pulmonary Disease (COPD) statistically for identifying the potential digital voice biomarkers.
- Trial name
- NCT06705647
- Testing
- Chronic Obstructive Pulmonary Disease (COPD)
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Blekinge Institute of Technology
Chronic Obstructive Pulmonary Disease
An Efficacy and Safety Profile of Inhaled TV48108 in Healthy Volunteers and COPD Patients
The primary objective of the study is to characterize the safety profile and duration of bronchodilation of a single dose of inhaled TV48108.
- Trial name
- NCT02315144
- Testing
- TV48108
- Where
- 7 sites in United States, Australia and 1 more
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Bullous Emphysema
Bronchoscopic Intrabullous Autologous Blood Instillation (BIABI) for Emphysema
Patients with large bullae (large empty air sacs in the lung) may benefit from bullectomy (surgery to resect these bullae), however this is a major surgery with significant potential morbidity and long hospital stays.
- Trial name
- BIABI (NCT01727037)
- Testing
- Bronchoscopic intrabullous autologous blood instillation
- Where
- 3 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Chronic Obstructive Pulmonary Disease
A Clinical Trial of TQC3721 Suspension for Inhalation
To evaluate the safety, tolerability and pharmacokinetic characteristics of TQC3721 suspension for inhalation in single/multiple administration(s) in healthy subjects; to evaluate the safety,tolerability and efficacy TQC3721…
- Trial name
- NCT05051930
- Testing
- TQC3721 suspension for inhalation
- Where
- China
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Chronic Obstructive Pulmonary Disease
Comparative Effects of ACBT and Slow Expiration in Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is characterized by nonreversible airway obstruction. A diagnosis of COPD is determined by clinical assessment of airflow limitation and symptoms such as cough and wheeze; however, the…
- Trial name
- NCT05922267
- Testing
- ACTIVE CYCLE OF BREATHING TECHNIQUES, SLOW EXPIRATION WITH OPEN GLOTTIS IN LATERAL POSITION
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Asthma, Chronic Obstructive Pulmonary Disease
Trial Comparing Effect of He/O2 to Medical Air on Pulmonary Function Disease
This clinical trial will include healthy volunteers, COPD patients and asthmatic patients who will breathe He/O2 78:22, He/O2 65:35 and medical air consecutively in a randomised order.
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Healthy
- Trial name
- NCT00801307
- Testing
- spirometer
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Air Liquide SA
Bacterial Infection in COPD
Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD)
Study hypothesis: Chronic Obstructive Pulmonary Disease (COPD) patients with chronic bacterial colonization have lower levels of mucins and antimicrobial peptides in their airways
- Trial name
- NCT01976130
- Testing
- Bronchoscopy
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
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