Clinical trials: Chronic Pulmonary Obstruction
Gastroesophageal Reflux, Chronic Obstructive Pulmonary Disease
COPD Patients Diagnosed With GERD,COPD Exacerbations After Treatment With High Dose PPI
The purpose of this study is to determine which COPD patients have GERD and if COPD patients with GERD treated with high dose lansoprazole for 1 year decreases the frequency of COPD exacerbations compared to the previous year…
- Trial name
- GERD/COPD (NCT00523367)
- Testing
- 24 hour pH testing
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Type 2 Diabetes, Chronic Obstructive Pulmonary Disease (COPD)
Measurements Before and After Participation in a Health Intervention Programme in Halsnaes Municipality
Based on the Danish Health Authority's quality standards for municipal prevention services for citizens with chronic diseases, Steno Diabetes Center Copenhagen (SDCC), Halsnaes Municipality, North Zealand Hospital, and others…
- Conditions
- Type 2 Diabetes, Chronic Obstructive Pulmonary Disease (COPD), Cardiovascular Disease
- Trial name
- NCT07641309
- Where
- Denmark
- Volunteers
- 194 people
- Sponsor
- Steno Diabetes Center Copenhagen
COPD
Novel Vascular Manifestations of Chronic Obstructive Pulmonary Disease
Cognitive impairment is a known consequence of cerebral small-vessel disease. Moderate to severe cognitive impairment has been shown in up to 60% of certain individuals with COPD and is likely to profoundly influence an…
- Trial name
- NOVASC COPD (NCT02060292)
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- North Bristol NHS Trust
COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis)
Creation of a Biological Collection of BRonchiaI and Pulmonary Tissues From Surgical wastE
The biological samples and associated data will facilitate the successful implementation of the research collaboration between Bordeaux University Hospital and the University of Bordeaux on the pathophysiology of bronchopulmonary…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis), Safe Volunteers
- Trial name
- BRISE (NCT07780630)
- Testing
- Fiberscopic samples, Sputum, Nasal brushing
- Where
- France
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Nasal Obstruction
Nasal Obstruction With Oxymetazoline and Corticosteroids
This study aims to examine the efficacy and safety of commination oxymetazoline/intranasal steroids for long-term management of chronic nasal obstruction that is recalcitrant to the current standard of care.
- Trial name
- NORTOC (NCT06830109)
- Testing
- Oxymetazoline Nasal Spray, Budesonide nasal spray
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Washington University School of Medicine
Lung; Disease, Interstitial, With Fibrosis, Pulmonary Disease, Chronic Obstructive
Deep Learning Diagnostic and Risk-stratification for IPF and COPD
Idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP), and chronic obstructive pulmonary disease (COPD) are severe, progressive, irreversibly incapacitating pulmonary disorders with modest response to…
- Conditions
- Lung; Disease, Interstitial, With Fibrosis, Pulmonary Disease, Chronic Obstructive, Artificial Intelligence
- Trial name
- DeepBreath (NCT05318599)
- Testing
- Lung auscultation, Lung ultrasound, Quality of Life's questionnaires
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- Pediatric Clinical Research Platform
Hypoxia, Inflammation
Effects of Hypoxia and Inflammation on Citrulline Synthesis by Ornithine Transcarbamylase in Human Enterocytes
Chronic Obstructive Pulmonary Disease (COPD) is characterized by chronic systemic hypoxia and low-grade inflammation as well as by an alteration of arginine (ARG) metabolism.
- Conditions
- Hypoxia, Inflammation, Chronic Obstructive Pulmonary Disease
- Trial name
- HYPOCITRE (NCT02820064)
- Testing
- duodenal biopsy during gastroduodenal endoscopy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Chronic Obstructive Pulmonary Disease (COPD)
Ketogenic Dietary Intervention in Men With Mild-to-Moderate COPD
Chronic obstructive pulmonary disease (COPD) is associated with persistent airflow limitation, systemic inflammation, reduced exercise capacity, and unfavorable changes in body composition.
- Trial name
- COPDKETO (NCT07664111)
- Testing
- Ketogenic diet, Standard Dietary Advice
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Agri Ibrahim Cecen University
Pulmonary Disease, Chronic Obstructive
A Study to Compare the Efficacy and Safety of Umeclidinium/Vilanterol and Fluticasone Propionate/Salmeterol in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
This is a multicenter, randomized, double-blind, double-dummy, parallel group study. The purpose of this study is to compare the efficacy and safety of umeclidinium/vilanterol (UMEC/VI) and fluticasone propionate/salmeterol (FSC)…
- Trial name
- NCT01817764
- Testing
- Umeclidinium/vilanterol, Fluticasone propionate/salmeterol
- Where
- 59 sites in United States, Argentina and 5 more
- Volunteers
- 707 people
- Sponsor
- GlaxoSmithKline
Smoking, COPD
Nurse Smoking Cessation of Patients With Chronic Obstructive Pulmonary Disease (COPD) With Nicotine Replacement Therapy (NRT) and Behavioral Support
This is a smoking cessation study with COPD patients where the researchers wanted to evaluate if nicotine sublingual tablets or placebo combined with low or high individual support could increase ½ and 1 year quit rates.
- Trial name
- NCT00132236
- Testing
- nicotine sublingual tablets, low and high behavior support
- Where
- 7 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Shortness of Breath
Effect of Senobi Versus Buteyko Technique on Functional Performance of Chronic Obstructive Pulmonary Disease Patient.
Effect of Senobi breathing exercise versus Buteyko breathing technique on functional performance among chronic obstructive pulmonary patient.
- Trial name
- NCT06196957
- Testing
- pursed lip breathing
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Pulmonary Disease, Chronic Obstructive
A Cross-sectional Study on COPD Prevalence
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality worldwide and hence, estimating its prevalence is important.
- Trial name
- NCT03028207
- Testing
- Medical tests, Questionnaire
- Where
- 20 sites in Spain
- Volunteers
- 9,362 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Nasal High Flow
Investigating the Effect of Nasal High Flow Oxygen Therapy on Regional Lung Function
This study aims to assess the effect of nasal high flow oxygen therapy on regional function measured by volumetric computed tomography, in patients with chronic obstructive pulmonary disease.
- Conditions
- Chronic Obstructive Pulmonary Disease, Nasal High Flow, Dynamic Volumetric Computed Tomography
- Trial name
- INVENT (NCT03821311)
- Testing
- Computed tomography
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
Chronic Obstructive Pulmonary Disease
Noninvasive Ventilation Weaning Protocol in COPD
Noninvasive ventilation (NIV) has revolutionized the management of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with hypercapnic respiratory failure (HcRF).
- Trial name
- NCT07133711
- Testing
- Noninvasive ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease (COPD)
Effect Of Acetazolamide On Altitude Related Illness In Patients With Respiratory Disease
Randomized, placebo controlled trial evaluating efficacy of acetazolamide in preventing altitude related adverse health effects (ARAHE) in lowlanders with chronic obstructive lung disease travelling from 760 m to 3200 m.
- Trial name
- NCT03156231
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 185 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease (COPD), Heart Failure
Breathlessness Patterns in Patients With Cancer, COPD and Heart Failure: an fMRI Feasibility Study
Dyspnea that persists despite optimal pathophysiological treatment is defined as persistent dyspnea. Currently all brain functional magnetic resonance imaging (fMRI) studies conducted to evaluate breathlessness have done so using…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Heart Failure, Cancer, Volunteers
- Trial name
- BREACH-fMRI (NCT07319039)
- Testing
- Cerebral fMRI, Immersive virtual reality
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Chronic Obstructive Pulmonary Disease
Feel Breathe, Restriction Device Ventilatory Nasal (COPD)
FEELBREATHE®, a nasal ventilatory restriction device, used during an exercise test in treadmill produces changes on breathing efficiency in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- BreatheCOPD (NCT01695265)
- Testing
- Exercie oronasal breathing (ONB), Exercie nasal breathing through the FB
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- University of Cadiz
Lung Cancer, Cardiovascular Disease (CVD)
Optimised Lung Cancer Screening to Prevent Cardiovascular and Pulmonary Diseases Coupled With Primary Prevention
This project aims to implement a health prevention program for smokers or former smokers including early detection of lung cancer, cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD).
- Conditions
- Lung Cancer, Cardiovascular Disease (CVD), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- SMAC-1 (NCT04315766)
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Pulmonary Disease, Chronic Obstructive
Spot Marching Exercise Test in Chronic Obstructive Pulmonary Disease
the aim of this study to assess the relationship and compare physiological response between spot marching exercise test and 6 minute walk test in patient with chronic obstructive pulmonary disease
- Trial name
- SMT (NCT02719457)
- Testing
- 6 minute walk test (6 MWT), Spot marching test (SMT)
- Where
- 2 sites in Thailand
- Volunteers
- 30 people
- Sponsor
- Khon Kaen University
COPD, Dyspnea
Ventilation Imbalances in Mild to Moderate Chronic Obstructive Pulmonary Disease
The Investigators plan a single center study to get preliminary data to answer a number of fundamental questions directly related to management of COPD.
- Conditions
- COPD, Dyspnea, Respiratory Disease, Lung Diseases
- Trial name
- VAPOR (NCT04880551)
- Testing
- Fluoroscopy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
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