Clinical trials: Chronic Pulmonary Obstruction
Chronic Obstructive Pulmonary Disease
Hyperpolarized Xenon-129 MRI: a New Multi-dimensional Biomarker to Determine Pulmonary Physiologic Responses to COPD Therapeutics
Hyper polarized xenon-129 MRI (HXe MRI) is a unique imaging test which can detect how air is flowing in and out of lungs and how oxygen can move from inhaled air into the blood.
- Trial name
- NCT03002389
- Testing
- Anoro Ellipta, Arnuity Ellipta
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- University of Virginia
Pulmonary Disease, Chronic Obstructive
Real-Time Telehealth to Promote Self-care Management for Chronic Obstructive Pulmonary Disease
HYPOTHESIS:The study purpose is to evaluate the effectiveness of a structured pursed-lips breathing (PLB) protocol taught via real-time interactive telecommunication with a home computer using the lnternet and Skype software in…
- Trial name
- E-Breathe (NCT01161290)
- Testing
- synchronous interactive audio/video telecommunication
- Volunteers
- 22 people
- Sponsor
- Breathe California, Los Angeles County
COPD
High Protein Diet and Physical Activity in COPD
COPD outpatients with severe and very severe (grade III-IV) disease at risk of malnutrition commencing rehabilitation (7-10-week physical activity program) were randomized to receive a high protein diet (≥ 25 energy percentage)…
- Trial name
- NCT04888182
- Testing
- intervention
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Jens Rikardt Andersen
Pulmonary Disease, Chronic Obstructive
A Long-term Safety Study of Fluticasone Furoate (FF)/GW642444 in Japanese Subjects With COPD
The primary purpose of the study is to evaluate the safety and tolerability of fluticasone furoate/GW642444 inhalation powder when administered once-daily for 52 weeks in Japanese patients with COPD.
- Trial name
- NCT01192191
- Testing
- Fluticasone Furoate/GW642444 Inhalation Powder 100/25mcg, Fluticasone Furoate/GW642444 Inhalation Powder 200/25mcg
- Where
- 35 sites in Japan
- Volunteers
- 187 people
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease
Home Mechanical Ventilation in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Hypercapnic Response
The objective of this study is to evaluate the clinical benefits of home mechanical ventilation associated to oxygen therapy in COPD patients with chronic respiratory failure (CRF) who develop hypercapnia and nocturnal…
- Trial name
- NCT01120574
- Testing
- Home mechanical ventilation
- Where
- Spain
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Coronary Artery Disease, Hypertension
China Elderly Comorbidity Medical Database
The objective of this observational cohort study is to provide comprehensive evaluation and early warning for elderly patients with chronic diseases.
- Conditions
- Coronary Artery Disease, Hypertension, Diabetes Mellitus, Osteoporosis
- Trial name
- CECMed (NCT06316544)
- Where
- China
- Volunteers
- 4,100 people
- Sponsor
- Beijing Friendship Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Mometasone Furoate/Formoterol Combination Versus Formoterol and Mometasone Furoate Alone in Chronic Obstructive Pulmonary Disease (COPD) (Study P04230AM4)(COMPLETED)
This is a randomized, placebo-controlled, parallel-group, multi-site, double-blind study evaluating the efficacy of mometasone furoate/formoterol fumarate (MF/F) metered dose inhaler (MDI) 400/10 mcg twice daily (BID) and MF/F…
- Trial name
- NCT00383721
- Testing
- Mometasone furoate/formoterol (MF/F) combination, Mometasone furoate MDI (MF MDI), Formoterol MDI
- Volunteers
- 1,196 people
- Sponsor
- Organon and Co
Chronic Obstructive Pulmonary Disease (COPD)
Artificial Intelligence-Based Motion Analysis for Early Detection of COPD
This study aims to develop a non-invasive and contact-free diagnostic system that uses artificial intelligence (AI) to detect Chronic Obstructive Pulmonary Disease (COPD) by analyzing walking patterns.
- Trial name
- NCT07010211
- Testing
- Gait Video Recording and Analysis
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Burcin Celik
COPD
Detection of Early Airway Obstruction in Patients With COPD Using RCexp
We hypothesize that Cexp during tidal and forced exhalation implemented to the routine spirometer may detect airway obstruction earlier than conventional spirometric indices such as FEV1 and FEV1/FVC.
- Trial name
- COPD TiCON (NCT06456047)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- East Slovak Institute for Cardiovascular Diseases
Chronic Obstructive Pulmonary Disease
Predictors of the Long-term Functional Benefits of a Pulmonary Rehabilitation Program?
The present study aims to assess the prevalence and impact of comorbid psychiatric disorders among patients with chronic obstructive pulmonary disease (COPD) undergoing pulmonary rehabilitation (PR), in order to determine the…
- Trial name
- NCT02528487
- Where
- 5 sites in Canada
- Volunteers
- 360 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation
Telemonitoring in Pulmonary Rehabilitation: Validity of a Remote Pulse Oxymetry System
The purpose of this study is to assess the feasibility and the reliability of a telemonitoring system during pulmonary rehabilitation in patients with chronicle obstructive pulmonary disease.
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation, Telemedicine
- Trial name
- TELE-REHAB (NCT03004716)
- Testing
- Aerobic training
- Where
- France
- Volunteers
- 5 people
- Sponsor
- ADIR Association
Chronic Obstructive Pulmonary Disease
A Study in Patients With Chronic Obstructive Pulmonary Disease (FAIR)
The purpose of the present study is to demonstrate the higher efficacy of small particles Foster® 100/6 (two puffs b.i.d.) versus large particles Symbicort® 200/6 (two inhalations b.i.d.), in terms of residual volume reduction…
- Trial name
- FAIR (NCT01351792)
- Testing
- Foster® 100/6 µg/unit dose, Symbicort® Turbohaler® 200/6 μg/actuation
- Where
- Netherlands
- Volunteers
- 113 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Obstructive Pulmonary Disease
Falling in Patients With COPD Referred to Pulmonary Rehabilitation: Incidence, Risk Factors and Prediction Tools
The primary aim of this study is to investigate the incidence of falling in a cohort of patients with chronic obstructive pulmonary disease (COPD) referred to a pulmonary rehabilitation program and to verify the risk factors.
- Trial name
- NCT02434198
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- KU Leuven
Chronic Obstructive Pulmonary Disease (COPD)
Physical Training and Heart Rate Variability in COPD
To contrast the potential effects of physical exercise training program (PTP) of a 6 versus 12 weeks on cardiac autonomic modulation by linear and non-linear heart rate variability (HRV) indices and functional capacity in…
- Trial name
- NCT01889563
- Testing
- Physical Exercise Training Program Exercise
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal de Sao Carlos
Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
N-Acetylcysteine for Patients With COPD and ChronicBronchitis
N-acetylcysteine (NAC) is described as having mucolytic and antioxidant properties. It is widely prescribed for patients with chronic obstructive pulmonary disease (COPD), particularly for those who have accompanying symptoms of…
- Trial name
- NCT01599884
- Testing
- N-acetylcysteine, Oral acetylcysteine
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Center for Veterans Research and Education
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Efficacy of Varenicline on Smoking Cessation at the Acute Phase of an Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the bronchi with an increasing prevalence. By 2020, the mortality related to COPD is expected to become the 3rd leading death worldwide.
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Smoking
- Trial name
- SAVE (NCT01694732)
- Testing
- Varenicline
- Where
- 13 sites in France
- Volunteers
- 83 people
- Sponsor
- University Hospital, Brest
Broncho-degenerative Disease, Chronic Obstructive Airway Disease
Evaluation of the Safety of the Medical Device Simeox®
The purpose of this study is to determine whether the medical device "simeox" is safe in the treatment of respiratory diseases, in comparison with traditional physiotherapy.
- Conditions
- Broncho-degenerative Disease, Chronic Obstructive Airway Disease, Cystic Fibrosis, Idiopathic Bronchiectasis
- Trial name
- SIMETOL (NCT02061852)
- Testing
- Simeox, Physiotherapy
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Physio-Assist
Chronic Obstructive Pulmonary Disease
Effects of Inspiratory Muscle Training on Dyspnea in Subjects With Chronic Obstructive Pulmonary Disease
The purpose of this study is to determinate whether inspiratory muscle training (IMT) associated with a conventional respiratory rehabilitation program is more effective than a conventional respiratory rehabilitation program…
- Trial name
- IMT (NCT01545011)
- Testing
- Inspiratory muscle training
- Where
- 2 sites in France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Brest
Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Postural Control in Patients With Respiratory Disease at Altitude
In this trial, the investigators will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on postural control at acute altitude exposure in patients with COPD.
- Trial name
- NCT03177811
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 127 people
- Sponsor
- University of Zurich
Chronic Obstructive Pulmonary Disease (COPD)
Safety Study of CTX-100 Inhalation Solution (Formerly ETX-100)
The purpose of the study is to evaluate the safety of administering repeated doses of CTX-100 (formerly ETX-100) to subjects with smoking-related chronic obstructive pulmonary disease.
- Trial name
- NCT00993707
- Testing
- CTX-100 (formerly ETX-100) (hyaluronic acid)
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Turino, Gerard, M.D.
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