Clinical trials: Chronic Pulmonary Obstruction
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation
This study will evaluate whether adding extracorporeal carbon dioxide removal (ECCO2R) to noninvasive ventilation can improve breathing in adults hospitalized with a severe worsening of chronic obstructive pulmonary disease…
- Trial name
- NCT07785375
- Testing
- Extracorporeal Carbon Dioxide Removal, Noninvasive Ventilation
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
COPD
Appropriate Admission in COPD Exacerbation From Emergency Department. Multicenter Study
Objectives: To estimate the rate of appropriate hospital admissions , and of discharge to home episodes that would have been appropriate admissions to the hospital, on patients with exacerbations of their COPD by using…
- Trial name
- IRYSS-COPD (NCT02434536)
- Volunteers
- 2,487 people
- Sponsor
- Hospital Galdakao-Usansolo
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.
The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab Dose 1 and Dose 2 administered subcutaneously (SC) in adult participants with symptomatic COPD and history of ≥ 2 moderate or ≥ 1 severe…
- Trial name
- TITANIA (NCT05158387)
- Testing
- Tozorakimab
- Where
- 212 sites in United States, Australia and 18 more
- Volunteers
- 1,172 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Effects of Non-invasive Ventilation on Rehabilitation Outcome in COPD-patients
The aim of the study is to find out if nocturnal non-invasive ventilation during pulmonary rehabilitation increases exercise capacity and quality of life more than pulmonary rehabilitation alone.
- Trial name
- NCT01384981
- Testing
- pulmonary rehabilitation
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Chronic Respiratory Disease, Chronic Pulmonary Aspergillosis
Pharmacological Evaluation of Antifungal in Chronic Pulmonary Aspergillosis
At present, pulmonary diffusion and target antifungal concentrations for APC in patients with sarcoidosis or chronic obstructive pulmonary disease (COPD) are unknown.
- Trial name
- EPAR-APC (NCT05064605)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD, Pulmonary Hypertension
An Open-Label Study to Evaluate the Safety and Efficacy of PRX-08066 in Patients With Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease
A 3-month open label study to evaluate the safety and efficacy of PRX-08066 in patients with pulmonary hypertension and COPD.
- Trial name
- NCT00677872
- Testing
- PRX-08066
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Epix Pharmaceuticals, Inc.
Respiratory Tract Diseases, Abnormal Mucus Secretions
A Clinical Trial to Compare the Efficacy and Safety of 1-week Treatment of Intravenous N-acetylcysteine (NAC) 600 mg Twice Daily, Ambroxol Hydrochloride 30 mg Twice Daily and Placebo as Expectorant Therapies in Adult Chinese Patients With Respiratory Tract Diseases and Abnormal Mucus Secretions
This is a phase 3, multicenter, randomized, rater- and patient-blind, placebo- and active-controlled, 3-arm parallel group clinical trial.
- Trial name
- NCT03843541
- Testing
- N-acetylcysteine (NAC) 600 mg, Ambroxol hydrochloride 30 mg
- Where
- 32 sites in China
- Volunteers
- 333 people
- Sponsor
- Zambon SpA
Chronic Obstructive Pulmonary Disease
Videogame Assisted Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease
Pulmonary rehabilitation programs (PRP) are a key factor of comprehensive management of patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT03567772
- Testing
- Wiifit Nintendo video game, Pulmonary rehabilitation program
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Universitas Sebelas Maret
Chronic Obstructive Pulmonary Disease
Oral Supplement and Acute Resistance Exercise
This study should provide the mechanistic basis for and evaluation of a new nutritional formulation to be used alongside exercise training to improve muscle function and exercise performance by minimizing exercise induced…
- Trial name
- HMB exercise (NCT06801951)
- Testing
- acute resistance exercise with oral nutrition supplementation, stable tracer infusion
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Chronic Obstructive Pulmonary Disease
Rethinking Pulmonary Rehabilitation - a Three-arm Randomised Multicentre Trial
Pulmonary rehabilitation (PR) is one of the cornerstones of care for people with COPD together with smoking cessation and medical treatment.
- Trial name
- REPORT (NCT05664945)
- Testing
- pulmonary tele-rehabilitation (PTR), home-based pulmonary rehabilitation (HPR), Control
- Where
- 7 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Metabolic Syndrome, Chronic Obstructive Pulmonary Disease
Digital Metabolic Rehabilitation COPD
People with Chronic Obstructive Pulmonary Disease (COPD) are at greater risk for Metabolic syndrome (MetS). Although the management of MetS will not cure COPD, it can beneficially impact health outcomes and quality of life…
- Trial name
- NCT05806294
- Testing
- Digital Metabolic Rehabilitation
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Alberta
Chronic Obstructive Pulmonary Disease With Chronic Bronchitis
A Study of 24 to 52 Weeks Treatment to Evaluate The Efficacy And Safety of Galvokimig in Study Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis
The purpose of the study is to investigate the efficacy of galvokimig versus placebo in the time to the first acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in study participants with moderate-to-severe COPD…
- Trial name
- SCALA (NCT07725939)
- Testing
- Galvokimig
- Where
- 23 sites in United States, China
- Volunteers
- 402 people
- Sponsor
- UCB Biopharma SRL
Chronic Obstructive Pulmonary Disease
Pain Assessment in Patients With Chronic Obstructive Pulmonary Disease (COPD) Exacerbations.
The prevalence of chronic obstructive pulmonary disease (COPD) is between 8 and 12% of the adult population. This prevalence is expected to increase over the coming decades due to the aging of the population and the continued…
- Trial name
- MorphoCOPD1b (NCT03102970)
- Where
- 2 sites in Canada, France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Pulmonary Disease, Chronic Obstructive
Trial to Determine the Comparability of Ipratropium Bromide Hydrofluoroalkane (HFA)-134a Inhalation Aerosol to ATROVENT® Chlorofluorocarbon (CFC) Inhalation Aerosol, in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The objective of this study was to determine the pharmacokinetic comparability of 84 µg ipratropium bromide HFA-134a inhalation aerosol and 84 µg ATROVENT® CFC Inhalation Aerosol in COPD patients
- Trial name
- NCT02236169
- Testing
- Ipratropium bromide HFA-134a inhalation aerosol, Atrovent CFC inhalation aerosol
- Volunteers
- 30 people
- Sponsor
- Boehringer Ingelheim
COPD, Emphysema
Regulation of Inflammatory Mediators in Chronic Obstructive Pulmonary Disease
The aim of this study is to investigate the mechanisms whereby lung function is decreased in COPD. The hypothesis is that in diseases such as COPD, inflammatory cells including neutrophils, macrophages and lymphocytes migrate to…
- Trial name
- NCT00147095
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College London
COPD Exacerbation, COPD Exacerbation Acute
Prehospital Non-invasive Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The goal of this clinical trial is to test if treatment with prehospital Non-invasive ventilation (NIV) for patients with acute respiratory failure (ARF), due to acute exacerbation of chronic obstructive pulmonary disease…
- Conditions
- COPD Exacerbation, COPD Exacerbation Acute, Noninvasive Ventilation, Emergency Medical Services
- Trial name
- PRENIV (NCT06211920)
- Testing
- Non-invasive ventilation
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Central Denmark Region
COPD, Dyspnea
Deventilation Dyspnea in COPD Patients Using NIV
Non-invasive ventilation (NIV) has shown to be an effective therapy for patients with Chronic Obstructive Pulmonary Disease (COPD) with Chronic Hypercapnic Respiratory Failure (CHRF).
- Conditions
- COPD, Dyspnea, Mechanical Ventilation Complication
- Trial name
- NCT03503123
- Testing
- Monitoring physiology with Electrical Impedance Tomography, Electromyography and transcutaneous carbon dioxide measurements.
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease (COPD)
A Crossover Study to Determine the Effect on Lung Function of Indacaterol in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD), Using Tiotropium as an Active Control
The study compared the 24-hour spirometry profile of indacaterol with that of placebo and with tiotropium as an active control in patients with chronic obstructive pulmonary disease.
- Trial name
- NCT00615459
- Testing
- Indacaterol, Tiotropium
- Where
- 20 sites in Australia, Germany and 5 more
- Volunteers
- 169 people
- Sponsor
- Novartis
Copd, Chest Disorders
Efficacy of Costal Mobilization Techniques and Manual Diaphragm Release Technique in Patients COPD
To evaluate the acute and chronic effects of costal mobilization techniques and diaphragmatic release in chest cavity kinematics, diaphragmatic mobility and functional capacity in patients with chronic obstructive pulmonary…
- Conditions
- Copd, Chest Disorders, Diaphragmatic Disorder
- Trial name
- NCT03022942
- Testing
- GROUP Costal mobilization & Diaphragm Release, GROUP Manual Diaphragm Release
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal de Pernambuco
Chronic Obstructive Pulmonary Disease
Safety Study of Arformoterol Tartrate Inhalation Solution in Chronic Obstructive Pulmonary Disease (COPD) Subjects
This is a multi-center study to evaluate the long-term safety of arformoterol 15 mcg twice daily (BID) in the treatment of subjects with moderate-to-severe COPD.
- Trial name
- NCT00909779
- Testing
- Arformoterol
- Where
- 73 sites in United States
- Volunteers
- 841 people
- Sponsor
- Sumitomo Pharma America, Inc.
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