Clinical trials: Chronic Respiratory Failure With Hypercapnia
Chronic Respiratory Failure, Acute Respiratory Failure
Automated Oxygen Titration With the EMILY.AI Device in a Respiratory Intermediate Care Unit
This study evaluates EMILY.AI, an investigational (non-CE-marked) smart oxygen valve that automatically adjusts the oxygen flow delivered to a patient, second by second, according to oxygen saturation (SpO2), heart rate and…
- Conditions
- Chronic Respiratory Failure, Acute Respiratory Failure, Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
- Trial name
- NCT06952816
- Testing
- Emily.AI, Manual oxygen titration
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Aether Tech S.L.
Pulmonary Disease, Chronic Respiratory Failure
Home Mechanical Ventilation Effectiveness and Air Leaks
Non invasive ventilation (NIV) usually presents air leaks that may determine the result of this treatment. The clinical usefulness of analyzing (and quantifying) these leaks during the adaptation period to NIV has not been…
- Conditions
- Pulmonary Disease, Chronic Respiratory Failure, COPD
- Trial name
- NCT01090986
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
COPD, Hypercapnic Respiratory Failure
HFNC vs NPPV After Early Extubation for Patients With COPD
High-flow nasal cannula oxygen therapy(HFNC) has proved no significant difference compared with noninvasive positive pressure ventilation (NPPV) in preventing postextubation respiratory failure and reintubation in patients with…
- Trial name
- NCT04156139
- Testing
- HFNC, NPPV
- Where
- China
- Volunteers
- 502 people
- Sponsor
- Chinese PLA General Hospital
Hypercapnic Respiratory Failure
Use of Nasal High Flow Oxygen During Breaks of Non-invasive Ventilation for Patients With Hypercapnic Respiratory Failure
Chronic respiratory insufficiency and COPD are the third leading cause of death worldwide. Patients decompensate at various stages of their disease and exhibit acute-on-chronic respiratory failure (ACRF), a frequent cause of ICU…
- Trial name
- HIGH FLOW ACRF (NCT03406572)
- Testing
- HFHO Group, Standard O2
- Where
- France
- Volunteers
- 161 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Diseases, Obstructive
ECCO2R in the Treatment of Acute Exacerbation of COPD With Severe Hypercapnia
Patients with moderate to severe acute exacerbation of chronic obstructive pulmonary disease are often complicated with hypercapnia and respiratory failure, so they need to be admitted to ICU for monitoring and respiratory…
- Trial name
- NCT04842344
- Testing
- ECCO2R
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Li Xuyan
Cystic Fibrosis, Chronic Respiratory Failure
Effect of Non-Invasive Ventilation in Cystic Fibrosis Patient With Chronic Respiratory Failure.
There is no randomised controlled trials to determine the clinical effects of long term Non-Invasive Ventilation in Cystic Fibrosis patients.
- Trial name
- NCT00208078
- Testing
- pressure support ventilator
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Cochin Hospital
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Validation of Chinese SRI Questionnaire
Assessment of health-related quality of life in COPD patients with severe chronic respiratory failure requires appropriate and highly specific measurement tools.
- Trial name
- VCSRI (NCT02240225)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Pulmonary Disease, Chronic Obstructive
Efficacy and Physiology of Nasal High Flow Therapy
The effects of a nasal high-flow (NHF) therapy in patients with chronic obstructive hypercapnic respiratory failure are still not sufficiently known yet.
- Trial name
- NCT02083120
- Testing
- NHF therapy, Long term Oxygen Therapy (LOT)
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis
Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis
The purpose of this study is to determine whether nasal high flow is non inferior to non invasive ventilation (NIV) in the early treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and…
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis, Respiratory Failure With Hypercapnia
- Trial name
- HiCOPD (NCT06114667)
- Testing
- Ventilatory support via nasal high flow, Ventilatory support via NIV
- Where
- 3 sites in France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Montpellier
Respiratory Failure, Neuromuscular Disease
Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Acute Exacerbation of Respiratory Failure
The aim of the study is to compare the efficacy and tolerance of autotitrating non-invasive ventilation (NIV) versus standard NIV in patients admitted to hospital with acute exacerbation of chronic respiratory failure.
- Conditions
- Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01174316
- Testing
- AutoVPAP™, VPAPIIIST-A™
- Where
- United Kingdom
- Sponsor
- ResMed
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Withdrawal of Non-invasive Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Acute Hypercapnic Respiratory Failure
The investigators design a pilot randomised, single-centred, controlled trial to compare different withdrawal methods of Non-invasive ventilation.
- Trial name
- NCT01523470
- Testing
- BIPAP Synchrony
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- United Christian Hospital
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Helmet Ventilation in Acute Hypercapnic Respiratory Failure
Lack of tolerance to the treatment, makes the interface choice for non-invasive ventilation (NIV) one of the key factor. To date the helmet is rarely used in Acute Hypercapnic Respiratory Failure (AHRF), because of its large dead…
- Trial name
- NCT01645358
- Testing
- Helmet (Starmed), Total Face mask (Respironics)
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
COPD
High-Flow Nasal Cannula Versus Noninvasive Ventilation After Extubation in Patients With COPD and Mild Hypercapnic Respiratory Failure
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) represent a leading cause of hospital admissions and respiratory intensive care unit (RICU) stays worldwide.
- Trial name
- NCT07381686
- Testing
- Non-Invasive Ventilation (NIV), High-Flow Nasal Cannula (HFNC)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Chronic Hypercapnic Respiratory Failure
Monitoring of Patients With Chronic Respiratory Failure Treated With Non-invasive Home Ventilation: Contribution of New Monitoring Tools
Single-center retrospective study conducted on a population of patients with chronic hypercapnic respiratory failure treated by non-invasive ventilation at home, followed at the CHRU of Nancy.
- Trial name
- NCT04872062
- Testing
- NIV cards, Medical file
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
High Flow Oxygen Therapy, Acute Hypercapnic Respiratory Failure
HFNC and Acute Hypercapnic Respiratory Failure
High-flow nasal cannula (HFNC) enables delivering humidified gas at high-flow rates controlling the oxygen inspired fraction (FiO2). Its efficacy has been demonstrated in hypoxemic acute respiratory failure.
- Conditions
- High Flow Oxygen Therapy, Acute Hypercapnic Respiratory Failure, COPD Exacerbation
- Trial name
- NCT04109560
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Argentinian Intensive Care Society
COPD
Sleep Ventilation for Patients With Advanced Hypercapnic COPD
Despite growing evidence showing benefit (in both clinical and cost standpoints), only a small percentage of COPD patients with chronic hypercapnic respiratory failure are managed with nocturnal ventilatory support.
- Trial name
- NCT04210050
- Testing
- Home noninvasive nocturnal ventilation with Breas VIVO 50 home ventilator or newer model as available, Breas Medical., Arterial blood gas (ABG) and serum bicarbonate level, Overnight home oximetry and transcutaneous CO2 monitoring
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center