Clinical trials: Chronic Respiratory Insufficiency
Postoperative Sore Throat, Nasal Obstruction
Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal Obstruction
Postoperative sore throat (POST) affects 21-65% of patients after endotracheal intubation and is among the most common complaints after general anesthesia.
- Conditions
- Postoperative Sore Throat, Nasal Obstruction, Septoplasty
- Trial name
- POST-MUCOSAL R (NCT07870252)
- Testing
- Nebulized 0.9% Normal Saline, Water-Soluble Lubricant Gel on Endotracheal Tube
- Where
- Saudi Arabia
- Volunteers
- 105 people
- Sponsor
- Mansoura University
Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome
Efficacy of Average Volume Assured Pressure Support With Bi-Level Pressure Support Nocturnal Ventilation
Patients with chronic hypercapnic respiratory failure can be successfully treated with home nocturnal non-invasive ventilation. Bi-level pressure support ventilators are at present the most frequently used ventilators for long…
- Conditions
- Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00479284
- Testing
- Average volume assured pressure support (AVAPS)
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- University Hospital, Geneva
Congestive Heart Failure, Diabetes
Study of the Effect on Clinical Outcomes Using Secure Text Messaging
In this study, the investigators will conduct a randomized, controlled trial to evaluate the impact of offering mobile secure text messaging on clinical outcomes.
- Conditions
- Congestive Heart Failure, Diabetes, Renal Failure, Copd
- Trial name
- NCT02568514
- Testing
- Secure text messaging
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
A Comparison of Three Nutritional Assessment Methods Predicting Prognosis in COPD With Respiratory Failure
This is a retrospective study of patients diagnosed with chronic obstructive pulmonary disease (COPD) with respiratory failure and admitted in West China Hospital during January 2014 to March 2016 by review of medical records.
- Trial name
- NCT02942784
- Where
- China
- Volunteers
- 750 people
- Sponsor
- West China Hospital
Bronchopulmonary Dysplasia, Chronic Pulmonary Insufficiency of Prematurity
Late Surfactant After a Recruitment Maneuver in Extremely Low Gestational Age Newborns - LATE-REC-SURF Trial
This is an unblinded monocentric pilot superiority trial that will be conducted in a IIIlevel NICU at Fondazione Policlinico Agostino Gemelli - IRCCS.
- Trial name
- LateRecSurf (NCT04825197)
- Testing
- Poractant Alfa Intratracheal Suspension [Curosurf]
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- VENTO GIOVANNI
COPD Exacerbation
NIV - NAVA vs NIV - PS for COPD Exacerbation
Number of Patients: Total no. of patients = 40 patients NIV-PSV group (Group A) = 20 NIV-NAVA group (Group B) = 20 Inclusion criteria a) Patients of Chronic obstructive pulmonary disease with acute hypercapnic respiratory failure…
- Trial name
- NAVA-NICE (NCT02912689)
- Testing
- Neurally Adjusted Ventilator Assist, Pressure support ventilation
- Where
- India
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences
COVID-19, Renal Insufficiency, Chronic
Efficiency and Safety of Paxlovid for COVID-19 Patients With Severe Chronic Kidney Disease
This is a prospective, single-center, open and self-controlled study.The purpose of this study is to evaluate the efficacy and safety of Paxlovid for the treatment of COVID-19 patients with severe chronic kidney disease.
- Trial name
- ESPTCSCKD (NCT05938140)
- Testing
- Nirmatrelvir/ritonavir
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
COPD, Postural; Defect
Spinal Structure and Mobility in Chronic Obstructive Pulmonary Disease
In recent studies with musculoskeletal system disorders in chronic respiratory patients, it has been reported that postural control is affected in COPD patients.
- Conditions
- COPD, Postural; Defect, Respiratory Function Impaired, Dyspnea
- Trial name
- NCT05021068
- Testing
- Postural Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Izmir Katip Celebi University
Chronic Respiratory Failure, Critical Illness Myopathy
Electric Muscle Stimulation for Patients With Chronic Respiratory Failure
Background: After mechanical ventilation, 5-20% of patients with acute respiratory failure would depend on ventilator support more than 14 days because of critical-illness weakness and their underlying diseases such as heart…
- Trial name
- NCT01930643
- Testing
- EMS
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- Mackay Memorial Hospital
Kidney Failure, Chronic, Covid19
Assessment of Immune Response After Vaccination Against COVID-19 in Patients Treated With Renal Replacement Therapy
Chronically dialyzed patients and kidney transplant recipients have been identified as particularly vulnerable to SARS-CoV-2 infection due to unavoidable exposure.
- Conditions
- Kidney Failure, Chronic, Covid19, Vaccine Reaction, Vaccine Adverse Reaction
- Trial name
- COViNEPH-1 (NCT04905862)
- Testing
- Immune response, Solicited common and expected adverse reactions shortly following vaccination (reactogenicity), use of antipyretic or pain medications and unsolicited adverse events and serious adverse events
- Where
- 4 sites in Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Gdansk
Respiratory Failure, Neuromuscular Disease
Ventilator Monitoring in Early Exacerbation Detection
The aim of this study is to determine whether respiratory disease exacerbations (a sudden worsening of symptoms) can be predicted by variables that are monitored by non-invasive ventilators (small machines that assist breathing)…
- Conditions
- Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01644162
- Testing
- iVAPS ventilation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- ResMed
Chronic Lung Disease of Prematurity, Chronic Respiratory Failure
Safe Use of Speaking Valve in Children During Sleep Using Trans-tracheal Pressure Measurement
Many children who are born medically fragile due to prematurity, multiple congenital abnormalities or an acquired insult (i.e. cardiac, neurologic, etc.) may require tracheostomy tube placement due to need of chronic respiratory…
- Trial name
- NCT02935140
- Volunteers
- 8 people
- Sponsor
- St Mary's Hospital for Children
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
NRS 2002 as a Predictor of Prognosis in COPD With Respiratory Failure
This is a prospective study of patients diagnosed with chronic obstructive pulmonary disease (COPD) with respiratory failure and admitted in West China Hospital during April 2017 to March 2019.
- Trial name
- NCT02942797
- Where
- China
- Volunteers
- 520 people
- Sponsor
- West China Hospital
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Home Non-invasive Ventilation for Chronic Obstructive Pulmonary Disease Patients
Chronic Obstructive Pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure are more likely to develop exacerbations.
- Trial name
- NIVOLD (NCT01526642)
- Testing
- Non Invasive Ventilation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Rouen
Malnutrition, COPD
Nutritional Status Evaluation of Hospitalized Patients With Acute Respiratory Failure and COPD
Malnutrition is a comorbidity oftenly seen in COPD patients who have progressive chronic inflammation and severity. The investigators aimed to determine the impact of nutritional status and nutrition-related factors on prolonged…
- Trial name
- NCT04639648
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione Fatebenefratelli
Chronic Respiratory Failure
Ambulatory Adaptation to Non-Invasive Mechanical Ventilation
A randomised study to assess the effectiveness of ambulatory adaptation to non-invasive mechanical ventilation in patient with hypercapnic respiratory failure secondary to neuromuscular diseases or alterations in thoracic cage in…
- Trial name
- NCT00698958
- Testing
- Ambulatory adaptation to non- invasive mechanical ventilation for 7 days, Hospital based adaptation to non- invasive mechanical ventilation for 7 days
- Volunteers
- 52 people
- Sponsor
- Hospital Clinic of Barcelona
Chronic Obstructive Pulmonary Disease Exacerbation
Evaluation of Oxygen Delivery Methods in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
To examine the effects of oxygen therapy methods applied as indicated in COPD acute exacerbations on blood gas results and spirometric measurements.
- Trial name
- NCT06561464
- Testing
- EzPAP®, Non-invasive mechanical ventilation (NIMV)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Ischemic Heart Disease, Heart Failure
Trial of an Internet-based Platform for Managing Chronic Diseases at a Distance
In 2005, more then one-third of Canadians were burdened with one or more chronic diseases. Patients with one chronic disease often have, or are at risk for, another chronic disease.
- Conditions
- Ischemic Heart Disease, Heart Failure, Chronic Kidney Disease, Diabetes
- Trial name
- iCDM (NCT01342263)
- Testing
- iCDM
- Where
- Canada
- Volunteers
- 234 people
- Sponsor
- Simon Fraser University
Pain, Anxiety
Active vs. Passive VR During Office-based ENT Procedures
The purpose of this research is to evaluate whether active virtual reality reduces pain and anxiety more effectively than passive virtual reality during office-based ENT procedures.
- Conditions
- Pain, Anxiety, Chronic Rhinosinusitis (CRS), Nasal Obstruction
- Trial name
- NCT07599826
- Testing
- Passive virtual reality headset or goggles, Active virtual reality headset or goggles
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Cedars-Sinai Medical Center
COPD, Respiratory Acidosis
Evaluation of the Effects on Carbon Dioxide (paCO2) of a New Oronasal Mask in Patients With Severe COPD Exacerbation Requiring Non-Invasive Mechanical Ventilation
This single-center, crossover study aims to investigate the effects of the new OptiNIV oronasal mask used during NIV in COPD patients with respiratory acidosis following an exacerbation.
- Trial name
- OPTIMUS-MASK (NCT07081776)
- Testing
- OptiNIV, Visairo
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna