Clinical trials: Chronic Respiratory Insufficiency
Respiratory Failure, COPD
Comparison of Humidification Devices During Non Invasive Ventilation, in Acute Respiratory Failure
Comparison of humidification devices during non invasive ventilation, in acute respiratory failure. The hypothesis was, due to dead space, lower humidification, a reduced efficiency of the technique (NIV) when HME are used in…
- Conditions
- Respiratory Failure, COPD, Hypoxemia, Non Invasive Ventilation
- Trial name
- NCT00190346
- Testing
- Humidification devices: HH vs HME
- Where
- 14 sites in Canada, France and 2 more
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD
High-Flow Nasal Cannula Versus Noninvasive Ventilation After Extubation in Patients With COPD and Mild Hypercapnic Respiratory Failure
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) represent a leading cause of hospital admissions and respiratory intensive care unit (RICU) stays worldwide.
- Trial name
- NCT07381686
- Testing
- Non-Invasive Ventilation (NIV), High-Flow Nasal Cannula (HFNC)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Chronic Respiratory Failure
Assist Control Versus Pressure Support Modes for Domiciliary Noninvasive Ventilation in Chronic Respiratory Failure
Noninvasive ventilation is a therapeutic option in some patients with chronic respiratory failure. Patients usually ventilate during nightime with a domiciliary ventilator either in assist control or in pressure support mode.
- Trial name
- NCT00189527
- Testing
- respiratory settings
- Volunteers
- 100 people
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Respiratory Insufficiency, Obesity Hypoventilation Syndrome
Juno Perth Clinical Trial
This study is to evaluate the efficacy of a new therapy (Automatic Expiratory Positive Airway Pressure with intelligent Volume Assured Pressure Support (AutoEPAP iVAPS)) designed to treat respiratory insufficiency, respiratory…
- Conditions
- Respiratory Insufficiency, Obesity Hypoventilation Syndrome, Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Disease
- Trial name
- NCT02317042
- Testing
- Juno
- Where
- 2 sites in Australia
- Volunteers
- 25 people
- Sponsor
- ResMed
Respiratory Therapy, Respiration, Artificial
Initiation of Home Mechanical Ventilation at Home in Patients With Chronic Hypercapnic Respiratory Failure
Objective: To prove that initiation of chronic ventilatory support at home, in patients with chronic hypercapnic respiratory failure due to neuromuscular disease (NMD) or thoracic cage problem is not inferior compared to…
- Conditions
- Respiratory Therapy, Respiration, Artificial, Positive-Pressure Respiration, Neuromuscular Diseases
- Trial name
- Homerun (NCT03203577)
- Testing
- Initiation of mechanical ventilation
- Where
- Netherlands
- Volunteers
- 96 people
- Sponsor
- University Medical Center Groningen
Chronic Obstructive Pulmonary Disease, Asthma
Vibration Response Imaging in Chronic Obstructive Pulmonary Disease and Asthma
Obstructive lung disease is usually a differential diagnostic consideration when a patient presents with breathlessness or cough.
- Trial name
- NCT00542282
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Deep Breeze
COVID-19 Pandemic, Vulnerable Subjects
Perceived Impact of the COVID-19 Pandemic on Medical Management and Symptoms in a High Risk Group
The Swiss population underwent a period of confinement related to the COVID-19 pandemic (March 16 to May 11, 2020) decided by the Swiss Federal Government.
- Conditions
- COVID-19 Pandemic, Vulnerable Subjects, Long-term Non-invasive Ventilation
- Trial name
- NCT04477473
- Testing
- Questionnaire-based observational study
- Where
- Switzerland
- Volunteers
- 66 people
- Sponsor
- University Hospital, Geneva
COPD, OSA
Validation of the AVAPS AE Algorithm in Chronic Obstructive Pulmonary Disease (COPD) Patients
COPD continues to be a cause of major morbidity for patients. Those patients who also have respiratory failure and obstructive sleep apnoea are at higher risk of exacerbations and death and have worse health related quality of…
- Trial name
- AVAPS-AE (NCT01601977)
- Testing
- AVAPS-AE, Usual care
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Patrick Murphy
Pulmonary Disease, Chronic Respiratory Failure
Home Mechanical Ventilation Effectiveness and Air Leaks
Non invasive ventilation (NIV) usually presents air leaks that may determine the result of this treatment. The clinical usefulness of analyzing (and quantifying) these leaks during the adaptation period to NIV has not been…
- Conditions
- Pulmonary Disease, Chronic Respiratory Failure, COPD
- Trial name
- NCT01090986
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Home Non-invasive Ventilation for Chronic Obstructive Pulmonary Disease Patients
Chronic Obstructive Pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure are more likely to develop exacerbations.
- Trial name
- NIVOLD (NCT01526642)
- Testing
- Non Invasive Ventilation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Rouen
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Withdrawal of Non-invasive Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Acute Hypercapnic Respiratory Failure
The investigators design a pilot randomised, single-centred, controlled trial to compare different withdrawal methods of Non-invasive ventilation.
- Trial name
- NCT01523470
- Testing
- BIPAP Synchrony
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- United Christian Hospital
Lung Transplantation, Cystic Fibrosis
Predictive Value of PIIINP Urinary for the Development of Chronic Renal Failure in Patients With Cystic Fibrosis After Lung Transplantation (MUCO-IRC)
Chronic renal failure is a serious complication of lung transplantation especially in patients with cystic fibrosis. Their medical history prior to the Lung Transplantation has already exposed to kidney damage.
- Conditions
- Lung Transplantation, Cystic Fibrosis, Renal Failure
- Trial name
- MUCO-IRC (NCT01572194)
- Testing
- Urinary levels of PIIINP as a marker of changes in renal function
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Nantes University Hospital
Chronic Venous Insufficiency, CVI
Respiratory Functions, Aerobic Capacity and Quality of Life in Chronic Venous Insufficiency
This study aims to retrospectively examine the dataset obtained from a previously conducted study titled 'Inspiratory muscle training in individuals with chronic venous insufficiency: randomized controlled trial'.
- Trial name
- NCT06785805
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Izmir Democracy University
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Sedation vs No Sedation in Mechanically Ventilated COPD Patients
This study aims to evaluate the safety and efficacy of no-sedation compared to daily interruption of sedation (DIS) in mechanically ventilated patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- SEDvsNO-COPD (NCT07620912)
- Testing
- Midalozam
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
Сohort Study to Evaluate Exacerbations, Respiratory Symptoms, Physical Exercise Intolerance and Lung Functions Among Participants Who Use IQOS With Heatsticks Compared to Smokers of Conventional Cigarettes
This study evaluates frequency of exacerbations, respiratory symptoms, physical exercise intolerance and abnormal lung functions among participants who use IQOS with heatsticks compared to smokers of conventional cigarettes
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency, Physical Disability, Respiratory Disease
- Trial name
- NCT03383601
- Testing
- Heated Tobacco product IQOS/heatstick, Smoking combustible cigarettes
- Where
- Kazakhstan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Kazakhstan Academy of Preventive Medicine
Chronic Obstructive Pulmonary Disease, Chronic Respiratory Failure
Yiqi Huoxue Huatan Granule for Reducing Mortality in COPD With Chronic Respiratory Failure
This study aims to establish the treatment scheme of Yiqi Huoxue Huatan granule for chronic obstructive pulmonary disease (COPD) with chronic respiratory failure (CRF), reducing mortality, improving quality of life and forming…
- Trial name
- NCT04208581
- Testing
- Yiqi Huoxue Huatan granule
- Where
- China
- Volunteers
- 372 people
- Sponsor
- Peking University People's Hospital
Chronic Kidney Disease, Diabetes
Improving Chronic Disease Management With Pieces
ICD-Pieces (Parkland Intelligent e-Coordination and Evaluation System) trial is a National Institutes of Health (NIH) Healthcare Systems(HCS) Collaboratory demonstration project to improve management of patients with a triad of…
- Conditions
- Chronic Kidney Disease, Diabetes, Hypertension, High BP
- Trial name
- ICD-Pieces (NCT02587936)
- Testing
- Collaborative Model of Primary care and Subspecialty care
- Where
- 4 sites in United States
- Volunteers
- 18,268 people
- Sponsor
- University of Texas Southwestern Medical Center
Lung Transplant Recipients, Muscle Weakness
Efficacy of Early Inspiratory Muscle Training in Lung Transplanted Patients
Lung transplantation is an effective therapeutic option in the end-stage of chronic respiratory diseases. Lung transplantation improves lung function in terms of capacity and volume.
- Conditions
- Lung Transplant Recipients, Muscle Weakness, Respiratory Insufficiency, Pulmonary Rehabilitation
- Trial name
- NCT05271019
- Testing
- Threshold load device
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Puerta de Hierro University Hospital
COPD (Chronic Obstructive Pulmonary Disease)
End-Inspiratory Pause in COPD Patients During Controlled Ventilation
In patients with airflow obstruction receiving mechanical ventilation, an important objective is to reduce lung hyperinflation often using controlled hypoventilation.
- Trial name
- PYE (NCT07207967)
- Testing
- END INSPIRATORY PAUSE DURING CONTROLLED VENTILATION, NO PAUSE VENTILATION
- Where
- Argentina
- Volunteers
- 14 people
- Sponsor
- Sanatorio Anchorena San Martin
Chronic Respiratory Failure
Adaptation to Nocturnal Noninvasive Ventilation in Patients With Chronic Respiratory Failure (ROOMILA)
BACKGROUND: Adaptation to noninvasive ventilation (NIV) is a critical step for acceptability and efficacy of this treatment during sleep in patients with chronic respiratory failure.
- Trial name
- ROOMILA (NCT01255111)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Groupe de Recherche sur le Handicap Respiratoire