Clinical trials: Chronic Sinus Disease
Endoscopic Sinus Surgery, Chronic Rhinosinusitis
Large Scale Cerebral Oximetry During Sinus Endoscopy
Deliberate hypotension, reverse Trendelenburg position, and hyperventilation are techniques utilized during functional endoscopic sinus surgery to attempt to reduce surgical bleeding.
- Trial name
- NCT02692794
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cancer
External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Indinavir and ritonavir may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00637637
- Testing
- indinavir sulfate, ritonavir, radiation therapy
- Where
- 3 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Oncology Institute of Southern Switzerland
Sick Sinus Syndrome, Complete Heart Block
Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.
The number of cardiac implantable electronic devices (CIEDs) implanted each year has grown rapidly over the past two decades. CIED infections, defined as infections involving the generator implant site (pocket) and/or…
- Conditions
- Sick Sinus Syndrome, Complete Heart Block, Syncope, Chronic Systolic Heart Failure
- Trial name
- ENVELOPE (NCT02809131)
- Testing
- polymixin/bacitracin, cephalexin, or levofloxacin, or clindamycin, Saline
- Where
- United States
- Volunteers
- 1,010 people
- Sponsor
- Vanderbilt University Medical Center
Sinusitis
Medical Therapy Versus Balloon Sinus Dilation for Patients With Chronic Rhinosinusitis
This post-market study aims to compare health outcomes for Chronic Rhinosinusitis (CRS) patients treated with balloon sinus dilation (BSD) versus continued medical management.
- Trial name
- MERLOT (NCT01685229)
- Testing
- Balloon sinus dilation, Medical Management
- Where
- 20 sites in United States
- Volunteers
- 198 people
- Sponsor
- Integra LifeSciences Corporation
Chronic Sinus Disease, Nasal Polyps
Does The Combined Use Of Local And Intravenous Tranexamic Acid Offer Better Surgical Field Quality During Functional Endoscopic Sinus Surgery? A Placebo-Controlled Clinical Trial
Functional Endoscopic Sinus surgery (FESS) is a surgery done for chronic rhinosinusitis after failure of medical treatment. Intraoperative bleeding poses a challenge to both the surgeon and anaesthetist.
- Trial name
- NCT03965767
- Testing
- Tranexamic Acid
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Chronic Rhinosinusitis (CRS), Emergence Agitation
Trans-nasal Sphenopalatine Ganglion Block for Prevention of Emergence Agitation Following Functional Endoscopic Sinus Surgery
This randomized double-blind controlled trial aims to evaluate whether bilateral trans-nasal sphenopalatine ganglion block (SPGB) using bupivacaine reduces the incidence of emergence agitation following Functional Endoscopic…
- Trial name
- SPGB-EA (NCT07645521)
- Testing
- Bilateral Trans-nasal Sphenopalatine Ganglion Block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Disorder of Maxillary Sinus, Aspirin-sensitive Asthma With Nasal Polyps
The Role of Canine Fossa Trephination in the Severely Diseased Maxillary Sinus
The hypothesis of this study is that canine fossa trephination (CFT) improves surgical outcomes for patients with a severely diseased maxillary sinus.
- Conditions
- Disorder of Maxillary Sinus, Aspirin-sensitive Asthma With Nasal Polyps, Rhinosinusitis
- Trial name
- CFT (NCT01615536)
- Testing
- Canine fossa trephine technique, Standard Endoscopic Sinus Surgery
- Where
- Canada
- Sponsor
- IWitterick
Chronic Kidney Disease Stage 5 (Disorder)
Acupressure and Fistula Needle Insert Pain Management
Introduction: This study was conducted to determine the effectiveness of acupressure application on Hegu (LI4) point on the severity of acute pain caused by fistula needle in patients with brescia-cimino, snuff-box and…
- Trial name
- NCT05971134
- Testing
- Acupreesure applied
- Where
- Turkey (Türkiye)
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Baskent University
Safety Issues, Efficacy, Self
Lower Silesia Sinus Reducer Registry
Lower Silesia Sinus Reducer Registry is a , single-center, single-arm registry including patients with chronic disabling refractory angina pectoris (Canadian Cardiovascular Society [CCS] classes 2-4) despite maximally tolerated…
- Trial name
- LSSRR (NCT06288165)
- Testing
- Coronary Sinus Reducer Implantation
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Miedziowe Centrum Zdrowia SA
Sinusitis
Validation of the Facial and Cephalic Pain Inventory
This study proposes to develop and validate a new instrument designed to measure facial and nasal discomfort related to chronic sinusitis.
- Trial name
- FACE PAIN (NCT01001039)
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Greg Davis
Chronic Sinusitis, Nasal Polyposis
S8 Sinus Implant in Chronic Sinusitis Patients With Recurrent Nasal Polyps
The RESOLVE II Study is a randomized, single-blind, parallel arm, concurrently controlled, multicenter study with 300 chronic sinusitis patients who had prior endoscopic sinus surgery but present with recurrent sinus obstruction.
- Trial name
- RESOLVE_II (NCT02291549)
- Testing
- S8 Sinus Implant, Mometasone furoate nasal spray
- Where
- 40 sites in United States
- Volunteers
- 300 people
- Sponsor
- Intersect ENT
End-stage Renal Disease
Propaten Randomized Investigation on Cost-benefit and Efficacy
The purpose for this study is to evaluate the patency and outcomes of conventional and heparin anticoagulant bonded arteriovenous grafts in patients with end stage renal disease.
- Trial name
- PRICE (NCT01601873)
- Testing
- PROPATEN, Standard Graft
- Where
- 5 sites in United States
- Volunteers
- 103 people
- Sponsor
- The University of Texas Health Science Center, Houston
Idiopathic Intracranial Hypertension (IIH)
Venous Stenting Evaluation in Patients With Intracranial Hypertension Under Long-term Acetazolamide
This study is aimed at patients suffering from long term intracranial hypertension (caracterized by visual loss, chronic headache and/or tinnitus), receiving acetazolamide for more than 1 year, having inadequate response to…
- Trial name
- DIVEIINLATE (NCT06945848)
- Testing
- Acetazolamide, Stent (Tentos 4F or Precise ProRX)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Montpellier
Renal Disease
Monocentric Retrospective Cohort Study of the Impact of Advanced Nursing Practice on the Follow-up of the End Stage Chronic Renal Disease Patient
With regard to the fields of competence of advanced practice defined by the Order of October 22, 2021 amending the Order of July 18, 2018 on the system of studies for the State diploma of advanced practice nurse mentioning renal…
- Trial name
- IPASIRC (NCT06036264)
- Testing
- Collected of Datas, semi-structured interview
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
AV Fistula
av Fistula Patency Loss as a Cause of Fistula Failure and Hyperphosphatemia
Assessment of arteriovenous fistula patency loss which leads to av fistula failure and its relation to high serum phosphate level in chronic hemodialysis patients.
- Trial name
- NCT05569109
- Testing
- doppler ultrasound
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Renal Insufficiency, Chronic, Arteriovenous Fistula
Artificial Intelligence-based Prediction of Radio-cephalic Arteriovenous Fistula Maturation Using Preoperative Duplex Examination
The goal of this observational study is to assess the efficacy of AI-driven models in analyzing comprehensive ultrasonographic variables across multiple forearm locations to predict successful AVF maturation.
- Conditions
- Renal Insufficiency, Chronic, Arteriovenous Fistula, Artificial Intelligence (AI), Machine Learning
- Trial name
- NCT06600750
- Testing
- Arteriovenous fistula
- Where
- South Korea
- Volunteers
- 494 people
- Sponsor
- Seoul National University Hospital
Chronic Rhinosinusitis, Nasal Polyps
Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial
This is a randomized, double blind, placebo controlled, parallel group, study in patients with chronic rhinosinusitis with or without nasal polyps.
- Trial name
- DOXYPOSTOP (NCT01198912)
- Testing
- doxycycline 100 mg
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 33 people
- Sponsor
- University Hospital, Ghent
Arhythmia, Atrioventricular Heart-block
Observation of ImageReady™ MR Conditional Pacing System in China
To observe the safety and efficacy of ImageReady™ MR Conditional Pacing System in Chinese subjects
- Conditions
- Arhythmia, Atrioventricular Heart-block, Chronic Bundle Branch or Branch Block, Carotid Sinus Hypersensitivity Reaction Syndrome
- Trial name
- NCT02636712
- Testing
- ImageReady™ MR Conditional Pacing System
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Boston Scientific Corporation
Breast Cancer, Chronic Myeloproliferative Disorders
Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors
RATIONALE: Interleukin-12 may kill tumor cells by stopping blood flow to the tumor and by stimulating a person's white blood cells to kill cancer cells.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Kidney Cancer
- Trial name
- NCT00003107
- Testing
- recombinant interleukin-12
- Where
- United States
- Sponsor
- Indiana University
Rhino Sinusitis
Analysis of Hemostatic Agents Compared to Physiologic Hemostasis
This study is a prospective comparison between absorbable hemostatic agents as a group and the body's natural hemostatic ability without aid of therapy in patients undergoing bilateral sinus surgery with or without septoplasty.
- Trial name
- NCT03068728
- Testing
- Arista, Nexfoam, Nasopore
- Volunteers
- 62 people
- Sponsor
- St. Louis University