Clinical trials: Chronic Sinus Disease
Sinusitis, Chronic, Asthma
Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative)
This randomized study compares operative techniques in chronic rhinosinusitis with polyposis (CRSwNP) surgery. It aims to evaluate outcomes in asthma and CRSwNP, safety and costs.
- Conditions
- Sinusitis, Chronic, Asthma, Nasal Polyps, Aspirin Sensitivity
- Trial name
- NCT03704415
- Testing
- Extended endoscopic sinus surgery, Limited endoscopic sinus surgery
- Where
- 3 sites in Finland, Netherlands
- Volunteers
- 97 people
- Sponsor
- Helsinki University Central Hospital
Rhinosinusitis, Intracranial Extension
Role of Imaging in Complications of Sinusitis
This study aims to assess the diagnostic performance of CT and MRI in the diagnosis of complications of rhinosinusitis in comparison to clinical and operative findings.
- Conditions
- Rhinosinusitis, Intracranial Extension, Rhinosinusitis Chronic, Rhinosinusitis Acute
- Trial name
- NCT05836935
- Testing
- Multislice CT scan of the paranasal sinuses., MRI examination of the paranasal sinuses
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Hidradenitis Suppurativa
Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa
This study will investigate how well adalimumab works in people with hidradenitis suppurativa (HS) in the short and long term.
- Trial name
- NCT00918255
- Testing
- adalimumab
- Where
- 26 sites in United States, Denmark and 2 more
- Volunteers
- 154 people
- Sponsor
- Abbott
Magnetic Therapy, Rhinosinusitis
Effect of Electromagnetic Therapy on Patients With Chronic Rhinosinusitis.
This study aimed to evaluate the efficacy of Pulsed electromagnetic field (PEMF) for Chronic sinusitis in a randomized, double-blind, placebo-controlled trial.
- Conditions
- Magnetic Therapy, Rhinosinusitis, Headache, Fatigue
- Trial name
- NCT05865613
- Testing
- Pulsed electromagnetic field
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Cairo University
Renal Disease, End Stage, Kidney Disease, End-Stage
Ellipsys Vascular Access System Post Market Surveillance (PS) Study
The proposed clinical study is a prospective, non-randomized, multi-center, single-arm, observational, post-market surveillance (PS) study of the Ellipsys Vascular Access System in subjects eligible for arteriovenous (AV) fistula.
- Conditions
- Renal Disease, End Stage, Kidney Disease, End-Stage, AV Fistula, Fistulas Arteriovenous
- Trial name
- NCT04484220
- Testing
- Ellipsys Vascular Access System
- Where
- 12 sites in United States
- Volunteers
- 142 people
- Sponsor
- Medtronic Endovascular
Complement Deficiency, Antibody Deficiency
Systematic Search for Primary Immunodeficiency in Adults With Infections
Antibody deficiencies and complement deficiencies are the most frequent Primary immunodeficiencies (PIDs) in adults, and are associated with greatly increased susceptibility to recurrent and/or severe bacterial infections …
- Conditions
- Complement Deficiency, Antibody Deficiency, Chronic Sinus Infection, Meningitis, Bacterial
- Trial name
- SPIDAC (NCT02972281)
- Testing
- Immunological diagnosis tests
- Where
- 19 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Lille
Sinusitis, Chronic Rhinosinusitis
Clinical Evaluation of the Ethmoid Sinus Spacer
Evaluation of treatment of the ethmoid sinuses with the Ethmoid Sinus Spacer and Access system
- Trial name
- SPACER (NCT01054703)
- Testing
- Ethmoid Sinus Spacer
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Integra LifeSciences Corporation
Sinusitis
Gold Laser Vs. Micro-Debriders for Functional Endoscopic Sinus Surgery
Sinusitis is a common medical problem, which significantly decreases patients' quality of life (QOL). Patients may have symptoms such as headaches, sinus pressure, nasal congestion and drainage, decreased sense of smell, and…
- Trial name
- NCT02900794
- Testing
- Gold Laser, Microdebridement
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Chronic Kidney Disease
Novel Endovascular Access Trial (NEAT)
The objective of this study is to evaluate the safety and efficacy of the FLEX System when used to create an arteriovenous fistula (AVF or AV fistula) percutaneously in patients with Chronic Kidney Disease (CKD) who require…
- Trial name
- NEAT (NCT02036671)
- Testing
- The FLEX System will be used to percutaneously create a fistula in CKD patients who require hemodialysis vascular access
- Where
- 9 sites in Australia, Canada and 1 more
- Volunteers
- 80 people
- Sponsor
- C. R. Bard
Chronic Rhinosinusitis (CRS), Frontal Sinusitis
Endoscopic Direct "Draf IIa" (Carolyn's Window Approach) Versus Endoscopic Angled "Draf IIa"Approach in Chronic Rhinosinusitis With Frontal Sinus Affection ( A Comparative Study ).
Patients with chronic rhinosinusitis with frontal sinus affection indicated for sinuscopy will be randomly categorized in 2 groups: group A will have endoscopic directDraf IIa frontal sinusotomy and group B will have endoscopic…
- Conditions
- Chronic Rhinosinusitis (CRS), Frontal Sinusitis, Draf I or IIa, Functional Endoscopic Sinus Surgery (FESS)
- Trial name
- NCT06668844
- Testing
- Endoscopic direct Draf IIa, Endoscopic angled Draf IIa
- Volunteers
- 68 people
- Sponsor
- Assiut University
Nurse's Role, Simulation
Training Procedural Simulation of Nurses in Reducing Complications Related to Arteriovenous Fistula Puncture
Interest of training in procedural simulation of nurses in the reduction of complications related to arteriovenous fistula puncture in hemodialysis patients
- Conditions
- Nurse's Role, Simulation, Arteriovenous Fistula
- Trial name
- SIMFAV (NCT03680209)
- Testing
- Simulation
- Where
- France
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Ethmoid Sinusitis
Sinopsys Lacrimal Stent Indicated for Sinus Irrigation
The purpose of this study is to collect preliminary clinical data related to the safety and performance of the Sinopsys Lacrimal Stent.
- Trial name
- SLS (NCT02297243)
- Testing
- Sinopsys Lacrimal Stent
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Sinopsys Surgical
Pilonidal Sinus, Wound Healing
ENVELOP: Wound Care Following Pilonidal Sinus Surgery
This is a single-blinded, multicentre, prospective randomised controlled trial (RCT) comparing post-operative and patient-reported outcomes for patients undergoing application of negative-pressure wound therapy (NPWT) after sinus…
- Trial name
- ENVELOP (NCT06647290)
- Testing
- Negative Pressure Wound Therapy, Standard wound care
- Where
- 10 sites in Ireland
- Volunteers
- 200 people
- Sponsor
- Royal College of Surgeons, Ireland
Chronic Rhinosinusitis (Diagnosis)
Propel Drug-Eluting Sinus Stent Family Open Cohort
The purpose of this study is to confirm the long-term clinical safety and performance, acceptability of identified risks, and to detect emerging risks based on factual evidence for the PROPEL family of products when used…
- Trial name
- NCT05925985
- Testing
- NA-Observational Registry
- Where
- 9 sites in Germany, United Kingdom
- Volunteers
- 215 people
- Sponsor
- Medtronic
Sinusitis
Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis
The purpose of this study is to determine the best duration(3 versus 6 weeks) of antibiotics as part of maximal medical therapy for treating chronic sinusitis and thus preventing patients from having to have sinus surgery.
- Trial name
- NCT01825408
- Testing
- Doxycycline, Azithromycin, Augmentin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Sinusitis, Frontal Sinusitis
Improvement of Outcomes in Draf III/Endoscopic Modified Lothrop Procedure
We propose a randomized, single-blinded, prospective trial in order to evaluate the efficacy of the Cook Biodesign ENT Repair graft in improving outcomes after the Draf III or Endoscopic Modified Lothrop procedure.
- Trial name
- NCT02981017
- Testing
- Porcine Intestinal submucosal xenograft
- Where
- United States
- Sponsor
- University of California, Los Angeles
Kidney Failure, Chronic
Effect of Exercise on Endothelial Function and Vascular Compliance in Chronic Kidney Disease
The study hypothesis is that 6 weeks of repetitive handgrip exercise will improve endothelial function and venous compliance in pre-dialysis patients with an estimated glomerular filtration rate of less than or equal to 20…
- Trial name
- NCT01068314
- Testing
- Repetitive arm exercise
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Iowa
Chronic Sinusitis, Nasal Polyposis
The Efficacy of MEDIHONEY® for Chronic Rhinosinusitis With Nasal Polyposis After Functional Endoscopic Sinus Surgery
This study will assess the effectiveness of MEDIHONEY® sinus rinses (alone or in combination with intranasal corticosteroids) vs.
- Trial name
- NCT02562924
- Testing
- MEDIHONEY®, Budesonide, Normal saline sinus rinse
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Vermont Medical Center
Chronic Sinusitis With Nasal Polyps
Adelmidrol in Chronic Sinusitis
The goal of this study is to evaluate whether a nasal spray containing adelmidrol, a mast cell modulator and precursor of palmitoylethanolamide, can reduce inflammation, improve symptoms, and decrease nasal polyp size in patients…
- Trial name
- AdeCroS (NCT07675512)
- Testing
- Adelmidrol spray -Rinidrol, Nasonex Nasal Spray, Nasonex Nasal Spray + Rinidrol
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Cancer
Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation
RATIONALE: White blood cells from donors who have been exposed to cytomegalovirus may be able to help prevent this infection from occurring in patients who are undergoing bone marrow or peripheral stem cell transplantation.
- Trial name
- NCT00002673
- Testing
- infection prophylaxis and management
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Fred Hutchinson Cancer Center