Clinical trials: Chronic Sinus Infection
Chronic Rhinosinusitis
Oral Steroid Treatment for Chronic Rhinosinusitis
Despite the common use of oral steroids in the management of chronic rhinosinusitis (CRS), the natural history and efficacy of this treatment modality has not been fully elucidated.
- Trial name
- NCT01255683
- Testing
- oral corticosteroid taper
- Where
- United States
- Sponsor
- Oregon Health and Science University
Chronic Sinusitis, Endoscopic Sinus Surgery
The Effect of Modified Radical Endoscopic Sinus Surgery on Eosinopilic Chronic Rhinosinusitus With Nasal Polyps
Functional endoscopic sinus surgery (FESS) is the pimary surgical treatment of CRS, characterized with the preservation of nasal structure and function.But the control of disease by surgery has been unsatisfactory.
- Conditions
- Chronic Sinusitis, Endoscopic Sinus Surgery, Nasal Polyps
- Trial name
- EMRESSECRS (NCT04852562)
- Testing
- Modified radical endoscopic sinus surgery, functional endoscopic sinus surgery
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zheng Liu
Sinus Disease
Peppermint and Decongestant Technique on Chronic Sinusitis
Chronic rhinosinusitis (CRS) is defined as persistent symptomatic inflammation of the nasal and sinus mucosa that lasts more than 3 months.
- Trial name
- peppermint (NCT07866937)
- Testing
- Sinus self-massage and inhalation of steated boiled peppermint
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rhinosinusitis
Prospective Study Investigating the Role of Occupational Exposure on Sinus Surgery Outcome
The pathophysiology of chronic rhinosinusitis (CRS) is complex and involves several immune, infectious and anatomic factors. When medical therapy fails, functional endoscopic sinus surgery (FESS) is the therapy of choice.
- Trial name
- NCT01350466
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Sinus Disease, Surgery
Efficacy of PuraSinus Versus Bioresorbable Nasal Dressings
Postoperative care of patients undergoing endoscopic sinus surgery (ESS) is important both to minimize discomfort for the patients and to obtain the optimal long-term outcomes.
- Trial name
- NCT04970966
- Testing
- PuraSinus, Bioresorbable Nasal Dressing
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS)
Study of Dupilumab 300 mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhinosinusitis (AFRS) on a Background Therapy With Intranasal Corticosteroid Spray
Background: Allergic fungal rhinosinusitis (AFRS) is a severe type of sinus infection. People with AFRS develop heavy mucus and growths called polyps that apply pressure to the sinuses and block their breathing.
- Conditions
- Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS), Asthma, Nasal Polyps
- Trial name
- NCT06461949
- Testing
- Dupilumab
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Chronic Sinusitis With or Without Nasal Polyps
Study Evaluating the Safety of Intranasal Administration of 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi-Directional Device in Subjects With Chronic Sinusitis With or Without Nasal Polyps
This is an open-label, multicenter study designed to assess the safety of intranasal administration of 400 μg of fluticasone propionate twice a day delivered by the OptiNose device in subjects with chronic sinusitis with or…
- Trial name
- NCT01623323
- Testing
- Fluticasone Propionate
- Where
- 18 sites in United States
- Volunteers
- 705 people
- Sponsor
- Optinose US Inc.
Chronic Rhinosinusitis With Polyposis, Chronic Hyperplastic Sinusitis
Intravenous Tranexamic Acid and Intraoperative Visualization During Functional Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is an effective treatment of sinus disease. FESS is carried out using cameras to view the surgical field. Bleeding during the surgery can lead to poor surgical field visualization.
- Trial name
- NCT01111669
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Chronic Sinusitis
Evaluating SPRC-AB01 in Post-Surgical Subjects With Chronic Sinusitis
The primary objective of the study is to evaluate the safety and efficacy of SPRC-AB01 versus placebo for treatment of chronic sinusitis in subjects who have had sinus surgery.
- Trial name
- NCT00447837
- Testing
- SPRC-AB01
- Where
- 43 sites in United States
- Volunteers
- 180 people
- Sponsor
- Naryx Pharma
Chronic Rhinitis, Chronic Sinus Congestion
Proof-of-Concept Interventional Study With a Nasal Spray of JT-1 in Patients With Chronic Rhinitis or Chronic Sinusitis
Proof-of-concept study with a novel nasal spray in chronic rhinitis or chronic sinusitis. The study will involve 25 patients completing the study for a per protocol analysis.
- Trial name
- NCT05331222
- Testing
- JT-1
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Jantar GmbH
Chronic Rhinosinusitis With Nasal Polyps, Allergic Fungal Sinusitis
Comparing Budesonide Via MAD or INSI Prospective Cohort Study
Chronic Rhinosinusitis (CRS) is a common disorder in North America, affecting more than 31 million people annually. Common therapy for CRS includes intranasal corticosteroids (INCS) such as budesonide.
- Trial name
- NCT04267042
- Testing
- Budesonide, Mucosal Atomization Device, NeilMed squeeze bottle for Impregnated Nasal Saline Irrigation
- Volunteers
- 60 people
- Sponsor
- St. Paul's Hospital, Canada
Rhinosinusitis Chronic
Effectiveness of Endonasal Polymeric Implant for Chronic Rhinosinusitis
Objective: The objective of this study is to evaluate a steroid-embedded Terpolymers polymer implant of L-lactide and trimethynele carbonate (TCM) at the level of disease control in patients with eosinophilic and central…
- Trial name
- NCT05450471
- Testing
- Corticosteroid Topical
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Sao Paulo
Chronic Sinusitis, Endoscopic Sinus Surgery
Postoperative Systemic Corticosteroids When Utilizing a Steroid-Eluting Spacer Following Endoscopic Sinus Surgery
Chronic rhinosinusitis (CRS) is an inflammatory condition of the nose and sinuses. It affects about 5 to 10% of Canadians. Patients suffer from congestion in the nose and sinuses, nasal discharge, pressure in the face, and a…
- Conditions
- Chronic Sinusitis, Endoscopic Sinus Surgery, Post-operative Care, Steroids
- Trial name
- NCT01564355
- Testing
- Steroid-eluting middle meatal spacer (Nasopore (TM) spacer impregnated with 1 cc of 40mg/mL triamcinolone liquid), Post-op Oral Steroids
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Calgary
Chronic Rhinosinusitis With Nasal Polyps
Thermosensitive Gel Nasal Spray With Stem Cell Exosomes, Mupirocin, and DNase I for Chronic Sinusitis
This study tests a new nasal spray for adults (18-65 years) with chronic rhinosinusitis (CRS) without nasal polyps. The spray contains a temperature-sensitive gel (thermosensitive gel) that turns into a soft gel inside the nose…
- Trial name
- NCT07635433
- Testing
- Exosomes (hUC-MSC-Exo), Mupirocin, DNase I
- Volunteers
- 108 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Chronic Obstructive Pulmonary Disease (COPD), Asthma Patients
Evaluation of Nasal Biomarkers for Objective Assessment of Disease Severity in Respiratory Disorders
This research study is an observational, single site study quantifying expression of biomarkers of respiratory disease in nasal fluid using the ABEL microsampler device.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma Patients, Asthma and Rhinitis, Asthmatic Patients
- Trial name
- ENBOARD (NCT06661252)
- Testing
- ABEL microsampler device
- Where
- Australia
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Diag-Nose Medical Pty Ltd
Rhinosinusitis, Headache
Effect of Low Level Laser Therapy in Patients With Chronic Rhinosinusitis.
This study aimed to evaluate the efficacy of low-level laser therapy (LLLT) for Chronic sinusitis in a randomized, double-blind, placebo-controlled trial.
- Conditions
- Rhinosinusitis, Headache, Fatigue, CT
- Trial name
- Sinusitis (NCT05861817)
- Testing
- Laser theapy
- Where
- 2 sites in Egypt
- Volunteers
- 31 people
- Sponsor
- Cairo University
Cancer
Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation
RATIONALE: Acupuncture may be effective in relieving mucositis-related pain caused by chemotherapy in patients undergoing stem cell transplantation.
- Trial name
- NCT00060021
- Testing
- acupuncture therapy, management of therapy complications, pain therapy
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)