Clinical trials: Chronic Sinus Infection
Chronic Sinusitis, Polyposis
Nasal Packing as a Drug Delivery System Postoperatively in Chronic Sinusitis With Polyposis
That high-dose steroid applied to the nasal cavity immediately post-operatively will improve olfaction and healing following endoscopic sinus surgery.
- Trial name
- NCT01197612
- Testing
- pulmicort
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan
Chronic Sinusitis
Randomized Evaluation of Maxillary Antrostomy Versus Ostial Dilation Efficacy Through Long-Term Follow-Up
The objective of this study is to show that long-term symptom improvement after sinus balloon dilation is not worse than symptom improvement after functional endoscopic sinus surgery (FESS) and that fewer postoperative…
- Trial name
- REMODEL (NCT01525849)
- Testing
- Balloon Sinus Dilation, Functional Endoscopic Sinus Surgery
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Entellus Medical, Inc.
Chronic Sinusitis
Balloon Sinus Dilation In Office or OR
Endoscopic sinus surgery will be performed either in the physician's office or in the operating room (OR). Patients treated in the physician's office will have endoscopic sinus surgery performed with balloon sinuplasty devices.
- Trial name
- ORIOS (NCT00939393)
- Testing
- FESS instruments with or without balloon treatment, Balloon Sinuplasty
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Integra LifeSciences Corporation
Chronic Sinusitis
Distribution of Topical Nasal Medication Within the Nasal Cavity and Sinuses by Radiographic Comparison
The purpose of this study is to determine the distribution of nasal sprays and nasal drops when used.
- Trial name
- NCT00626366
- Testing
- Sinus CT Scan, Omnipaque 240 Contrast Solution, Omnipaque 240 mg I/mL
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Chronic Rhinosinusitis, Rhinosinusitis
Xylitol for Chronic Sinusitis
The purpose of this investigation is to conduct a randomized controlled trial within a subgroup of difficult-to-treat patients with CRS, evaluating the use of topical xylitol treatment concurrently with topical…
- Conditions
- Chronic Rhinosinusitis, Rhinosinusitis, Sinusitis, Drain Sinus
- Trial name
- NCT03229551
- Testing
- Xylitol, Saline
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Chronic Sinusitis
A Clinical Evaluation of the Sinexus Intranasal Splint Following Functional Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis
The purpose of this study is to assess the safety and performance of the Sinexus Intranasal Splint when used following Functional Endoscopic Sinus Surgery (FESS) in patients with Chronic Rhinosinusitis.
- Trial name
- CONSENSUS II (NCT00840970)
- Testing
- non-coated Intranasal Splint, Sinexus Intranasal Splint
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Intersect ENT
Chronic Sinus Infection
Use of Perioperative Antibiotics in Endoscopic Sinus Surgery
The objective of this study is to determine whether the use of postoperative antibiotics following endoscopic sinus surgery (ESS) decreases postoperative infection rates.
- Trial name
- NCT03369717
- Testing
- Amoxi Clavulanate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Rhinosinusitis
Manuka Honey Nasal Rinse Study
The purpose of this study is to evaluate whether high-volume nasal rinses with a manuka honey/saline mixture will improve symptom scores, nasal endoscopic findings and CT scan findings compared to nasal saline rinse without…
- Trial name
- NCT02097576
- Testing
- Saline mixed with Manuka Honey, NeilMed Saline Sinus Rinse
- Sponsor
- University of Florida
Chronic Sinusitis
Vitamin D Supplementation in Chronic Rhinosinusitis With Nasal Polyps
The purpose of this study is to determine if Vitamin D supplementation improves clinical and immunologic parameters in chronic rhinosinusitis with nasal polyps.
- Trial name
- VDinCRS (NCT01185808)
- Testing
- Vitamin D
- Where
- United States
- Sponsor
- Medical University of South Carolina
Allergic Rhinitis, Rhinosinusitis Chronic
Treatment of Allergic Rhinitis and Chronic Polypous Rhinosinusitis With Olfactory Mucosa-derived Mesenchymal Stem Cells
Treatment of patients with allergic rhinitis and chronic polypous rhinosinusitis with olfactory mucosa-derived mesenchymal stem cells
- Trial name
- NCT05167552
- Testing
- Olfactory mucosa-derived mesenchymal stem cells, Standard treatment of type Allergic Rhinitis according to the clinical protocols, Standard treatment of type Chronic Polypous Rhinosinusitis according to the clinical protocols
- Volunteers
- 60 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Chronic Sinusitis
Randomized Controlled Trial to Evaluate of Dexmedetomidine for the Effect on Operative Visibility in Patients Undergoing Endoscopic Sinus Surgery
Various maneuvers are commonly used to achieve the ideal operative field necessary for successful endoscopic sinus surgery (ESS).
- Trial name
- NCT01569048
- Testing
- Propofol and dexmedetomidine, propofol and remifentanil
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Yonsei University
Chronic Sinus Infection
The Use of Prophylactic Antibiotics in Endoscopy Sinus Surgery for Chronic Rhinosinusitis With or Without Polyp
This is a randomized, double-blind clinical trial on the prophylactic use of antibiotics in postoperative endoscopic sinus vs placebo surgery.
- Trial name
- NCT03809312
- Testing
- Amoxicillin / Clavulanic acid 875mg / 125mg
- Where
- Canada
- Volunteers
- 134 people
- Sponsor
- CHU de Quebec-Universite Laval
Cancer
Study of Previously Collected and Stored Tissue Samples From Patients Previously Enrolled in a Completed National Cancer Institute Clinical Trial
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00904514
- Testing
- gene expression analysis, microarray analysis, mutation analysis
- Volunteers
- 241 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Asthma, Rhinitis
Study of Asthma and Nasal Steroids
The trial will study the effectiveness of nasal steroids for the treatment of chronic rhinitis and/or sinusitis on asthma control.
- Conditions
- Asthma, Rhinitis, Sinusitis
- Trial name
- STAN (NCT01118312)
- Testing
- Mometasone Furoate monohydrate
- Where
- 19 sites in United States
- Volunteers
- 388 people
- Sponsor
- JHSPH Center for Clinical Trials
Peri-Implantitis, Sinusitis
"Association of Peri-implantitis and Maxillary Sinusitis: a Case-control Study".
Scientific evidence regarding the influence of peri-implantitis on Schneider's membrane thickening is scarce and limited. Similarly, to date, there is no literature documenting the resolution of implant-associated maxillary…
- Conditions
- Peri-Implantitis, Sinusitis, Sinusitis, Acute, Sinusitis, Chronic
- Trial name
- NCT05924711
- Testing
- Retrospective analysis of demographic and radiographic data previously obtained from the patient.
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Universitat Internacional de Catalunya
Rhinosinusitis
The Clinical Significance of the Uncinate Process Histopathology in Chronic Rhinosinusitis
Given that the uncinate process is the gatekeeper of the sinuses, we hypothesize that inflammation of the uncinate process is associated with decreased ventilation and drainage of the paranasal sinuses and consequently with the…
- Trial name
- NCT01296919
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Assuta Hospital Systems
Rhinosinusitis, Chronic Polyposis
Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis With Polyposis Nasi
The study should create data for the selection of a clinically relevant primary endpoint to assess the efficacy and safety of Buparid/PARI SINUS as compared to Budes Nasal Spray in the therapy of chronic rhinosinusitis (CRS) with…
- Trial name
- NCT01946711
- Testing
- Budesonide
- Where
- 4 sites in Germany
- Volunteers
- 14 people
- Sponsor
- Pari Pharma GmbH
Chronic Sinusitis
A Study Evaluating the Efficacy of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES) Combined With Stapokibart in the Treatment of Type 2 Chronic Rhinosinusitis
Through a prospective study, the efficacy of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES) in the surgical treatment of patients with type 2 chronic rhinosinusitis was verified.
- Trial name
- NCT07073664
- Testing
- The surgical side of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES), The surgical side of Endoscopic Sinus Surgery (ESS)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China-Japan Union Hospital
Sinus; Empyema, Maxillary (Chronic)
The Osteogenic Potential of Human Maxillary Sinus Shneiderian Membrane
The objectives of this study are : 1. to test the the osteogenic potential of human maxillary sinus schneiderian membrane (hMSSM). 2.
- Trial name
- HMSSM (NCT02676921)
- Where
- Lebanon
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- BERBERI ANTOINE
Sinusitis, Nasal Polyps
Trial of Topical Verapamil in Chronic Rhinosinusitis With Nasal Polyps
Verapamil is an L-type calcium channel blocker(CCB) which has been shown to reduce inflammation in a variety of tissues. Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by eosinophilic inflammation as well as…
- Trial name
- NCT03102190
- Testing
- Verapamil Hydrochloride Intranasal
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Benjamin Bleier