Clinical trials: Chronic Sinus Infection
Non-cystic Fibrosis Bronchiectasis、Chronic Sinusitis Without Nasal Polyps、Chronic Obstructive Pulmonary Disease
Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 Tablet
This study is a single-center, single-sequence, self-controlled, open design, aiming to investigate the effects of rifampicin and clarithromycin on the pharmacokinetics of RSS0343 in humans.
- Trial name
- NCT07696091
- Testing
- RSS0343 Tablet; Rifampicin Capsules, RSS0343 Tablet; Clarithromycin Tablets
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Reistone Biopharma Company Limited
Chronic Sinusitis
In-office Placement of the Propel Mini Sinus Implant in the Frontal Sinus Ostia
A randomized controlled trial
- Trial name
- FRONTIER (NCT02880514)
- Testing
- PROPEL Mini Sinus Implant, Balloon Sinus Dilation Alone
- Where
- 9 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Intersect ENT
Chronic Sinusitis
Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery
The purpose of our study is to assess the effect of topical vasoconstriction (cocaine 4% versus adrenaline 1/1000) on the surgical field during endoscopic sinus surgery.
- Trial name
- NCT01706952
- Testing
- Cocaine, Adrenaline
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Marc Tewfik
Cystic Fibrosis
Impact of Triple Combination CFTR Therapy on Sinus Disease.
The study's main goal is to observe how effective elexacaftor-tezacaftor-ivacaftor is for improving the symptoms and signs of CF-related sinus disease.
- Trial name
- NCT04056702
- Testing
- Elexacaftor-tezacaftor-ivacaftor exposure
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Jennifer Taylor-Cousar
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Clinical Trial of TQC2731 Injection in Patients With Chronic Sinusitis and Nasal Polyps
TQC2731 injection is a humanized monoclonal antibody that targets Thymic Stromal Lymphopoietin (TSLP), blocks the TSLP pathway, and inhibits the production of downstream cytokines, thereby exerting anti-inflammatory effects.
- Trial name
- NCT07107256
- Testing
- TQC2731 injection
- Where
- 60 sites in China
- Volunteers
- 246 people
- Sponsor
- Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.
Chronic Sinusitis
Steroid-eluting Sinus Stent for Chronic Rhinosinusitis Patients With Uncontrolled Postoperative Symptoms
Stent-001 study is a randomized controlled clinical trial with the steroid-eluting Sinus in 96 chronic rhinosinusitis patients with uncontrolled postoperative symptoms
- Trial name
- NCT06198894
- Testing
- steroid-eluting sinus stent implant, Systemic glucocorticoids, saline irrigations
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Zheng Liu
Sinusitis
Validation of the Facial and Cephalic Pain Inventory
This study proposes to develop and validate a new instrument designed to measure facial and nasal discomfort related to chronic sinusitis.
- Trial name
- FACE PAIN (NCT01001039)
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Greg Davis
Sinusitis, Nasal Polyps
Association of Periostin Levels and Chronic Sinusitis
The purpose of this study is to see if a protein in blood, called periostin, can determine if patients have chronic sinusitis. This protein is in everyone's body, but the level of the protein may indicate certain conditions such…
- Trial name
- NCT02071667
- Testing
- Blood draw
- Where
- United States
- Sponsor
- University of Virginia
Chronic Rhinosinusitis (Diagnosis)
Use of Budesonide Diluted to Maximum Clinical Treatment of Patients With Chronic Rhinosinusitis With Polyoposis.
This is a double-blind, randomized, double-blind, randomized, double-blind, randomized block design with two intervention groups of 30 patients each.
- Trial name
- CRS (NCT05541419)
- Testing
- Budesonide Nasal
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Universidade Estadual de Londrina
Rhinosinusitis Chronic, Sinus Cancer
TIVA vs TXA in Sinus Surgery to Evaluate Operative Blood Loss and Surgical Field Quality
The goal of this interventional study is to compare the efficacy (surgical field quality and intra-operative blood loss) or cost of TIVA alone to general inhalational anesthetics with intravenous TXA in patient participants who…
- Conditions
- Rhinosinusitis Chronic, Sinus Cancer, Sinus Polyp, Encephalocele
- Trial name
- NCT05639686
- Testing
- Tranexamic acid injection, Total Intravenous Anesthesia, Inhalational isoflurane
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Our Lady of the Lake Hospital
Chronic Sinusitis
Nasospore Stent For Use in Enodscopic Sinus Surgery
The purpose of this study is to evaluate a stenting material called Nasopore. This is a synthetic material approved by FDA for use as a stent in postoperative sinus surgery patients.
- Trial name
- NCT00671541
- Testing
- Merogel Nasal Stent and Nasopore Stent, Nasopore Stent and either Gentamycin or Bacitracin
- Where
- United States
- Sponsor
- Lahey Clinic
Chronic Sinusitis, Nasal Polyps
Biologics in Chronic Rhinosinusitis With Nasal Polyposis
The prevalence of Chronic Sinusitis with Nasal Polyps (CRSwNP) in the United States is estimated at roughly 4%, which equates to over 13 million Americans.
- Trial name
- CRSwNP (NCT06824649)
- Testing
- Biologic Agents
- Where
- 3 sites in United States
- Volunteers
- 504 people
- Sponsor
- Medical University of South Carolina
Sinusitis
Xolair in Patients With Chronic Sinusitis
The purpose of this study is to determine if treatment with the anti-IgE antibody, Xolair (omalizumab), will improve objective and subjective evidence of chronic sinusitis.
- Trial name
- NCT00117611
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Chicago
Chronic Sinusitis
Esmolol vs. Labetalol in Endoscopic Sinus Surgery
The purpose of this study is to compare esmolol and labetalol bleeding and intra-operative visibility scores in functional endoscopic sinus surgery.
- Trial name
- NCT03661346
- Testing
- Labetalol, Esmolol
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Endoscopic Sinus Surgery, Chronic Rhinosinusitis
Large Scale Cerebral Oximetry During Sinus Endoscopy
Deliberate hypotension, reverse Trendelenburg position, and hyperventilation are techniques utilized during functional endoscopic sinus surgery to attempt to reduce surgical bleeding.
- Trial name
- NCT02692794
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Sinusitis
Sinus Balloon Dilation in Pediatric Patients
Safety and effectiveness of sinus balloon dilation in patients 2-21 years old.
- Trial name
- NCT02278484
- Testing
- XprESS device and PathAssist confirmation tools
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Entellus Medical, Inc.
Chronic Sinusitis
The Feasibility of Using MRI During ESS
Before performing endoscopic sinus surgery (ESS-Endoscopic Sinus Surgery), every candidate for surgery is referred to perform a sinus CT scan of the sinuses.
- Trial name
- ESS (NCT03903432)
- Testing
- MRI
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Roee Landsberg
Chronic Rhinitis, Inflammation of the Nasal Mucosa
Surgical Reduction of the Inferior Turbinates for Nasal Obstruction
The primary goal of this post-marketing surveillance study is to assess whether surgical turbinate reduction performed using a Coblation® device is associated with reduced nasal obstruction symptoms.
- Conditions
- Chronic Rhinitis, Inflammation of the Nasal Mucosa, Inflammation of Nasal Tissue
- Trial name
- NCT00737906
- Testing
- Surgical turbinate reduction procedure
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- ArthroCare Corporation
Pilonidal Sinus Disease, Sacrococcygeal Pilonidal Sinus
Primary Closure vs Open Technique for Pilonidal Sinus
The purpose of this randomized controlled trial is to compare two commonly used surgical techniques for the treatment of pilonidal sinus disease: excision with primary closure and excision with open (lay-open) technique.
- Conditions
- Pilonidal Sinus Disease, Sacrococcygeal Pilonidal Sinus, Chronic Infected Sinus Tract, Post-surgical Wound Healing
- Trial name
- NCT07311707
- Testing
- Primary Suturing of Surgical Wound, Open Surgical Wound Management
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Teaching Hospital
Chronic Sinusitis, Nasal Polyps
A Clinical Study of TQC2731 Injection in the Treatment of Chronic Rhinosinusitis With Nasal Polyps
This is a multicenter, randomized, double-blind, placebo-controlled Phase II clinical trial to evaluate the efficacy, safety and pharmacokinetics of TQC2731 injection in the treatment of Chronic Sinusitis with Nasal Polyps.
- Trial name
- NCT06036927
- Testing
- TQC2731 injection
- Where
- 16 sites in China
- Volunteers
- 80 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.