Clinical trials: Chronic Skin Ulcers
Diabetic Foot Ulcer, Foot Ulcer Chronic
Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
The study is a multicenter, prospective, controlled modified multi-platform trial assessing the efficacy of human placental membrane products and standard of care in the management of nonhealing diabetic foot ulcers and venous…
- Conditions
- Diabetic Foot Ulcer, Foot Ulcer Chronic, DFU, Ulcer Foot
- Trial name
- BIORESCUE (NCT07364630)
- Testing
- Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU, Membrane Wrap-Lite™ DFU
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- BioLab Holdings
Diabetic Foot Ulcer
Efficacy and Safety Study in the Treatment of Chronic Diabetic Foot Ulcers
The purpose of this study is to determine the safety and efficacy of Dermal-LSR plus Standard of Care (SOC) for the treatment of diabetic foot ulcers (DFU)in comparison to the treatment to SOC alone.
- Trial name
- NCT00387101
- Testing
- Dermal - Living Skin Replacement (Dermal - LSR)
- Where
- 12 sites in United States
- Volunteers
- 288 people
- Sponsor
- ApoPharma
Diabetic Foot, Foot Ulcer
Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds
The primary objective of this study is to detect differences in anti-S. aureus antibody assays (IgM, IgA, IgG and its subclasses) between (1) a group of patients with bacteremia due to a chronic wound (cases) and (2) a group of…
- Conditions
- Diabetic Foot, Foot Ulcer, Leg Ulcer, Bacteremia
- Trial name
- ORISA (NCT01551667)
- Testing
- Antibody assays for S. aureus, Basic blood work
- Where
- 6 sites in France
- Volunteers
- 69 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Venous Ulcer
Venous Ulcer Treatment With Foam Versus Conservative Treatment
The venous ulcer due to venous insufficiency causes an important morbility to those people suffering from this condition. Most of therapies available under the obligatory health plan (POS, acronym in spanish) to date cover the…
- Trial name
- VUTEF (NCT01594658)
- Testing
- Foam sclerotherapy, conservative
- Where
- Colombia
- Volunteers
- 46 people
- Sponsor
- Hospital Occidente de Kennedy
Diabetic Foot, Immune Defect
Immune Cells in Diabetic Chronic Foot Ulcers
The goal of this observational study is to learn about the role of immune cells in patients with diabetes and chronic foot ulcers.
- Trial name
- NCT06154915
- Testing
- medical treatments
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Skin Ulcer, Pressure Ulcer
Negative Pressure Wound Therapy for the Treatment of Chronic Pressure Wounds
The purpose of this study is to assess the difference in the percent reduction in wound surface area, without surgery, of chronic pressure ulcers of the pelvic region for Negative Pressure Wound Therapy (NPWT) compared to the…
- Trial name
- NPWT (NCT00691821)
- Testing
- Standard Dressings, Negative Pressure Wound Therapy (Vacuum-Assisted Closure System [V.A.C.® Therapy™, KCI Medical Canada Inc., Mississauga, Ontario])
- Where
- 4 sites in Canada
- Volunteers
- 184 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Venous Leg Ulcer
Allogeneic ABCB5-positive Dermal Mesenchymal Stromal Cells for Treatment of Therapy-resistant CVU (Phase III)
The aim of this clinical trial is to investigate the efficacy and safety of allo-APZ2-CVU, administered topically on therapy-resistant non-healing CVUs compared to placebo.
- Trial name
- NCT06489028
- Testing
- allo-APZ2-CVU
- Where
- 15 sites in United States, Austria and 10 more
- Volunteers
- 250 people
- Sponsor
- RHEACELL GmbH & Co. KG
Surgical Incision, Ulcer Foot
Study to Evaluate the PICO 14 Negative Pressure Wound Therapy System in the Management of Acute and Chronic Wounds
This is a prospective, multi-center, open label study evaluating the performance of PICO14 Negative Pressure Wound Therapy (NPWT) in the management of chronic open wounds (pressure ulcers, venous leg ulcers, diabetes related foot…
- Conditions
- Surgical Incision, Ulcer Foot, Ulcer Venous, Ulcer, Leg
- Trial name
- PICO14 (NCT05234632)
- Testing
- PICO 14 single-use Negative Pressure Wound Therapy System
- Where
- 6 sites in Germany, United Kingdom
- Volunteers
- 45 people
- Sponsor
- Smith & Nephew, Inc.
Diabetic Foot, Critical Limb Ischemia
Umbilical Cord Mesenchymal Stem Cells Injection for Diabetic Foot
The purpose of this study is to determine whether umbilical cord Mesenchymal Stem Cells of treatment for diabetic foot is safe and effective in the management of diabetic foot ischemia, the therapeutic effect of stem cells is…
- Conditions
- Diabetic Foot, Critical Limb Ischemia, Mesenchymal Stem Cells, Umbilical Cord
- Trial name
- NCT01216865
- Testing
- umbilical cord mesenchymal stem cells, Standard Therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qingdao University
Diabetic Foot Ulcer
Randomized Clinical Study Assessing NuShield Versus Standard of Care in Diabetic Foot Ulcers
This prospective, multi-center, randomized, controlled clinical study compares NuShield® plus SOC to SOC alone in subjects with chronic DFUs.
- Trial name
- DFUs (NCT03855514)
- Testing
- NuShield
- Where
- 9 sites in United States
- Volunteers
- 200 people
- Sponsor
- Organogenesis
Diabetic Foot
SkinTE® for the Treatment of Wagner 1 Diabetic Foot Ulcers (COVER DFUS II)
The purpose of this study is to assess the safety and efficacy of SkinTE for treatment of Wagner grade 1 diabetic foot ulcers.
- Trial name
- NCT06140303
- Testing
- SkinTE, Control
- Where
- 23 sites in United States
- Volunteers
- 100 people
- Sponsor
- PolarityTE
Chronic Venous Insufficiency, CVI, Chronic Venous Insufficiency C2 or Higher
Reducing Skin Tone Inequities in Chronic Venous Insufficiency
The aim of this project is to define assessment criteria for chronic venous insufficiency (CVI) in people with dark skin tones. It will inform future interventions and modifications to practice for the assessment of CVI in people…
- Conditions
- Chronic Venous Insufficiency, CVI, Chronic Venous Insufficiency C2 or Higher, Chronic Venous Disease of Lower Limbs, Venous Leg Ulcer (VLU)
- Trial name
- NCT06798766
- Where
- 2 sites in United Kingdom
- Volunteers
- 51 people
- Sponsor
- King's College London
Chronic Disease
Integrative Therapy of Chronic Diseases
The observational study aims to investigate the extent to which a two-week stay in an internal medicine clinic for integrative medicine and naturopathy results in an improvement of complaints, impairments, quality of life…
- Trial name
- InteChron (NCT04927403)
- Testing
- multimodal integrative naturopathic therapy concept
- Where
- 3 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Universität Duisburg-Essen
Leg Ulcer
Treatment of Chronic Leg Ulcers With Autologous Stromal Vascular Fraction
Chronic leg ulcers are associated with decreased quality of life and an increased mortality. In many cases these ulcers are treated conservatively and the healing time can be several months.
- Trial name
- NCT02987101
- Testing
- Liposuction, Standard wound care, Adipose-Derived Regenerative Cells
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Odense University Hospital
Chronic Leg Ulcer, Chronic Diabetic Foot Ulcer
A PMCF Investigation on Chronic LU and DFU in Need of Debridement With ChloraSolv®
This is a single-arm, observational, multicenter PMCF investigation designed to confirm clinical performance and safety of ChloraSolv when exposed to larger population of clinical users.
- Trial name
- ChloraSolv02 (NCT04838600)
- Testing
- ChloraSolv
- Where
- 7 sites in Sweden
- Volunteers
- 34 people
- Sponsor
- RLS Global
Chronic Leg Ulcers
Interest of a Systematic Biopsy for Hard-to-heal Leg Ulcers
Primary aim of the study : to evaluate the prevalence of ulcerated cutaneous carcinoma or malignant degeneration, in leg ulcers, presumed of vascular origin and without evidence of healing despite 3 months of adequate…
- Trial name
- ULCERE (NCT00709631)
- Where
- France
- Volunteers
- 155 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Foot Ulcer, Amniotic Membrane Placental Allograft
a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Diabetic Foot Ulcers
BIOxHEAL is an investigational placental-derived biologic being evaluated for the treatment of nonhealing diabetic foot ulcers. Adults with type 1 or type 2 diabetes who have a diabetic foot ulcer that has not healed with…
- Conditions
- Diabetic Foot Ulcer, Amniotic Membrane Placental Allograft, Biologic
- Trial name
- AB BIOH - DFU (NCT07852338)
- Testing
- Standard of Care, BIOxHEAL (human amniotic membrane allograft)
- Where
- United States
- Volunteers
- 253 people
- Sponsor
- Applied Biologics, LLC
Bee Venom, Pressure Ulcers
Tackling Pressure Ulcer Via Bee Venom Phonophoresis
This study aimed to investigate the efficiency of topical Bee Venom gel versus phonophoresis of Bee Venom gel to accelerate healing of chronic pressure ulcer
- Conditions
- Bee Venom, Pressure Ulcers, Phonophoresis
- Trial name
- ulcer (NCT06374563)
- Testing
- group 1 received topical Bee venom gel, Group 2: Phonophoresis of Bee Venom gel
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Badr University
Chronic Ulcer of Lower Extremity
Safety and Preliminary Efficacy of PalinGen Flow Amniotic Tissue Allograft in Chronic Ulcers of the Lower Extremities
The purpose of this study is to assess the safety and preliminary efficacy of PalinGen® Flow for the treatment of chronic ulcers of the lower legs and feet.
- Trial name
- NCT04667416
- Testing
- PalinGen Flow Amniotic Tissue Allograft
- Where
- 7 sites in United States
- Volunteers
- 82 people
- Sponsor
- Amnio Technology, LLC
Skin Wound
Dermal Regeneration Photosynthetic Matrix
The aim of the study is to demonstrate that dermal regeneration photosynthetic matrix applied in patients with acute clean skin wound is safe.
- Trial name
- HULK (NCT03960164)
- Testing
- Dermal regeneration photosynthetic matrix (DRPM)
- Where
- 3 sites in Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile