Clinical trials: Chronic Spinal Cord Injury
Pain
Effect of Guided Imagery on Patients With Chronic Pain Related to Spinal Cord Injury
Chronic pain after spinal cord injury in or below the level of injury is a common problem and can be severe. The purpose of our study is to investigate the effect of pleasant guided imagery on spinal cord injured patients with…
- Trial name
- NCT00678548
- Testing
- Pleasant guided imagery, Pain diary
- Sponsor
- Norwegian University of Science and Technology
Aortic Aneurysm, Thoracoabdominal
Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging
Aortic aneurysms represent the most common and dangerous aortic diseases. Although conventional aortic repair techniques cure the disease, there is a high risk of paraplegia particularly in extensive thoracoabdominal aneurysms…
- Trial name
- PAPAartis (NCT03434314)
- Testing
- Minimally-Invasive Segmental Artery Coil-Embolization
- Where
- 29 sites in Austria, France and 7 more
- Volunteers
- 500 people
- Sponsor
- University of Leipzig
Chronic Spinal Cord Injury
A Trial Investigating the Efficacy and Safety of NVG-291 in Subjects With Chronic Spinal Cord Injury
The goal of this clinical trial is to learn if NVG-291 can improve function in adults with chronic cervical motor-incomplete spinal cord injury. It will also learn about the safety of NVG-291.
- Trial name
- RESTORE (NCT07799532)
- Testing
- NVG-291
- Where
- 23 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- NervGen Pharma
Spinal Cord Injury
Administration of Expanded Autologous Adult Bone Marrow Mesenchymal Cells in Established Chronic Spinal Cord Injuries
The purpose of this study is to analyze the potential clinical efficacy of intrathecal administration, in the subarachnoid space, of in vitro expanded autologous adult bone marrow mesenchymal stem cells in the treatment of…
- Trial name
- NCT02570932
- Testing
- Autologous Mesenchymal Bone Marrow Cell
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Puerta de Hierro University Hospital
Spinal Cord Injuries
Acute Intermittent Hypoxia on Leg Function Following Spinal Cord Injury
The purpose of this study is to determine how the nervous system controlling leg muscles is altered following spinal cord injury and how they may be affected by brief periods of low oxygen inhalation over time.
- Trial name
- NCT02274116
- Testing
- AIH - Intermittent Hypoxia - hypoxia air mixture
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Spaulding Rehabilitation Hospital
Tetraplegia, Asthma
Exhaled Breath Condensate Biomarkers of Inflammation in Individuals With Chronic Cervical Spinal Cord Injury
The purpose of this study is to obtain markers of airway inflammation from the exhaled breath condensate (the moisture in exhaled air) for comparison to blood based markers.
- Trial name
- NCT02235714
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Electric Stimulation Therapy, Bowel Dysfunction
The Effect of NMES on Bowel Management in People With Chronic SCI
It has been reported that 62% of all people with Spinal Cord Injury (SCI) have experienced faecal incontinence and that neurogenic bowel dysfunction (NBD) is a major sequela.
- Conditions
- Electric Stimulation Therapy, Bowel Dysfunction, Spinal Cord Injuries, Defecation Disorder
- Trial name
- FES_Bowel (NCT04914975)
- Testing
- Neuromuscular electrical stimulation
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spinal Cord Injuries
FES Cycling and Nutritional Counseling for Battling Obesity After SCI
Individuals who suffer from paralysis after spinal cord injury (SCI) are estimated to have an even greater (66%) prevalence of obesity.
- Trial name
- NCT03810963
- Testing
- HIIT-FES Cycling combined with Nutritional Counseling, Nutritional Counseling Only
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- William Carey University
Spinal Cord Injury, Chronic Pain
Spaulding-Harvard Model System: Effects of Transcranial Direct Current Stimulation (tDCS) on Chronic Pain in Spinal Cord Injury
The purpose of this study is to see the effects of transcranial direct current stimulation (tDCS) on the pain associated with spinal cord injury. This study is part of the Spaulding-Harvard Model System.
- Conditions
- Spinal Cord Injury, Chronic Pain, Neuropathic Pain
- Trial name
- NCT01599767
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury
Mechanisms of Arterial Hypotension in Chronic Spinal Cord Injury
This clinical study is designed to investigate the mechanisms of blood pressure regulation and respiratory motor function affected by spinal cord injury (SCI).
- Trial name
- NCT02154412
- Testing
- Respiratory Training
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Spinal Cord Injuries, Chronic Spinal Cord Injury
NVG-291 in Spinal Cord Injury Subjects
A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2a Study of NVG-291 in Spinal Cord Injury Subjects
- Conditions
- Spinal Cord Injuries, Chronic Spinal Cord Injury, Subacute Spinal Cord Injury
- Trial name
- NCT05965700
- Testing
- NVG-291
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NervGen Pharma
Central Neuropathic Pain, Allodynia
Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial
This randomized, placebo-controlled, double-blind 4x4 crossover clinical trial was part of a larger NIH-funded study to evaluate the analgesic efficacy of multiple dose-combinations of chronic oral (PO) dextromethorphan and…
- Conditions
- Central Neuropathic Pain, Allodynia, Spinal Cord Injury
- Trial name
- NCT02218203
- Testing
- Dextromethorphan, Lidocaine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Brigham and Women's Hospital
Spinal Cord Injury, Chronic Spinal Cord Injury
First-in-Human Clinical Trial of STUP-001, an In Vivo Direct Cell Conversion Gene Therapy for AIS-A/B Chronic Spinal Cord Injury
This study aim to investigate the safety and exploratory efficacy of STUP-001 which is AAV-based spinal cord injury investigational product.
- Trial name
- STUP-001 (NCT06922890)
- Testing
- STUP-001
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Yonsei University
Spinal Cord Injuries, Pain, Chronic
Hypnotic Cognitive Therapy Reduce Acute & Chronic SCI Pain in Inpatient Rehabilitation
Chronic spinal cord injury (SCI) pain is complex and difficult to treat. For individuals with SCI, pain often begins early in the course of their SCI and continues longitudinally.
- Conditions
- Spinal Cord Injuries, Pain, Chronic, Spinal Cord Injury, Acute
- Trial name
- HYPCT (NCT05047120)
- Testing
- Hypnosis enhanced cognitive behavioral therapy, Pain Education
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Washington
Spinal Cord Injuries
Daily Intermittent Hypoxia and Task-Specific Upper Limb Training in Persons With Chronic Incomplete SCI
The purpose of this research study is to investigate the effectiveness of a combinatorial therapy of breathing low oxygen in short bursts-acute intermittent hypoxia (AIH) and upper limb training on arm strength and function, and…
- Trial name
- NCT03262766
- Testing
- Acute Intermittent Hypoxia (AIH), Upper extremity training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries (SCI), Paralysis, Lower Limbs
Epidural Electrical Stimulation to Restore Standing and Walking in Patients With Chronic Paralysis Due to Spinal Cord Injury: A Study on Motor Recovery, Spasticity Reduction, and Quality of Life Improvement Through Neuromodulation and Intensive Rehabilitation
Spinal cord injury (SCI) is a major cause of morbidity and disability worldwide, significantly impacting patients' quality of life and functional independence.
- Trial name
- EPISTIM-SCI (NCT06847295)
- Testing
- Epidural Electrical Stimulation (EES) using an implanted paddle lead and pulse generator combined with a 12-month intensive rehabilitation program.
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Chronic Spinal Cord Disorder
The Effects of rTMS and tDCS Combined With Robotic Rehabilitation In Patients With Spinal Cord Injury
The purpose of this study is to assess the effect of rTMS and tDCS combined with robotic therapy on motor functional recovery and gait parameters
- Trial name
- NCT06188130
- Testing
- active rTMS, active tDCS
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara City Hospital Bilkent
Spinal Cord Injuries
A Multi-Centre Clinical Study in Chronic Spinal Cord Injury Patients
To establish a solid foundation, e.g. network and a coordinating centre for testing new SCI therapies in forthcoming randomized controlled multi-centre clinical trials following international standards and guidelines
- Trial name
- NCT00592722
- Where
- 5 sites in China, Taiwan
- Volunteers
- 60 people
- Sponsor
- China Spinal Cord Injury Network
Spinal Cord Injury
Wheelchair Indoors Curling With SCI patients_RCT
This study investigates if, patients with diagnosed chronic spinal cord injury will benefit from an Indoor Curling Exercise program on their control capabilities of trunk movements and on their intrinsic motivation for physical…
- Trial name
- SCI-RCT (NCT02550834)
- Testing
- Wheelchair indoors curling training
- Where
- 2 sites in Switzerland
- Volunteers
- 32 people
- Sponsor
- HES-SO Valais-Wallis
Pain, Inflammatory Response
Association Between Body Composition and Pain in Spinal Cord Injury
The purposes of the study are to quantify and compare relationships among acute changes in inflammatory markers and evoked pain sensitivity after a high-fat meal (HFM) challenge, compared to a moderate-fat meal challenge, and…
- Trial name
- NCT05459207
- Testing
- Moderate Fat Meal, High Fat Meal
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami