Clinical trials: Chronic Spinal Pain
Chronic Low Back Pain
Investigating the Hypoalgesic Effects of Manipulative Therapy Using Pain Conditioning and Expectations in Low Back Pain
The objective of this study will be to identify whether a conditioning procedure by the surreptitious downgrade of a noxious stimulus intensity associated with induced positive expectations about treatment will result in greater…
- Trial name
- NCT05202704
- Testing
- Procedure/Surgery: Experimental: Hidden conditioning + Positive Expectation, Procedure/Surgery: Active Comparator: Positive Expectation, Procedure/Surgery: Active Comparator: Neutral Expectation
- Where
- Brazil
- Volunteers
- 264 people
- Sponsor
- Universidade Federal de Sao Carlos
Mechanical Low Back Pain, Chronic Pain
Comparison of the Effect of Spinal Manipulation by Gender
The purpose of the study was to compare and evaluate the effects of spinal manipulation in patients with chronic mechanical low back pain by gender.
- Conditions
- Mechanical Low Back Pain, Chronic Pain, Gender, Neuromuscular Subluxation of Joint
- Trial name
- CESMG (NCT06578208)
- Testing
- Spinal Manipulation
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- SEFA HAKTAN HATIK
Shoulder Pain, Shoulder Impingement Syndrome
Micro-Fragmented Adipose Tissue (Lipogems®) Injection for Chronic Shoulder Pain in Persons With Spinal Cord Injury
Rotator cuff disease (i.e., rotator cuff tendinopathy or tear) is a common cause of shoulder pain in persons with chronic spinal cord injury (SCI).
- Conditions
- Shoulder Pain, Shoulder Impingement Syndrome, Rotator Cuff Impingement Syndrome, Rotator Cuff Tendinitis
- Trial name
- NCT03167138
- Testing
- Autologous micro-fragmented adipose tissue, Lipogems system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kessler Foundation
Chronic Pain, Brain Injuries, Traumatic
Telehealth Pain Self-Management for Employed Adults
The E-TIPS trial will evaluate an evidence-based, telehealth pain self-management intervention compared to standard care (a waitlist) for chronic pain in adults with physical disabilities who are employed.
- Conditions
- Chronic Pain, Brain Injuries, Traumatic, Multiple Sclerosis, Spinal Cord Injuries
- Trial name
- E-TIPS (NCT04248725)
- Testing
- E-TIPS
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Washington
Arthritis, Arthritis, Juvenile Idiopathic
Pain in Inflammatory Joint Diseases
Our primary objective is to better understand the etiology and consequences of chronic paint by using an explorative approach to identify phenotypes and endotypes of patients with inflammatory joint diseases, with a special focus…
- Conditions
- Arthritis, Arthritis, Juvenile Idiopathic, Arthritis,Rheumatoid, Arthritis, Reactive
- Trial name
- Nor-Pain (NCT06718569)
- Testing
- Biological or targeted synthetic DMARD
- Where
- Norway
- Volunteers
- 350 people
- Sponsor
- Diakonhjemmet Hospital
Postoperative Pain, Neuropathic Pain
Impact of Pregabalin in Chronic Users vs. a Perioperative Limited Prescription on Oxycodone Requirement
Spinal surgery is associated with intense pain and associated to a history of preoperative chronic pain. Pregabalin is licensed to treat chronic neuropathic pain, particularly when high dose of opioid are required.
- Trial name
- PREGAB (NCT02866396)
- Testing
- Pregabalin, Naive patient
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Christophe Aveline, MD
Breast Cancer Surgery, Postoperative Pain, Acute
Chronic Pain in Post-Mastectomy Patients; The Difference Between Pectoral Nerve (PECS I-II) and Erector Spinal Plane (ESP) Blocks
This study looks at two types of injections (called PECS and ESP blocks) to see which one works better for reducing pain after breast cancer surgery (mastectomy).
- Conditions
- Breast Cancer Surgery, Postoperative Pain, Acute, Postoperative Pain, Chronic, Post-mastectomy Pain Syndrome
- Trial name
- NCT06900842
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Hacettepe University
Chronic Pain, Neuropathic Pain
Intraoperative Neuromonitoring Recording With a Novel SCS Paddle: Phase II
The purpose of this study is to demonstrate safety and efficacy of a new spinal cord stimulation paddle electrode which is able to target the dorsal horns, dorsal nerve roots, and dorsal columns.
- Conditions
- Chronic Pain, Neuropathic Pain, Failed Back Surgery Syndrome, Complex Regional Pain Syndromes
- Trial name
- NCT05459324
- Testing
- HD Study Electrode
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Albany Medical College
Chronic Pain, Hypertension
Epidural Spinal Cord Stimulation for Hypertension in Patients With Neuropathic Pain
The purpose of the ESCAPE Study is to determine the extent to which epidural spinal cord stimulation (SCS) reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension.
- Conditions
- Chronic Pain, Hypertension, Implanted Stimulation Electrodes
- Trial name
- ESCAPE (NCT04598035)
- Testing
- Diagnostic Tests
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of Kansas Medical Center
Chronic Low Back Pain, Pain in Leg, Unspecified
Effect of Spinal Cord Stimulation on Gait and Balance in Chronic Low Back Pain Patients
Spinal Cord Stimulation (SCS) uses electrical signals to disrupt noxious signals arising from painful areas, thereby reducing pain perception.
- Trial name
- NCT03586882
- Testing
- Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Texas Back Institute
Spondyloarthritis (SpA), Rheumatoid Arthritis & Other Inflammatory Polyarthropathies
Ecological Momentary Assessment and Physical Activity in Patients With Inflammatory Rheumatic Diseases
Chronic inflammatory rheumatic diseases (IRDs), such as rheumatoid arthritis and spondyloarthritis, can cause pain, fatigue, and mobility issues, significantly impacting patients' quality of life.
- Trial name
- DYNAMIC (NCT07167784)
- Testing
- Ecological Momentary Assessment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Neuropathic Pain
Identifying Biomarkers and Changes in Cerebrospinal Fluid Collected Pre and Post Spinal Cord Stimulation in Subjects Suffering From Chronic Refractory Pain Conditions
This is a single center exploratory study in subjects suffering from chronic refractory pain to identify cellular, molecular and protein biomarkers within cerebrospinal fluid (CSF).
- Trial name
- CSF-STIM (NCT03986255)
- Testing
- Lumbar Puncture
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Spinal Cord Injuries, Anxiety Disorders
UK Prevalence of Mental Health After SCI
Mental health decline after Spinal Cord Injury (SCI) is commonly reported but minimally investigated in the United Kingdom. The current study aims to explore the prevalence and impact of mental health challenges after SCI to…
- Conditions
- Spinal Cord Injuries, Anxiety Disorders, Depression, PTSD
- Trial name
- NCT06618404
- Testing
- No intervention - cross-sectional cohort analysis
- Where
- United Kingdom
- Volunteers
- 318 people
- Sponsor
- University of Reading
Shoulder Pain, Rotator Cuff Tendinitis
Platelet-Rich Plasma Therapy for Shoulder Pain in Persons With Spinal Cord Injury
Shoulder pain is common in persons with spinal cord injury (SCI). It is most often caused by overuse injuries to the muscles and tendons that can occur during wheelchair propulsion, transfers, and other activities of daily…
- Conditions
- Shoulder Pain, Rotator Cuff Tendinitis, Rotator Cuff Syndrome, Spinal Cord Injury
- Trial name
- NCT01355549
- Testing
- Platelet-rich plasma (PRP) therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Kessler Foundation
Pain, Myofacial, Pain, Neck
Does Dry Needling Affect Treatment Outcomes of Interlaminar Epidural Steroid Injection in Cervical Disc Herniation?
Chronic neck pain is among the most frequently seen chronic painful conditions. As an important cause of disability, chronic neck pain is a musculoskeletal disorder that negatively affects quality of life.
- Conditions
- Pain, Myofacial, Pain, Neck, Pain, Chronic
- Trial name
- NCT04914637
- Testing
- Cervical interlaminar epidural steroid injection, Dry needling
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Marmara University
Low Back Pain
Evaluation of the Effectiveness of Transforaminal Epidural Injections in Lumbar Disc Herniation or Radiculitis
To evaluate differences in outcomes in patients receiving steroids compared to those patients randomized to the local anesthetic group who did not receive steroids.
- Trial name
- NCT01052571
- Testing
- lumbar transforaminal epidural injections
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Pain Management Center of Paducah
Osteoporosis, Vertebral Fracture
A Trial of Vertebroplasty for Painful Chronic Osteoporotic Vertebral Fractures (Vertos V)
Background The standard care in patients with a painful osteoporotic vertebral compression fracture (VCF) is conservative therapy.
- Trial name
- VERTOSV (NCT01963039)
- Testing
- percutaneous vertebroplasty
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Elisabeth-TweeSteden Ziekenhuis
Degenerative Disc Disease
Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease
The goal of this study is to evaluate the safety and tolerability of TG-C in subjects with chronic discogenic lumbar back pain due to degenerative disc disease.
- Trial name
- NCT06144970
- Testing
- TG-C High Dose, TG-C Mid Dose, TG-C Low Dose
- Volunteers
- 24 people
- Sponsor
- Kolon TissueGene, Inc.
Chronic Pain
Evoke Data Collection Study Germany
The objective of this multicentre study is to collect electrophysiological and device data from the Evoke Closed-Loop SCS system in the treatment of chronic pain of the trunk and/or limbs, in a real world setting under normal…
- Trial name
- NCT05272137
- Testing
- Evoke Spinal Cord Stimulation (SCS) System
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- Saluda Medical Pty Ltd
Endometriosis
Spinal Cord Stimulation for Intractable Chronic Lower Abdominal Neuropathic Pain Caused by Endometriosis
Endometriosis is a chronic, inflammatory disease where endometrium-like tissue is present outside the uterus. Nerve cells in the proximity of this tissue express cytokine receptors causing a signaling cascade.
- Trial name
- NCT05558540
- Testing
- spinal cord stimulator
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Prof. Velja Mijatovic