Clinical trials: Chronic Systolic Heart Failure
Periodic Breathing
Different Loop Gain Phenotypes in Patients With Chronic Systolic Heart Failure and Periodic Breathing
Central sleep apnoea (CSA) is common in patients with chronic systolic heart failure (HFrEF). Various trials have shown a prevalence of 21 - 37% in this group of people.
- Trial name
- NCT03532412
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Systolic Chronic Heart Failure, Congestion, Venous
Ultrasound-assessed Internal Jugular Vein Distensibility in Advanced Chronic Heart Failure (US-IJVD in CHF)
Prospective validation of the ultrasound-assessed internal jugular vein distensibility (JVD) ratio to identify patients with systolic chronic heart failure and right atrial pressure (RAP) of 7 or less mmHg measured by the right…
- Conditions
- Systolic Chronic Heart Failure, Congestion, Venous, Advanced Heart Failure
- Trial name
- US-IJVD-CHF (NCT03874312)
- Testing
- Linear ultrasound (US) assessment of the internal jugular vein
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Niguarda Hospital
Heart Failure, Systolic
Physiological Effects of Lactate in Individuals With Chronic Heart Failure
Background: Lactate is continuously produced in the human body through two primary processes: glycolysis and microbial fermentation in the gastrointestinal tract.
- Trial name
- NCT06121323
- Testing
- Sodium lactate infusion, Sodium lactate ingestion
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Henrik Wiggers
Heart Failure, Systolic
A Novel Home-based Physical Activity Intervention for Stable Chronic Heart Failure Patients
The project focuses on heart failure (HF), a complex clinical syndrome of symptoms and signs that suggest the efficiency of the heart as a pump is impaired. Around 950,000 people in the UK have HF.
- Trial name
- PAHF (NCT03677271)
- Testing
- Physical Activity
- Volunteers
- 20 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Acute on Chronic Systolic Congestive Heart Failure
Reversible Pulmonary Artery Banding as Simplified Management of End-stage Dilated Left Ventriculopathy in Early Life
The purpose of this study is to: 1) Remodel and restore left ventricular geometry and function. 2) Avoid the need for mechanical circulatory support (MCS) and/or cardiac transplantation (CT).
- Trial name
- NCT02652676
- Testing
- Reversible Pulmonary Artery Banding, GORE-TEX DualMesh EMERGE PLUS Biomaterial
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Loma Linda University
Chronic Heart Failure With Reduced Ejection Fraction
Exercise Capacity Study of LCZ696 vs. Enalapril in Patients With Chronic Heart Failure and Reduced Ejection Fraction.
The purpose of the study was to determine the effect of LCZ696 vs. enalapril on improvement of exercise capacity in patients with chronic heart failure with reduced ejection fraction.
- Trial name
- NCT02768298
- Testing
- LCZ696, Enalapril
- Where
- 34 sites in Germany
- Volunteers
- 201 people
- Sponsor
- Novartis Pharmaceuticals
Pulmonary Disease, Chronic Obstructive, Heart Failure, Systolic
Inspiratory Muscle Training for Breathless Patients With Chronic Obstructive Pulmonary Disease and Heart Failure
The purpose of this study is to determine whether inspiratory muscle training is effective to improve breathless and exercise intolerance in symptomatic patients with chronic obstructive pulmonary disease (COPD) plus chronic…
- Trial name
- NCT02579200
- Testing
- POWERbreathe®KHA (IMT group)
- Where
- 3 sites in Belgium, Brazil
- Volunteers
- 50 people
- Sponsor
- Queen's University
Heart Failure, Congestive
Rosuvastatin Impact on Ventricular Remodelling Lipids and Cytokines
The purpose of this study is to assess the effect of rosuvastatin (up-titrated to a dose of 40mg/day) compared to placebo on cardiac remodelling, estimated by change in left ventricular ejection fraction on radionuclide…
- Trial name
- NCT00240292
- Testing
- Rosuvastatin
- Where
- 13 sites in Australia
- Volunteers
- 160 people
- Sponsor
- AstraZeneca
Chronic Systolic Heart Failure
Evaluation of the Effect of Injectable Neucardin on Cardiac Function and Reversal Ventricular Remodeling in Patients With Chronic Systolic Heart Failure
A multicenter, randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the effect of recombinant human Neuregulin-1 for injection on cardiac function and reverse ventricular remodeling in male patients…
- Trial name
- NCT05949801
- Testing
- Neucardin
- Where
- 103 sites in China
- Volunteers
- 202 people
- Sponsor
- Zensun Sci. & Tech. Co., Ltd.
Chronic Heart Failure
Clinical Trial to Evaluate the Efficacy and Safety of Recombinant Human Neuregulin-1 for Subcutaneous Administration in Patients With Chronic Systolic Heart Failure
Evaluate the Efficacy and Safety of Recombinant Human Neuregulin-1 for Subcutaneous Administration in Patients With Chronic Systolic Heart Failure
- Trial name
- NCT01214096
- Testing
- rhNRG-1
- Where
- 4 sites in China
- Volunteers
- 15 people
- Sponsor
- Zensun Sci. & Tech. Co., Ltd.
Systolic Heart Failure
Udenafil Therapy to Improve Symptomatology, Exercise Tolerance and Hemodynamics in Patients With Chronic Systolic Heart Failure
The purpose of this study is to determine if udenafil improves exercise tolerance in patients with systolic heart failure.
- Trial name
- ULTIMATE-SHF (NCT01646515)
- Testing
- Udenafil (Zydena)
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- Seoul National University Hospital
Heart Failure, Heart Failure With Reduced Ejection Fraction
Pilot Study Lp299v Supplementation in Chronic Heart Failure
The goal of this study is to determine the impact of 12 weeks of Lp299v supplementation (20 million cfu/day vs. placebo) on exercise capacity, circulating biomarkers of cardiac remodeling, quality of life, and vascular…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure, Systolic, Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT05752760
- Testing
- Lactobacillus Plantarum 299v Freeze Dried Capsule, Freeze Dried Potato Starch Capsule
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical College of Wisconsin
Pulmonary Hypertension, Right Heart Failure
RV Systolic and Diastolic Function and Contractile Reserve Under Acute Exercise and in Response to Chronic Exercise-based Rehabilitation
Exercise training in Pulmonary arterial hypertension in the setting of rehabilitation leads to an enormous improvement of functional state and haemodynamics. However the underlying mechanism is still unkown.
- Conditions
- Pulmonary Hypertension, Right Heart Failure, Heart Failure, Contractility
- Trial name
- Reserve (NCT04188756)
- Testing
- Exercise
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- University of Giessen
Chronic Heart Failure
Study of the Survival of Recombinant Human Neuregulin-1β in Chronic Heart Failure (CHF) Patients
The purpose of this study is to evaluate efficacy of rhNRG-1 in reducing the death rate of heart failure.
- Trial name
- NCT01131637
- Testing
- rhNRG-1
- Where
- 43 sites in China
- Volunteers
- 331 people
- Sponsor
- Zensun Sci. & Tech. Co., Ltd.
Heart Failure, Systolic
Metformin Pharmacokinetics in Patients With Chronic and Acute Heart Failure
The study evaluates the pharmacokinetics of metformin in heart failure patients in acute and chronic state in relation to metformin transporter genotypes.
- Trial name
- MetKin (NCT02797340)
- Testing
- Blood draws and urine samples for metformin concentration measurements, Metformin
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Aarhus University Hospital
Chronic Systolic Heart Failure
Evaluate the Effect of Injectable Neucardin on the Cardiac Function of Subjects With Chronic Systolic Heart Failure
A multi-center, randomized, double-blind, placebo-controlled phase III clinical trial to evaluate the effect of injectable Neucardin on the heart function in male patients with NT-proBNP ≤ 1700 pg/ml and female patients with…
- Trial name
- NCT04468529
- Testing
- Recombinant human Neuregulin for injection
- Where
- 29 sites in China
- Volunteers
- 154 people
- Sponsor
- Zensun Sci. & Tech. Co., Ltd.
Sick Sinus Syndrome, Complete Heart Block
Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.
The number of cardiac implantable electronic devices (CIEDs) implanted each year has grown rapidly over the past two decades. CIED infections, defined as infections involving the generator implant site (pocket) and/or…
- Conditions
- Sick Sinus Syndrome, Complete Heart Block, Syncope, Chronic Systolic Heart Failure
- Trial name
- ENVELOPE (NCT02809131)
- Testing
- polymixin/bacitracin, cephalexin, or levofloxacin, or clindamycin, Saline
- Where
- United States
- Volunteers
- 1,010 people
- Sponsor
- Vanderbilt University Medical Center
Congestive Heart Failure
A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure
The purpose of this study is to determine if Coreg CR is as effective as Coreg IR in improving heart function in subjects with stable chronic heart failure.
- Trial name
- COMPARE (NCT00323037)
- Testing
- carvedilol controlled release, carvedilol immediate release
- Where
- 75 sites in United States
- Volunteers
- 318 people
- Sponsor
- CTI-1, LLC
Hypertension
Systolic Blood Pressure Intervention Trial
Elevated blood pressure (BP) is an important public health concern. It is highly prevalent, the prevalence may be increasing, and it is a risk factor for several adverse health outcomes, especially coronary heart disease, stroke…
- Trial name
- SPRINT (NCT01206062)
- Testing
- Intensive control of SBP, Standard control of SBP
- Where
- United States
- Volunteers
- 9,361 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure, Systolic, Ischemic Heart Disease Chronic
Growth Hormone in Ischemic Heart Failure
In a double-blind, placebo-controlled trial, we randomly assigned 37 patients (mean age 66 years; 95% male) with ischemic heart failure (HF) (ejection fraction (EF) < 40%) to a 9-month treatment with either recombinant human GH…
- Trial name
- NCT04420481
- Testing
- Somatropin
- Volunteers
- 37 people
- Sponsor
- Göteborg University