Clinical trials: Chronic Thromboembolic Disease
Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension
129Xe MRI Cardiopulmonary
The goal of this NIH-sponsored study is to characterize three biomarkers derived from 129Xe gas exchange MRI and to understand how they change in response to interventions.
- Conditions
- Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension, Acute Pulmonary Embolism, Anemia
- Trial name
- NCT06038630
- Testing
- Hyperpolarized Xe129, Oxygen Administration
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Bastiaan Driehuys
Primary Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH
This is an open-label, single-armed, prospective single-centre clinical study to evaluate the effect of riociguat on right heart size and function in patients with manifest PAH and CTEPH.
- Trial name
- RIVERII (NCT04954742)
- Testing
- Riociguat
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heidelberg University
Pulmonary Hypertension
Smoking: a Risk Factor for Pulmonary Arterial Hypertension?
Environmental factors may play a role in the genesis of pulmonary hypertension, especially in endothelial dysfunction. One widespread environmental factor associated with systemic endothelial dysfunction is cigarette smoke.
- Trial name
- DACH (NCT01484899)
- Where
- 9 sites in Austria, Germany and 1 more
- Volunteers
- 500 people
- Sponsor
- University of Zurich
Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Retrospective Data Analysis of Data From the Zurich PH Registry
The collected data from the Zurich Registry for pulmonary Hypertension (PH) are evaluated in a retrospective analysis. This study examines the number of patients and their exact diagnoses who are treated at the University…
- Conditions
- Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Artery Hypertension
- Trial name
- NCT03198910
- Where
- Switzerland
- Volunteers
- 313 people
- Sponsor
- University of Zurich
Chronic Thromboembolic Disease
BPA in CTEPD Without PH
The goal of this clinical trial is to assess the effect of Balloon Pulmonary Angioplasty (BPA) on quality of life and exercise capacity in patients with chronic tromboembolic pulmonary disease (CTEPD) without pulmonary…
- Trial name
- BALLOON (NCT06090838)
- Testing
- Balloon Pulmonary Angioplasty (BPA)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Amsterdam UMC, location VUmc
Chronic Thromboembolic Pulmonary Hypertension, Acute Lung Injury
Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by unresolved thromboemboli in the pulmonary arteries, which lead to pulmonary hypertension and, left untreated, right heart failure.
- Trial name
- NCT00747045
- Testing
- Ventilation Strategy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of California, San Diego
Dyspnea, Pulmonary Embolism
Inhaled Nitric Oxide (iNO) in Post-Pulmonary Embolism (Post-PE)
Following acute pulmonary embolism (PE), up to a third of patients develop post-PE syndrome described as having persistent breathlessness (dyspnea), impaired exercise capacity, and a reduced quality of life.
- Trial name
- NCT04920695
- Testing
- Nitric Oxide
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Dr. Denis O'Donnell
Post Thrombotic Syndrome, Chronic Thromboembolic Pulmonary Hypertension
Long Term Outcomes of Venous Thromboembolism
This prospective observational follow-up study is designed to assess the long-term outcomes after Venous thromboembolism (VTE) and to assess the effect of the new oral anticoagulant (NOAC) rivaroxaban on the prevalence of…
- Conditions
- Post Thrombotic Syndrome, Chronic Thromboembolic Pulmonary Hypertension, Venous Thrombosis
- Trial name
- LOVE (NCT02268630)
- Where
- 3 sites in Norway
- Volunteers
- 460 people
- Sponsor
- Ostfold Hospital Trust
Thromboembolism, Thrombosis
Tecarfarin Anti-Coagulation Trial (TACT)
TACT is a "real world" randomized controlled trial of tecarfarin, a novel vitamin K antagonist, vs. warfarin. The quality of anticoagulation control will be compared for the two groups of subjects who require chronic oral…
- Trial name
- TACT (NCT02522221)
- Testing
- Warfarin, tecarfarin
- Volunteers
- 1,000 people
- Sponsor
- Espero Biopharma
Hypertension, Pulmonary
Riociguat in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
The aim of the study is to assess safety, tolerability and clinical effects of different doses of riociguat in patients with inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and who are not satisfactorily treated…
- Trial name
- EAS (NCT01784562)
- Testing
- Adempas (Riociguat, BAY63-2521)
- Where
- 102 sites in United States, Austria and 18 more
- Sponsor
- Bayer
Chronic Thromboembolic Disease (CTED), Exercise Intolerance Post PEA Surgery
Treatment of Exercise-Induced Pulmonary Vascular Dysfunction After Pulmonary Thromboendarterectomy or Balloon Pulmonary Angioplasty
This is an open label study of Riociguat in patients with continued exercise intolerance at least 6 months following pulmonary endarterectomy (PEA).
- Trial name
- NCT03409588
- Testing
- Adempas
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Venous Thromboembolism, Pulmonary Embolism
Epidemiology of Venous Thromboembolism
More than 5 years ago the DVT FREE Registry was conceived. Its database consists of 5,451 ultrasound-confirmed DVT patients from 183 institutions.
- Conditions
- Venous Thromboembolism, Pulmonary Embolism, Cancer, Deep Vein Thrombosis
- Trial name
- NCT00456196
- Where
- United States
- Volunteers
- 5,451 people
- Sponsor
- Brigham and Women's Hospital
Hypertension, Pulmonary, Pulmonary Thromboembolisms
Functional Pulmonary Capillary Surface Area in BPA for CTEPH
Chronic thromboembolic pulmonary hypertension [CTEPH] is caused by pulmonary emboli that have enlarged in pulmonary arteries and have become organized into the vessel wall.
- Trial name
- NCT05719415
- Testing
- Measurement of pulmonary functional capillary surface area
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Jewish General Hospital
Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Non-Invasive Measurement of Cardiac Output and Stroke Volume in PAH/CTEPH
Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are severe clinical conditions that, despite advances in therapeutics over the past 20 years, lead to serious morbidity and…
- Trial name
- NCT05618093
- Testing
- Non-invasive hemodynamic measurements
- Where
- United States
- Sponsor
- University of California, Los Angeles
Thromboembolism, Cardiac Event
Influence of Cardiac Implantable Electronic Devices on the Hemostatic System
The hemostasis system is one of the many biological systems of the human body, designed to preserve the liquid state of blood and prevent its loss during vascular injuries.
- Conditions
- Thromboembolism, Cardiac Event, Hemostatic Disorder
- Trial name
- NCT04499612
- Testing
- Cardiac implantable electronic device implantation., Cardiac implantable electronic device replace., Duplex ultrasound.
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Ryazan State Medical University
Heart Failure With Preserved Ejection Fraction, Chronic Pulmonary Thromboembolism (Disorder)
The Prognostic Role and Diagnostic Efficacy of Exercise Right Heart Catheterization With a Simultaneous Echocardiography in Patients With Dyspnea on Exertion
To evaluate the role of exercise hemodynamic testing in the diagnostic workup for patients with dyspnea on exertion referred to the catheterization lab.
- Trial name
- EX_CATH (NCT05490901)
- Testing
- Exercise hemodynamic test
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Samsung Medical Center
Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Arterial Hypertension
DataBase of pulmoNary hyPertesion in PoLish Population - BNP-PL
The BNP-PL is a multicenter, observational study in which patients are prospectively followed in order to investigate clinical course and management of pulmonary hypertension in Poland.
- Trial name
- BNP-PL (NCT03959748)
- Where
- Poland
- Volunteers
- 3,000 people
- Sponsor
- Polish Cardiology Association
Chronic Thromboembolic Pulmonary Hypertension, Inspiratory Muscle Training
Inspiratory Muscle Training in Pulmonary Hypertension
Inspiratory muscle training for 8 weeks in patients with pulmonary hypertension.
- Conditions
- Chronic Thromboembolic Pulmonary Hypertension, Inspiratory Muscle Training, Inspiratory Muscle Weakness, Pulmonary Arterial Hypertension
- Trial name
- NCT03102294
- Testing
- inspiratory muscle training
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Federal University of São Paulo
Hypertension, Pulmonary
A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice
The aim of this study is to understand the treatment patterns in patients with Pulmonary Arterial Hypertension (PAH) or Chronic Thromboembolic Pulmonary Hypertension (CTEPH) during a switch of treatment to Adempas in real-life…
- Trial name
- CAPTURE (NCT02545465)
- Testing
- Riociguat (Adempas, BAY63-2521)
- Where
- 7 sites in Belgium, Canada and 5 more
- Volunteers
- 125 people
- Sponsor
- Bayer
Chronic Subdural Hematoma, Anticoagulant-induced Bleeding
Management of Anticoagulants and Antithrombotics in Patients With CSDH
Primary objective of the study will be to compare, up to 6 months after surgery, number of relapses (post operative re-bleeding) or intracerebral hemorrhage (others than subdural hematomas) and thromboembolic or cardiovascular…
- Conditions
- Chronic Subdural Hematoma, Anticoagulant-induced Bleeding, Thromboembolic Stroke, Cardiovascular Stroke
- Trial name
- THERCA (NCT05079295)
- Testing
- CSDH evacuation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University Hospital of Ferrara