Clinical trials: Chronic Total Coronary Occlusions
Coronary Artery Chronic Total Occlusion
Facilitated Antegrade Steering Technique in Chronic Total Occlusions (FAST-CTOs)
Prospective, non-randomized, multicenter study in subjects with coronary artery chronic total occlusions (CTOs). Published results of safety and effectiveness of conventional techniques will be used for comparison.
- Trial name
- FAST-CTOs (NCT00886899)
- Testing
- Recanalization of a coronary chronic total occlusion
- Where
- 16 sites in United States
- Volunteers
- 147 people
- Sponsor
- BridgePoint Medical
Coronary Heart Disease, Diabetes
OPtimized Stenting Using Intravascular Ultrasound(IVUS) in Long lEsion: Rationale for Simplified criteriA
Rationale IVUS has shown to be efficient for bare metal stent deployment, but has not been specifically studied for Drug Eluting Stents.
- Conditions
- Coronary Heart Disease, Diabetes, Vascular Lesions, Chronic Total Occlusion of Coronary Artery
- Trial name
- OPERA (NCT01861860)
- Testing
- TAXUS™ Element long stent
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Ischemic Heart Disease, Coronary Atherosclerosis
Stress-MRI Assessment After Right Coronary Artery CTO Recanalization
The hypothesis of this study is that Stress-MRI is a clinically significant method of myocardial perfusion assessment after coronary angioplasty with stenting of right coronary artery (RCA) chronic total occlusion (CTO) is…
- Conditions
- Ischemic Heart Disease, Coronary Atherosclerosis, Coronary Artery Disease, Coronary Artery Stenosis
- Trial name
- NCT02769650
- Testing
- CTO coronary angioplasty, Optimal medicamentous treatment, Stress-MRI
- Where
- Russia
- Volunteers
- 72 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Heart Failure, Chronic Heart Failure
Wearable Tissue Oximetry During Arm Cuff Occlusion, Walking, and Standing Tests in Outpatients With Chronic Heart Failure
This prospective, single-center, observational pilot study evaluated an investigational wearable tissue oximeter (NIRSense Argus Oximetry System, also called Envello Core) in adult outpatients with chronic heart failure in New…
- Trial name
- NCT07874386
- Testing
- Argus Oximetry System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NIRSense Inc.
Chronic Coronary Occlusion
Femoral or Radial Approach in Coronary Chronic Total Occlusion
Pecutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is most commonly performed using bilateral transfemoral access and 8 French guiding catheters.
- Trial name
- NCT03265769
- Testing
- radial access site, femoral access site
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 610 people
- Sponsor
- Acibadem University
Chronic Total Occlusion of Coronary Artery
OCT Explores Vascular Response and Healing Profile After Stenting in CTO
True-false-true occurred during wire penetration in coronary CTO procedure. Subintimal stenting influences vascular response. Intravenous ultrasound confirmed wire position in the procedure. Then stenting procedure was performed.
- Trial name
- NCT03939299
- Testing
- OCT
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease, Chronic Total Occlusion of Coronary Artery
The SHINE-CTO Trial
Design: Single center, double-blind, sham-controlled trial that will randomize symptomatic patients with a coronary chronic total occlusion (CTO) to CTO percutaneous coronary intervention (PCI) or a sham procedure.
- Conditions
- Coronary Artery Disease, Chronic Total Occlusion of Coronary Artery, Percutaneous Transluminal Coronary Angioplasty
- Trial name
- SHINE-CTO (NCT02784418)
- Testing
- Chronic Total Occlusion Percutaneous Coronary Intervention
- Sponsor
- Minneapolis Heart Institute Foundation
Coronary Chronic Total Occlusion
Ultrasonic Cardiogram Evaluate the Prognosis of Percutaneous Revascularization of Chronic Total Occlusions
Chronic total occlusions (CTO) are encountered in almost one-fourth of patients undergoing coronary angiography. The presence of an untreated CTO has been related to adverse clinical prognosis, both in stable angina and acute…
- Trial name
- NCT03300011
- Testing
- stent
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southeast University, China
Coronary Artery Disease, Chronic Total Occlusion
The Paclitaxel-Eluting Percutaneous Transluminal Coronary Angioplasty (PTCA) - Balloon Catheter in Coronary Artery Disease to Treat Chronic Total Occlusions
The aim of the study is to assess the safety and efficacy of a Paclitaxel-eluting PTCA-balloon in combination with bare-metal stenting for treatment of chronic total occlusions in native coronary arteries with reference diameters…
- Conditions
- Coronary Artery Disease, Chronic Total Occlusion, Native Coronary Artery
- Trial name
- PEPCAD-CTO (NCT00670436)
- Testing
- paclitaxel eluting PTCA balloon catheter (SeQuent Please), paclitaxel eluting Taxus stent (Boston Scientific)
- Where
- 2 sites in Germany
- Volunteers
- 48 people
- Sponsor
- University of Ulm
Chronic Total Occlusion of Coronary Artery, Chronic Angina
VasoStar Vibrational Guidewire System to Facilitate Crossing Coronary Artery Chronic Total Occlusions
The goal of this project is to provide an improvement in wire performance to expedite crossing difficult lesions in the coronary vasculature.
- Trial name
- VST100 (NCT06193954)
- Testing
- VasoStar guidewire system
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- VasoStar, LLC
Acute Coronary Syndrome, Coronary Artery Disease
The Physiological Impact of CTO PCI on Coronary Pressure Measurements and Correlation in Donor Vessel
This study will be recording pressure wire readings from both blocked and narrowed arteries, to better guide treatment options; medications, stents or potentially bypass surgery, for patients with Chronic Total Occlusion (CTO).
- Trial name
- IMPACT-CTO (NCT02643940)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Coronary Arteriosclerosis
P2Y12 Inhibitors Utilization in Bifurcation and Chronic Total Occlusion PCI
Prasugrel and ticagrelor were both associated with a significant reduction in the risk of MACE in patients undergoing PCI for an ACS, mostly through a reduced stent thrombosis.
- Trial name
- P2BiTO (NCT01967615)
- Volunteers
- 4,500 people
- Sponsor
- G. d'Annunzio University
Chronic Total Occlusion of Coronary Artery
Viable Myocardium Detected by Hybrid PET/MR and SPECT for the Prediction of the Efficacy of PCI in Patients With CTO.
CTO intervention is controversial, and viable myocardium is critical to the improvement of cardiac function and prognosis of patients.
- Trial name
- NCT06113835
- Testing
- CTO PCI
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Arteriosclerosis, Coronary Artery Disease
Comparison of a CrossBoss First Versus Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusion: the "CrossBoss First" Trial
CrossBoss First is a single-blind randomized controlled trial that will randomize 246 patients undergoing clinically-indicated Chronic Total Occlusion Percutaneous Coronary Intervention, to upfront use of the CrossBoss catheter…
- Conditions
- Arteriosclerosis, Coronary Artery Disease, Myocardial Ischemia, Coronary Disease
- Trial name
- NCT02510547
- Testing
- CrossBoss Catheter, Antegrade Wire Escalation Strategy
- Where
- 11 sites in United States
- Volunteers
- 246 people
- Sponsor
- North Texas Veterans Healthcare System
Chronic Total Occlusion
Antiplatelet Therapy After Successful Percutaneous Coronary Intervention for Chronically Occluded Coronary Artery
Coronary arteries are in charge of oxygen supply for the myocardium. When coronary arteries develop stenosis the coronary blood flow (i.e. oxygen flow) is reduced.
- Trial name
- DAPT-CTO (NCT06175377)
- Testing
- Percutaneous coronary intervention, Short dual Aspirin/Clopidogrel therapy, Long dual Aspirin/Clopidogrel therapy
- Volunteers
- 660 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Coronary Artery Disease
The DECISION-CTO Extended 10 Y Follow-up
The goal of this study is to compare the 10-year clinical outcomes of an initial strategy of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO-PCI) with an initial strategy of no CTO-PCI in patients with…
- Trial name
- DecisionCTO10Y (NCT06908499)
- Where
- 19 sites in India, Indonesia and 3 more
- Volunteers
- 804 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease
PowerAssert Radio-Frequency (RF) Guidewire Coronary In-Stent Chronic Total Occlusion (CTO)
A single center Pilot Clinical Registry Study of the" Acute Procedural" Safety and Efficacy of Stereotaxis PowerAssert(TM)RF Coronary Total Occlusion System assisted Angioplasty in the Treatment of Refractory Coronary Total…
- Trial name
- TOTAR (NCT01131793)
- Testing
- PowerAssert RF wire in crossing coronary in-stent chronic total occlusions
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Stereotaxis
Ischemic Heart Disease, Coronary Artery Stenosis
A Clinical Evaluation of the MINI TREK RX 1.20 mm Coronary Dilatation Catheter in Stenotic Lesions
This is a prospective, single-arm, open-label, multi-center, observational study to assess the acute safety and efficacy of MINI TREK RX 1.20 mm for enlarging coronary luminal diameter during percutaneous coronary intervention…
- Conditions
- Ischemic Heart Disease, Coronary Artery Stenosis, Chronic Coronary Total Occlusion, Coronary Bypass Graft Stenosis
- Trial name
- CROSS (NCT01186198)
- Testing
- MINI TREK RX 1.20 mm Coronary Dilatation Catheter
- Where
- 4 sites in United States
- Volunteers
- 71 people
- Sponsor
- Abbott Medical Devices
Percutaneous Coronary Intervention, Chronic Total Occlusion of Coronary Artery
The BLIMP Balloon in Coronary Interventions
The purpose of this study is to investigate the effectivness of the Blimp Scoring balloon compared to current available CTO balloon catheters.
- Trial name
- NCT03947398
- Testing
- BLIMP balloon, Low profile balloon
- Where
- 2 sites in Belgium
- Volunteers
- 128 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Austria Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- NCT01667016
- Where
- 8 sites in Austria
- Volunteers
- 305 people
- Sponsor
- Biotronik Vertriebs-GmbH