Clinical trials: Cicatrization
HIV, Hepatitis C
Impact of an Antibiotic (Rifaximin) on Liver Scarring in HIV-Infected Patients With Liver Disease
For HIV-infected patients who have access to treatment, liver diseases are a major cause of morbidity and mortality. Hepatitis C is the most frequently encountered liver condition in this population.
- Trial name
- NCT01654939
- Testing
- Rifaximin
- Sponsor
- Douglas T. Dieterich
Scar Prevention, Scar Reduction
A Phase 2a Study to Evaluate the Safety and Efficacy of AZX100 in Trocar Sites of Arthroscopic Shoulder Surgery Patients
The purpose of this study was to determine the safety of AZX100 Drug Product and to determine whether it was effective in preventing or reducing scars that were made from trocars following arthroscopic shoulder surgery.
- Trial name
- NCT00811577
- Testing
- AZX100
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Capstone Therapeutics
Scar Prevention, Scar Reduction
A Study to Evaluate the Safety and Efficacy of AZX100 Drug Product Following Excision of Keloid Scars
The purpose of this study was to determine the safety of AZX100 Drug Product and to determine whether it was effective in preventing or reducing re-growth of surgically removed keloid scars.
- Trial name
- NCT00825916
- Testing
- AZX100 Drug Product
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Capstone Therapeutics
Corneal Scarring Fibrosis
Losartan for Corneal Fibrosis
This is a prospective, randomized, double-blinded, controlled clinical trial designed to evaluate the efficacy and safety of topical losartan in improving visual acuity, contrast sensitivity and reducing corneal densitometry…
- Trial name
- NCT07449000
- Testing
- Topical losartan
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Scarring, Skin Aging
Open-label, Prospective, Multicenter Study to Evaluate the Cutera Excel V™ Laser and a Micro-Lens Array Attachment
Open-label, Prospective, Study to Evaluate the Cutera excel V laser at 532 nm in a low fluence, high repetition rate mode and the Micro-Lens Array attachment used with excel V laser at 1064 nm and 532 nm for the improvement of…
- Trial name
- NCT03424148
- Testing
- Excel V™ Laser & Micro-Lens Array Attach
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cutera Inc.
Androgenetic Alopecia, Alopecia
The Effect of Platelet Rich Plasma on Non-scarring Alopecia
The purpose of this study is to evaluate the clinical efficacy of platelet rich plasma (PRP) injections for non-scaring alopecia in women.
- Trial name
- NCT03689452
- Testing
- Platelet Rich Plasma, Normal saline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Burns
ST266 Versus Standard Care In Treating Partial Thickness Burns
The objective of this protocol is to perform a safety and dose-determination efficacy clinical trial in patients having a degree of partial-thickness burn wounds.
- Trial name
- NCT00886470
- Testing
- ST266
- Where
- 14 sites in United States
- Volunteers
- 16 people
- Sponsor
- Noveome Biotherapeutics, formerly Stemnion
Burns
Study of Silicone Material Inserts To Treat Burn Scars
The purpose of this study is to determine if the use of silicone material inserts within pressure garments is effective in decreasing hypertrophic burn scar formation as compared to standard pressure garment therapy.
- Trial name
- NCT03159182
- Testing
- Pressure garment and silicone insert, Pressure garment
- Sponsor
- University of Manitoba
Hypertrophic Scarring
Clinical Evaluation of the Efficacy OF Botulinum Toxin A for Improving Facial Scars
Background: Scars widen when the overlying musculature pulls apart suture lines. Because Botulinum Toxin A (BTA) is known to prevent fibroblast proliferation and it also induces temporary muscle paralysis, the purpose of this…
- Trial name
- NCT04756882
- Testing
- AbobotulinumtoxinA 500 UNT
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Burns, Hypertrophic Scar
Differential Pressure Distribution Orthosis by 3D Printing Process in the Treatment of Post-burn Hypertrophic Scarring
This is a pilot, single-center, feasibility study to evaluate a new 3D printing method for ORDP design. To our knowledge, there is no technical or clinical evaluation of ORDPs, particularly in the treatment of hypertrophic scars.
- Trial name
- EPIDERM (NCT06487910)
- Testing
- 3D scan measurment
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Acne Scarring
Safety and Efficacy of 1550nm Fractional Laser Treatment for Acne Scars in Fitzpatrick Type IV-VI Skin
Fractionated laser resurfacing is commonly used as a treatment for acne scarring in fair skinned individuals. This study aims to test the efficacy and safety in darker skin types.
- Trial name
- NCT00641420
- Testing
- Fractionated Laser Resurfacing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
EGFR, Non Small Cell Lung Cancer
The HER Project: HRD in EGFR-mutated NSCLC
This observational retrospective-prospective study aims to evaluate the prevalence of homologous recombination deficiency (HRD) in metastatic EGFR mutated NSCLC and to assess its correlation with clinical and molecular features.
- Conditions
- EGFR, Non Small Cell Lung Cancer, Homologous Recombination Deficiency, PARP Inhibitor
- Trial name
- HER (NCT07303218)
- Testing
- No Intervention: Observational Cohort
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Hair Diseases, Alopecia
Efficacy and Safety of TargetCool + Benev Exosomes in Patients With Hair Thinning
This clinical trial is testing a new approach to help improve hair thinning using a combination of cosmetic treatments. The purpose of the study is to learn whether applying exosomes to the scalp, along with microneedling and a…
- Conditions
- Hair Diseases, Alopecia, Hair Thinning
- Trial name
- NCT06999408
- Testing
- Scalp tattoo, Canfield HairMetrix®, TargetCool
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Recens Medical, Inc.
Skin Scarring, Skin Elasticity
Skin Elasticity Measurements of the Face and Surgical Scars Stratified by Age and Skin Type
The primary objective of Part A is to compare the change in elasticity measurements at baseline and at 3 months between subjects who have had a resurfacing or tightening procedure and those who have not.
- Trial name
- NCT01688063
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Burn Scar
Efficacy of Spray Silicone in Alteration of Burn Scar
In a burn population, conduct a prospective, double-blinded, randomized, controlled clinical trial to determine the ability of spray silicone to alter the physical characteristics of burn scar compared to a placebo.
- Trial name
- NCT01075165
- Testing
- silicone spray, saline spray
- Where
- 2 sites in United States
- Sponsor
- United States Army Institute of Surgical Research
Ovarian Cancer, Epithelial Ovarian Cancer
A Study of Rucaparib in Patients With Platinum-Sensitive, Relapsed, High-Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARIEL2)
The purpose of this study is to determine which patients with ovarian, fallopian tube, and primary peritoneal cancer will best respond to treatment with rucaparib.
- Conditions
- Ovarian Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- ARIEL2 (NCT01891344)
- Testing
- Oral rucaparib
- Where
- 75 sites in United States, Australia and 4 more
- Volunteers
- 491 people
- Sponsor
- pharmaand GmbH
Myocardial Scarring
Viability Imaging in Volumetric Angiography (VIVA 1)
The primary objective of this study is twofold: 1. To define inter-reader variability of myocardial viability imaging within the first pass and delayed enhancement cardiac CT perfusion imaging 2.
- Trial name
- VIVA 1 (NCT01408134)
- Testing
- DE CT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medstar Health Research Institute
Facial Scars
Botulinum Toxin and Mesotherapy on Enhancement of Facial Scarring
Most of the body's tissues can undergo wound repair following a disruption of tissue integrity. Upon healing, these wounds result in scar formation. The scars widen when the overlying musculature pulls apart suture lines.
- Trial name
- NCT06562023
- Testing
- Botulinum Toxin Type A, Mesotherapy
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Hams Hamed Abdelrahman
Scarring
Prevascar in African Continental Group Scarring
There is considerable variation in scarring, within and between people, and between different ethnic groups. Individuals with more pigmented skin are more prone to severe scarring than those traditionally termed white.
- Trial name
- NCT01115868
- Testing
- Prevascar 5ng, Prevascar 25ng, Prevascar 100ng
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Renovo
Scald Burn, Itching
Comparison of the Effects of Liquid Vaseline and Olive Oil on Itching and Scarring in Scald Burns
Pain, itching, hypertrophic scar formation after wound healing in burn patients complications, sleep disturbances in patients, anxiety, depression, and daily life It may disrupt activities and deterioration in quality of life.
- Conditions
- Scald Burn, Itching, Hypertrophic Scarring
- Trial name
- NCT06104540
- Testing
- Experimental I liquid vaseline groups, Experimental II extra virgin olive oil groups, Control Croup
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University