Clinical trials: Cicatrization
Pediatric Burns
Silver in Partial Thickness Pediatric Burns
Most burns in children are due to scalds and with proper dressings will heal on their own without the need for surgery such as skin grafting.
- Trial name
- NCT06971562
- Testing
- Aquacel AG, Aquacel
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Pain, Postoperative, Palate; Wound
Use of Tilapia Skin for Palate Repair and Protection After Graft Removal
Randomised Clinical Study to evaluate the efficacy of tilapia skin as an occlusive biological dressing on palatal wound healing after free gingival graft harvesting.
- Conditions
- Pain, Postoperative, Palate; Wound, Cicatrization
- Trial name
- NCT04168125
- Testing
- Tilapia skin, Surgical Wound Dressing
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pregnancy Related, Labor Complication
Mechanical Dilation of the Cervix in a Scarred Uterus
To determine if mechanical labour induction can offer a safer and effective alternative to prostaglandins to women with previous caesarean section attempting trial of labour after caesarean (TOLAC).
- Conditions
- Pregnancy Related, Labor Complication, Cesarean Section; Dehiscence
- Trial name
- MEDICS (NCT03471858)
- Testing
- Cervical balloon, Prostaglandins
- Where
- Singapore
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Singapore
Gynecomastia, Delayed Wound Healing
Nitropaste in Breast Reduction
The purpose of this study is evaluate the effect of Nitroglycerin paste on wound healing and scarring. Previous research has shown that Nitroglycerin paste can improve the blood flow to a wound, which may be associated with…
- Trial name
- NCT04321967
- Testing
- Nitroglycerin Paste, Dermabond
- Where
- United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
Crohn Disease, Fistula
Anal Crohn Fistula Surgery
The purpose of this study is to demonstrate, in patients treated with adalimumab, the efficacy of proctological surgery in anoperineal fistula healing after the removal of seton drain.
- Conditions
- Crohn Disease, Fistula, Anoperineal Fistula, Anal Fistula
- Trial name
- FACC (NCT01388257)
- Testing
- All types of surgery procedures, Simple seton drain removal
- Where
- 15 sites in France
- Volunteers
- 180 people
- Sponsor
- French Society of Coloproctology
Atrophic Acne Scarring
Poly-L-Lactic Acid in Atrophic Acne Scars
Background: Management of atrophic acne scars remains challenging due to their heterogeneous morphology and suboptimal response to conventional therapies.
- Trial name
- NCT07523217
- Testing
- injectable PLLA, PLLA threads
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Scar Prevention
Safety and Efficacy Study of Different Dose Levels of EXC 001 to Improve the Appearance of Scars in Subjects Undergoing Elective Abdominoplasty
This study will compare how well EXC 001 works versus placebo in reducing the appearance of scars in subjects undergoing elective abdominoplasty. The study will also evaluate the safety of EXC 001 in healthy adult subjects.
- Trial name
- NCT01038297
- Testing
- EXC 001
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pfizer
Myocardial Scarring
Viability Imaging in Volumetric Angiography (VIVA 1)
The primary objective of this study is twofold: 1. To define inter-reader variability of myocardial viability imaging within the first pass and delayed enhancement cardiac CT perfusion imaging 2.
- Trial name
- VIVA 1 (NCT01408134)
- Testing
- DE CT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medstar Health Research Institute
Acne Scars - Mixed Atrophic and Hypertrophic, Hyperpigmentation
Efficacy and Tolerability of a Hybrid Fractional Laser for the Treatment of Acne Scars in Patients With Skin of Color
The investigators aim to investigate the efficacy and tolerability of a hybrid non-ablative/ablative laser for acne scarring in skin of color.
- Conditions
- Acne Scars - Mixed Atrophic and Hypertrophic, Hyperpigmentation, Laser-Induced Hyperpigmentation
- Trial name
- NCT05362929
- Testing
- Sciton Halo
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Myocardial Infarct, Bone Marrow Cells
Efficacy Study of Intramuscular or Intracoronary Injection of Autologous Bone Marrow Cells to Treat Scarred Myocardium
The purpose of this study is to determine whether the administration of patient's own bone marrow cells into scar areas of the heart, can improve the contractile function of these areas.
- Trial name
- NCT00560742
- Testing
- Control, Intramuscular administration of bone marrow cells, Intracoronary administration of bone marrow cells
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- University Hospitals, Leicester
Diabetes Mellitus, Diabetic Nephropathy
Pirfenidone: A New Drug to Treat Kidney Disease in Patients With Diabetes
The purpose of this study is to determine whether a new investigational drug, pirfenidone, will be an effective therapy for diabetic patients with kidney dysfunction.
- Trial name
- NCT00063583
- Testing
- Pirfenidone
- Where
- 3 sites in United States
- Volunteers
- 77 people
- Sponsor
- Sharma, Kumar, M.D.
Central Centrifugal Cicatricial Alopecia (CCCA)
Tirzepatide for Treatment of CCCA
The goal of this pilot clinical trial is to learn if tirzepatide can treat active central centrifugal cicatricial alopecia (CCCA), a type of permanent scarring hair loss, in adults.
- Trial name
- NCT07734870
- Testing
- Tirzepatide
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Scarred Uterus
Planned Mode of Delivery After Caesarean: a Comparative Prospective National Population-based Cohort Study
In women with one previous caesarean, the choice of mode of delivery is determined by a shared decision-making process between the women and the obstetrician, with the two options being a trial of labour after caesarean (TOLAC)…
- Trial name
- CICAMODA (NCT05439733)
- Testing
- Questionnaire completion
- Where
- France
- Volunteers
- 16,764 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Twin; Complicating Pregnancy, Advanced Maternal Age Pregnancy
Birth Cohort Study of China Medical University
The CMUBCS is a birth cohort study located in Shenyang, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology.
- Conditions
- Twin; Complicating Pregnancy, Advanced Maternal Age Pregnancy, Scarred Uterus, Overweight and Obesity
- Trial name
- NCT03561766
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Acne Vulgaris, Acne Scars
Efficacy of Microneedling With Topical Vitamin C in Treatment of Acne Scarring
This study aimed to evaluate the efficacy of dermaroller and topical vitamin C- either separate or combined- in treatment of post acne scars.
- Trial name
- NCT03522922
- Testing
- Dermaroller, Topical Vitamin C
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Termination of Pregnancy
Termination of Pregnancy in Previous Scarred Uterus: PGE1 Versus Cervical Folleys
As mentioned above, previous studies have shown variable results and the best among these two is still in debate, so there must be re-evaluation of results on this topic.
- Trial name
- NCT07604051
- Testing
- PGE1 tablet, cervical folleys
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Dr Mudassar Saeed Pansota
Sudden Death, Cardiac, Myocardial Scarring
Cardiac Magnetic Resonance - PROgnostic HEart Scar for Sudden Cardiac Death Prediction StudY
The purpose of this observational study is to investigate whether myocardial scar characteristics assessed by cardiac magnetic resonance (CMR) can predict the risk of out-of-hospital sudden cardiac death (SCD) after myocardial…
- Conditions
- Sudden Death, Cardiac, Myocardial Scarring, Myocardial Infarction (MI)
- Trial name
- NCT07137936
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Skin Scarring, Eyebrow Ptosis
Use of Botulinum Toxin A in Direct Eyebrow Lift Scar
Prospective, controlled and randomized study in which participants indicated for surgery to direct eyebrow lift will be randomized into two groups.
- Trial name
- NCT06465056
- Testing
- Botulinum toxin type A
- Where
- 2 sites in Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cicatrix, Wound Healing
Safety and Efficacy Study of Avotermin (Juvista) in Female Subjects
To assess safety and toleration, systemic exposure and anti-scarring potential of intradermal avotermin (Juvista) in young females.
- Trial name
- NCT00984581
- Testing
- Avotermin
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Renovo
Scarring Alopecia, Frontal Fibrosing Alopecia
Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia
This study will serve as a pilot study to determine the efficacy and safety of topical gabapentin in the treatment of symptomatic scarring alopecia.
- Conditions
- Scarring Alopecia, Frontal Fibrosing Alopecia, Lichen Planopilaris, Central Centrifugal Cicatricial Alopecia
- Trial name
- NCT03346668
- Testing
- Topical gabapentin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Minnesota