Clinical trials: Cigarette Smoker
Sex, Cigarette Smoking
Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers
The proposed study evaluated sex differences in glutamate (Glu), with a focus on the dorsal anterior cingulate cortex (dACC), anterior insula, and thalamus, as well as how it is influenced by sex (males vs.
- Trial name
- NCT05279053
- Testing
- Abstinence and Smoking
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Smoking, Tobacco
A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers
The overall purpose of this study will be to assess primary combustible cigarette users' abstinence from smoking their usual brand of combustible cigarettes at the end of the study, when provided with an electronic nicotine…
- Trial name
- NCT07598136
- Testing
- P2613422, P2611222, P2615522
- Where
- 7 sites in United States
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking, Tobacco
A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System
This is a multi-site, open-label, single arm study to evaluate the rate of smoking abstinence by the end of the study with healthy adult consumers of cigarettes when provided with an e-cigarette over a 13 week study period.
- Trial name
- NCT07879638
- Testing
- FT25614, FT25615, FT25616
- Where
- 5 sites in United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Nicotine
Nicotine Pharmacokinetics and Pharmacodynamics of Two Variants of VM 1.0 Compared to Cigarettes in Adult Current Smokers
A single-center, randomized, controlled, partially blinded, crossover study to evaluate the pharmacokinetics and pharmacodynamics of nicotine following use of two variants of VM 1.0, VM16 and VM32, a nicotine-containing aerosol…
- Trial name
- NCT07135648
- Testing
- VM16, VM32, Cigarette (CC)
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Schizophrenia, Cigarette Smoking
Mobile Health Technology to Enhance Abstinence in Smokers With Schizophrenia
This study is designed to evaluate if a treatment the investigators call iCOMMIT is effective at helping smokers with schizophrenia stop smoking.
- Trial name
- NCT02420015
- Testing
- Nicotine replacement therapy, Bupropion, cognitive-behavioral smoking cessation counseling
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Duke University
Smoking
A Study to Investigate a Research Drug as an Aid for Smoking Cessation in Chronic Cigarette Smokers (0364-007)
The purpose of this study is to evaluate the safety and tolerability of an investigational drug that may help individuals to stop smoking.
- Trial name
- NCT00109135
- Testing
- taranabant
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Cigarette Smoking, Home Access to Internet and Email
Web-based Smoking Cessation Intervention: Transition From Inpatient to Outpatient
This project, "Web-based Smoking Cessation Intervention: transition from inpatient to outpatient," addresses smoking among hospitalized patients, whose rates are higher than among the general population.
- Conditions
- Cigarette Smoking, Home Access to Internet and Email, Cognitively and Physically Able to Participate, English Speaking and Reading
- Trial name
- NCT01277250
- Testing
- Web-based smoking cessation program
- Where
- United States
- Volunteers
- 1,548 people
- Sponsor
- University of Alabama at Birmingham
Cigarette Smoking, Smoking Cessation
Benefits of Tobacco Free Cigarette
Background. Smoking is considered a global public health problem. For this reason, the smoking dependence was called by experts as a global epidemic.
- Trial name
- BETOFREE (NCT02422914)
- Testing
- Smoking cessation program TFC and activity tracker, Smoking cessation program TFC-free and activity tracker, Smoking cessation program and activity tracker
- Where
- Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Milan
Tobacco Dependence
Harm Reduction for Smokers With Mental Illness
To compare the efficacy of e-cigarette (e-cig) provision with or without behavioral support (SWITCH IT) delivered via telehealth to reduce harm among smokers with MI who cannot quit smoking and are not ready to pursue cessation…
- Trial name
- NCT06543407
- Testing
- SWITCH IT, E-cig Provision Only
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Smoking ( Cigarette), Periodontitis Stage II
Study of Gum Tissue Proteins in Smokers vs. Non-smokers After Cleaning
The aim of this study is to evaluate how smoking affects the healing process of the gums after treatment. The researchers will measure the levels of two specific proteins (PLAP-1 and Sclerostin) in the gum fluid of patients with…
- Trial name
- NCT07339670
- Testing
- Non Surgical Periodontal Treatment includes post operative mouth wash with Listerine® (ethanol 21.6%, methyl salicylate 0.06%, menthol 0.042%, thymol 0.064% and eucalyptol 0.092%)
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Al-Azhar University
Tobacco Use
Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes
This study is designed to evaluate the abuse liability of very low nicotine cigarettes compared to nicotine gum and usual brand cigarettes
- Trial name
- NCT03559751
- Testing
- VLN cigarettes (A), Usual Brand Cigarettes (B), Nicotine gum (C)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- 22nd Century Group, Inc.
COPD, Smoking
Modulation of Genes Responsible for Cilia Length by Exposure to Cigarette Smoke
Cigarette smoking is the major risk factor for developing chronic obstructive pulmonary disease (COPD). Patients with COPD have difficulty clearing mucus and debris from their airways.
- Trial name
- NCT02168673
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Smoking
"Effects of Balloon-blowing Exercises With Abdominal & Lumbar Core Muscle Activation Position Among Smokers"
The principle function of the lungs is the facilitation of the gaseous exchange, commonly referred as respiratory or breathing. Cigarette smoking has detrimental effects on nearly every organ in the body, leading to a higher…
- Trial name
- NCT06671288
- Testing
- Balloon-blowing exercises with abdominal & lumbar core muscle activation position., Diaphragmatic breathing exercise
- Where
- Pakistan
- Volunteers
- 21 people
- Sponsor
- Foundation University Islamabad
Anxiety Disorders, Anxiety
Personalized Feedback for Smokers With Elevated Anxiety Sensitivity
This project will develop and refine a computer-delivered integrated Personalized Feedback Intervention (PFI) that directly addresses smoking and anxiety sensitivity (AS).
- Conditions
- Anxiety Disorders, Anxiety, Tobacco Dependence, Smoking, Cigarette
- Trial name
- NCT03382093
- Testing
- Personalized Feedback Intervention, Smoking Information Control
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Houston
Cigarette Smoking-Related Carcinoma
Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers
This phase II trial tests whether broccoli seed and sprout extract works to break down cancer causing substances of tobacco in heavy smokers. Smokers are at increased risk for developing lung, head and neck, and other cancers.
- Trial name
- NCT05121051
- Testing
- Biospecimen Collection, Broccoli Sprout/Broccoli Seed Extract Supplement, Questionnaire Administration
- Where
- 3 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Cigarette Smoking, Mindfulness
Mindfulness Training for Smokers Online Feasibility Study
The Mindfulness Training for Smokers Online Feasibility Study is a pilot study designed to test Mindfulness Training for Smokers in an Internet format with phone counseling.
- Trial name
- MTS3 (NCT02164656)
- Testing
- mindfulness for smokers
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Schizophrenia, Nicotine Addiction
Effects of rTMS on Cigarette Smoking and Cognition in Schizophrenia
Cigarette smoking rates are extremely high in persons with schizophrenia and this increases the risk of disease and death due to tobacco-related disorders.
- Trial name
- rTMSsmokelab (NCT01523730)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Smoking
Evaluation of Biological and Functional Changes in Healthy Smokers After Switching to THS 2.2 for 26 Weeks
The aim of the study is to demonstrate clinical, biological and functional health changes in smokers switching to the candidate modified risk tobacco product: Tobacco Heating System 2.2 (THS 2.2) as compared to smokers continuing…
- Trial name
- NCT02396381
- Testing
- THS 2.2, CC
- Where
- 19 sites in United States
- Volunteers
- 1,039 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking
Reduced Exposure Study Using CHTP 1.0 During 5 Days in Confinement.
The overall goal of the study is to demonstrate the reduction of biomarkers of exposure (BoExp) to selected harmful and potentially harmful constituents (HPHCs) in adult smokers switching for 5 days from conventional cigarette…
- Trial name
- NCT02503254
- Testing
- CHTP 1.0, Conventional Cigarette (CC)
- Where
- Poland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Tobacco Dependence, Cigarette Craving
Acute Effects of Exercise in Smokers With Schizophrenia
People with schizophrenia have two- to three-times the mortality risk of the general population. This is primarily due to their unusually high rates of cigarette smoking, as well as other cardiovascular risk factors such as…
- Conditions
- Tobacco Dependence, Cigarette Craving, Smoking Behavior
- Trial name
- NCT01635075
- Testing
- Exercise, passive control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brown University