Clinical trials: Cigarette Smokers
Smoking
Feasibility of Conducting a Pilot Telehealth Study Assessing the Removal of Filter Ventilation on Smoking Behavior and Biomarkers in Menthol Smokers Switched to Non-menthol Cigarettes
This decentralized clinical trial assesses the feasibility of conducting a tobacco product evaluation study remotely via telehealth visits and mailed samples.
- Trial name
- NCT04514471
- Testing
- Minimally Ventilated non-menthol cigarettes, Ventilated non-menthol cigarettes
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Toxicant Exposure
Effects Among Smokers Who Use and Do Not Use E-Cigarettes
This study compares effects among Latino and African American cigarette smokers who use e-cigarettes with those who continue smoking as usual.
- Trial name
- NCT03511001
- Testing
- E-Cigarette Vs. Smoking as Usual
- Where
- 2 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- California State University, San Marcos
Nicotine Dependence
Combination Bupropion / Varenicline for Smoking Cessation in Male Smokers
Previous results from the investigators' Center have shown that combination treatment with Chantix and Zyban is more successful in helping men quit smoking. The investigators hope to replicate these findings with this study.
- Trial name
- ConNic5 (NCT01806779)
- Testing
- Chantix, Zyban, Nicotine patches
- Where
- 4 sites in United States
- Volunteers
- 376 people
- Sponsor
- Duke University
Alcoholism, Nicotine Dependence
Varenicline and Alcohol in Inpatient Addictions Program (IAP)
The overall hypothesis of this line of research is that varenicline will decrease alcohol consumption and tobacco use and will increase alcohol and tobacco abstinence rates.
- Trial name
- NCT01169610
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Tobacco Dependence
Low Nicotine Cigarettes Plus Electronic Cigarettes
This study aims to determine the health effects of very low nicotine content in cigarettes, in conjunction with the availability of nicotine-containing electronic cigarettes (e-cigs) among smokers with mental health conditions…
- Trial name
- NCT04058717
- Testing
- Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Nicotine Dependent Cigarette Smoker
The Get Quit - Stay Quit Study
Narrative: Tobacco smoking remains the single biggest cause of premature death in the United States and the leading cause of cancer and death from cancer.
- Trial name
- GQSQ (NCT01980485)
- Testing
- Lung Age feedback and exhaled carbon monoxide, No Lung Age Feedback
- Where
- 4 sites in United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Tobacco Abuse Smoke
Effect of an Inhaled Glucocorticosteroid (ICS) on Endothelial Dysfunction in Cigarette Smokers
The hypothesis underlying the proposed study is that the blunted endothelium-dependent vasodilation seen in the airway of current smokers is also present in the brachial artery, and that the same inhaled corticosteroid (ICS)…
- Trial name
- NCT01216735
- Testing
- Fluticasone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Miami
Smoking
Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting and 85 Days in an Ambulatory Setting
The main goal of the study is to evaluate if the ad libitum use of the THS 2.2 Menthol (mTHS 2.2) for 5 days in confinement and after 85 days of product use in an ambulatory setting, by Japanese adult healthy smokers results in a…
- Trial name
- NCT01970995
- Testing
- THS 2.2 Menthol (mTHS 2.2), Smoking Abstinence (SA), Menthol Conventional Cigarette (mCC)
- Where
- Japan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Tobacco Use, Tobacco Smoking
Connecting Alaska Native People to Quit Smoking
The prevalence of smoking among US adults is highest among American Indians and Alaska Native (AI/AN) persons; however, there are a lack of tobacco cessation interventions developed specific to this disparity group.
- Conditions
- Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Smoking Cessation
- Trial name
- CAN Quit (NCT03645941)
- Testing
- Facebook Group
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Alcohol Dependence, Nicotine Dependence
New Treatment for Alcohol and Nicotine Dependence
This research study aims to test whether topiramate (a drug that is being used for seizure) will help individuals who have problems with both alcohol and nicotine.
- Trial name
- NCT01182766
- Testing
- Low-Dose Topiramate, High-Dose Topiramate
- Where
- 4 sites in United States
- Volunteers
- 236 people
- Sponsor
- University of Virginia
Smoking
Effect of Donepezil on Smoking
The objective of this proof-of-concept pilot study is to evaluate Donepezil HCL (Aricept) for side effects and effects on smoking behavior and performance on neurocognitive tasks in a population of dependent smokers.
- Trial name
- NCT01250977
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Pharmacokinetics
Product Use and Adaptation, Safety and Tolerability of P3P in Adult Healthy Smokers Switching to it
The purpose of the study is to evaluate the product use and adaptation in adult, current cigarette smoking subjects between baseline and after one month of use of one of two P3P variants.
- Trial name
- NCT03953183
- Testing
- P3P-1mg, P3P-2mg
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking
Pilot Study: Preoperative Nicotine Lozenges
The goal of this pilot study is to determine the feasibility and potential effect size of nicotine lozenges as an adjunct to maintain brief preoperative abstinence, defined as not smoking the day of surgery.
- Trial name
- NCT00586482
- Testing
- Nicotine Lozenge, Abstinence Advisement
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mayo Clinic
Smoking
Very-Low Nicotine Cigarettes and Non-Daily Smokers
The purpose of this research study is to investigate the impact of different nicotine levels in cigarettes among non-daily smokers.
- Trial name
- NCT02228824
- Testing
- Very low nicotine content cigarettes, Normal nicotine content cigarettes
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- Saul Shiffman
Electronic Cigarettes
The Effect of Electronic Cigarette Liquid Characteristics in Smokers.
The purpose of this study is to determine differences in nicotine delivery, user behaviors, subjective effects, and physiological effects, when cigarette smokers use an electronic cigarette with different nicotine (and sweetener)…
- Trial name
- NCT03861078
- Testing
- Own Brand Cigarette, ECIG 15 mg nicotine, sweetened, ECIG 15 mg nicotine, unsweet
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Smoking
Palatability of Experimental Cigarettes - Study 2
Smoking remains a leading cause of preventable disease and premature death worldwide. Approximately 1 out of every 5 deaths is associated with cigarette smoking, and roughly half of all daily smokers will die prematurely from…
- Trial name
- NCT01568905
- Testing
- Low level nicotine cigarette, Intermediate nicotine level cigarette, High level nicotine cigarette
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking, Tobacco Use
IQOS (Non-Cigarette Tobacco Product) Pilot Study
A novel type of non-cigarette tobacco product was recently approved for sale in the US, the heated tobacco product (HTP) IQOS. IQOS may be less harmful than cigarettes, and there are some reports that it may produce more…
- Trial name
- NCT04357379
- Testing
- IQOS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Tobacco Use
Predictors and Consequences of Combustible Cigarette Smokers' Switch to Standardized Research E-Cigarettes
The primary goal of this study is to examine whether cigarette smokers can reduce their use of conventional, combustible cigarettes by switching to a Standardized Research E-Cigarette (SREC); whether participants can maintain…
- Trial name
- NCT03277495
- Testing
- Brief behavioral counseling
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Vaping, E-Cig Use
A Study of Cytisinicline for Vaping Cessation in Adult Smokers
This placebo-controlled Phase 2 study is being conducted at sites within the United States to evaluate the efficacy and safety profile of 3 mg cytisinicline administered TID for 12 weeks for vaping cessation.
- Trial name
- ORCA-V1 (NCT05431387)
- Testing
- cytisinicline, Behavioral support
- Where
- 5 sites in United States
- Volunteers
- 160 people
- Sponsor
- Achieve Life Sciences
Tobacco Use
The Abuse Liability of a Novel Heated Tobacco Product (IQOS) and Its Feasibility as a Menthol Cigarette Substitute
This project examines the influence of flavor availability on switching to an MRTP known as IQOS, part of the Heated Tobacco Product (HTP) class, among menthol smokers using clinical lab and naturalistic evaluations of abuse…
- Trial name
- NCT05499377
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University