Clinical trials: Ciliary Motility Disorders
Primary Ciliary Dyskinesia, Caries,Dental
Assessment of Oral Health Status of Children With Primary Ciliary Dyskinesia
The aim of this study is to compare the oral health findings, salivary parameters and pediatric oral health related quality of life of children with Primary Ciliary Dyskinesia (PCD) with healthy children
- Conditions
- Primary Ciliary Dyskinesia, Caries,Dental, Quality of Life, Saliva Altered
- Trial name
- NCT06618209
- Testing
- physical and chemical methods, biochemical methods, Oral Findings
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Marmara University
Primary Ciliary Dyskinesia
Feasibility of Consumption of Nutritional Supplementation in Primary Ciliary Dyskinesia
Feasibility study to understand and gain preliminary information on tolerability and palatability of an oral nutritional supplement gel in a clinical Primary Ciliary Dyskinesia population.
- Trial name
- (PCD) (NCT06028607)
- Testing
- QD-27
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Leeds
Cystic Fibrosis, Primary Ciliary Dyskinesia
Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia
Cytobacteriological examination of sputum and bacteriological sampling in the middle meatus.
- Trial name
- BAVASI (NCT03494894)
- Testing
- Middle meatus aspirations and sputum
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Kartagener Syndrome
Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease
Primary ciliary dyskinesia (PCD), also known as Kartagener syndrome, is a genetic disorder of the cilia, which are microscopic hair-like cells.
- Trial name
- NCT00722878
- Where
- 6 sites in United States, Canada
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Cystic Fibrosis (CF), Primary Ciliary Dyskinesia (PCD)
Upper Extremity Exercise Capacity, Muscle Oxygenation, and Balance in Pediatric CF and PCD
The number of studies evaluating respiratory functions and upper extremity functional exercise capacity in patients with CF and PCD is limited in the literature.
- Trial name
- NCT07148362
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Gazi University
Primary Ciliary Dyskinesia
Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia
To evaluate the safety and efficacy of treatment with VX-371 with and without ivacaftor, and the effect of VX-371 with and without ivacaftor on quality of life (QOL) in subjects with primary ciliary dyskinesia (PCD).
- Trial name
- CLEAN-PCD (NCT02871778)
- Testing
- VX-371, Hypertonic Saline, VX-371 + HS
- Where
- 34 sites in United States, Canada and 6 more
- Volunteers
- 123 people
- Sponsor
- Parion Sciences
Primary Ciliary Dyskinesia, Kartagener Syndrome
Swiss Primary Ciliary Dyskinesia Registry
The Swiss Primary Ciliary Dyskinesia (PCD) Registry is a national patient registry that collects information on diagnosis, symptoms, treatment and follow-up of patients with PCD in Switzerland and provides data for national and…
- Trial name
- CH-PCD (NCT03606200)
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- University of Bern
Primary Ciliary Dyskinesia
In Vivo Measurements of Nasal Ciliary Beat Frequency by Using Interferometry
1. Assessment of a high speed video camera with a green light source for the measurement of ciliary beat frequency (CBF) in the nasal airways of patients. 2.
- Trial name
- NCT02699177
- Testing
- CBF measurements
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Cystic Fibrosis, Primary Ciliary Dyskinesia
MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia
This is a small pilot / feasibility study (Approximately 50 patients) to assess the possibility of clinical implementation of MRI assessment of patients with cystic fibrosis and primary ciliary dyskinesia.
- Trial name
- NCT03279965
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Primary Ciliary Dyskinesia (PCD), Fertility
Developing Resource Interventions for Healthcare Professionals and Patients to Improve Knowledge About Fertility in Primary Ciliary Dyskinesia
This project will involve working with people with PCD and medical professionals to develop resources that will help patients and the people providing their care to better understand fertility and pregnancy safety in people with…
- Conditions
- Primary Ciliary Dyskinesia (PCD), Fertility, Pregnancy, Health Information Exchange
- Trial name
- REPRoDUCE (NCT07531277)
- Testing
- Online educational resource, Toolkit for healthcare professionals
- Volunteers
- 30 people
- Sponsor
- University of Southampton
Primary Ciliary Dyskinesia
Utility of PCD Diagnostics to Improve Clinical Care
This cross-sectional and longitudinal observational study is to gather data on the utility of tests that are used to make a diagnosis of primary ciliary dyskinesia (PCD).
- Trial name
- PCD (NCT05889013)
- Testing
- Nasal Nitric Oxide testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Connecticut Children's Medical Center
Primary Ciliary Dyskinesia, Cystic Fibrosis
Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children
The aim of this study is to compare pulmonary function, respiratory muscle strength, exercise capacity and peripheral muscle strength of patients with CF, PCD and healthy childrens.
- Trial name
- NCT04161313
- Testing
- Measurement of functional capacity, pulmonary function test, Functional capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Cystic Fibrosis, Primary Ciliary Dyskinesia
Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia
The objective of this study is to compare the lower airways inflammatory response to infection/pulmonary exacerbation among children known to have Primary Ciliary Dyskinesia (PCD) with children known to have Cystic Fibrosis (CF)…
- Trial name
- NCT01155115
- Testing
- Sputum Collection, Pulmonary Function Testing, Exhaled Nitric Oxide
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis, COPD
High Resolution Micro OCT Imaging
The purpose of this study is to learn about using the imaging to make images of the lungs and nose with the long-term goal of the research leading to potential treatments and new therapies for patients with cystic fibrosis.
- Conditions
- Cystic Fibrosis, COPD, PCD - Primary Ciliary Dyskinesia, Covid19
- Trial name
- NCT03256773
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Primary Ciliary Dyskinesia (PCD)
International Primary Ciliary Dyskinesia (PCD) Registry
The purpose of the international prospective PCD Patient Registry is to systematically measure, survey and compare different aspects of PCD manifestation, course and treatment, to provide data for epidemiological research and to…
- Trial name
- PCDregistry (NCT02419365)
- Where
- 2 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Muenster
PCD
NIOX VERO Nasal Application in Primary Ciliary Dyskinesia
This is a multi-centre, single visit clinical investigation involving patients with known PCD vs. age matched healthy volunteers. This study involves 1 visit which will last one (1) to two (2) hours.
- Trial name
- NCT02622061
- Where
- 5 sites in United States, Denmark and 2 more
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Aerocrine AB
Primary Ciliary Dyskinesia
Thermal Spa Treatment and Improvement of Primary Ciliary Dyskinesia
The goal of this clinical trial is to evaluate whether a 3-week thermal spa treatment can improve quality of life and reduce ENT (ear, nose, and throat) symptoms in adults with Primary Ciliary Dyskinesia (PCD).
- Trial name
- CANDY (NCT07029594)
- Testing
- balneotherapy
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Association Francaise pour la Recherche Thermale
Idiopathic Bronchiectasis
Primary Ciliary Dyskinesia in Adult Bronchiectasis
The purpose of this study is to help determine how often primary ciliary dyskinesia (PCD) is present but undiagnosed in adults with bronchiectasis.
- Trial name
- NCT07566611
- Testing
- Nasal Nitric Oxide Measurement, Nasopharyngeal (Nasal) Samples
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Primary Ciliary Dyskinesia
Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide
Background: Primary ciliary dyskinesia (PCD) is a rare genetic disease characterised by recurrent respiratory infections and subfertility due to dysfunction of cilia (brushes) of the lining cells.
- Trial name
- NCT00739817
- Where
- Israel
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Primary Ciliary Dyskinesia
Muscle Function, Exercise Capacity and Physical Activity Level in Primary Ciliary Dyskinesia and Kartagener Syndrome
Studies evaluating respiratory and peripheral muscle functions in PCD patients and comparing them with healthy children are limited in the literature.
- Trial name
- NCT05816876
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Gazi University