Clinical trials: Ciprofol
Anesthesia
Ciprofol Versus Propofol for Anesthesia Induction in Cardiac Surgery: A Randomized Double-blind Controlled Clinical Trial
Ciprofol, a novel intravenous general anesthetic with a chemical structure akin to propofol, boasts significantly enhanced potency.
- Trial name
- NCT06312345
- Testing
- Drug: ciprofol injection
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Le Yu
Insomnia, Digestive Endoscopy
Changes in Ciprofol Dosage in Patients With Insomnia Undergoing Intravenous Anesthesia
To compare the dosage requirement of ciprofol under intravenous anesthesia between patients with insomnia and those with normal sleep pattern.
- Trial name
- NCT06897007
- Testing
- No interventions, it is a observational study
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Beijing Tiantan Hospital
Gynecological Outpatient Surgery
Phase III Clinical Trial Evaluating the Efficacy and Safety of Ciprofol Injection for the Induction of Sedation/Anesthesia in Subjects Undergoing Gynecological Outpatient Surgeries
This study is a multi-center, randomized, double-blind, Propofol parallel-controlled phase III clinical study, with the primary objective of evaluating the efficacy of Ciprofol vs.
- Trial name
- NCT04958746
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Gastric Cancer, Gastric Ulcer
Dose Exploration of Ciprofol for Sedation in Gastrointestinal Endoscopic Diagnosis and Treatment of Obese Patients.
Ciprofol is a new anesthetic, which combines with γ- Aminobutyric acid-a (GABAA) receptor. Ciprofol has shown equivalent anesthetic efficacy of propofol at 1/4 to 1/5 of the dosage.
- Conditions
- Gastric Cancer, Gastric Ulcer, Intestinal Polyps, Intestinal Cancer
- Trial name
- NCT05517408
- Testing
- ciprofol
- Where
- China
- Volunteers
- 30 people
- Sponsor
- RenJi Hospital
Intubation, Intratracheal, Adverse Effects
The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal Intubation
Preliminary studies have illuminated the promising nature of ciprofol, indicating its enhanced safety spectrum, superior potency, and a diminished likelihood of experiencing injection-related discomfort.
- Trial name
- NCT06095570
- Testing
- Ciprofol, Remimazolam
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Hainan Medical University
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
At the initiation of induction for non-intubated general anesthesia, ciprofol or propofol will be administered intravenously at a rate of 10 mL/min.
- Trial name
- NCT07670923
- Testing
- Propofol Injection, Ciprofol Injection
- Where
- China
- Volunteers
- 108 people
- Sponsor
- General Hospital of Ningxia Medical University
Pediatric Hernia, Laparoscopic Surgery
Ciprofol Based on Total Intravenous Anesthesia During Pediatric Laparoscopic Surgery
a prospective, double-blind, fully randomized controlled, non-inferiority clinical trial to investigate the use of total intravenous anesthesia in pediatric laparoscopic surgery.
- Conditions
- Pediatric Hernia, Laparoscopic Surgery, Appendicitis, Surgery
- Trial name
- NCT06735430
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Tongji Hospital
Neurocognitive Function
Comparison of the Effects of Ciprofol and Propofol on Cognitive Function After Painless Gastroenteroscopy
This randomized platform trial compared ciprofol and propofol for early neurocognitive recovery in adults undergoing painless gastrointestinal endoscopy.
- Trial name
- NCT07887594
- Testing
- Ciprofol
- Where
- China
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Anesthesia, Pain
Clinical Observation of Ciprofol for Anesthesia Induction
To evaluate the effect of ciprofol anesthesia Induction on hemodynamics in elderly patients undergoing elective noncardiac surgery，a prospective, randomized, controlled trial.
- Conditions
- Anesthesia, Pain, Hemodynamic Instability
- Trial name
- NCT05706337
- Testing
- Propofol, Ciprofol
- Volunteers
- 90 people
- Sponsor
- Xiumei Song
Hemodynamics, Transcatheter Aortic Valve Replacement
Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement
Aortic valve stenosis is the most common debilitating valvular heart lesion in old patients. Transcatheter aortic valve replacement (TAVR) is an emergent technique for high-risk patients with aortic stenosis.
- Conditions
- Hemodynamics, Transcatheter Aortic Valve Replacement, General Anesthesia, Post-induction Hypotension
- Trial name
- NCT05881291
- Testing
- ciprofol, propofol
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intraoperative Hypotension, Ciprofol
Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors
The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors.
- Conditions
- Intraoperative Hypotension, Ciprofol, Renin-angiotensin System Inhibitors
- Trial name
- NCT06952608
- Testing
- Ciprofol group, Propofol group
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Tonsillectomy With or Without Adenoidectomy
Effects of Remimazolam and Ciprofol TIVA on PRAE in Pediatric Tonsillectomy and Adenoidectomy
To observe the effects of remimazolam versus ciprofol TIVA on PRAE in pediatric tonsillectomy and adenoidectomy.
- Trial name
- NCT07118579
- Testing
- Remimazolam, Propofol, Ciprofol
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Tongji Hospital
Bariatric Surgery
Efficacy and Safety of Ciprofol in Laparoscopic Sleeve Gastrectomy
To evaluate the efficacy and safety of ciprofol for the induction of general anesthesia in obese patients undergoing laparoscopic sleeve gastrectomy.
- Trial name
- NCT05522998
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 212 people
- Sponsor
- The Third People's Hospital of Chengdu
Ciprofol, Propofol
Comparing Ciprofol and Propofol for Sedation in Hypotensive ICU Patients: a Single Center Prospective Cohort Study
This study was a single-center, prospective, 2-year observational cohort study. The study subjects were ICU patients requiring vasopressor drugs and requiring sedation.
- Conditions
- Ciprofol, Propofol, Sedation, Low Blood Pressure
- Trial name
- NCT05971121
- Testing
- ciprofol
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Ciprofol, Hysteroscopy
Efficacy and Safety of Ciprofol for the Sedation in Patients Undergoing Hysteroscopy
Eligible patients undergoing hysteroscopy were randomly assigned in a 1:1 ratio to receive intravenous anesthesia with either propofol (2 mg/kg) or remifentanil (0.4 mg/kg).Continuous monitoring of pulse oximetry (SpO2), blood…
- Trial name
- NCT06172140
- Testing
- Ciprofol group, Propofol group
- Where
- China
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Ciprofol
Changes of Ciprofol Dosage and Bispectral Index Required for Loss of Consciousness in Patients of Different Ages
This study aims to explore dose requirements for loss of consciousness and bispectral index changes during general anesthesia induction with ciprofol in patients of different ages, providing a reference for its rational clinical…
- Trial name
- NCT07148596
- Testing
- It is an observational study without any intervention measures.
- Where
- China
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Circadian Rhythm, Ciprofol
Effect of Circadian Rhythm on the Sedative Efficacy and Recovery Quality of Ciprofol General Anesthesia: A Multi-Center Observational Study
The goal of this multi-center observational study is to learn about the effect of circadian rhythm (morning vs. afternoon surgery) on the sedative efficacy, hemodynamic stability (especially induction-associated hypotension), and…
- Conditions
- Circadian Rhythm, Ciprofol, Hemodynamic Instability, Anesthetics Adverse Reaction
- Trial name
- NCT07686432
- Testing
- Surgery commences in the morning., Surgery commences in the afternoon.
- Volunteers
- 480 people
- Sponsor
- Jie Chen
Anesthesia
Safety and Effectiveness of Ciprofol in Cardiac Surgery Anesthesia
Ciprofol, a novel intravenous general anesthetic with a chemical structure akin to propofol, boasts significantly enhanced potency.
- Trial name
- seccsa (NCT05892471)
- Testing
- ciprofol injection, Propofol injection
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Le Yu
Hypotension During Surgery
Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial
Elderly patients are frequently burdened with age-associated comorbidities and frailty, accompanied by physiological changes such as vascular stiffening, cardiac dysfunction, and impaired autonomic regulation.
- Trial name
- TAPH (NCT07328958)
- Testing
- titrated anesthesia
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Hypotension
Propofol vs. Ciprofol for Anesthesia Induction in Frail Elderly Patients
Post-induction hypotension (PIH) is a common and critical complication during general anesthesia, particularly in frail elderly patients whose physiological reserves are significantly diminished.
- Trial name
- NCT07663695
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 96 people
- Sponsor
- General Hospital of Ningxia Medical University