Clinical trials: Circadian Dysregulation
Circadian Dysregulation, Light Exposure
Feasibility of Light Therapy in the Pediatric Intensive Care Unit (ICU)
The goal of this clinical trial is to understand how easy or difficult it is for critically ill children (4-17 years old) to have light therapy while in the pediatric ICU.
- Conditions
- Circadian Dysregulation, Light Exposure, Pediatric Critical Illness
- Trial name
- NCT07384585
- Testing
- Light Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Laura Beth Kalvas
Eating Disorder, Binge Eating
A Pilot Test of Mood and Circadian Rhythm Mechanisms Driving Binge Eating
Mood and circadian rhythm disruptions are associated with binge eating (BE). BE is a discrete, episodic behavior characterized by 1) eating an objectively large amount of food and 2) experiencing a subjective sense of loss of…
- Conditions
- Eating Disorder, Binge Eating, Circadian Dysregulation
- Trial name
- NCT03680989
- Testing
- Bright Light Exposure, Natural Light Exposure
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Wyoming
Circadian Rhythm Disorders
Effects of Blocking Blue Light at Night Post CABG, AVR, MVR, CABG AVR, CABG MVR, or SAH
Purpose The purpose of this study is to determine whether filtering out blue light at nighttime reduces post-surgical inflammation and/or moderates cognitive decline and mood and sleep alterations in patients undergoing elective…
- Trial name
- NCT04578249
- Testing
- Blue light-blocking goggles, Clear goggles
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- West Virginia University
Cancer-related Problem/Condition, Fatigue
Systematic Light Exposure for Fatigue in Breast Cancer Patients
Cancer related fatigue (CRF) is a stressful and constant tiredness related to cancer and/or its treatment. CRF is the most intense during treatment and can severely interfere with activities of daily living, such as tasks that…
- Conditions
- Cancer-related Problem/Condition, Fatigue, Circadian Rhythm Disorders
- Trial name
- NCT03217201
- Testing
- Light Glasses (Experimental), Light Glasses (Comparison)
- Where
- 3 sites in United States
- Volunteers
- 194 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Sleep Disorder, Circadian Dysregulation
Implementing and Sustaining a Sleep Treatment to Improve Community Mental Health Part 2: Train-the-Trainer
The train-the-trainer (TTT) approach is a promising method of sustaining training efforts in community mental health centers (CMHCs).
- Trial name
- NCT05805657
- Testing
- Standard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Usual Care Delayed Treatment
- Where
- 9 sites in United States
- Volunteers
- 196 people
- Sponsor
- University of California, Berkeley
Cystic Fibrosis
Circadian Rhythm Disorders in Children With Cystic Fibrosis Under CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Modulators
Cystic fibrosis (CF) is a rare disease affecting one out of 4,500 newborns in France (INSERM 2021). Despite major advances in patient care over the past two decades, with significant improvements in life expectancy, cystic…
- Trial name
- CHRONO-MUCO (NCT06370962)
- Where
- 3 sites in France
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Cushing Syndrome, Adrenal Insufficiency
Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders
This is a multicentric, prospective, intervention study on circadian genes expression in peripheral blood mononuclear cells as biomarkers of circadian rhythm derangement in patients affected by alterations of endogenous…
- Conditions
- Cushing Syndrome, Adrenal Insufficiency, Cushing Disease, Addison Disease
- Trial name
- CHROnOS (NCT04374721)
- Testing
- circadian gene expression evaluation
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Sleep Deprivation, Circadian Dysregulation
Cardiometabolic Risk of Shiftwork
The overall goal of the present application is to test the hypothesis that shift workers, who are chronically exposed to circadian misalignment and sleep loss, have a higher cardio-metabolic risk than day workers, and that the…
- Conditions
- Sleep Deprivation, Circadian Dysregulation, Shift-Work Sleep Disorder
- Trial name
- SW (NCT01264913)
- Testing
- sleep extension & circadian alignment
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Chronic Insomnia Disorder, Circadian Rhythm Disorders
Translation and Validation of the French Version of the Sleep Regularity Questionnaire: a New Tool to Address the the Challenge of Sleep Health
Sleep is an essential function for physical and mental health. The mismatch between biological rhythms and the social rhythms of individuals is increasingly common in modern societies.
- Trial name
- PRIMO (NCT06727448)
- Testing
- SRQ questionnaire
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Circadian Rhythm Disorders
Melatonin Agonist for Shift-time Workers.
The study of the relationship between sleep pattern, attention performance, and heart rate variability among night workers.
- Trial name
- NCT07382843
- Testing
- Ramelteon
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Sleep Deprivation, Diabetes
Home Sleep and Circadian Phase: Mediators of Diabetes Risk
The purpose of this study is to determine if deficient sleep and/or disruption with the body's internal clock ("circadian rhythms") are associated with diabetes risk.
- Conditions
- Sleep Deprivation, Diabetes, Circadian Dysregulation
- Trial name
- NCT01786564
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Circadian Dysregulation
Maintaining Behavior Change: An Evaluation of a Habit-based Sleep Health Intervention
The study will test a sleep-health intervention that leverages the science on habit formation. It will evaluate if adding a text messaging intervention improves habit formation. The participants will be 18-30 years old.
- Trial name
- NCT05167695
- Testing
- Habit-based Sleep Health Intervention, Text messaging intervention
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm
Biomarkers for Circadian Timing in Healthy Adults
Study investigators want to learn more about the underlying biological clock and to see if the timing of that clock can be estimated from a single blood sample.
- Conditions
- Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Sleep Disorders, Intrinsic, Advanced Sleep Phase Syndrome (ASPS)
- Trial name
- NCT03956745
- Testing
- sleep-wake timing, constant routine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obesity, Shift-work Disorder
Night Shift Work and Biomarkers of Obesity Risk in Hospital and Industry Workers
Shift work is a well-known risk factor for the development of overweight and obesity, which may lead to downstream effects such as increased risk of cardiometabolic diseases and cancer.
- Conditions
- Obesity, Shift-work Disorder, Circadian Rhythm Disorders
- Trial name
- Shift2Health (NCT06288568)
- Testing
- No intervention
- Where
- Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Anesthesia, Colonoscopy
Ambulatory Anesthesia and Light Therapy
We previously evidenced in both animal models and patients that a short duration ambulatory anesthesia impacts the circadian rest-activity biological rhythm, at least during the first 3 days.
- Trial name
- LI-AMB (NCT00813345)
- Testing
- light therapy (1500 lux), standard light (100 LUX)
- Where
- 6 sites in France
- Volunteers
- 360 people
- Sponsor
- University Hospital, Strasbourg, France
Circadian Dysrhythmia, Sleep Disturbance
PICU-related Sleep and Circadian Dysregulation Pilot Study
A single center pilot trial investigating the feasibility of using actigraphy and salivary melatonin levels to measure the sleep and circadian rhythm of critically ill children aged 3 to 6 years old.
- Conditions
- Circadian Dysrhythmia, Sleep Disturbance, Critical Illness, Children, Only
- Trial name
- NCT06505447
- Testing
- Daytime light exposure, Daytime restricted feeding
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Circadian Rhythm Disorders, Sleep
The Effects of Bright Light Exposure on ICU Nurses
In the majority of intensive care units, nurses work 12 hour shifts that consist of days and nights. Shift work outside of 6am-6pm has been reported to cause fatigue, induce sleep disorders, and cause metabolic disturbances.
- Trial name
- NCT03331822
- Testing
- Bright Light
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Pittsburgh
Suicidal Ideation, Circadian Rhythm Disorders
Mind After Midnight
This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts.
- Conditions
- Suicidal Ideation, Circadian Rhythm Disorders, Sleep Deprivation, Sleep Wake Disorders
- Trial name
- MaM (NCT07438912)
- Testing
- Sleep Pressure Manipulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona
Fatigue, Sleep Disturbance
Feasibility of Bright Light Therapy on Fatigue, Sleep and Circadian Activity Rhythms in Lung Cancer Survivors
The purpose of this study is to determine the feasibility of a morning bright light therapy intervention for fatigue, sleep disturbances, and circadian activity rhythms in lung cancer survivors.
- Conditions
- Fatigue, Sleep Disturbance, Circadian Dysregulation
- Trial name
- NCT02954809
- Testing
- Morning bright light therapy, Dim light
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- State University of New York at Buffalo
Insomnia Chronic, Sleep Disorder
Light Therapy for Chronic Insomnia in General Practice
Sleep disorders, especially insomnia Attention deficits (or disorders), daytime somnolence and drug dependence The goal is to evaluate whether light therapy could be used as an efficient alternative treatment with direct…
- Conditions
- Insomnia Chronic, Sleep Disorder, Circadian Rhythm Disorders
- Trial name
- Insolux (NCT04612192)
- Testing
- Active luminette
- Where
- 3 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Strasbourg, France