Clinical trials: Circadian Rhythm Disorders
Ulcerative Colitis
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
The purpose of this study is to investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut.
- Trial name
- NCT05180279
- Testing
- 7-day sleep lab
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Shift Work Type Circadian Rhythm Sleep Disorder, Insomnia, Psychophysiological
Shift Worker Intervention for Sleep Health
The aim of this study is to pilot test a comprehensive, personalized, media-augmented telehealth intervention ("SWISH") designed to improve sleep health among shift workers.
- Trial name
- SWISH (NCT06384742)
- Testing
- Shift Worker Intervention for Sleep Health
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon State University
Bipolar Disorder
Pilot Study of the Effects of Circadian Rhythms on the Treatment of Bipolar I Depression.
The objective of this pilot study is to test the feasibility of a larger planned trial. The objective of this larger trial will be to determine the extent to which aspects of circadian rhythmicity, including, sleep/wake rhythms…
- Trial name
- Rhythms (NCT00726154)
- Testing
- IPSRT, Collaborative Care
- Where
- United States
- Sponsor
- University of Pittsburgh
Obesity Type I and II, Obesity and Overweight
Metabolic Investigation, Physical Performance, Physical Training At Different Times of the Day in Obese Women
Obesity is a disease characterized by the accumulation of adipose tissue, which is multifactorial and can be caused by environmental, social, behavioral, biological and genetic issues, and affects people health and well-being.
- Trial name
- MOT-time (NCT06601660)
- Testing
- Morning Physical Training, Night Physical Training, No intervention
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- State University of Minas Gerais
Sleep, Sleep Disorders, Circadian Rhythm
Effects of Delayed School Start Times on Sleep, Mental Health, and Academic Performance Among Norwegian Adolescents
The aim is to investigate whether later school start times have positive effects on high school students' sleep patterns, mental health and daytime functioning.
- Conditions
- Sleep, Sleep Disorders, Circadian Rhythm, Psychiatric Disorder, Sleepiness, Daytime
- Trial name
- NCT06657482
- Testing
- Delayed school start time
- Where
- Norway
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Circadian Rhythm Sleep Disorders, Non-24 Hour Sleep-Wake Disorder
Study of the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents
Open-label Study to Investigate the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents.
- Conditions
- Circadian Rhythm Sleep Disorders, Non-24 Hour Sleep-Wake Disorder, Autism Spectrum Disorder, Smith-Magenis Syndrome
- Trial name
- NCT02776215
- Testing
- tasimelteon
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanda Pharmaceuticals
Fatigue Intensity, Sleep
MorphECOS - Evaluation of the Influence of Fatigue and Sleep on the Performance of 2nd Cycle Medical Students (OSCE)
Objective and Structured Clinical Examinations (OSCEs) has been incorporated recently in the certification process as a final national undergraduate ranking examination. This exam is a challenge for medical students.
- Conditions
- Fatigue Intensity, Sleep, Sleep Deprivation, Circadian Rhythm
- Trial name
- MorphECOS (NCT06952972)
- Where
- France
- Volunteers
- 619 people, healthy volunteers welcome
- Sponsor
- Claude Bernard University
Circadian Dysregulation
Efficacy of Ramelteon on Insomnia Symptoms Associated With Jet Lag in Healthy Adult Volunteers
The purpose of this study to determine the degree to which ramelteon, once daily (QD), can reduce the insomnia symptoms associated with rapid, eastward travel across 5 time zones.
- Trial name
- NCT00492011
- Testing
- Ramelteon
- Where
- 4 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Takeda
Obesity
Randomized Study of Daytime vs. Delayed Eating: Effect on Weight and Metabolism
The purpose of this study is to determine if, controlling for eating and sleep timing, caloric intake, and exercise, daytime vs. delayed eating affects body mass, adiposity, and energy metabolism in healthy adults.
- Trial name
- NCT04414644
- Testing
- Eating Condition
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Circadian Rhythm Disorders
Managing Sleep-wake Disruption Due to Hospitalisation: the Circadian Care Project
Sleep is regulated by the interaction of homeostatic and circadian processes. The homeostatic process determines sleep propensity in relation to sleep-wake history, the circadian one is responsible for the alternation of high/low…
- Trial name
- CircadianCare (NCT05228444)
- Testing
- CircadianCare
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova
Sleep, Shift Work
Sleep Survey for Medical Trainees
Background This is a survey to understand sleep in the context of medical trainees (on call) and the participants knowledge about the relevance of sleep, shiftwork, and the impact that sleep may have on their working performance.
- Conditions
- Sleep, Shift Work, Circadian Rhythm, Sleep Apnea
- Trial name
- SSMT (NCT06706453)
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- King's College London
Delayed Sleep Phase Syndrome
The Clinical Utility of Measuring the Circadian Clock in Treatment of Delayed Sleep-Wake Phase Disorder
This study will test whether measuring the circadian clock during treatment of delayed sleep-wake phase disorder results in greater improvements in sleep compared to estimating the circadian clock.
- Trial name
- NCT03715465
- Testing
- Melatonin 0.5 MG, Dim Light Melatonin Onset (salivary)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Psychological Stress, Physiological Stress
Bright Light Intervention to Reduce Students' Stress
Increased stress levels are a significant problem for many students and represent a risk factor for impaired mental and physical health as well as academic performance.
- Conditions
- Psychological Stress, Physiological Stress, Sleep Disorders, Circadian Rhythm
- Trial name
- BLISS (NCT04900675)
- Testing
- Bright light intervention
- Where
- Austria
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Universitaet Innsbruck
Sleep Deprivation, Circadian Dysregulation
Cardiometabolic Risk of Shiftwork
The overall goal of the present application is to test the hypothesis that shift workers, who are chronically exposed to circadian misalignment and sleep loss, have a higher cardio-metabolic risk than day workers, and that the…
- Conditions
- Sleep Deprivation, Circadian Dysregulation, Shift-Work Sleep Disorder
- Trial name
- SW (NCT01264913)
- Testing
- sleep extension & circadian alignment
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Full Enteral Nutrition, the Day and Night Cycle
The Effect of Day-Night Cycle on the Transition Time to Full Enteral Feeding in Preterm Newborns Receiving Oropharyngeal Colostrum
The aim of this study was to examine the effect of the day-night cycle on the transition time to full enteral nutrition in premature infants receiving oropharyngeal colostrum.
- Trial name
- PRETERM (NCT06883903)
- Testing
- day-night cycle application, routine practice
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Biruni University
Parkinson Disease, Sleep Disorder
Light Therapy in Parkinson's Disease
The aim of this randomized controlled trial (RCT) is to clarify the effect of bright light therapy on motor symptoms and sleep disorders in patients with Parkinson's disease.
- Conditions
- Parkinson Disease, Sleep Disorder, Circadian Rhythm Disorders
- Trial name
- NCT06129942
- Testing
- Bright light box, Dim Light box
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Inflammatory Bowel Diseases, Circadian Dysregulation
Circadian Rhythms in Patients With IBD or Celiac Disease Upon Diagnosis and Medical Follow-up
patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed IBD patients/ Celiac disease and healthy controls.
- Trial name
- NCT03662646
- Testing
- no intervention performed- observational only
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Cataract, Sleep
The Effect of Cataract Surgery on Sleep Quality
A cataract is a clouding of the crystalline lens inside the eye, which leads to a decrease in vision. It is the most prevalent, treatable cause of visual impairment and blindness in the world.
- Trial name
- NCT02593669
- Testing
- Phacomulsification lens removal cataract surgery with neutral Intraocular lens(IOL) implantation, Phacomulsification lens removal cataract surgery with blue-blocking Intraocular lens(IOL) implantation, Subconjunctival dexamethasone and general anesthesia
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Sun Yat-sen University
Shift-Work Sleep Disorder
Effects of Daytime Eszopiclone Administration in Shift Workers
The purpose of this study is to test the effects of eszopiclone on daytime sleep and overnight wakefulness in shift workers.
- Trial name
- NCT00900159
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Depression, Postpartum Depression
Personalized Integrated Chronotherapy for Perinatal Depression
Perinatal depression and anxiety are common, serious, and frequently overlapping disorders that increase morbidity and mortality in new mothers (including suicide) and result in poor infant/child outcomes.
- Conditions
- Depression, Postpartum Depression, Prenatal Disorder, Circadian Dysregulation
- Trial name
- NCT04364646
- Testing
- Personalized Integrated Chronotherapy
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Rhode Island Hospital