Clinical trials: Circadian Rhythm Sleep Disorder
Sleep Disorders, Circadian Rhythm, Circadian Rhythm Disorders
Validation of Circadian Biomarkers in Patients With Sleep Disorders
Current methods for assessing circadian timing require sampling over hours (or even up to a day) while the patient is in controlled conditions.
- Conditions
- Sleep Disorders, Circadian Rhythm, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder, Advanced Sleep Phase Syndrome (ASPS)
- Trial name
- NCT04690504
- Testing
- dim light melatonin onset (DLMO)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Shift Work Schedule, Circadian Rhythm
Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance
The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction.
- Conditions
- Shift Work Schedule, Circadian Rhythm, Insulin Resistance, Circadian Misalignment
- Trial name
- NCT07494084
- Testing
- Metyrapone And Hydrocortisone, Dextrose, insulin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington State University
Bipolar Disorder, Circadian Rhythm
Effects of Sex Hormones on Circadian Rhythm in Men and Women
For many years researchers have been trying to better understand the regulation of sleep and activity by studying circadian (daily) rhythms of human beings.
- Conditions
- Bipolar Disorder, Circadian Rhythm, Depressive Disorder
- Trial name
- NCT00001285
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Critical Illness, Delirium
Electroencephalography and Sleep Quality With Lormetazepam in the Intensive Care Unit
The goal of this clinical trial is to test the effect of continuous lormetazepam infusion on EEG patterns in critically ill patients who are given continuous infusion of lormetazepam in an intensive care unit setting.
- Conditions
- Critical Illness, Delirium, Sleep Disorders, Circadian Rhythm
- Trial name
- CLIO-ICU (NCT06473415)
- Testing
- Electroencephalography
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Ischemic Stroke, Acute, Sleep Disorders, Circadian Rhythm
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional)
There is a lack of complex studies which could establish the association between genetic circadian factors with the features and short-term outcomes of ischemic stroke, as well as the effects of various auxiliary therapies for…
- Trial name
- NCT05247125
- Testing
- Blue light exposure + Melatonin treatment, Melatonin treatment, Blue light exposure
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Shift Work Sleep Disorder
A Pilot of a Personalized Circadian mHealth to Improve Sleep in Night Shift Workers
The goal of this project is to establish the evidence base for equitable accessibility and implementation of the precision sleep medicine mobile application, SHIFT.
- Trial name
- SAIL (NCT06809335)
- Testing
- Personalized circadian mHealth
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Henry Ford Health System
Sleep Disturbance, Circadian Rhythm Sleep Disorders
Effect of an Eye Mask-Based Blackout Protocol on Sleep Quality and Melatonin
Sleep disturbance is a common problem among patients hospitalized in intensive care units due to continuous light exposure, noise, and frequent medical interventions.
- Conditions
- Sleep Disturbance, Circadian Rhythm Sleep Disorders, Intensive Care Unit Patients
- Trial name
- NCT07385768
- Testing
- Eye Mask-Based Blackout Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Circadian Rhythm Sleep Disorders, Non-24 Hour Sleep-Wake Disorder
Study of the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents
Open-label Study to Investigate the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents.
- Conditions
- Circadian Rhythm Sleep Disorders, Non-24 Hour Sleep-Wake Disorder, Autism Spectrum Disorder, Smith-Magenis Syndrome
- Trial name
- NCT02776215
- Testing
- tasimelteon
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanda Pharmaceuticals
Circadian Rhythm Disorders
Managing Sleep-wake Disruption Due to Hospitalisation: the Circadian Care Project
Sleep is regulated by the interaction of homeostatic and circadian processes. The homeostatic process determines sleep propensity in relation to sleep-wake history, the circadian one is responsible for the alternation of high/low…
- Trial name
- CircadianCare (NCT05228444)
- Testing
- CircadianCare
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova
Sleep Deprivation, Circadian Rhythm Disorders
PBM Effects on Health and Well-being in Humans
The goal of this clinical study is to assess the effects of different photobiomodulation (PBM) conditions in men and women between 25 and 65 years old with daytime sleepiness/drowsiness and /or mild mood complaints but be…
- Trial name
- NCT05619133
- Testing
- PBM
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seaborough Life Science B.V.
Delayed Sleep Phase Syndrome, Delayed Sleep Phase
Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder
The goal of this study is to understand factors that contribute to delayed sleep wake phase disorder (DSWPD). The investigators will examine whether patients with DSWPD exhibit alterations in circadian rhythms and sensitivity to…
- Trial name
- NCT06471374
- Testing
- Circadian rhythm assessment, Light sensitivity assessment
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Cataract
The Effect of Cataract on Photoentrainment of the Circadian Rhythm in Humans
Cataract is globally the most common cause of blindness and in Denmark the operation with - 50.000 treatments per year - is the most common eye operation. The cause of cataract is growth and denaturation of the lens proteins.
- Trial name
- CIRCAT (NCT01686308)
- Testing
- Yellow Intra Ocular Lens (IOL), Conventional Intra Ocular Lens (IOL)
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Huntington's Disease, Parkinson's Disease
Treating Sleep/Wake Cycle Disturbances in Basal Ganglia Disorders With Ramelteon
The proposed study is a double-blind, placebo controlled pilot study of HD, PD, and DLB subjects with sleep disturbances. This study is designed to determine the effects of 4 weeks Ramelteon treatment on the sleep patterns of…
- Conditions
- Huntington's Disease, Parkinson's Disease, Dementia With Lewy Bodies, Sleep Disorders
- Trial name
- NCT00907595
- Testing
- Ramelteon
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Chronic Insomnia, Melatonin
Effect of Suanzaoren Decoction and Huanglian Wendan Decoction on Biorhythm of Insomnia Patients
The purpose of this study was to examine the impact of Chinese medicine on melatonin levels in patients with insomnia
- Conditions
- Chronic Insomnia, Melatonin, Circadian Rhythm, Suanzaoren Decoction and Huanglian Wendan
- Trial name
- NCT06467851
- Testing
- Suanzaoren Decoction and Huanglian Wenda Decoction
- Where
- 2 sites in China
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Circadian Rhythm Sleep Disorder, Jet Lag Type
Factors Associated With Infant Circadian Rhythm, Growth, and Temperament
The goal of this observational study is to learn about the role of modifiable factors affecting infant circadian rhythm so that recommendations can be made for better health outcomes for the mother and infant.
- Trial name
- NCT05700136
- Testing
- MOMENT
- Where
- 10 sites in Malaysia
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- UCSI University
Sleep Quality, Meal Timing
This Trial Examines How Last Meal Composition and Timing Affect Sleep Quality and Circadian Gene Expression Among Medical Residents. Recruitment Not Yet Started; Study Begins Dec 2025 and Ends Dec 2026.
This randomized controlled trial aims to evaluate the effects of last meal composition and timing on sleep quality and circadian gene expression among medical residents in Jordanian hospitals.
- Conditions
- Sleep Quality, Meal Timing, Circadian Rhythm, Medical Residents
- Trial name
- CHRONO-MED (NCT07339592)
- Testing
- High-Carbohydrate Last Meal, High-Protein Last Meal, Balanced Standard Dinner
- Where
- Jordan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Postpartum Women, Diabetes, Gestational
Circadian Clocks and Eating Patterns (Cohort)
For women of reproductive age, the overall postpartum weight retention (weight gain between pregnancies) plays a significant role in long-term obesity.
- Trial name
- NCT04642534
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Circadian Rhythm Sleep Disorders
Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers
The purpose of this study is to assess the safety and efficacy of VEC-162 compared to matching placebo on circadian phase shift and sleep parameters.
- Trial name
- NCT00490945
- Testing
- VEC-162
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Type 2 Diabetes, Circadian Rhythm
Determining Circadian Metabolic and Behavioural Rhythms in Patients with and Without Type 2 Diabetes
The goal of the present clinical descriptive study is to characterize and quantify the potential hormonal chronobiological differences between individuals with type 2 diabetes (T2D) and healthy age and weight-matched controls as…
- Trial name
- Cir-D-Brain (NCT06243172)
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Lung Cancer (NSCLC), Sleep Disorders, Circadian Rhythm
A Prospective Study: the Impact of Sleep Disturbances on Immunotherapy in Patients With Lung Cancer
In recent years, immunotherapy has made significant progress in the treatment of lung cancer, especially immune checkpoint inhibitors (such as PD-1/PD-L1 antibodies) against non-small cell lung cancer (NSCLC).
- Conditions
- Lung Cancer (NSCLC), Sleep Disorders, Circadian Rhythm, PD-1
- Trial name
- NCT06953765
- Testing
- PSQI, PQSI
- Volunteers
- 350 people
- Sponsor
- Shanghai Zhongshan Hospital