Clinical trials: Circadian Rhythm Sleep-Wake Disorder
Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm
Biomarkers for Circadian Timing in Healthy Adults
Study investigators want to learn more about the underlying biological clock and to see if the timing of that clock can be estimated from a single blood sample.
- Conditions
- Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Sleep Disorders, Intrinsic, Advanced Sleep Phase Syndrome (ASPS)
- Trial name
- NCT03956745
- Testing
- sleep-wake timing, constant routine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cancer, Circadian Rhythm Disorders
Identifying Circadian Rest-Activity Rhythm Disorders in Patients With Advanced Cancer
Circadian rest-Activity Rhythm disorders (CARDs) are common in patients with cancer, particularly in advanced disease. CARDs are associated with increased symptoms, poorer quality of life, poorer response to anticancer treatments…
- Conditions
- Cancer, Circadian Rhythm Disorders, Sleep Disturbance, Activity, Motor
- Trial name
- NCT06023654
- Where
- 2 sites in Ireland
- Volunteers
- 100 people
- Sponsor
- University of Dublin, Trinity College
Sleep Disorders, Circadian Rhythm
Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers
EuRhythDia II is a multicenter, randomized, double-blind controlled study. The rationale of EuRhythdia is to explore the effects of 12 weeks of timed melatonin treatment on circadian rhythm, metabolic control and cardiovascular…
- Trial name
- NCT02108353
- Testing
- Melatonin 2mg
- Where
- 3 sites in Germany, Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Shift Work Type Circadian Rhythm Sleep Disorder
The Influence of Nocturnal Food Intake in Eating Behavior of Night Workers
This study aimed to verify the influence of night work and food intake during the night shift on the eating behavior of fixed night workers the next day.
- Trial name
- NCT03800732
- Testing
- With Meal during night work, Without Meal during night work, Sleep night
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Sleep Disorder Circadian Rhythm, Delayed Sleep Phase Type
SleepHelsinki! CIRCADIAN SLEEP REGULATION IN ADOLESCENCE
Adolescence associates with alterations in sleep-wake organization, such as later circadian phase preference. Simultaneously external pressures, such as evening-driven social activities increase.
- Trial name
- SleepHel (NCT02964598)
- Testing
- Gamified intervention, Sleep coaching, Bright light
- Where
- Finland
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Sleep Disorders, Circadian Rhythm
The Efficacy of Melatonin in the Burning Mouth Syndrome
Burning mouth ( BMS) syndrome is the oral disorder characterized by an intraoral burning sensation for which no medical or dental cause can be found.
- Trial name
- BMS (NCT03788733)
- Testing
- Melatonin 3 mg
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Sleep Wake Disorders, Circadian Rhythm Disorders
Implementing and Sustaining a Sleep Treatment to Improve Community Mental Health Part 3: Sustainment
Research on the sustainment of implemented evidence-based psychological treatments in routine practice settings, such as community mental health centers, is limited.
- Trial name
- NCT05956678
- Testing
- Standard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)
- Where
- 10 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Chronic Insomnia, Melatonin
Effect of Suanzaoren Decoction and Huanglian Wendan Decoction on Biorhythm of Insomnia Patients
The purpose of this study was to examine the impact of Chinese medicine on melatonin levels in patients with insomnia
- Conditions
- Chronic Insomnia, Melatonin, Circadian Rhythm, Suanzaoren Decoction and Huanglian Wendan
- Trial name
- NCT06467851
- Testing
- Suanzaoren Decoction and Huanglian Wenda Decoction
- Where
- 2 sites in China
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cardiovascular Diseases, Circadian Rhythm Sleep Disorder, Shift Work Type
Effect of a Grape Seed Proanthocyanidin Extract (GSPE) on LDL Cholesterol Levels in Rotating Night Shift Workers
The physiological processes of the body present daily oscillations called circadian rhythm. The circadian rhythm is essential for maintaining the vital functions of organisms, intervening directly and indirectly in a multitude of…
- Conditions
- Cardiovascular Diseases, Circadian Rhythm Sleep Disorder, Shift Work Type, Cholesterol Level, High
- Trial name
- CIRCAFENOL (NCT06422741)
- Testing
- grape seed proanthocyanidin extract
- Where
- 2 sites in Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Shift Work Type Circadian Rhythm Sleep Disorder, Insomnia, Psychophysiological
Shift Worker Intervention for Sleep Health
The aim of this study is to pilot test a comprehensive, personalized, media-augmented telehealth intervention ("SWISH") designed to improve sleep health among shift workers.
- Trial name
- SWISH (NCT06384742)
- Testing
- Shift Worker Intervention for Sleep Health
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon State University
Parkinson Disease, Depression
the Efficacy and Safety of Agomelatine in the Patients With Parkinson's Disease
Among the patients with Parkinson's disease, about 40%~50% will suffer from depression, 40% will suffer from anxiety, and 40%~60% will suffer from sleep disorder.
- Conditions
- Parkinson Disease, Depression, Sleep Disorders, Circadian Rhythm Disorders
- Trial name
- NCT03977441
- Testing
- Agomelatine or PIacebo
- Volunteers
- 240 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Sleep, Shift Work
Sleep Survey for Medical Trainees
Background This is a survey to understand sleep in the context of medical trainees (on call) and the participants knowledge about the relevance of sleep, shiftwork, and the impact that sleep may have on their working performance.
- Conditions
- Sleep, Shift Work, Circadian Rhythm, Sleep Apnea
- Trial name
- SSMT (NCT06706453)
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- King's College London
Sleep
Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their…
- Trial name
- CARRS-P1 (NCT05336084)
- Testing
- Ultradian sleep/wake protocol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Osteoporosis, Circadian Rhythm Sleep Disorder, Shift Work Type
Skeletal Response to Simulated Night Shift
This small intervention study will determine if simulated short-term night shift work (NSW) negatively alters bone metabolism. The specific aim of the study is to determine if NSW acutely uncouples bone turnover markers (BTMs)…
- Trial name
- SPOTLIGHT (NCT05074277)
- Testing
- Simulated short term night shift work schedule
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sleep Disorders, Circadian Rhythm
Actigraphic Measurement of a Neurosurgical Procedure
The study examines and illustrates the utility of utilizing actigraphic measurements to assess treatment response.
- Conditions
- Sleep Disorders, Circadian Rhythm, Pain, Rehabilitation
- Trial name
- NCT00945230
- Testing
- Re-section of a large left anterior cranial fossa meningioma
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Child Psychopharmacology Institute
Major Depressive Disorder (MDD), Sleep Disorders
A Longitudinal Follow-Up Study on Predicting Major Depressive Disorder From Rest-Activity Rhythm Profiles
This proposed study will be a longitudinal follow-up study of a case-control study of 160 participants (CREC Ref: 2023.234). This study aims to follow up on the trajectory of depression and rest-activity rhythm (RAR) disruptions…
- Conditions
- Major Depressive Disorder (MDD), Sleep Disorders, Circadian Rhythm
- Trial name
- NCT07388849
- Where
- Hong Kong
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Sleep Disorders, Circadian Rhythm
Effects of Vitamin B12 on the Body's Internal Clock
Circadian rhythms are 24-hour cycles that influence natural functions in the body such as heart rate, blood pressure, and body temperature. Circadian rhythms provide the body with an internal clock and affect sleep patterns.
- Trial name
- NCT00120484
- Testing
- Vitamin B12
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Disorder, Shift-Work
Examination of the Effectiveness of Suvorexant in Improving Daytime Sleep in Shift Workers
The purpose of this study is to test the hypothesis that ingestion of the wake-inhibiting drug suvorexant 30 minutes prior to daytime sleep initiation in individuals working overnight shifts will significantly improve both…
- Trial name
- NCT02491788
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Critical Illness, Delirium
Electroencephalography and Sleep Quality With Lormetazepam in the Intensive Care Unit
The goal of this clinical trial is to test the effect of continuous lormetazepam infusion on EEG patterns in critically ill patients who are given continuous infusion of lormetazepam in an intensive care unit setting.
- Conditions
- Critical Illness, Delirium, Sleep Disorders, Circadian Rhythm
- Trial name
- CLIO-ICU (NCT06473415)
- Testing
- Electroencephalography
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Shift-work Disorder, Insomnia
SHIFTPLAN: an RCT Investigating the Effect of a Shift Work Intervention on Fatigue, Sleep and Health.
Shift work is associated with disturbed life rhythms resulting from chronic exposure to circadian misalignment and sleep restriction, with long-term participation in most shift schedules causing serious health problems.
- Conditions
- Shift-work Disorder, Insomnia, Fatigue, Mental Health Issue
- Trial name
- SHIFTPLAN (NCT05452096)
- Testing
- Education program and ergonomic schedulling
- Volunteers
- 176 people
- Sponsor
- University Hospital, Antwerp