Clinical trials: Circadian Rhythms
Shift-Work Sleep Disorder
The Effects of Lemborexant on the Ability to Sleep During Daytime
This study aim to evaluate whether a dose of 5 mg of lemborexant, as compared to a placebo, may improve daytime recovery sleep, without producing lingering sleepiness during wakefulness, using a 3-day simulated night shift…
- Trial name
- NCT06231641
- Testing
- Lemborexant 5 MG [Dayvigo]
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Alzheimer's Disease
Effect of Therapeutic Light on Sleep, Circadian Rhythm, and Global Function in Women With Alzheimer's
Determine effect and duration of effect of timed therapeutic light compared to control light on parameters of circadian rhythmicity, physiologic plasticity, sleep, and global function in women with Alzheimer's Disease.
- Trial name
- NCT02502045
- Testing
- Morning Simulated Sunlight, Non-therapeutic Red Light
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Yale University
Circadian Rhythm Sleep Disorder
Circadian Rhythms and Sleep in Familial DSPS and ASPS
The purpose of this study is to determine the properties of circadian rhythms and sleep propensity in familial advanced and delayed sleep phase syndrome (DSPS).
- Trial name
- NCT00246454
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Northwestern University
Sleep, Sleep Disturbance
WEsleep Trial: Improving Sleep in Hospitalized Patients
In the WEsleep study, the investigators will perform a cluster randomized controlled trial. 3 surgical and 3 medical departments will be randomized to implement low-cost and simple interventions aimed at improving sleep in…
- Conditions
- Sleep, Sleep Disturbance, Sleep Hygiene, Circadian Dysrhythmia
- Trial name
- WEsleep (NCT05683483)
- Testing
- WEsleep Interventions
- Where
- Netherlands
- Volunteers
- 396 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Melanoma (Skin Cancer), NSCLC (Non-small Cell Lung Cancer)
Bright Light Therapy in Patients With Melanoma or Non-small Cell Lung Cancer (NSCLC) Who Are Receiving First-Line Immune Checkpoint Blockade
This study is being done to test whether bright light therapy can be used to synchronize patients' circadian rhythms and allow ICB (immune-checkpoint blockade) therapy to be administered at a time in the circadian rhythm that…
- Trial name
- IIT BLT (NCT07661966)
- Testing
- Bright Light Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Weill Medical College of Cornell University
Ulcerative Colitis
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
The purpose of this study is to investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut.
- Trial name
- NCT05180279
- Testing
- 7-day sleep lab
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Shift Work Type Circadian Rhythm Sleep Disorder, Insomnia, Psychophysiological
Shift Worker Intervention for Sleep Health
The aim of this study is to pilot test a comprehensive, personalized, media-augmented telehealth intervention ("SWISH") designed to improve sleep health among shift workers.
- Trial name
- SWISH (NCT06384742)
- Testing
- Shift Worker Intervention for Sleep Health
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon State University
Bipolar Disorder
Pilot Study of the Effects of Circadian Rhythms on the Treatment of Bipolar I Depression.
The objective of this pilot study is to test the feasibility of a larger planned trial. The objective of this larger trial will be to determine the extent to which aspects of circadian rhythmicity, including, sleep/wake rhythms…
- Trial name
- Rhythms (NCT00726154)
- Testing
- IPSRT, Collaborative Care
- Where
- United States
- Sponsor
- University of Pittsburgh
Obesity Type I and II, Obesity and Overweight
Metabolic Investigation, Physical Performance, Physical Training At Different Times of the Day in Obese Women
Obesity is a disease characterized by the accumulation of adipose tissue, which is multifactorial and can be caused by environmental, social, behavioral, biological and genetic issues, and affects people health and well-being.
- Trial name
- MOT-time (NCT06601660)
- Testing
- Morning Physical Training, Night Physical Training, No intervention
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- State University of Minas Gerais
Sleep, Sleep Disorders, Circadian Rhythm
Effects of Delayed School Start Times on Sleep, Mental Health, and Academic Performance Among Norwegian Adolescents
The aim is to investigate whether later school start times have positive effects on high school students' sleep patterns, mental health and daytime functioning.
- Conditions
- Sleep, Sleep Disorders, Circadian Rhythm, Psychiatric Disorder, Sleepiness, Daytime
- Trial name
- NCT06657482
- Testing
- Delayed school start time
- Where
- Norway
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Behavioral Responses to Bright Light Therapy in Elders
Effect of Bright Light Treatment On Elders In a Long Term Care Environment
The investigators hypothesize that significant exposure to artificial morning bright light (approximately 200 lux of primarily blue light at eye level for thirty minutes daily) as compared to sham bright red light (placebo) will…
- Trial name
- BrightLights (NCT01042587)
- Testing
- exposure to bright light, low luminosity red light
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Circadian Dysrhythmia
Stabilization of Circadian Rhythms in Delirious ICU Patients Through Light Intervention
The investigators will examine the effects of dynamic light therapy on circadian rhythms in delirious intensive care unit (ICU) patients.
- Trial name
- NCT05807178
- Testing
- Dynamic Light Therapy Device, LSA-1, Dynamic Light Therapy Device, LSA-2
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Circadian Rhythm Sleep Disorders, Non-24 Hour Sleep-Wake Disorder
Study of the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents
Open-label Study to Investigate the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents.
- Conditions
- Circadian Rhythm Sleep Disorders, Non-24 Hour Sleep-Wake Disorder, Autism Spectrum Disorder, Smith-Magenis Syndrome
- Trial name
- NCT02776215
- Testing
- tasimelteon
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanda Pharmaceuticals
Head and Neck Squamous Cell Carcinoma
Sleep and Circadian Rhythm Study in Head and Neck Cancer Patients
This clinical trial studies the effect and underlying mechanisms of sleep and circadian rhythm factors on oral mucositis pain in head and neck cancer patients treated by chemoradiotherapy.
- Trial name
- NCT05099952
- Testing
- Biospecimen Collection, Counseling, Educational Intervention
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Fatigue Intensity, Sleep
MorphECOS - Evaluation of the Influence of Fatigue and Sleep on the Performance of 2nd Cycle Medical Students (OSCE)
Objective and Structured Clinical Examinations (OSCEs) has been incorporated recently in the certification process as a final national undergraduate ranking examination. This exam is a challenge for medical students.
- Conditions
- Fatigue Intensity, Sleep, Sleep Deprivation, Circadian Rhythm
- Trial name
- MorphECOS (NCT06952972)
- Where
- France
- Volunteers
- 619 people, healthy volunteers welcome
- Sponsor
- Claude Bernard University
Circadian Dysregulation
Efficacy of Ramelteon on Insomnia Symptoms Associated With Jet Lag in Healthy Adult Volunteers
The purpose of this study to determine the degree to which ramelteon, once daily (QD), can reduce the insomnia symptoms associated with rapid, eastward travel across 5 time zones.
- Trial name
- NCT00492011
- Testing
- Ramelteon
- Where
- 4 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Takeda
Obesity
Randomized Study of Daytime vs. Delayed Eating: Effect on Weight and Metabolism
The purpose of this study is to determine if, controlling for eating and sleep timing, caloric intake, and exercise, daytime vs. delayed eating affects body mass, adiposity, and energy metabolism in healthy adults.
- Trial name
- NCT04414644
- Testing
- Eating Condition
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Circadian Rhythm Disorders
Managing Sleep-wake Disruption Due to Hospitalisation: the Circadian Care Project
Sleep is regulated by the interaction of homeostatic and circadian processes. The homeostatic process determines sleep propensity in relation to sleep-wake history, the circadian one is responsible for the alternation of high/low…
- Trial name
- CircadianCare (NCT05228444)
- Testing
- CircadianCare
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova
Sleep, Shift Work
Sleep Survey for Medical Trainees
Background This is a survey to understand sleep in the context of medical trainees (on call) and the participants knowledge about the relevance of sleep, shiftwork, and the impact that sleep may have on their working performance.
- Conditions
- Sleep, Shift Work, Circadian Rhythm, Sleep Apnea
- Trial name
- SSMT (NCT06706453)
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- King's College London
Breast Feeding, Exclusive, Hospitalization
The Effect of Chronobiologic Feeding Model on Circadian Rhythm in Newborns
This study was planned to evaluate the effect of "feeding model with chronobiologic approach" on circadian rhythm, growth and physiologic parameters of newborns.
- Conditions
- Breast Feeding, Exclusive, Hospitalization, Feeding Patterns
- Trial name
- NCT05923437
- Testing
- Feeding model group with a chronobiological approach
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Selcuk University