Clinical trials: Circadian Rhythms
Migraine, Sleep Disturbance
The Effect of Bright Light Therapy on Migraine With Sleep Disturbance
Migraine is a common disabling disorder and its substantial burden is associated with considerable negative impact on quality of life.
- Trial name
- NCT04890691
- Testing
- Feel Bright Light
- Volunteers
- 60 people
- Sponsor
- Hungkuang University
Sleep, Sleep Disorders
The BEST Study: The Efficacy of Brain Entrainment Sleep Technology in Military Healthcare Beneficiaries
Brain Entrainment Technology (BET), also known as Binaural Beat Technology (BBT); is an auditory-neurophysiologic technique which uses auditory tones (often embedded in music, nature sounds or white noise) dichotically via stereo…
- Conditions
- Sleep, Sleep Disorders, Sleep Deprivation, Sleep Disturbance
- Trial name
- BEST (NCT03169309)
- Testing
- Brain Entrainment Technology
- Where
- Germany
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Landstuhl Regional Medical Center
Delirium in Old Age, Sleep Disturbance
Sleep & Postoperative Delirium in Hispanic/ Latino Patients After Cardiothoracic Surgery
The purpose of this research is to study pre-operative sleep problems and delirium in Hispanic/Latino patients after heart and lung surgery.
- Conditions
- Delirium in Old Age, Sleep Disturbance, Circadian Rhythm Sleep Disorder
- Trial name
- NCT04786899
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Miami
Diabetes Mellitus, Type 2, Circadian Dysregulation
Metabolic Effects of Natural Office Light in Type 2 Diabetes
This study will investigate the potential benefit of scheduled natural daylight exposure to improve glucose control in type 2 diabetes (T2D) patients and to unravel molecular mechanisms underlying the effects of natural daylight…
- Trial name
- NCT05263232
- Testing
- Natural or artificial office light exposure
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Maastricht University
Sleep-wake Disorder in Blind Individuals
Patient Registry of Blind Subjects With Sleep-related Problems
Non-24-hour sleep-wake disorder (Non-24) is a condition experienced primarily by totally blind individuals that results in abnormal night sleep patterns and chronic daytime sleepiness.
- Trial name
- NCT01195558
- Testing
- Data collection on blindness and sleep problems
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Vanda Pharmaceuticals
Inflammatory Bowel Diseases, Circadian Dysregulation
Circadian Rhythms in Patients With IBD or Celiac Disease Upon Diagnosis and Medical Follow-up
patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed IBD patients/ Celiac disease and healthy controls.
- Trial name
- NCT03662646
- Testing
- no intervention performed- observational only
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Type 2 Diabetes
The Effect of Exercises Performed According to Circadian Rhythm in Type 2 Diabetes
Type 2 diabetes is a metabolic disease characterized by partial insulin deficiency or insulin resistance in peripheral tissue. Type 2 diabetes, which has a very high prevalence worldwide, is a socially serious health problem.
- Trial name
- Circadian (NCT04427488)
- Testing
- Morning Chronotype group, Evening Chronotype group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Medipol University Hospital
Disorders of Consciousness
The Core Body Temperature Rhythms: Distinguishing MCS From UWS
In this study, the core body temperature of 7 disorders of consciousness ( DOC ) patients were measured every 2 hour for 168 h .
- Trial name
- NCT02930213
- Volunteers
- 7 people
- Sponsor
- Jing Wang
Skipping Breakfast, Circadian Rhythms
Effect of Skipping Breakfast on Metabolic Function
The purpose of this study is to test the hypothesis that the disruption of the "normal" (three meals a day) eating pattern and prolonged overnight fasting caused by skipping breakfast: i) alters the expression of specific clock…
- Trial name
- NCT02093572
- Testing
- 3 standard meals/day, 2 meals/day (omit breakfast)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cannabis Use, Sleep
Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults
The goal of this study is to learn how cannabis use and discontinuation affect sleep, circadian rhythms, and sensitivity to light. The main questions it aims to answer are: 1.
- Conditions
- Cannabis Use, Sleep, Circadian Rhythm
- Trial name
- CASCILS (NCT06743373)
- Testing
- Cannabis Discontinuation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Sleep Disorders, Circadian Rhythm, Circadian Rhythm Disorders
Validation of Circadian Biomarkers in Patients With Sleep Disorders
Current methods for assessing circadian timing require sampling over hours (or even up to a day) while the patient is in controlled conditions.
- Conditions
- Sleep Disorders, Circadian Rhythm, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder, Advanced Sleep Phase Syndrome (ASPS)
- Trial name
- NCT04690504
- Testing
- dim light melatonin onset (DLMO)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Metastatic Colorectal Cancer
"Cancersensor": Circadian Rhythms
Observational, non randomized study aimed at measuring the circadian rhythms in the urinary concentrations of physiological modified nucleosides in 30 patients with metastatic colorectal cancer and in 30 age and sex-matched…
- Trial name
- NCT01693835
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Advanced Solid Tumors
Pharmacokinetic Study To Evaluate Effect of Food and Diurnal Variation on ABT-869
To estimate the effect of food on the oral bioavailability and effect of diurnal variation on the pharmacokinetics of ABT-869.
- Trial name
- NCT00733187
- Testing
- ABT-869
- Volunteers
- 34 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Atherosclerosis, Cardiovascular Diseases
Randomized Comparison of Morning Versus Bedtime Administration of Aspirin: A Cardiovascular Circadian Chronotherapy (C3) Trial
Wide variability in the antiplatelet effects of aspirin may lead to recurrent thromboembolic events. Several pilot studies have suggested potential benefits of taking aspirin at bedtime rather than in the morning.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Drug Effect
- Trial name
- ASPIRIN-C3 (NCT05932472)
- Testing
- Aspirin
- Where
- Denmark
- Volunteers
- 32,706 people
- Sponsor
- Tor Biering-Sørensen
Elderly Housing Residents With Frailty or Dementia
Circadian Adjusted LED Light's Effect in People Living in Elderly Housing
Europe is undergoing a demographic change with a rapidly growing population of 65 years+. This challenges municipalities and hospitals as the ageing citizens need care and treatment due to an age-related decline in physical and…
- Trial name
- Lightel (NCT03263234)
- Testing
- 8 weeks of circadian adjusted LED-based lighting (CALED)
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Ove Andersen
Intraocular Pressure
Aqueous Humor Dynamics and Brimonidine
This single-center, investigator-masked, crossover study is designed to investigate the circadian rhythms of aqueous humor dynamics in human subjects with ocular hypertension (OHT) before and after intervention with a commonly…
- Trial name
- Brimonidine (NCT01144494)
- Testing
- Brimonidine, Artificial tears
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Nebraska
Cardiovascular Diseases, Circadian Rhythm Sleep Disorder, Shift Work Type
Effect of a Grape Seed Proanthocyanidin Extract (GSPE) on LDL Cholesterol Levels in Rotating Night Shift Workers
The physiological processes of the body present daily oscillations called circadian rhythm. The circadian rhythm is essential for maintaining the vital functions of organisms, intervening directly and indirectly in a multitude of…
- Conditions
- Cardiovascular Diseases, Circadian Rhythm Sleep Disorder, Shift Work Type, Cholesterol Level, High
- Trial name
- CIRCAFENOL (NCT06422741)
- Testing
- grape seed proanthocyanidin extract
- Where
- 2 sites in Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Sleep, Circadian Rhythm
Dexmedetomidine Trial for Effects on Rhythms, Sleep Architecture, and Biomarker Dynamics in Older Adults
The DEXTER study is a cross-over, double-blind, placebo-controlled pilot research study led by Dr. Peng Li. The goal of this project is to evaluate the safety, feasibility, and biological effects of a single dose of sublingual…
- Trial name
- DEXTER (NCT07800910)
- Testing
- Dexmedetomidine sublingual film
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Sleep Disorders, Circadian Rhythm
Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift
Anesthesiology residency requires extended and overnight shifts, which may negatively impact the quantity and quality of sleep. Previous studies have investigated the effect of night float shift work on anesthesiology resident…
- Trial name
- NCT05701969
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Rheumatoid Arthritis
Circadian RA Study in Rheumatoid Arthritis Subjects
Primary objective: To determine the changes in circadian activity rhythms and disease activity in rheumatoid arthritis (RA) patients from pre-treatment to one month after Enbrel initiation.
- Trial name
- NCT03178955
- Testing
- Etanercept
- Where
- United States
- Sponsor
- University of California, Davis