Clinical trials: Circadian Rhythms
Delayed Sleep Phase Syndrome
Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their…
- Trial name
- CARRS-P2 (NCT04792697)
- Testing
- Increase morning bright light, Decrease evening blue light, Sleep Scheduling
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Endocrine Disorders, Hypertension
EndoSense: Continuous Real-Time Monitoring of Health Markers in Endocrine and Metabolic Disorders
The goal of this trial is to learn whether wearable devices and hormone sampling can measure how the body changes during daily-life challenges in adults with endocrine or metabolic disorders.
- Conditions
- Endocrine Disorders, Hypertension, Primary Aldosteronism, Cortisol Excess
- Trial name
- EndoSense (NCT07727356)
- Testing
- Sequential Dietary Sodium Modulation
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Felix Beuschlein
Narcolepsy, Obstructive Sleep Apnea
The Nuvigil and Provigil Pregnancy Registry
The primary objective of the Nuvigil/Provigil Pregnancy Registry is to characterize the pregnancy and fetal outcomes associated with Nuvigil and Provigil exposure during pregnancy.
- Conditions
- Narcolepsy, Obstructive Sleep Apnea, Shift Work Sleep Disorder
- Trial name
- NCT01792583
- Testing
- Modafinil/armodafinil
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Cephalon, Inc.
Normal Physiology
Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms
The goal of this clinical trial is to learn how the pupil responds to different light stimuli and how that relates to sleep and daily rhythms in healthy people of different ages.
- Trial name
- NCT05829044
- Testing
- Pupillometry, Light box exposure
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Circadian Rhythm, Cardiometabolic Health
The Influence of Sleep on Cardiovascular Outcomes
The goal of this study is to identify the effects of sleep regularity on cardiovascular regulatory mechanisms. The investigators are hoping to discover if improving the regularity of sleep timing will improve metabolic and…
- Conditions
- Circadian Rhythm, Cardiometabolic Health, Vascular Health, Pain
- Trial name
- DISCO (NCT06535178)
- Testing
- Sleep Regularity Group
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Shift Work Disorder, Shift Work Type Circadian Rhythm Sleep Disorder
Circadian Rhythm and Health in Heavy Industry Shift Workers
Shift work can disrupt the body's circadian rhythm, which may negatively affect sleep, musculoskeletal health, and quality of life.
- Trial name
- NCT07702344
- Testing
- Questionnaire-Based Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 226 people
- Sponsor
- Istanbul Gedik University
Infection
Disruption of Circadian Rhythm and Healthcare-related Infection in Patients With Severe Trauma
Circadian rhythms, which play crucial roles in physiology, are emerging as important regulators of specific immune functions. Hospitalization in intensive care unit leads to a deep impairment of circadian rhythm.
- Trial name
- NCT02307747
- Testing
- blood samples
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Chronic Kidney Disease
Arterial Stiffness in Chronic Kidney Disease
Diurnal variations in the cardiovascular system apparent in healthy individuals, are different in chronic kidney disease patients.
- Trial name
- NCT01770847
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
End Stage Cancer
Artificial Intelligence-based Mortality Prediction Among Cancer Patients in the Hospice Ward
The purpose of this study is to develop a novel deep-learning-based survival prediction model employing patient activity data recorded by a wearable device.
- Trial name
- NCT04883879
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Medical University
Mild Cognitive Impairment
Phase 2 - Rhythmic Light Therapy for Alzheimer's Disease Patients
Participants will randomly be placed into one of four groups and experience one of the four following conditions: (1) a placebo light that provides a 40 hertz (Hz) flicker (rhythmic light [RL]); (2) a placebo light with a random…
- Trial name
- NCT05016219
- Testing
- Circadian-Effective Light, Rhythmic Light
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Circadian Misalignment, Sex Differences
Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?
This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag).
- Trial name
- NCT07441265
- Testing
- Day shift, Night shift
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy Aging
Vestibular Stimulation, Exercise and Light Optimization for Circadian Clock Enhancement (Velocce)
This study investigates the effects of remote interventions based on the exposure to one or more zeitgebers (i.e. adapted physical activity alone or combined with bright light exposure, or galvanic vestibular stimulation)…
- Trial name
- velocce (NCT05030389)
- Testing
- Adapted Physical Activity (APA), Bright Light Exposure (BLE), Galvanic Vestibular Stimulation (GVS)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université de Caen Normandie
Health Behavior, Healthy
Effects of Fasting in the Bahá'í Faith
The aim of the study is to find out the effects a specific religious fast (i.e. Bahá'í fast) has on certain metabolic parameters, hydration, psyche and circadian clock.
- Trial name
- BF (NCT03443739)
- Testing
- Intermittent Fasting
- Where
- Germany
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Sleep, Metabolism Changes
Nighttime Synchrony of Your Nutrition and Circadian Health
Sleep is an important factor for overall health. This study will see how different light exposure patterns and food intake impact a person's metabolism (how the body breaks down food) when sleeping is reduced.
- Conditions
- Sleep, Metabolism Changes, Circadian Rhythm, Lifestyle Factors
- Trial name
- N-Sync (NCT07329283)
- Testing
- Central Clock Misalignment, Peripheral Misalignment
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Utah
Shift Workers' Health, Time Restricted Eating
The Healthy Heroes Study
This is the first study of its kind to assess and test an intervention to improve biological rhythms and general health of shift workers, specifically first responders with San Diego Fire and Rescue.
- Conditions
- Shift Workers' Health, Time Restricted Eating, Fasting
- Trial name
- NCT03533023
- Testing
- Time Restricted Eating + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Circadian Rhythm Disorders, Cancer
A Feasibility Trial for Circadian Rest-activity Rhythm Disorders in Cancer (RALI)
Circadian rest-activity rhythm disorders are common in patients with cancer, particularly in advanced disease. A recent international e-Delphi study has outlined recommendations for the assessment and reporting of the disorder…
- Trial name
- NCT06329479
- Testing
- Cognitive behavioural therapy for Insomnia (CBT-I), Bright Light Therapy, Individualised activity plan
- Where
- 2 sites in Ireland
- Volunteers
- 30 people
- Sponsor
- University of Dublin, Trinity College
Disorders of Consciousness
The Core Body Temperature Rhythms: Distinguishing MCS From UWS
In this study, the core body temperature of 7 disorders of consciousness ( DOC ) patients were measured every 2 hour for 168 h .
- Trial name
- NCT02930213
- Volunteers
- 7 people
- Sponsor
- Jing Wang