Clinical trials: Circadian Timing
Obesity, Postpartum Weight Retention
ClockWork Postpartum Weight Management Study
The ClockWork Postpartum Weight Management Pilot Study is an intervention study that will assess the feasibility, acceptability, and initial efficacy of the ClockWork intervention among women with prepregnancy overweight/obesity…
- Conditions
- Obesity, Postpartum Weight Retention, Weight Gain, Maternal
- Trial name
- NCT04992637
- Testing
- ClockWork, Usual Care
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Pittsburgh
Diet, High-Fat, Circadian Rhythm
Food and Circadian Timing
The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to…
- Trial name
- FACT (NCT04743271)
- Testing
- High-Fat Diet, Low-Fat Diet
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Light Exposure, Meal Timing
Role of Photic and Non-photic Time Cues in Resetting Circadian Rhythms
The aim of this study is to determine the principal time cue (light or meals) for resetting circadian rhythms in melatonin and metabolic outcomes.
- Trial name
- LipidPRC (NCT05276739)
- Testing
- Bright Light, Time-restricted eating, Dim light
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Type 2, Insulin Resistance
The Acute T-Rex (Timing of Resistance Exercise) Study
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Glucose Intolerance, Sleep Disturbance
- Trial name
- NCT06366399
- Testing
- Resistance Exercise Timing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Prostate Cancer
The Impact of Medication Timing Adjustment on the Effect of Novel Hormonal Therapy
The purpose of this study is to assess the impact of medication timing adjustment on the effect of novel hormonal therapy (NHT) agents in patients with metastatic hormone-sensitive prostate cancer (mHSPC).
- Trial name
- NCT06505278
- Testing
- Receive Abiraterone plus prednisone/Enzalutamide/Apalutamide/Rezvilutamide in the evening
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Sun Yat-sen University
Cluster Headache
Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraphic Study
The aim is to investigate circadian rhythm in episodic cluster headache using actigraphy.
- Trial name
- NCT02853487
- Testing
- Actigraphy, Diary
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Stress
Morning Light Treatment for Traumatic Stress: The Role of Amygdala Reactivity
The purpose of this study is to determine the effect of different amounts of time of morning light on brain emotional processing.
- Trial name
- NCT04117347
- Testing
- Light therapy A via the Re-Timer®, Light therapy B via the Re-Timer®, Light therapy C via the Re-Timer®
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Obesity, Sarcopenia
Chrono-restricted Diet and Physical Activity as a New Preventive Strategy for Sarcopenia in Postmenopausal Women With Obesity and Type 2 Diabetes
The aim of TIMEDIAB is to demonstrate that early TRE (eTRE) combined to late (afternoon) exercise will outperform eTRE combined to morning exercise on muscle function as primary endpoint, and glucose homeostasis as secondary…
- Conditions
- Obesity, Sarcopenia, Post Menopause, Type 2 Diabetes
- Trial name
- TIMEDIAB (NCT07075133)
- Testing
- Antidiabetic diet (control), eTRE diet, Physical activity in the morning
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Insomnia, Circadian Rhythm Disorders
Older Adults Exercising On Time
There are indications from epidemiological cohort studies and animal experiments that timing of physical activity (also referred as "chronoactivity"), irrespective of intensity, impacts health and disease.
- Trial name
- ON TIME (NCT06613958)
- Testing
- Physical activity timing
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Overweight, Obesity
Timing of Meals for Weight Loss
While eating the majority of energy earlier in the day appears to have a positive effect on weight and cardiometabolic outcomes, it is not clear how eating earlier in the day influences other behaviors that have a circadian…
- Conditions
- Overweight, Obesity, Weight Loss
- Trial name
- TIME (NCT02204735)
- Testing
- Eat majority of calories in the morning, Eat the majority of calories in the evening
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Obesity, Overweight
Effects of Meal Energy Density on Body Measures and Metabolism in Women
This study investigates whether the timing of energy intake during the day-specifically consuming more calories at breakfast or at dinner-affects body measurements, blood sugar levels, cholesterol, and feelings of hunger in women…
- Conditions
- Obesity, Overweight, Appetite Regulation, Meal Timing
- Trial name
- NCT07066618
- Testing
- Breakfast-Loaded Hypocaloric Diet, Dinner-Loaded Hypocaloric Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Melike Nur Eroğlu
Colorectal Cancer
Abnormal Food Timing and Circadian Dyssynchrony in Alcohol Induced Colon Carcinogenesis
The purpose of this study is to study the impact of Western lifestyle, including moderate alcohol consumption and delayed eating patterns on studying individuals' susceptibility to colorectal cancer.
- Trial name
- AFT (NCT03955510)
- Testing
- Right time eating, Delayed time eating, Sigmoidoscopy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rush University Medical Center
Obesity, Chronobiology Disorders
Chronobiology and Childhood Obesity in a Mediterranean Spanish Population
The main objective is to investigate chronobiological aspects of childhood obesity studying the potential relationship between meal patterns and circadian rhythmicity in a cross-sectional sample of obese, overweight and normal…
- Trial name
- ONTIME-JR (NCT02895282)
- Where
- 2 sites in Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Critical Illness, Cognitive Impairment
Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors
More than 60% of intensive care unit (ICU) patients are adults ages 60 and older, who are at high risk for ICU-acquired cognitive impairment.
- Conditions
- Critical Illness, Cognitive Impairment, Circadian Dysrhythmia, Intensive Care Unit Delirium
- Trial name
- OPTIMIZE (NCT05467410)
- Testing
- COG-AM, COG-PM
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Obesity (Disorder), Morbid Obesity
Chrono-ALIGN: A Chronotype-Based Chrono-Nutrition Intervention in Post-Bariatric Patients
This randomized controlled trial will evaluate the impact of chrono-nutrition, a dietary approach that aligns meal timing with the body's circadian rhythms, on weight change, metabolic outcomes, appetite, and gut microbiota in…
- Conditions
- Obesity (Disorder), Morbid Obesity, Bariatric Sleeve Gastrectomy, Meal Time
- Trial name
- Chrono-ALIGN (NCT07324044)
- Testing
- Standard Post-Bariatric Care (Control), Early Time-Restricted Eating (eTRE), Chronotype-Based Chrono-Nutrition (CB-CN)
- Where
- Saudi Arabia
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- King Saud University
Chronobiology, Light
Light Timing Study
Chronic circadian misalignment and sleep restriction peak during late adolescence, and are associated with morning daytime sleepiness, poor academic performance, conduct problems, depressed mood, suicidal ideation, substance use…
- Conditions
- Chronobiology, Light, Sleep, Circadian Rhythm
- Trial name
- ALT (NCT04753190)
- Testing
- Baseline Sleep Satiation and Phase Stabilization, Gradually Shifted Sleep
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Obesity
Daytime vs. Delayed Eating Among Obese Individuals
The randomized, cross-over design study is designed to determine how timing of eating affects weight, adiposity, energy metabolism, and gene expression.
- Trial name
- NCT03354169
- Testing
- Eating Condition, No Intervention; withdrawn before randomization
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Shift-Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder
Breath Biomarkers for Sleep Loss and Circadian Timing
Insufficient sleep has both health and safety risks, but currently there are no quick, accurate and inexpensive ways to measure sleep deficiency.
- Conditions
- Shift-Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder, Sleep Disorders, Circadian Rhythm, Sleep Disorders, Intrinsic
- Trial name
- NCT03980340
- Testing
- Short Nap Intervention, No Nap Intervention
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Quality, Meal Timing
This Trial Examines How Last Meal Composition and Timing Affect Sleep Quality and Circadian Gene Expression Among Medical Residents. Recruitment Not Yet Started; Study Begins Dec 2025 and Ends Dec 2026.
This randomized controlled trial aims to evaluate the effects of last meal composition and timing on sleep quality and circadian gene expression among medical residents in Jordanian hospitals.
- Conditions
- Sleep Quality, Meal Timing, Circadian Rhythm, Medical Residents
- Trial name
- CHRONO-MED (NCT07339592)
- Testing
- High-Carbohydrate Last Meal, High-Protein Last Meal, Balanced Standard Dinner
- Where
- Jordan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Obesity, Hypertension
Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans
Experimental data have shown that timing of sodium intake impacts diurnal patterns of sodium excretion. The purpose of this study is to test the hypothesis that the time of day for salt intake impacts (1) blood pressure rhythms…
- Conditions
- Obesity, Hypertension, Circadian Dysregulation, Salt; Excess
- Trial name
- NCT04021355
- Testing
- Oral sodium supplementation
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham