Clinical trials: Circulating Endothelial Cells
Acute Ischemic Stroke
Vascular Endothelial Growth Factor and Endostatin in Angiogenesis After Acute Ischemic Stroke
Vascular endothelial growth factor (VEGF) and Endostatin (ES) participate angiogenesis after cerebral ischemia. Circulating endothelial progenitor cells (EPCs) also play a crucial role in neovascularization and tissue repair…
- Trial name
- NCT02157896
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai 6th People's Hospital
Atherosclerosis, Coronary
Effects of Rivaroxaban on Vascular FMD in Patients With Stable Atherosclerotic Vascular Diseases
The specific mechanistic benefit of rivaroxaban versus other FXa inhibitors on atherothrombotic events remain unclear. Therefore plan to initiate a prospective, randomized study to investigate the effect of rivaroxaban and…
- Trial name
- NCT06986369
- Testing
- Rivaroxaban 2.5 MG Oral Tablet [Xarelto]
- Where
- China
- Volunteers
- 140 people
- Sponsor
- The University of Hong Kong
Atherosclerosis, Stroke
Influence of Circulating Endothelial Progenitor Cells and Modifiable Vascular Risk Factors on Carotid Plaque Vulnerability
Ischemic stroke is a leading cause of death and disability worldwide. Atherosclerosis, responsible for the 20% of ischemic strokes, is characterized by lipid accumulation in the artery wall that leads to chronic inflammation…
- Conditions
- Atherosclerosis, Stroke, Inflammation
- Trial name
- IMPROVE (NCT03218527)
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cardiovascular Disease, Cardiomyopathy
Statin Therapy for Ischemic and Nonischemic Cardiomyopathy
The purpose of this study is to see if taking a cholesterol lowering drug Lipitor (Atorvastatin Calcium)will increase the number of endothelial progenitor cells (EPC's) circulating in the blood of heart failure patients taking…
- Conditions
- Cardiovascular Disease, Cardiomyopathy, Heart Disease, Myocardial Disease
- Trial name
- NCT00701220
- Testing
- Atorvastatin Calcium
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Philip Binkley
PAH
Impact of an Optimized Omega-3 Formulation on Inflammation and Endothelial Dysfunction in Pulmonary Arterial Hypertension
The objective of this research project is to evaluate the biological effects of long-chain omega-3 supplementation, administered in an optimized, high-purity formulation (EPA:DHA 6:1, >95% v/v), as an adjunct to standard-of-care…
- Trial name
- OMEGA-PAH (NCT07697235)
- Testing
- OMega 3
- Volunteers
- 22 people
- Sponsor
- University Hospital, Strasbourg, France
Non Small Cell Lung Cancer
To Predict Efficacy by Detecting Circulating Endothelial Cell Subsets and Blood Perfusion Parameters Changes in Vivo Tumor in Study of QL1101 and Avastin® in Patients With Non-squamous Non-small Cell Lung Cancer
To reveal changes of peripheral markers and blood perfusion parameters in vivo tumor in the study of QL1101 and Avastin® in patients with Non-squamous Non-small Cell Lung Cancer
- Trial name
- NCT03195569
- Testing
- QL1101, Avastin®, Paclitaxel
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Breast Cancer
Studying Blood Samples in Women With Breast Cancer or a History of Breast Cancer
RATIONALE: Studying samples of blood in the laboratory from patients with current or previous cancer may help doctors learn more about biomarkers related to cancer.
- Trial name
- NCT00898703
- Testing
- flow cytometry, immunoenzyme technique, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Acute Myocardial Infarction
Molecular and Morphologic Characterization of Circulating Endothelial Cells
The primary hypothesis of this study is that circulating endothelial cells (CECs) harbor key genetic and structural characteristics predisposing individuals to acute atherosclerotic plaque rupture and heart attack.
- Trial name
- CEC (NCT01005485)
- Where
- United States
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Type 2 Diabetes
Effect of Vildagliptin vs. Glibenclamide on Circulating Endothelial Progenitor Cell Number Type 2 Diabetes
The purpose of this study is to evaluate the effect of Dipeptidyl peptidase (DPP) -IV inhibitor Vildagliptin vs. Glibenclamide on circulating endothelial progenitor cells (EPCs) number in type 2 diabetes patients in metformin…
- Trial name
- NCT01822548
- Testing
- Vildagliptin, Glibenclamide, Metformin
- Where
- 2 sites in Italy
- Volunteers
- 64 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
- Aortic Aneurysm
Circulating Endothelial Progenitor Cells and Aortic Aneurysm
We aimed to see if aortic aneurysms could be followed-up by circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14- blood level.
- Trial name
- ANOPEC3 (NCT01918982)
- Volunteers
- 40 people
- Sponsor
- Hopital Jean Minjoz
Non-small Cell Lung Cancer
To Predict Efficacy by Detecting Circulating Endothelial Cell Subsets and Blood Perfusion Parameters Changes in Vivo Tumor in the Phase II/III Study of Anlotinib in Patients With Advanced Non-small Cell Lung Cancer
1. To reveal changes of peripheral markers and blood perfusion parameters in vivo tumor in the phase II study of anlotinib in patients with advanced non-small cell lung cancer. 2.
- Trial name
- NCT02029209
- Testing
- Anlotinib
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Primary Gougerot-Sjögren Syndrome, Systemic Sclerosis, Diffuse
Quantification and Characterization of Circulating Epithelial and Endothelial Cells in Gougerot-Sjögren Syndrome, Compared to Systemic Sclerosis
Primary Gougerot-Sjögren's syndrome is a systemic autoimmune disease belonging to the group of connectivities, whose physiopathology remains largely unknown.
- Trial name
- CIRCEE (NCT05528809)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Graft Versus Host Disease, Acute, Endothelial Dysfunction
Origin of CEC in Patients After Allo-HSCT
We believe that CEC, besides coming from cells shedding from patient vasculature, could partly belong to donor, originating from the cellular graft.
- Conditions
- Graft Versus Host Disease, Acute, Endothelial Dysfunction, Immune Tolerance
- Trial name
- DCEC-PIANO (NCT04038827)
- Testing
- D-CEC counting
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Aneurysmal Subarachnoid Hemorrhage
Prognostic Value of Circulating Endothelial Progenitor Cells in Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage is a common and serious disease associated to a high rate of mortality and morbidity. Severe definitive neurological impairment can concern up to 30% of patients in relation with elevated…
- Trial name
- EVAPROPEC (NCT01773200)
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Critical Illness With or Without Sepsis
TRanscriptomic Analysis of Circulating Endothelial Cells During Sepsis - TRACES Study
Vascular dysfunction is an important mechanism involved in organ failure, in the setting of sepsis condition, with different types of circulating endothelial cells.Transcriptom analysis via RNAseq in different types of…
- Trial name
- TRACES (NCT04841824)
- Testing
- Observational study
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Renal Cell Carcinoma
Circulating Tumors Cells and Circulating Endothelial Cells in Renal Cell Carcinoma
The purpose of this study is to see if researchers can detect circulating tumor cells (CTC) and circulating endothelial cells (CEC) in the blood.
- Trial name
- NCT01173445
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Kansas
Graft vs Host Disease, Complications of Organ Transplant Stem Cells
CEC Count Changes to Support GvHD Diagnosis.
In consideration of the fact that the vascular endothelium has been shown to be a target of GvHD in early stage and that the count of CEC may represent a marker of endothelial damage, we want to evaluate the changes in CEC counts…
- Conditions
- Graft vs Host Disease, Complications of Organ Transplant Stem Cells, Endothelial Dysfunction
- Trial name
- ALLOCEC (NCT02064972)
- Testing
- Patients undergoing allo-HSCT, who manifest GvHD.
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Atheroma; Myocardial
Plaque Erosion Prospective Study ii
Plaque erosion is associated with myocardial infarction (MI) in about 30% of cases and may require a different management approach to plaque rupture.
- Trial name
- PEPSii (NCT04701385)
- Testing
- Optical Coherence Tomography (OCT)
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Aortic Aneurysm
Reference Values of Circulating Endothelial Progenitor Cells
Circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- have been shown to be inversely correlated to aortic aneurysm size. However reference values have not yet been determined.
- Trial name
- ANOPEC2 (NCT01918969)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hopital Jean Minjoz
Psoriasis With Cell-derived Microparticles
The Difference of Microparticles in Patients With Psoriasis Vulgaris Who Received Stelara(Ustekinumab)
Background: Psoriasis, a common inflammatory disease, is associated with atherosclerotic vascular diseases, including stroke, myocardial infarction, and impaired microcirculations, among which circulating microparticles play an…
- Trial name
- NCT02693470
- Testing
- Ustekinumab
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital