Clinical trials: Circulating Markers
Pulmonary Hypertension Due to Chronic, Obstructive Pulmonary Disease
The Significance of Circulating Microvesicles in Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease
Mild to moderate pulmonary hypertension is a common complication of chronic obstructive pulmonary disease (COPD); such a complication is associated with increased risks of exacerbation and decreased survival.
- Conditions
- Pulmonary Hypertension Due to Chronic, Obstructive Pulmonary Disease, Circulating Microvesicles, Circulating Markers of Endothelium Damage
- Trial name
- MICROBOPH (NCT05250128)
- Testing
- Catheterization
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Bone Resorption, Stress Fracture
The Effects of NSAIDs on Bone Metabolism Following Exercise
The purpose of this study is to determine the effects of a single dose of non-steroidal anti-inflammatory drugs on post-exercise markers of bone and muscle metabolism.
- Conditions
- Bone Resorption, Stress Fracture, Bone Injury
- Trial name
- NCT05512013
- Testing
- Ibuprofen 800 mg, Celecoxib 200mg, Flurbiprofen 100 mg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Airway Obstruction
Lung Function and Inflammatory Markers in Cement Dust Exposed Workers: A Cross-shifts Study
The aim of the study is to examine possible changes in lung function, nitric oxide levels and systemic inflammatory markers in cement dust exposed workers, during one shift (6-8 hours).
- Trial name
- LIS (NCT00727714)
- Where
- Norway
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Sykehuset Telemark
End Stage Renal Disease, Hemodialysis
Oxidative Stress and Hemodialysis Access Failure
Complications of hemodialysis access are the most frequent single reason for hospitalization among patients with End Stage Renal Disease (ESRD).
- Trial name
- NCT00410449
- Testing
- Alpha tocopherol
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Hydrogen Sulfide, Osteoporosis
Effect of Sulfur Thermal Water on Circulating H2S Levels and Markers of Bone Metabolism in Osteopenic Subjects.
The aim of the study is to investigate whether inhalation treatment with high-sulfide waters from some spas (referred to as "thermal waters"), performed for 12 consecutive days, is able to change circulating H2S levels and alter…
- Trial name
- FORST3 (NCT06095349)
- Testing
- inhalatory treatment with sulfureous aerosol
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli
Diabetes Mellitus
Effect of Pulsatile IV Insulin on Circulating Risk Markers of Vascular and Metabolic Complications in Pts With Diabetes
The purpose of this study is to determine the effect of Pulsatile Intravenous Insulin therapy on circulating blood markers. These blood markers are selected due to their correlation to and possible pathogenetic roles in vascular…
- Trial name
- NCT00361907
- Testing
- Effect of Pulsatile IV insulin on diabetic pt blood markers, Effect of Pulsatile IV Insulin on blood markers
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Florida Atlantic University
Obesity, Type 2 Diabetes
Changes of Biomarkers in Response to Training and Antioxidant Treatment
The aim of the study is to compare the effects of an intensive 4 weeks exercise training program with or without additional treatment with antioxidants.
- Trial name
- NCT00638560
- Testing
- Vitamin C, Vitamin E, Antioxidant treatment
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Morbidly Adherent Placenta, Placenta Accreta
Cell-free Fetal DNA Circulating in the Maternal Plasma as a Marker for Morbidly Adherent Placenta
The purpose of this study is to determine whether, in a high risk population (placenta praevia and previous caesarean or prenatal suspicion of morbidly adherent placenta (MAP)), the concentration of cell-free fetal DNA…
- Conditions
- Morbidly Adherent Placenta, Placenta Accreta, Placenta Increta, Placenta Percreta
- Trial name
- DNA-Accreta (NCT02784886)
- Testing
- Women at high risk of MAP
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Angers
Cancer
Analysis of Circulating Tumor mArkers in Blood 4 - ALCINA 4
Multi-cohort exploratory prospective study. Participation in the ALCINA 4 study does not change the standard management of the patient, including the treatments administered. A sampling schedule will be set up for each cohort.
- Trial name
- ALCINA4 (NCT05088395)
- Testing
- Blood sample, Biopsy
- Where
- 2 sites in France
- Volunteers
- 2,050 people
- Sponsor
- Institut Curie
Leukemia, Lymphoma
Circulating microRNAs as Disease Markers in Pediatric Cancers
MicroRNAs are small molecules which have recently been discovered in cells. They are known to be responsible for the normal development of cells and when they are disrupted can contribute to the development of cancer.
- Conditions
- Leukemia, Lymphoma, Central Nervous System
- Trial name
- NCT01541800
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Lung Cancer
Exploration of Predictive Markers of Neoadjuvant Immunotherapy in Non-Small Cell Lung Cancer
Neoadjuvant immunotherapy has become the standard perioperative treatment in lung cancer, but its effective predictive biomarkers are lacking.
- Trial name
- NCT05965557
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Geneplus-Beijing Co. Ltd.
Non Small Cell Lung Cancer
Circulating and Molecular Markers Involved in the Processes of Cachexia, Anorexia and Sarcopenia in Patients With NSCLC
The study aim to evaluate whether some substances produced by muscle or adipose tissue may play a role in the course of the disease by interfering with the effectiveness of therapies.
- Trial name
- SARCLUNG (NCT06808113)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Heart Failure, Cardiovascular Diseases
Heart Failure and Related Risk-factors After Preeclampsia
This study is a cross-sectional case-control study where classical as well as more innovative risk factors for CVD will be explored.
- Conditions
- Heart Failure, Cardiovascular Diseases, Pre-Eclampsia
- Trial name
- QoH (NCT02347540)
- Where
- Netherlands
- Volunteers
- 2,580 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Colorectal Cancer
Cancer Stem Cell Markers and Prognostic Markers in Circulating Tumor Cells
The study will enroll patients with metastatic colorectal cancer receiving chemotherapy. A total of approximately 22 cc of blood will be drawn during various chemotherapy infusions.
- Trial name
- NCT01286883
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Milton S. Hershey Medical Center
Traumatic Brain Injury
Application of Circulating Extracellular Vesicles in Early Disease Assessment and Prognosis After Traumatic Brain Injury
The purpose of this study was to observe the relationship between the changes of circulating extracellular vesicles and disease development and outcome in patients with traumatic brain injury, and to find early serum markers and…
- Trial name
- NCT05279599
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Metastatic Colorectal Cancer
Study of Circulating Markers in Serum of Patients Treated for Metastatic Colorectal Cancer
The primary purpose of the study is to confirm the results of previous study about the usefulness of the serum Carcinoembryonic antigen (CEA) kinetic for chemotherapy monitoring in patients with unresectable metastasis of…
- Trial name
- Coca-Colon (NCT01212510)
- Testing
- Blood sampling
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Rouen
Cancer
Analysis of Circulating Tumor Markers in the Blood (ALCINA)
Exploratory study on blood-borne biological markers and their correlation with clinical and pathological characteristics.
- Trial name
- ALCINA (NCT02866149)
- Testing
- Blood sampling, Tumor sampling, Stool sampling
- Where
- 5 sites in France
- Volunteers
- 682 people
- Sponsor
- Institut Curie
Prostatic Neoplasms
Identification of Prostate Cancer Specific Markers in Patients Compared to Healthy Participants
This is an exploratory research study with the aim of identifying specific cancer biomarkers in various subtypes of prostate cancer.
- Trial name
- NCT04964271
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tethis S.p.A.
Atherosclerotic Vascular Disease, Type2 Diabetes
The Effects of Evolocumab in Patients With Diabetes and Atherosclerotic Vascular Disease
Experimental models have linked lipid lowering therapies with systemic inflammation; however, relatively little is known about this network in clinical populations and specifically how it changes with PCSK9 inhibition.
- Conditions
- Atherosclerotic Vascular Disease, Type2 Diabetes, Microvascular Dysfunction
- Trial name
- NCT03829046
- Testing
- Evolocumab
- Where
- 2 sites in United States, Canada
- Volunteers
- 41 people
- Sponsor
- Robert Rosenson
Bone Growth Abnormal, Inflammation
Effects of Increased Greek Yogurt Consumption in Youth and Young Adult Athletes
Physical activity and dairy consumption during growth and development are each known to improve peak bone mass in young adults. Peak bone mass, the maximum amount of bone a person will have in their lifetime, is typically reached…
- Trial name
- NCT05922462
- Testing
- Greek yogurt, Whey protein
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brock University