Clinical trials: Circulating Tumor Cell;
HPV-Negative Squamous Cell Carcinoma
Personalized, Adaptive Treatment for Locally Advanced Head and Neck Cancer
This clinical trial will assess whether or not blood based biomarker testing can be used to personalize cancer treatment for patients with locally advanced head and neck cancer.
- Trial name
- NCT06005324
- Testing
- Paclitaxel, Carboplatin, Cetuximab
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Chicago
Prostate Cancer
Cultured Circulating Tumor Cells in Prostate and Other Cancers
The purpose of this study is to evaluate the number of circulating tumor cells (CTC) before and after treatment using an experimental method for detecting CTC, compared to commercial CTC assay results, in patients with prostate…
- Trial name
- NCT02123862
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Oscar Goodman, Jr.
Female Breast Carcinoma
Anesthesia and Circulating Tumor Cells in Breast Cancer
Serious concern about the role of anesthesia in tumor recurrence has considerably risen over years, but the lack of surrogate markers for tumor spreading made trials addressing this issue difficult to realize.
- Trial name
- NCT02005770
- Testing
- Sevoflurane, Propofol
- Where
- 2 sites in Switzerland
- Volunteers
- 221 people
- Sponsor
- University of Zurich
Metastatic Head-and-neck Squamous-cell Carcinoma
Circulating Tumor Cells as an Early Predictive head-and -Neck Squamous-cell Carcinoma
In France, the incidence of head and neck squamous cell carcinomas (HNSCC) is 16 000 new cases/year. During these last years, many new chemotherapies and targeted therapies have been developed improving significantly the overall…
- Trial name
- CIRCUTEC (NCT02119559)
- Testing
- Blood analysis by EPISPOT and CellSearch®
- Where
- France
- Volunteers
- 115 people
- Sponsor
- University Hospital, Montpellier
Colorectal Cancer, Liver Metastases
ctDNA-guided Adjuvant Chemotherapy in Liver Metastasis of Colorectal Cancer
The goal of this clinical trial is to compare in resectable colorectal cancer liver metastasis patients.The main question it aims to answer is whether the 3-year progression-free survival rate (PFS) of "watching and waiting" is…
- Conditions
- Colorectal Cancer, Liver Metastases, Circulating Tumor Cell, Chemotherapy Effect
- Trial name
- NCT05815082
- Testing
- Colorectal cancer resection combined with liver metastasis resection., FOLFOX chemotherapy regimen
- Where
- China
- Volunteers
- 490 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Melanoma
"Dabrafenib and Trametinib in Circulating Free DNA BRAFV600 Mutated Metastatic Melanoma Patients: a Prospective Phase II, Open Label, Multicentre Study - (Bioliquid TAILOR Study - BIOTAILOR)"
There is evidence from cohort studies and metanalysis that a shift from BRAFWT to BRAF mutated melanomas can occur (Colombino JCO 2012, Valchis EJC 2017).
- Trial name
- NCT05299580
- Testing
- dabrafenib, Trametinib
- Where
- 16 sites in Italy
- Sponsor
- Fondazione Melanoma Onlus
Non Small Cell Lung Cancer
Changes in Circulating Tumor-Specific DNA in Patients With Non-Metastatic Non-Small Cell Lung Cancer
The purpose of this research study is to evaluate a blood test to measure circulating tumor DNA (ctDNA). It is hypothesized that ctDNA may identify patients who can be considered for additional therapy.
- Trial name
- NCT03746262
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
High Grade Glioma
Circulating Tumor DNA Collection From Patients With High Grade Gliomas
Improved outcomes for high-grade gliomas (HGG) require advances in our ability to monitor changes to tumour biology using non-surgical approaches.
- Trial name
- m-ctDNA (NCT05925218)
- Testing
- Radiotherapy as per standard of care
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Hepatocellular Carcinoma, Circulating Tumor Cell
Value of Dynamic Monitoring of Early Recurrence of Hepatocellular Carcinoma After Radical Resection Based on CTCS
On the basis of previous retrospective studies, the Task Force will further optimize the CTCs longitudinal surveillance model and initially validate the subclonal origin (CTC-DNA) of recurrent/metastatic foci derived from CTCs at…
- Conditions
- Hepatocellular Carcinoma, Circulating Tumor Cell, Recurrence, Surgery
- Trial name
- NCT06317896
- Testing
- circulating tumor cells
- Where
- 3 sites in China
- Volunteers
- 82 people
- Sponsor
- Zhujiang Hospital
Breast Cancer, Circulating Tumor Cell
CTCs in Breast Cancer After Neoadjuvant Treatment and Surgery: a Multicenter, Prospective Clinical Trial
The GILUPI CellCollector® is the first in vivo CTC isolation product worldwide, which is CE approved. This is a prospective, multicenter study to evaluate the prognostic value of circulating tumor cells in breast cancer patients…
- Trial name
- CTCNeoBC-E (NCT05360290)
- Testing
- GILUPI CellCollector®
- Where
- China
- Volunteers
- 484 people
- Sponsor
- RenJi Hospital
Glioblastoma, Glioblastoma Multiforme
Anti-Cancer Effects of Carvedilol With Standard Treatment in Glioblastoma and Response of Peripheral Glioma Circulating Tumor Cells
The purpose of this pilot study is to evaluate the addition of carvedilol with standard of care treatment to determine if it will improve progression-free survival in the front line setting in patients with glioblastoma…
- Trial name
- NCT03980249
- Testing
- Carvedilol
- Where
- United States
- Sponsor
- West Virginia University
Breast Cancer
Circulating Fetal Cells and Breast Cancer
After pregnancy, fetal cells remain in a woman's body for years. These cells may be involved in different physiological situations (e.g. wound healing) and diseases (e.g.
- Trial name
- MoSaiC2 (NCT04903990)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-hematologic Cancer
Specimen Collection From Patients With Non-Hematologic Cancer for Use in Development of a Liquid Biopsy Assay
This specimen collection is designed to obtain whole blood and tumor tissue from subjects diagnosed with cancer for the purpose of the development of a noninvasive liquid biopsy assay using next generation sequencing (NGS).
- Trial name
- NCT02586389
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Sequenom, Inc.
Prostate Cancer, Renal Cell Carcinoma
Characterization of Circulating Tumor Cells Captured by c-MET (CTC-MET)
This pilot study will aim to determine whether circulating tumor cells (CTCs) can be captured using the novel cMET based ferrofluid.
- Conditions
- Prostate Cancer, Renal Cell Carcinoma, Bladder Cancer, Colorectal Cancer
- Trial name
- NCT02080650
- Testing
- Mesenchymal-marker based ferrofluid (c-MET), Epithelial cell adhesion molecule (EpCAM) ferrofluid
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Duke University
Prostate Cancer
Abiraterone Acetate for Castrate Resistant Prostate Cancer
This research study is a Pilot clinical trial. Pilot clinical trials often examine new tests (such as laboratory or radiology tests) in patients who receive either standard cancer treatments or new treatments that have been…
- Trial name
- NCT01961843
- Testing
- Abiraterone, Prednisone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer, Surgery
Cetuxibab to Reduce Circulating Tumor Cells in Early Stage NSCLC
Cetuximab to reduce the amound of circulating tumor cells in early stage NSCLC
- Conditions
- Lung Cancer, Surgery, Circulating Tumor Cell
- Trial name
- NCT04648189
- Testing
- Cetuximab
- Where
- 2 sites in Netherlands
- Sponsor
- The Netherlands Cancer Institute
Cervical Cancer, Ovarian Clear Cell Carcinoma
Asian Multicenter Prospective Study of ctDNA Sequencing
This study is a genetic analysis of aberrations in circulating tumor DNA (ctDNA) in patients in Asian countries. This study protocol is divided into parts describing several subanalyses that differ in terms of cancer types…
- Conditions
- Cervical Cancer, Ovarian Clear Cell Carcinoma, Nasopharyngeal Carcinoma, Ovarian Cancer
- Trial name
- A-TRAIN (NCT05099978)
- Testing
- NGS analysis of ctDNA
- Where
- 19 sites in Japan, Malaysia and 6 more
- Volunteers
- 506 people
- Sponsor
- National Cancer Center, Japan
Prostate Carcinoma, Castration-resistant Prostate Cancer
Treatment of Metastatic Castrate Resistant Prostate Cancer Patients According to Circulating Tumor Cells Kinetic
This study compares the biological activity of cabazitaxel (6 cycles) to that of docetaxel (6 cycles) in metastatic castrate-resistant prostate cancer (mCRPC) patients with docetaxel resistant mCRPC defined as ≥5 circulating…
- Conditions
- Prostate Carcinoma, Castration-resistant Prostate Cancer, Circulating Tumor Cells, Chemotherapy
- Trial name
- TACTIK (NCT03101046)
- Testing
- Cabazitaxel, Docetaxel
- Where
- 5 sites in France
- Volunteers
- 40 people
- Sponsor
- UNICANCER
Lung Cancer
MRD Monitoring in Lung Cancer After Resection
The conception of molecular residual disease (MRD) extending from hematologic tumor to solid tumors. Evidences supporting MRD evaluation for lung cancer by liquid biopsy has gradually accumulated, especially circulating tumor DNA…
- Trial name
- NCT04976296
- Testing
- MRD detection
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Guangdong Provincial People's Hospital
Non-Small Cell Lung Cancer
MRD-Guided Aumolertinib-Based Adjuvant Therapy for Resected EGFR-Mutant NSCLC
Despite complete (R0) resection, patients with EGFR-mutant stage IIA-IIIB non-small cell lung cancer (NSCLC) still face a substantial risk of postoperative recurrence.
- Trial name
- NCT07873086
- Testing
- Aumolertinib, Pemetrexed, Carboplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital