Clinical trials: Circulatory Failure (Shock)
Anxiety Disorders
Expectation of Unpleasant Events in Anxiety Disorders
Fear and anxiety are normal responses to a threat. However, anxiety is considered abnormal when the response to the threat is excessive or inappropriate.
- Trial name
- NCT00055224
- Testing
- Threat of shock
- Where
- United States
- Volunteers
- 921 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Septic Shock, Fluid Therapy
Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock
The purpose of the study is to determine if a protocol that assesses patients' daily fluid intake and output can decrease the overall amount of fluid patients receive during the first five days in the ICU.
- Conditions
- Septic Shock, Fluid Therapy, Hypotension
- Trial name
- NCT02473718
- Testing
- Fluid minimization protocol, Ultrasound
- Volunteers
- 82 people
- Sponsor
- Washington University School of Medicine
Septic Shock
Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study
The investigators propose a dose finding study to determine the feasibility of Angiotensin II (AII) to increase mean arterial pressure in high-output shock.
- Trial name
- ATHOS (NCT01393782)
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- George Washington University
Septic Shock, Acute Kidney Injury
Renin and Renal Biomarker Response to Angiotensin II
Septic shock continues to exert a large economic burden around the world. Several developments have occurred that lead to the current study.
- Trial name
- NCT04558359
- Testing
- Standard of Care, Angiotensin II
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alexander Flannery
Sepsis
Immunomodulatory Properties of Ketamine in Sepsis
The aim of the study is to assess the effect of short-term infusion of ketamine at analgesic dosage on the immune response, morbidity and mortality among patients suffering from septic shock.
- Trial name
- NCT01089361
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Beth Israel Deaconess Medical Center
Septic Shock
Resuscitation With Plasma in Surgical and Trauma Patients With Septic Shock
There is a knowledge gap regarding the optimal initial fluid to achieve effective resuscitation and improved outcomes in septic shock.
- Trial name
- NCT03366220
- Testing
- Plasma, Balanced crystalloids
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center, Houston
Septic Shock
High MAP in Septic Shock With Hypertension
We hypothesized that the increase in MAP from 65 mmHg to patients' usual level improved sublingual microcirculation.
- Trial name
- NCT01443494
- Testing
- NE
- Where
- China
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Abdominal Surgery, Respiratory Failure
Metabolites of Tramadol in the Postoperative Surgical Patients
Tramadol is opioid analgesic widely used to treat moderate to severe pain. It is metabolized by cytochrome CYP2D6 into two major metabolites: pharmacologically active metabolite O-desmethyltramadol (M1) and inactive…
- Conditions
- Abdominal Surgery, Respiratory Failure, Renal Failure, Liver Dysfunction
- Trial name
- METRAS (NCT04004481)
- Testing
- Postoperative analgesia using tramadol
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- Osijek University Hospital
Circulatory Shock, Cardiovascular Shock
Physiologic Effect of Topical Nitroglycerin on Microcirculation Capacity in Patients With Circulatory Shock.
This is an open-label, single center, trial that will enroll up to 25 participants with circulatory shock after cardiac surgery.
- Trial name
- NCT05102734
- Testing
- Nitroglycerin Topical Product
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Pennsylvania
Shock
High Dose Vitamin C in the Critically Ill Patient
The purpose of this study is to determine the effectiveness of high doses of Vitamin C in critically ill patients.
- Trial name
- VitC (NCT01587963)
- Testing
- Ascorbic Acid, Ringers Lactate or Normal Saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Rutgers, The State University of New Jersey
Toxic Shock Syndrome
Clinical Trial of the BioMed rTSST-1 Variant Vaccine in Healthy Adults
Toxic Shock Syndrome (TSS) is a severe condition with high morbidity and mortality from the hosts overwhelming inflammatory response and cytokine storm. Staphylococcal superantigen toxins are the main causative agents.
- Trial name
- NCT02814708
- Testing
- rTSST-1v
- Where
- Austria
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Biomedizinische Forschungs gmbH
Treatment of Hypovolemia and Shock
Gelatines in Pediatric PatientS
The aim of volume replacement is to compensate a reduction in the intravascular volume e.g. during surgery and to counteract hypovolemia in order to maintain hemodynamics and vital functions.
- Trial name
- GPS (NCT02495285)
- Testing
- Gelofusine 4%, Gelaspan 4%
- Where
- 11 sites in Bulgaria, Germany and 3 more
- Volunteers
- 601 people
- Sponsor
- B. Braun Melsungen AG
Shock
Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study
Approximately 20,000 children per year in North America present to the hospital with severe shock. Children who develop this condition have very low blood pressures and as a result may suffer damage to their internal organs and…
- Trial name
- STRIPES (NCT02044159)
- Testing
- Hydrocortisone
- Where
- 7 sites in Canada
- Volunteers
- 57 people
- Sponsor
- Children's Hospital of Eastern Ontario
Hypotension and Shock, Excessive Amount of Blood / Fluid Infusion
Predict Fluid Responsiveness in Spinal Anesthesia
Spinal anesthesia is still the regional anesthesia technique most widely employed in everyday clinical practice. The most feared and common of its well known side effects consist in an abrupt reduction of systemic vascular…
- Trial name
- CERU-1401 (NCT02070276)
- Testing
- Trans-thoracic echocardiography, Passive Leg Raising Test
- Where
- Switzerland
- Volunteers
- 429 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Severe Sepsis
AZD9773 Dose Escalation Study
This is a double-blind, placebo-controlled, multi-center, dose-escalation study to assess the safety, tolerability, Pharmacokinetics and Pharmacodynamics of single and multiple ascending intravenous infusions of CytoFab (AZD9773)…
- Trial name
- NCT00615017
- Testing
- AZD9773 (CytoFab)
- Where
- 26 sites in United States
- Volunteers
- 70 people
- Sponsor
- AstraZeneca
Preventive Medicine, Multi Organ Failure
Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Prevention of Multi-Organ Failure on Patients After Open Surgery for a RAAA
A study to assess effectiveness and safety of a drug FP-1201-lyo (Recombinant Human Interferon Beta-1a) in the Prevention of Multi-Organ Failure on patients after Open Surgery for a Ruptured Abdominal Aortic Aneurysm
- Trial name
- INFORAAA (NCT03119701)
- Testing
- Interferon Beta-1A
- Where
- 9 sites in Estonia, Finland and 1 more
- Volunteers
- 40 people
- Sponsor
- Faron Pharmaceuticals Ltd
Pediatric Sepsis-induced MODS
GM-CSF for Reversal of immunopAralysis in pediatriC sEpsis-induced MODS Study
This study is an open-label, multi-center, interventional trial in which children with sepsis-induced MODS undergo surveillance immune function testing beginning on Day 2 of MODS.
- Trial name
- GRACE (NCT03769844)
- Testing
- GM-CSF
- Where
- 8 sites in United States
- Volunteers
- 75 people
- Sponsor
- Nationwide Children's Hospital
Atrial Fibrillation
Clinical Trial Comparing Devices Used for Cardioversion of Atrial Fibrillation
The goal of this single center, investigator initiated, open label prospective randomized controlled trial is to compare the efficacy of a single 200J RBW shock and a single 360J BTE shock.
- Trial name
- NCT05992623
- Testing
- Zoll external defibrillator, Lifepak external defibrillator
- Where
- United States
- Volunteers
- 546 people
- Sponsor
- Inova Health Care Services
Shock, Surgical, Shock
Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant Recipients
The current standard of catecholamine vasopressor management of perioperative hypotension in kidney transplant patients carries significant risks and falls short in many ways.
- Conditions
- Shock, Surgical, Shock, Hypotension and Shock, Kidney Transplant; Complications
- Trial name
- NCT04529005
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois Chicago
PreDiabetes, Neuropathy
Heat Shock Therapy to Improve Mitochondrial Function in Neuropathy
Sensory dysfunction as a result of peripheral nerve damage is a significant problem that leads to reduced quality of life for patients.
- Trial name
- HOTFUN (NCT05070741)
- Testing
- Heat Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Kansas Medical Center