Clinical trials: Cirrhoses, Liver
Cirrhoses, Liver, Decompensated Cirrhosis of Liver
Role of Allopurinol in Prevention of Complications Related to Decompensated Cirrhosis of Liver
Cirrhosis, a leading cause of global mortality, progresses to life-threatening complications like ascites, hepatic encephalopathy, and hepatorenal syndrome.
- Trial name
- NCT07800598
- Testing
- Allopurinol Tablet
- Where
- 2 sites in Bangladesh
- Volunteers
- 54 people
- Sponsor
- Bangladesh Medical University
Liver Cirrhoses
The Spectrum and Profile of COVID-19 Infection and Its Impact on Liver.
To address the existing deficiencies in the knowledge regarding liver involvement and spectrum of clinical presentation and the impact of COVID-19 infection in patients of liver disease was planned.
- Trial name
- NCT04345640
- Testing
- no intervention
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Fibroses, Liver Cirrhoses
Prevalence of Liver Fibrosis and Cirrhosis in Patients With Squamous Cell Carcinoma of the Head and Neck
Tobacco and alcohol are the two major risk factors for upper respiratory tract cancer (VADS).
- Conditions
- Liver Fibroses, Liver Cirrhoses, Squamous Cell Carcinoma of the Head and Neck
- Trial name
- fibr'HOM (NCT03139058)
- Testing
- Evaluation of the hepatic fibrosis
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cirrhoses, Liver, Oesophageal Varices
Beta-blockers for Oesophageal Varices
To determine if carvedilol reduces the rate of variceal haemorrhage in patients with cirrhosis and small oesophageal varices
- Trial name
- BOPPP (NCT03776955)
- Testing
- Carvedilol
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- King's College Hospital NHS Trust
Gastric Varix, Sepsis
Antibiotic Prophylaxis in Patients Undergoing GVO
We design a randomized trial to clarify the necessity of antibiotic prophylaxis for the patients chronic liver disease with gastric varices treated by elective GVO.
- Conditions
- Gastric Varix, Sepsis, Liver Cirrhoses, Fever
- Trial name
- ABX-GV (NCT04140578)
- Testing
- Ertapenem
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Liver Cirrhoses, Peripheral Neuropathy
Electrophysiological Evaluation of Motor Dysfunction in Liver Cirrhotic Patients
cross sectional observational study, aimed to assess the electrophysiological function of the motor units in liver cirrhotic patients.
- Trial name
- NCT04340999
- Testing
- Nerve conduction studies and Quantitative EMG ( MUNE and IPA)
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Esophageal Varices, Liver Cirrhoses
Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices
This study evaluates the safety and efficacy of 24-hour vs 72-hour octreotide infusion after variceal banding in cirrhotic patients with bleeding esophageal varices.
- Conditions
- Esophageal Varices, Liver Cirrhoses, Bleeding Esophageal Varices, Upper Gastrointestinal Bleeding
- Trial name
- LOVARB (NCT03624517)
- Testing
- Octreotide
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Medical University of South Carolina
Antibiotic Resistant Infection, Liver Cirrhoses
Antibiotic-resistant Bacterial Infection of Hepatic Patients
the investigators want to identify the microbial profile, antibiotic resistant bacteria in hepatic patients with infections in Liver ICU, and explore risk factors and outcomes in those patients with antibiotic resistant bacteria.
- Trial name
- NCT03855709
- Testing
- microbiological culture and sensetivity
- Volunteers
- 200 people
- Sponsor
- Assiut University
Liver Cirrhoses
N-Acetyl Cysteine in the Prevention of Contrast Induced Nephropathy in Cirrhosis of Liver-NEPHRO Trial
Contrast induced nephropathy has an incidence of 7-11 % in patients undergoing Contrast imaging for various conditions. The risk associated with the development of CIN are still under evaluation.
- Trial name
- NCT03759158
- Testing
- N-Acetyl Cysteine
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhoses, Hepatic Encephalopathy
Role of MRI in Detection of Minimal Hepatic Encephalopathy
Introduction Liver cirrhosis (LC) is irreversible fibrosis of the liver (1) and it remains a public health problem. One of the complications of the cirrhosis is hepatic encephalopathy (HE) which is defined as brain dysfunction…
- Trial name
- NCT04131205
- Testing
- Magnetic Resonance Imaging
- Where
- Slovenia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Hepatitis C, Liver Inflammation
Treatment of HOsPitalised Inpatients for Hepatitis C (TOPIC): Therapeutic Intervention Enhancing Care Linkage in People Who Inject Drugs
This study will evaluate the proportion of patients achieving confirmed SVR12 (undetectable HCV RNA at time point 12 weeks plus post treatment commencement) in patients hospitalised for IRID (injecting related infectious…
- Conditions
- Hepatitis C, Liver Inflammation, Liver Cirrhoses
- Trial name
- TOPIC (NCT03981211)
- Testing
- Glecaprevir/Pibrentasvir 100 MG-40 MG Oral Tablet, Sofosbuvir 400 MG + Glecaprevir/Pibrentasvir 100 MG-40 MG Oral Tablet
- Where
- 7 sites in Australia
- Volunteers
- 21 people
- Sponsor
- Kirby Institute
Liver Cirrhoses, Malignant Ascites
International Alfapump Cohort Study
This Registry is designed to follow patients who have been implanted with an alfapump system, which is a newly marketed product from Sequana Medical AG, a Swiss Medical Device company.
- Trial name
- TOPMOST (NCT04326946)
- Testing
- Alfapump
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 400 people
- Sponsor
- Sequana Medical N.V.
Cirrhoses, Liver
Nursing Needs of Patients With Cirrhosis
The primary objective of this study is to examine the quality of life, disease-related knowledge, and perceived nursing needs of adult patients diagnosed with liver cirrhosis who attend the outpatient clinic at Landspítali…
- Trial name
- NCT07273331
- Testing
- blood sample, blood samples for analysis of cirrhosis
- Where
- 2 sites in Iceland
- Volunteers
- 150 people
- Sponsor
- Landspitali University Hospital
Liver Cirrhoses
Alterations in Intestinal Mucosal Barrier Visualized by Confocal Laser Endomicroscopy in Liver Cirrhosis: a Pilot Trial (AMBIC)
Clinical trial with medical devices. A diagnostic trial conducted to find a better (less invasive) procedure for predicting the onset of spontaneous bacterial peritonitis(SBP), which is a complication of liver cirrhosis with…
- Trial name
- AMBIC (NCT03878563)
- Testing
- Cellvisio 100 Series (fibered confocal microscopic system)
- Where
- 2 sites in Switzerland
- Volunteers
- 26 people
- Sponsor
- Dr.med. Monica Rusticeanu
Liver Cancer, Liver Cirrhoses
Gadolinium Contrast-enhanced Abbreviated MRI (AMRI) vs. Standard Ultrasound for Hepatocellular Carcinoma (HCC) Surveillance in Patients With Cirrhosis
This study compares gadolinium contrast-enhanced Abbreviated MRI (AMRI) to standard ultrasound for Hepatocellular Carcinoma (HCC) screening and surveillance in subjects with liver cirrhosis.
- Conditions
- Liver Cancer, Liver Cirrhoses, Liver Carcinoma
- Trial name
- NCT04288323
- Testing
- Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- University of California, San Diego
Liver Cirrhoses
To Study the Efficacy and Safety of TIPS (Trans Intrahepatic Portosystemic Shunt) Versus Self Expanding Metallic Stent (SEMS) in the Management of Refractory Variceal Bleed in Cirrhotics.
A total of 50 patients will be enrolled and will be randomized into either Group A(TIPS) or Group B (SEMS). Primary end point of the study will be to compare efficacy of TIPS versus SEMS for survival at 6 week or Early re Bleed.
- Trial name
- NCT03827681
- Testing
- Trans Intrahepatic Portosystemic Shunt, Self Expanding Metallic Stent, Vasoactive Agent
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Portal Hypertension, Liver Diseases
Hemodynamic Alterations in Liver Cirrhosis Validated by Non-invasive MR Compared to Invasive Assessment
Liver cirrhosis is a chronic disease characterized by a progressive accumulation of fibrosis, loss of liver function and portal hypertension leading to several hemodynamic changes.The exact pathophysiological mechanisms causing…
- Conditions
- Portal Hypertension, Liver Diseases, Liver Cirrhoses, Cirrhosis
- Trial name
- NCT03443934
- Where
- Denmark
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Spontaneous Bacterial Peritonitis, Cirrhoses, Liver
Comparative Study of Secondary Prophylaxis for SBP
The goal of this clinical trial is to learn if norfloxacin, nitazoxanide, and colistin work as secondary prophylactic agents for spontaneous bacterial peritonitis (SBP) in cirrhotic patients with ascites.
- Conditions
- Spontaneous Bacterial Peritonitis, Cirrhoses, Liver, Ascites
- Trial name
- 3C-SPS (NCT06827756)
- Testing
- Norfloxacin 400 MG, Nitazoxanide 500 MG, Colistin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Portal Hypertension Related to Cirrhosis, Variceal Bleeding
Clinical Outcomes in Patients Presenting With Acute Variceal Bleeding
The goal of this observational study is to learn about the outcomes of patients presenting with acute variceal bleeding and treated by endoscopic intervention.
- Conditions
- Portal Hypertension Related to Cirrhosis, Variceal Bleeding, Cirrhoses, Liver
- Trial name
- BLEED-OUTcomes (NCT07870850)
- Where
- Romania
- Volunteers
- 149 people
- Sponsor
- Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
Cirrhoses, Liver, Splenectomy; Status
Laparoscopic Partial Splenectomy for Hypersplenism in Liver Cirrhosis Patients
In this study,the researchers compared the changes in immune function-related indicators in patients with liver cirrhosis following laparoscopic partial splenectomy,to determine whether this surgical intervention can enhance…
- Conditions
- Cirrhoses, Liver, Splenectomy; Status, Partial
- Trial name
- LPSH (NCT07205471)
- Testing
- Laparoscopic Partial Splenectomy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital