Clinical trials: Cirrhosis Liver
Liver Disease, Cirrhosis
Resting Energy Expenditure in Patients on the Waiting List for Liver Transplantation
Metabolic disorders and malnutrition are well known and have been reported in patients with chronic liver disease, but the relationship of energy metabolism and changes in nutritional status in patients on the waiting list for…
- Trial name
- NCT01761851
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Federal University of Minas Gerais
Non-alcoholic Steatohepatitis (NASH)
Study of Safety, Tolerability, and Efficacy of a Combination Treatment of LJN452 and CVC in Adult Patients With NASH and Liver Fibrosis
The purpose of this study was to assess the safety, tolerability, and efficacy of a combination treatment of tropifexor (LJN452) and cenicriviroc (CVC) in adult patients with nonalcoholic steatohepatitis (NASH) and liver fibrosis.
- Trial name
- TANDEM (NCT03517540)
- Testing
- Tropifexor (LJN452), Cenicriviroc (CVC)
- Where
- 65 sites in United States, Argentina and 15 more
- Volunteers
- 193 people
- Sponsor
- Novartis Pharmaceuticals
Alcoholic Liver Disease
Herbal Supplements for Improvement of Liver Function in Participants With Alcoholic Liver Disease
Alcoholic liver disease represents the major health issues and it ranges from simple steatosis to cirrhosis. There is a paucity of data to support the allopathic intervention among these group of patients.
- Trial name
- NCT03503708
- Testing
- Livitol-70
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Composite Interceptive Med Science
Alcoholic Cirrhosis
Pangenomic Study During Alcoholic Cirrhosis
Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome.
- Trial name
- CDCHC (NCT01065233)
- Testing
- DNA extraction
- Where
- 4 sites in France
- Volunteers
- 1,325 people
- Sponsor
- Nantes University Hospital
Liver Cirrhosis, Liver Failure
Associated Balance of Risk Score - Comprehensive Complication Index for the Prediction of Post-transplant Survival
In recent years, several scoring systems have been developed aimed at predicting early post-LT graft function. However, many of them showed poor efficacy when long-term survivals were tested.
- Conditions
- Liver Cirrhosis, Liver Failure, Liver Diseases, Transplant Failure
- Trial name
- NCT03723317
- Testing
- Liver transplantation
- Where
- Belgium
- Volunteers
- 1,782 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
Hypertension, Portal
Radiomics Signature of Hepatic Venous Pressure Gradient (rHVPG) With CT Angiography (CHESS1701)
This is a prospective, multi-center diagnostic trial conducted at 5 high-volume liver centers in China designed to determine the diagnostic performance of radiomics-based hepatic venous pressure gradient (rHVPG) (investigational…
- Trial name
- rHVPG (NCT03138915)
- Testing
- HVPG measurement, CTA
- Where
- 6 sites in China
- Volunteers
- 385 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Obesity, NAFLD
Bariatric Endoscopy and NAFLD
Find out how bariatric endoscopy will influence the clinical course of non-alcoholic fatty liver disease.
- Conditions
- Obesity, NAFLD, Liver Steatosis, Liver Fibrosis
- Trial name
- NCT04895943
- Testing
- bariatric endoscopy, mainly intragastric balloons, plication of the stomach too
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
Liver Cirrhosis, Liver Transplant; Complications
Home-based Bimodal Lifestyle Intervention in Patients With Liver Cirrhosis Awaiting Orthotopic Liver Transplantation
Chronic liver disease eventually results in liver cirrhosis and is associated with an increasing deterioration in patients' physical fitness.
- Conditions
- Liver Cirrhosis, Liver Transplant; Complications, Physical Inactivity
- Trial name
- FIT4Cirrhotics (NCT05853484)
- Testing
- Bimodal lifestyle program
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- University Medical Center Groningen
Liver Cirrhosis
EUS Share-wave in Patients With Liver Cirrhosis
Patients with chronic liver disease may develop progressive hepatic fibrosis. Liver cirrhosis should be detected at the early stages in order to avoid the complications related to these two conditions.
- Trial name
- NCT04644055
- Testing
- EUS- share wave of the liver
- Where
- Ecuador
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Cirrhosis
Evaluation of Patient Care Support for Cirrhosis and/or Liver Transplants
Cirrhosis is a major challenge in France, with a growing prevalence of 1,500 to 2,500 cases per million inhabitants, and the discovery of 150 to 200 new cases per million inhabitants each year.
- Trial name
- PACCHUPS (NCT06544863)
- Testing
- Data collection; biological samples
- Where
- 3 sites in France
- Volunteers
- 3,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Elastography, Fibrosis, Liver
The Use of the Transient Elastography Paediatric Probe, Compared to the M Probe, Indirect Biomarkers and Histology
The purpose of this study is to assess the reliability, reproducibility and accuracy of the paediatric probe of transient elastography in detecting liver fibrosis in children, besides its limitations and side effects.
- Conditions
- Elastography, Fibrosis, Liver, Pediatrics, Chronic Liver Disease
- Trial name
- NCT04380493
- Testing
- hepatic transient elastography using S probe and M probe
- Where
- Spain
- Volunteers
- 141 people
- Sponsor
- Hospital Vall d'Hebron
Hepatitis B
Follow-up of HBsAg Inactive Carriers Study
The definition of HBs antigen (HBsAg) inactive carrier status has evolved during time. We spoke first from HBsAg" healthy carrier ", then from " asymptomatic carrier ", last from HBsAg" inactive carrier ".
- Trial name
- PIBAC (NCT02247752)
- Testing
- inactive carrier
- Where
- 32 sites in France
- Volunteers
- 619 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Advanced Hepatocellular Carcinoma
Phase 1 Study of SF1126 in Combination With Nivolumab in Patients With Advanced Hepatocellular Carcinoma
Primary Objectives: 1. To determine the maximum tolerated dose (MTD) or maximum recommended dose of SF1126 in combination with nivolumab in adult patients with advanced (unresectable or metastatic) HCC and Child-Pugh A or…
- Trial name
- NCT03059147
- Testing
- SF1126, Nivolumab
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- SignalRX Pharmaceuticals, Inc.
Cirrhosis, End Stage Liver Disease
Mechanism and the Effect of Midodrine on Portal Pressures in Patients With Cirrhosis
Ascites is a frequent complication of patients with portal hypertension. As portal hypertension progresses, a percentage of these patients develop refractory ascites.
- Conditions
- Cirrhosis, End Stage Liver Disease, Ascites, Hypotension
- Trial name
- NCT01331785
- Testing
- Midodrine
- Where
- United States
- Sponsor
- The Cleveland Clinic
Primary Biliary Cholangitis
Mindfulness - Based Intervention in the Treatment of Fatigue in Patients With Primary Biliary Cholangitis
To assess the efficacy of mindfulness-based intervention (MBI) intervention in the treatment of moderate or severe fatigue in patients with primary biliary cholangitis (PBC).
- Trial name
- NCT03684187
- Testing
- Mindfulness Based Intervention
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Yale University
Refractory Ascites, Children, Only
Safety and Efficacy of Midodrine Hydrochloride in the Management of Refractory Ascites Due to Cirrhosis in Children
Ascites in liver cirrhosis is explained by increased production of vasoactive substances leading to renal vasoconstriction and salt and water retention.
- Trial name
- NCT04043858
- Testing
- Midodrine 2.5 mg tab
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- National Liver Institute, Egypt
Liver Dysfunction
Mivacurium Chloramine Muscle Relaxation Effect in Patients With Liver Cirrhosis
Observed the muscle relaxation of mivacurium in patients with liver cirrhosis.Clear of mivacurium in patients with liver cirrhosis without muscle relaxant accumulation and delayed recovery phenomenon
- Trial name
- NCT02473601
- Testing
- Mivacurium Chloride
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tang-Du Hospital
Liver Cirrhosis, Portal Vein Thrombosis
Efficacy and Safety of Dabigatran in Patients With Cirrhosis and Portal Vein Thrombosis
A randomized controlled trial to study the efficacy and safety of Dabigatran in Cirrhotic patients who develop PVT.In this study the patients who meet the inclusion criteria will be randomized to either receive Dabigatran or…
- Trial name
- NCT04433481
- Testing
- Dabigatran
- Where
- India
- Volunteers
- 84 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatocellular Carcinoma, Liver Cirrhosis
The Role of Long Non-coding RNAs WRAP53 and UCA-1 as Potential Biomarkers in Diagnosis of Hepatocellular Carcinoma
The aim of this work is to study the role of long non-coding RNAs WRAP53 and urothelial carcinoma-associated 1 (UCA1) as potential biomarkers in diagnosis of hepatocellular carcinoma.
- Conditions
- Hepatocellular Carcinoma, Liver Cirrhosis, Diagnoses Disease
- Trial name
- NCT05088811
- Testing
- WRAP53, UCA-1
- Where
- 2 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Portal Hypertension
8mm-TIPS Versus Endoscopic Variceal Ligation (EVL) Plus Propranolol for Prevention of Variceal Rebleeding in Patients With Child A Cirrhosis
The aim of this study was to conduct a prospective randomized trial to compare TIPS with 8mm expanded polytetrafluoroethylene(ePTFE)-covered stents and endoscopic variceal ligation plus propranolol for the prevention of recurrent…
- Trial name
- NCT03094234
- Testing
- 8mm-TIPS, endoscopic variceal ligation (EVL), Propranolol
- Where
- China
- Volunteers
- 72 people
- Sponsor
- West China Hospital
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