Clinical trials: Cirrhosis Liver
Cirrhosis, Esophageal Varices
Effect of Meal on Portal and Esophagus Variceal Pressure
The reason why esophagus varices suddenly rupture and start to bleed is unclear. Food intake increase the hepatic blood flow and the portal pressure, but it is yet unknown if there is also an increase in variceal pressure.
- Trial name
- VIPE (NCT00485290)
- Testing
- meal (food intake)
- Where
- Denmark
- Sponsor
- Hvidovre University Hospital
Cirrhosis, Liver
Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis
Loss of skeletal muscle mass or sarcopenia is the most common and potentially reversible complication in cirrhosis that increases morbidity and mortality before, during and after liver transplantation.
- Trial name
- NCT03208868
- Testing
- Leucine enriched essential amino acid (EEA/LEU), Balanced amino acid supplement (BAA)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
NASH Related Cirrhosis
Effect of Metformin on Disease Progression in Patients With Cryptogenic Cirrhosis (NASH-related Cirrhosis) With Diabetes or Impaired Glucose Tolerance or Insulin Resistance
In this study, consecutive patients with cryptogenic cirrhosis (NASH-related cirrhosis), coming to ILBS (Institute of Liver \& Biliary Sciences) OPD (Out patient Department) or getting admitted in the ward will be enrolled on…
- Trial name
- NCT02234440
- Testing
- Metformin, Insulin
- Where
- India
- Volunteers
- 86 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Portal Hypertension, Clinically Significant Portal Hypertension
Assessment of Portal Hypertension With Multiparametric MRI
The purpose of this study is to determine whether new multiparametric magnetic resonance imaging (MRI) methods (including diffusion-weighted MRI, dynamic contrast-enhanced MRI, MR elastography and phase-contrast imaging) can be…
- Trial name
- NCT03436550
- Testing
- mpMRI, ARFI US
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cirrhosis With Septic Shock
Efficacy and Safety of Monotherapy With Noradrenaline and Terlipressin in Patients of Cirrhosis With Septic Shock Admitted to Intensive Care Unit
The Patient evaluated in Emergency room since admission and detailed history and clinical examination done .The in hospital cases where sepsis is the culprit and shifted to Intensive Care Unit (ICU) in view of septic shock were…
- Trial name
- NCT01836224
- Testing
- Terlipressin, Noradrenaline
- Where
- India
- Volunteers
- 84 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis
The Effect of a Personalized Protein- and Energy-optimized Diet on Muscle Strength in Adult Patients With Chronic Liver Disease
Liver cirrhosis can lead to weakness, frailty, and poor quality of life, even in patients whose disease is still in a relatively stable phase.
- Trial name
- NCT07625085
- Testing
- Individualized diet
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Roma La Sapienza
All Cause Mortality, Cardiovascular Diseases
Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality
The goal of this clinical trial is to test two advices on alcohol drinking in more than 10.000 Spanish adult drinkers (men of 50 or more years and women of 55 or more years).
- Conditions
- All Cause Mortality, Cardiovascular Diseases, Invasive Cancer, Liver Cirrhosis
- Trial name
- UNATI (NCT06338215)
- Testing
- Moderate Alcohol Drinking Pattern, Abstention
- Where
- Spain
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Liver Cirrhosis
Alfapump-albumin Replacement Therapy
The study will be a single centre, open-label trial. The patients will have a diagnosis of refractory ascites and will meet specified inclusion/exclusion criteria Informed consent will be obtained from all patients.
- Trial name
- NCT02448160
- Testing
- alfapump, salt-poor Human Albumin solution
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Sequana Medical N.V.
Chronic Liver Disease and Cirrhosis
Non-invasive Methods for Predicting Decompensation of Chronic Liver Disease
Preliminary studies have suggested that non-invasive methods can not only be applied to CSPH but also to predict the risk of decompensation in cirrhosis.
- Trial name
- NCT06741904
- Where
- China
- Volunteers
- 2,334 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Hepatic Encephalopathy, Liver Cirrhosis
Endoscopic Shunts Embolization for Refractory Hepatic Encephalopathy
The goal of this clinical trial is to learn if endoscopic ultrasound guided (EUS guided) spontaneous porto-systemic shunt (SPSS) embolization works to treat refractory hepatic encephalopathy in adults.
- Conditions
- Hepatic Encephalopathy, Liver Cirrhosis, Portal Shunt Systemic
- Trial name
- NCT07553858
- Testing
- Endoscopic ultrasound-guided transgastric embolization of the spontaneous portosystemic shunts, Interventional Radiology for shunt embolization/retrograde tranvenous obliteration
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Rutgers, The State University of New Jersey
NAFLD, NASH
The European NAFLD Registry
The European NAFLD Registry is a prospectively recruited, observational study supporting the study of the clinical phenotype, natural history, disease outcomes and pathophysiology of Non-Alcoholic Fatty Liver Disease and…
- Conditions
- NAFLD, NASH, NASH - Nonalcoholic Steatohepatitis, Fibrosis, Liver
- Trial name
- NCT04442334
- Where
- 37 sites in Belgium, Finland and 10 more
- Volunteers
- 10,000 people
- Sponsor
- Newcastle University
Liver Cirrhosis
Pentoxifylline Plus Carvedilol vs Carvedilol Monotherapy in Preventing New Decompensation in Stable Cirrhotic Patients With Prior Decompensation
Cirrhotics with decompensation have increased risk of morbidity and mortality. There is increased portal pressure leading to decompensation.
- Trial name
- NCT06041932
- Testing
- Carvedilol, Pentoxifylline
- Where
- India
- Volunteers
- 180 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Hepatocellular Carcinoma
Study of High-Dose Oral Vitamin D for the Prevention of Liver Cancer
The purpose of this study is to evaluate the safety and tolerability of a high dose of vitamin D (VD) in patients with cirrhosis.
- Trial name
- NCT01956864
- Testing
- Vitamin D
- Where
- United States
- Sponsor
- Johns Hopkins University
Decompensated Liver Cirrhosis
Mesenchymal Stem Cells Treatment for Decompensated Liver Cirrhosis
Decompensated liver cirrhosis is a life-threatening chronic liver disease with high mortality. Liver transplantation is the only option that can improve the survival of these patients; however, this procedure is associated with…
- Trial name
- NCT03945487
- Testing
- umbilical cord-derived mesenchymal stem cell, Comprehensive treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing 302 Hospital
Liver Cirrhosis, Ascites
Peritoneal Dialysis Catheters for the Treatment of Refractory Ascites
One complication of liver disease is the buildup of fluid within the belly. This is known as ascites. Patients who have ascites have a decreased appetite, pain, nausea and shortness of breath.
- Trial name
- NCT02975726
- Testing
- Peritoneal Dialysis Catheter, Large Volume Paracentesis, 25% Human Serum Albumin injection
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Manitoba
Hepatorenal Syndrome
Treatment of Type I Hepatorenal Syndrome (HRS) With Pentoxyfylline
Pentoxyfylline therapy in addition to the standard of care of albumin, midodrine and octreotide therapy is superior to the standard of care alone in the treatment of Type I hepatorenal syndrome in the first 14 days of…
- Trial name
- NCT02123576
- Testing
- Pentoxyfylline, AMO Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Patrick Northup, MD
Primary Biliary Cholangitis
A Study Observing Everyday Effectiveness and Safety of the Drug Elafibranor in Participants With Primary Biliary Cholangitis Who Are Receiving Ongoing Treatment
This study will collect information from participants with Primary Biliary Cholangitis (PBC) as they use the drug elafibranor in real world setting.
- Trial name
- ELFINITY (NCT06447168)
- Where
- 72 sites in United States, Australia and 9 more
- Volunteers
- 424 people
- Sponsor
- Ipsen
Muscle Cramps, Cirrhosis
Safety and Efficacy of Baclofen for Treatment of Muscle Spasms in Patients With Cirrhosis: A Pilot Study
The purpose of this study is to determine the safety and efficacy of the medication Baclofen for treatment of muscle cramps in patients with cirrhosis.
- Trial name
- NCT02298868
- Testing
- Baclofen
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Cirrhosis, Ascites Hepatic
Continuous Infusion Terlipressin for Patients With Cirrhosis and Refractory Ascites
Low-dose continuous infusion of terlipressin will be administered to six cirrhotic patients with refractory ascites.
- Trial name
- NCT03107091
- Testing
- Terlipressin acetate continuous infusion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- BioVie Inc.
Mobile Health, Liver Cirrhosis
Web-based Mobile Health Application for Patients With Liver Cirrhosis (ReLiver-N App)
This study evaluates the effect of a web-based mobile health application for patients with liver cirrhosis (ReLiver-N App) developed for enhancing patients' activation on the level of patient activation, self-efficacy, and…
- Conditions
- Mobile Health, Liver Cirrhosis, Patient Activation
- Trial name
- ReLiver-NApp (NCT05658393)
- Testing
- ReLiver-N App
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Akdeniz University
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