Clinical trials: Cirrhosis Liver
Intrahepatic Cholangiocarcinoma (Icc)
Liver Transplantation for Unresectable Intrahepatic Colangiocarcinoma After Sustained Response to Neoadjuvant Treatments
This is single-arm, observational, academic, investigator-driven study investigating the efficacy of liver transplantation after successful and sustained downstaging/tumor control of liver-limited unresectable intrahepatic…
- Trial name
- iCOLA (NCT06862934)
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Hepatitis B, Fibrosis and Cirrhosis of Liver
TAF Switch in F3/4 CHB pt With Partial Response to NUC (ESTAB-AFPVR)
A total of 80 adult chronic hepatitis B patients with advanced liver fibrosis (including fibrosis stage 3 and cirrhosis), who are currently on nucleot(s)ide analogs (except tenofovir alafenamide) therapy with detectable HBV DNA…
- Trial name
- NCT03798119
- Testing
- Tenofovir Alafenamide
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Hepatocellular Carcinoma
Serum Visfatin and Serum Vaspin in Patients With Hepatocellular Carcinoma on Top of Liver Cirrhosis
Hepatocellular carcinoma (HCC) has a global importance due to its high rate of progression and high mortality rates. Significant risk factors for the development of HCC are metabolic syndrome, obesity and type 2 diabetes…
- Trial name
- NCT04763707
- Where
- Egypt
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Sohag University
Esophageal Varices in Cirrhosis of the Liver
Gastric Slow Wave and Autonomic Nervous Function in Cirrhotic Patients With Esophageal Varices After Ligation-A Clinical Research
This study is intended to include 20 patients with esophageal varices caused by liver cirrhosis who were admitted to the first affiliated hospital of nanjing medical university from May 2019, and randomly select 8 patients with…
- Trial name
- NCT04125875
- Testing
- Electrogastrogram(EGG), Heart Rate Variability(HRV)
- Where
- China
- Volunteers
- 28 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cirrhosis, Liver, Liver Fibrosis
Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics
This 2-part study will evaluate PHIN-214 given as a single one-time dose (Part 1) and in multiple doses (given as daily doses for 28-days) (in Part 2).
- Conditions
- Cirrhosis, Liver, Liver Fibrosis, Ascites Hepatic
- Trial name
- NCT05490888
- Testing
- PHIN-214 Subcutaneous injection
- Where
- 9 sites in United States
- Volunteers
- 74 people
- Sponsor
- PharmaIN
Cirrhosis
Remote Electrical Stimulation for Pain and Depression Treatment in Cirrhosis
This study is being done to better understand how the study team can treat pain for people with cirrhosis and depression. Enrolled participants on this feasibility study will be randomized to Transcutaneous Electrical…
- Trial name
- RESTORE (NCT06932783)
- Testing
- Transcutaneous Electrical Acustimulation (TEA)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Cirrhosis With Spontaneous Bacterial Peritonitis
Clinical Study on the Effectiveness of Antibiotics Combined With Bifidobacterium Quadruple Live Tablets in Treating Cirrhosis With Spontaneous Bacterial Peritonitis and Preventing Recurrence
This is a prospective, randomized, double-blind, placebo-controlled multicenter clinical study targeting cirrhosis patients with Spontaneous Bacterial Peritonitis(SBP), aiming to evaluate whether adding Bifidobacterium quadruple…
- Trial name
- NCT07686861
- Testing
- Bifidobacterium quadruple live tablets
- Where
- 30 sites in China
- Volunteers
- 360 people
- Sponsor
- Peking University First Hospital
Cirrhosis, Liver, Splenectomy; Status
Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)
Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome).
- Conditions
- Cirrhosis, Liver, Splenectomy; Status, Renal Function Abnormal, Portal Hypertension
- Trial name
- LSD-RFPH (NCT07585786)
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Decompensated Liver Cirrhosis
An Follow-Up Study of Liver Cirrhosis
This is a follow-up study to assess safety and preliminary clinical activity of ADR-001 in patients with liver cirrhosis (Child-Pugh score; Grade B) caused by Hepatitis C or Nonalcoholic Steatohepatitis.
- Trial name
- NCT03472742
- Testing
- Mesenchymal Stem Cell
- Where
- Japan
- Volunteers
- 19 people
- Sponsor
- Rohto Pharmaceutical Co., Ltd.
End-stage Liver Diseases
Effect of Different Dosage of Umbilical Cord-mesenchymal Stem Cells Through Peripheral Vein in Patients With ESLD
There is a rise in the prevalence of end-stage liver disease during the last decade. End-stage liver disease has become one of the leading causes of death in Western countries.
- Trial name
- NCT06167473
- Testing
- umbilical cord-mesenchymal stem cells
- Where
- China
- Volunteers
- 22 people
- Sponsor
- General Hospital of Shenyang Military Region
Hepatitis, Autoimmune, Cholangitis
Remission Induction of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome
Biochemical response of primary biliary cholangitis-autoimmune hepatitis overlap syndrome induced by ursodeoxycholic acid only or combination therapy of immunosuppressive agents
- Conditions
- Hepatitis, Autoimmune, Cholangitis, Liver Cirrhosis, Biliary, Cholestasis
- Trial name
- NCT02936596
- Testing
- Ursodeoxycholic acid combination of immunosuppressive agents, Ursodeoxycholic Acid
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Xiaoli Fan
Hepatocellular Carcinoma
Prognostic Role of HVPG and ICG-R15 in the Short- and Medium-term Results of the Surgery of HCC on Cirrhosis
AIMS To evaluate the accuracy of HVPG (direct method), ICG-R15 and LSM/SSM (non-invasive methods) in predicting the risk of PHLF and hepatic decompensation; to evaluate the correlation between hepatic functional reserve (ICG-R15)…
- Trial name
- ProHype-ICG (NCT05800561)
- Testing
- Hepatic venous-portal gradient (HVPG) measurement
- Where
- Italy
- Volunteers
- 208 people
- Sponsor
- Federico II University
Cirrhosis
Sarcopenia and Cirrhosis
The study investigates the effect of aminoacid infusion on proteinturnover in muscle from cirrhosis subjects, compared to healthy controls.
- Trial name
- NCT02132962
- Testing
- Amino acid infusion, Bloodsamples, Biopsies.
- Where
- Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Steatohepatitis
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of AZD7503 in Participants With Suspected NASH.
The purpose of this study is to measure the safety, tolerability, and PK (measurement of drug activity in the body over time) of AZD7503 injected subcutaneously, and compared to placebo, in participants with suspected NASH, a…
- Trial name
- NCT05864391
- Testing
- AZD7503
- Where
- 10 sites in United States, Puerto Rico
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
End of Life Care, Liver Cirrhosis
Palliative Care for Patients With Liver Cirrhosis
Background: Patients with liver cirrhosis rarely receive palliative care although the Danish Health Authorities and WHO recommend it.
- Conditions
- End of Life Care, Liver Cirrhosis, Nurse-Patient Relations, Quality of Life
- Trial name
- LiverCare (NCT05431946)
- Testing
- Advance Care Planning and the consequent actions
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Liver Failure, Liver Cirrhosis
Study of Oxidized Albumin in Liver Transplant Patients
The overall goal is to describe the oxidation state of albumin before, during and after liver transplantation. This is a pilot observational study in which the oxidative state in 10 patients undergoing liver transplantation will…
- Conditions
- Liver Failure, Liver Cirrhosis, Liver Transplant Disorder
- Trial name
- SALT (NCT06772298)
- Volunteers
- 10 people
- Sponsor
- Region Stockholm
Liver Cirrhosis
Gabapentin in Treatment of Muscle Cramps in Patients With Liver Cirrhosis
Muscle cramps markedly affect the quality of life in cirrhotic patients with no highly effective drug. Quinine was suggested for treatment of patients with muscle cramps in patients with liver cirrhosis.
- Trial name
- NCT02642484
- Testing
- Gabapentin, Calcium Carbonate
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Tanta University
Cirrhosis
Carvedilol + VSL#3 Versus Endoscopic Variceal Ligation for Primary Prophylaxis of Esophageal Variceal Bleeding in Cirrhotic Patients Non Responder to Carvedilol.
Patients of cirrhosis will be enrolled who have large esophageal varices, which have never bled. After successful screening baseline hepatic venous pressure gradient (HVPG) will be measured.
- Trial name
- NCT01196481
- Testing
- Carvedilol+VSL#3, Endoscopic variceal ligation
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Splenectomy
Efficacy of Apixaban in Treating Portal Vein Thrombosis Occurring More Than One Year After LSD
The purpose of this study is to determine whether Apixaban is effective and safe in the treatment of portal vein thrombosis Occurring more than one year after laparoscopic splenectomy and azygoportal disconnection.
- Conditions
- Cirrhosis, Splenectomy, Portal Vein Thrombosis, Hypertension, Portal
- Trial name
- NCT07461532
- Testing
- Apixaban 2.5 MG
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Northern Jiangsu People's Hospital
Bacterial Infections
Clinical Efficacy and Population Pharmacokinetics of β-lactams in Cirrhotic Patients
Patients may benefit from the personalized β-lactams dosing strategy based on pharmacokinetics. The objective of this study is to retrospectively review, prospective observe and analyze the clinical outcomes of patients with…
- Trial name
- NCT07612163
- Testing
- β-lactams
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
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