Clinical trials: Cirrhosis Liver
Cirrhosis, Hepatocellular Carcinoma
Prospective Cohort for Early Detection of Liver Cancer
This study aims to recruit 3000 people with liver cirrhosis into a Prospective cohort for early detection of Liver cancer - the Pearl cohort.
- Trial name
- Pearl (NCT05541601)
- Testing
- Blood and Urine samples
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- University of Oxford
Lipid Profile, Blood Glucose
Prickly Pear Pulp Powder Along With an Anti-inflammatory Diet in Patients Having Liver Fibrosis
This RCT will evaluate the 12-week therapeutic effects of prickly pear pulp powder lozenges (0.5, 1.0, and 1.5 g/day) combined with an anti-inflammatory diet in adults with liver fibrosis (F1-F3).
- Conditions
- Lipid Profile, Blood Glucose, Liver Enzymes
- Trial name
- NCT07903103
- Testing
- Experimental
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis
Endohepatology-Based Reclassification of Treatment Indication in High-Risk MASLD
This prospective observational study evaluates whether endohepatology changes treatment indications in adults at high risk of metabolic dysfunction-associated steatotic liver disease.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis, Liver Fibrosis, Portal Hypertension
- Trial name
- ENDO-MASH (NCT07877272)
- Testing
- Non-invasive MASLD and portal hypertension assessment, Single-session endohepatology assessment
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital Muenster
Decompensated Cirrhosis, Portal Hypertension
The Effectiveness of L-ornithine-L-aspartate (LOLA) on Plasma Ammonia in Cirrhotic Patients After TIPS
The aim of this study is to evaluate the effectiveness of L-ornithine-L-aspartate (LOLA) on plasma ammonia in cirrhotic patients after Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedure.
- Conditions
- Decompensated Cirrhosis, Portal Hypertension, Bleeding Varices, Refractory Ascites
- Trial name
- NCT01440829
- Testing
- L-ornithine-L-aspartate
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Air Force Military Medical University, China
Spontaneous Bacterial Peritonitis
Asymptomatic Spontaneous Bacterial Peritonitis in Patients With Decompensated Liver Cirrhosis
Spontaneous bacterial peritonitis is defined as the presence of an infection in a previously sterile ascites in the absence of an intra-abdominal source of infection or malignancy .
- Trial name
- NCT03163745
- Testing
- paracentesis
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Fibrosis of Liver
Establishment of NAFLD Cohort and Development of Fibrosis Markers
This study is designed for establishment of non-alcoholic fatty liver disease patients cohort to development of markers to predict histologic progression of liver fibrosis.
- Trial name
- NAFLD (NCT02206841)
- Testing
- Liver biopsy, ARFI, SWE
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Boramae Hospital
Liver Fibrosis
Optimized Treatment and Regression of HBV-induced Liver Fibrosis
Patients with chronic hepatitis B histologically confirmed of liver fibrosis S2/S3 (similar to metavir F2/F3, Ishak 2/3/4) are randomly assigned in a 1:1 ratio.
- Trial name
- NCT01938781
- Testing
- entecavir, Peg-IFN
- Where
- 21 sites in China
- Volunteers
- 400 people
- Sponsor
- Beijing Friendship Hospital
Primary Biliary Cirrhosis
Pentoxifylline for Primary Biliary Cirrhosis
Primary biliary cirrhosis (PBC) is cholestatic liver disease characterized by progressive destruction of small bile ducts within the liver that can lead to end stage liver disease and all its complications.
- Trial name
- NCT01249092
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Peritonitis Bacterial, Liver Cirrhosis
Meropenem Pharmacokinetics in Spontaneous Bacterial Peritonitis
The emergence of multidrug-resistant bacteria has increased the use of meropenem in spontaneous bacterial peritonitis (SBP). Additionally, recent studies suggested female gender as an independent risk factor for mortality in SBP.
- Trial name
- NCT03571711
- Testing
- Meropenem Injection
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Hannover Medical School
Cirrhosis, Esophagogastric Varices
Clinical Management Strategies for Patients With Cirrhosis and Esophagogastric Varices Complicated by Early-stage Upper Gastrointestinal Cancer
Managing early-stage upper gastrointestinal cancer in patients with liver cirrhosis and esophagogastric varices (EGV) poses substantial clinical challenges.
- Conditions
- Cirrhosis, Esophagogastric Varices, Early-stage Upper Gastrointestinal Cancer
- Trial name
- NCT07368309
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Renmin Hospital of Wuhan University
Visceral Stiffness, Liver Fibrosis
Visceral Stiffness Measurement Using Acoustic Radiation Force Impulse
The acoustic radiation force impulse (ARFI) technology provides real-time measurements of tissue stiffness. Aim: Using the ARFI ultrasonography, the investigators aims are to complete the correlation and validity studies between…
- Trial name
- ARFI (NCT01311934)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Abdominal Obesity Metabolic Syndrome, HIV
Evaluation of Liver Fibrosis in HIV-infected Patients With Metabolic Syndrome
This study aims to estimate the prevalence of bridging liver fibrosis and cirrhosis (METAVIR score ≥ F2) according to METAVIR score in HIV infected patients not chronically infected by viral hepatitis but exhibiting a metabolic…
- Conditions
- Abdominal Obesity Metabolic Syndrome, HIV, Liver Fibrosis
- Trial name
- METAFIB (NCT02353767)
- Testing
- Noninvasive evaluation of liver fibrosis and steatosis
- Volunteers
- 478 people
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Liver Cirrhosis
To Study the Effects of Host Genetic Factors on Liver Cirrhosis
The purpose of this study is to identify genetic determinants of susceptibility to liver cirrhosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of…
- Trial name
- NCT05095181
- Testing
- SNP analysis of the DNA
- Where
- Kazakhstan
- Volunteers
- 1,000 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
Decompensated Cirrhosis, CMV Reactivation
Prospective Cohort Study of Complications and Outcomes in Cirrhosis
This is a multi-center, nested cohort study intended to investigate the prevalence, risk factors, and outcomes of complications in patients with acutely decompensated cirrhosis, especially focused on Cytomegalovirus (CMV)…
- Conditions
- Decompensated Cirrhosis, CMV Reactivation, Overt Hepatic Encephalopathy
- Trial name
- NCT06374511
- Testing
- Test for CMV reactivation
- Where
- China
- Volunteers
- 660 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Bleeding Esophageal Varices
RCT of Stent Versus Standard Therapy in Oesophageal Variceal Haemorrhage
The mortality rates from Acute Variceal Haemorrhage remain significant and first line therapy may fail in 15-25% of patients. The self-expandable metal stent has been described in case series as having a very high efficacy at…
- Trial name
- SOV (NCT01851564)
- Testing
- Self-expanding mesh-metal oesophageal stent (SEMS), Standard Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College, London
Liver Cirrhosis
Effect of Naltrexone in Achieving and Maintaining Abstinence From Alcohol in Patients With Cirrhosis.
The aim of the study is to study the safety and tolerability of Naltrexone in patients with Alcohol liver disease over a 12 week duration without liver related side effects.
- Trial name
- NCT04391764
- Testing
- Naltrexone
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatic Encephalopathy
Therapeutic Efficacy of Oral L-Ornithine-L-Aspartate on Minimal Encephalopathy
The study aimed to assess the effectiveness and safety of L-ornithine-L-aspartate in the management of hepatic encephalopathy.
- Trial name
- PORTOALEGRE (NCT00896831)
- Testing
- L-ornithine-L-aspartate
- Where
- Brazil
- Volunteers
- 96 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Type 2 Hepatorenal Syndrome, Refractory Ascites
The Use of Drugs to Improve Kidney Function in Patients With Liver and Kidney Dysfunction
We will address the hypothesis that refractory ascites and Type 2 hepatorenal syndrome are mediated in part by diminished circulatory volume and that treatment with midodrine, octreotide and albumin can improve renal and patient…
- Trial name
- NCT00240045
- Testing
- Midodrine, albumin, octreotide LAR, midodrine, octreotide, albumin
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- University of Alberta
Liver Cirrhosis, Chronic Hepatitis C
Pilot Study Of The Effect Of Rifaximin On B-Cell Dysregulation In Cirrhosis
Hepatitis C is the leading cause of chronic liver disease and cirrhosis in United States veterans. Cirrhosis is associated with impaired antibody responses and increased risk of bacterial infections.
- Trial name
- NCT01951209
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- David E. Kaplan, MD MSc
Liver Fibrosis, Alcohol Abuse
Efficacy of Simvastatin in Alcoholic Liver Fibrosis
Evaluate the efficacy of simvastatin in reducing liver fibrosis in patients with advanced fibrosis due to alcohol
- Trial name
- SIMFIB (NCT04971577)
- Testing
- Simvastatin 40mg
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Anna Cruceta
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