Clinical trials: Cirrhosis Liver
End Stage Liver Disease
Functional Assessment in Liver Transplantation
This will be a prospective cohort study of patients with liver disease. Subjects will undergo geriatric assessments of frailty, functional status, and disability using functional status measures at baseline and at every clinic…
- Trial name
- FrAILT (NCT03228290)
- Where
- 12 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- University of California, San Francisco
Non Alcoholic Steatohepatitis
Effect of Alternate Day Fasting Over Standard Medical Management Alone to Reverse Non-alcoholic Steatohepatitis.
The aims of this study are as follows: To compare the role of alternate-day fasting over standard medical management alone to reverse NASH.
- Trial name
- NCT06676813
- Testing
- Alternate day fasting
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis, Hyponatremia
Efficacy and Safety of Tolvaptan in Cirrhotic Patients With Hyponatremia
This is a phase IV, open-label, prospective cohort study for 7 days.The recommended starting dose of tolvaptan is 15 mg daily orally.
- Trial name
- OASIS (NCT01850940)
- Testing
- Tolvaptan, conventional thearpy
- Where
- 19 sites in China
- Volunteers
- 98 people
- Sponsor
- Beijing Friendship Hospital
Non Alcholic Fatty Liver Disease, Hepatic Steatosis
Efficacy of Sodium Glucose Cotransporter 2 Inhibitors on Non-Alcoholic Fatty Liver Disease
evaluate the effectiveness of sodium-glucose cotransporter-2 (SGLT.2) inhibitors in improving hepatic steatosis and hepatic fibrosis using imaging biomarkers and histopathology in patients with non-alcoholic fatty liver disease
- Conditions
- Non Alcholic Fatty Liver Disease, Hepatic Steatosis, Hepatic Fibrosis, NAFLD (Nonalcoholic Fatty Liver Disease)
- Trial name
- NCT06739486
- Volunteers
- 100 people
- Sponsor
- Assiut University
Hepatocellular Carcinoma, Multiple Tumors
Resection for Multiple Hepatocellular Carcinomas (HCC)
Surgical resection in patients with multiple hepatocellular carcinomas (HCC) remains controversial. The aim of this study was to investigate the outcome of a consecutive cohort of patients resected for multiple HCC, without…
- Conditions
- Hepatocellular Carcinoma, Multiple Tumors, Cirrhosis
- Trial name
- NCT01387061
- Testing
- hepatic resection
- Where
- Italy
- Volunteers
- 87 people
- Sponsor
- University of Milan
Liver Cirrhosis
PiCCO Guided Therapy in Liver Cirrhosis
Prospective comparison of standard therapy in liver cirrhosis versus standard therapy plus intensified hemodynamic monitoring using the PiCCO system.
- Trial name
- NCT00232427
- Testing
- Hemodynamic monitoring system PiCCO
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Heidelberg University
Primary Biliary Cholangitis
Combination Antiretroviral Therapy (cART) for PBC
Placebo Controlled, double-blind randomized controlled trial (RCT) with 12 months Tenofovir Disoproxil and Raltegravir for primary biliary cholangitis (PBC) patients unresponsive to Ursodeoxycholic Acid (UDCA).
- Trial name
- NCT03954327
- Testing
- Emtricitabine (FTC)/Tenofovir Disoproxil (TDF), Raltegravir
- Where
- 6 sites in Canada
- Volunteers
- 37 people
- Sponsor
- University of Alberta
Hepatic Encephalopathy
Efficacy and Safety of Nifuroxazide in the Treatment of Hepatic Encephalopathy in Egyptian Patients With Liver Cirrhosis
This is a pilot study designed to evaluate the efficacy and safety of nifuroxazide in the treatment of hepatic encephalopathy in patients with grade II-III hepatic encephalopathy
- Trial name
- NCT05754996
- Testing
- Nifuroxazide, Lactulose, Rifaximin 550Mg Tab
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Hypoalbuminemia, Hepatic Cirrhosis
A Study to Evaluate the Efficacy and Safety of OsrHSA in Patients of Hepatic Cirrhosis With Hypoalbuminemia
The goal of this clinical trial is to evaluate the efficacy of OsrHSA works to treat hypoalbuminemia in hepatic cirrhosis patients. It will also learn about the safety and immunogenicity of OsrHSA.
- Trial name
- NCT06355479
- Testing
- OsrHSA, Plasbumin®-20
- Where
- 37 sites in China
- Volunteers
- 328 people
- Sponsor
- Healthgen Biotechnology Corp.
Hepatic Impairment
A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD2389
The purpose of this study is to examine the safety and tolerability of AZD2389 in participants with hepatic impairment and participants with normal hepatic function.
- Trial name
- CAMPOLINA (NCT06812780)
- Testing
- AZD2389
- Where
- 5 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Liver Cirrhosis
ADAMTS-13 LEVEL AS PREDICTIVE BIOMARKER FOR DEVELOPMENT OF PORTAL VEIN THROMBOSIS IN LIVER CIRRHOSIS (ADAPTHRO)
Patients with cirrhosis of viral etiology (HCV/HBV); Patients with cirrhosis of any other etiology (alcohol, idiopatic, autoimmune).
- Trial name
- ADAPTHRO (NCT03322696)
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- Raimondo De Cristofaro
Liver Fibrosis, Hepatitis C
Study of Simtuzumab in HIV and/or Hepatitis C- Infected Adults With Liver Fibrosis
The primary objective of this study is to assess the safety and tolerability of simtuzumab (formerly GS-6624) in HIV and/or hepatitis C virus (HCV)-infected adults with evidence of liver fibrosis.
- Conditions
- Liver Fibrosis, Hepatitis C, HIV, HIV/HCV Co-infection
- Trial name
- NCT01707472
- Testing
- Simtuzumab
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Gilead Sciences
Intrahepatic Cholangiocarcinoma
VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF Receptor Mediated Pathway
The investigators study the VEGF signaling in ICC cell lines／human tissues and its mechanism in HCC growth, proliferation and apoptosis.
- Trial name
- icc (NCT01917370)
- Testing
- surgical treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hepatocellular Carcinoma, CHILD B
Palliative Treatment of Hepatocellular Carcinoma in Patient With CHILD B Cirrhosis
The incidence of Hepatocellular Carcinoma (HCC) is currently increasing in Europe and in France and about 2 / 3 of patients, are not eligible for curative treatment at the time of diagnosis.
- Trial name
- PRODIGE 21 (NCT01357486)
- Testing
- sorafenib, Pravastatin, Sorafenib + Pravastatin
- Where
- 35 sites in France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Bordeaux
Liver Cirrhosis
Faecal Microbiota Transplantation for Liver Cirrhosis
The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis.
- Trial name
- CHiFT (NCT04932577)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Neutrophil Extracellular Trap Formation, Portal Vein Thrombosis
Analysis of Neutrophil Extracellular Traps in Hypercoagulability and Portal Vein Thrombosis in Liver Cirrhosis Patients
The aim of this study was to investigate whether NETs markers can enhance procoagulant activity and predict portal vein thrombosis in patients with live cirrhosis, so as to establish a novel predictor to guide clinical…
- Conditions
- Neutrophil Extracellular Trap Formation, Portal Vein Thrombosis, Liver Cirrhosis
- Trial name
- NCT05012501
- Testing
- test NETs markers
- Where
- China
- Volunteers
- 79 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Ascites Hepatic, Cirrhosis, Liver
Continuous Passive Paracentesis for Intra-abdominal Hypertension
Liver cirrhosis patients in Intensive Care present intra-abdominal hypertension and this is an independent risk factor for increased organ disfunction and mortality.
- Conditions
- Ascites Hepatic, Cirrhosis, Liver, Hypertension, Intraabdominal, Critical Illness
- Trial name
- COPPTRIAHL (NCT04322201)
- Testing
- continuous drainage of ascitic fluid using an intra-abdominal double lumen central venous catheter, Ultrasound-guided intermittent large-volume paracentesis
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Chronic Hepatitis C
The SIM-SOF Trial for Hepatitis C
Randomized trial of Hepatitis C-genotype 1-infected patients with compensated cirrhosis comparing the standard of care (Peginterferon/Ribavirin/Sofosbuvir) versus the off-label combination of simeprevir+ sofosbuvir without…
- Trial name
- NCT02168361
- Testing
- Pegylated Interferon alfa-2b, Simeprevir, Ribavirin
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Center For Hepatitis C, Atlanta, GA
Liver Fibrosis
The Phase Ⅰd Clinical Trial of Hydronidone Capsules
Based on the Phase I (Ia, Ib, Ic) clinical pharmacokinetic study of Hydronidone Capsules, a clinical pharmacokinetic trial of Hydronidone Capsules (specification: 30 mg/capsule) was conducted, including single-dose…
- Trial name
- NCT07262346
- Testing
- Hydronidone capsules
- Where
- China
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Beijing Continent Pharmaceutical Co, Ltd.
Portal Hypertension, Liver Cirrhosis
Study to Assess Safety and Efficacy of Ifetroban for Treatment of Portal Hypertension in Cirrhotic Patients
This placebo-controlled study will assess the safety and efficacy of a 90-day course of treatment with ifetroban for portal hypertension in cirrhotic patients
- Trial name
- NCT02802228
- Testing
- Ifetroban
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Cumberland Pharmaceuticals
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